WO1996014791A2 - Indicateur universel pour etats physiologiques et pathologiques - Google Patents
Indicateur universel pour etats physiologiques et pathologiques Download PDFInfo
- Publication number
- WO1996014791A2 WO1996014791A2 PCT/US1995/014549 US9514549W WO9614791A2 WO 1996014791 A2 WO1996014791 A2 WO 1996014791A2 US 9514549 W US9514549 W US 9514549W WO 9614791 A2 WO9614791 A2 WO 9614791A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- measuring
- indicator
- results
- processing
- programs
- Prior art date
Links
- 230000001575 pathological effect Effects 0.000 title abstract description 3
- 210000004369 blood Anatomy 0.000 claims description 12
- 239000008280 blood Substances 0.000 claims description 12
- 238000012545 processing Methods 0.000 claims description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
- 201000010099 disease Diseases 0.000 claims description 5
- 230000000241 respiratory effect Effects 0.000 claims description 5
- 210000000748 cardiovascular system Anatomy 0.000 claims description 4
- 229940000032 cardiovascular system drug Drugs 0.000 claims description 4
- 238000011835 investigation Methods 0.000 claims description 4
- 230000029058 respiratory gaseous exchange Effects 0.000 claims description 4
- 210000000056 organ Anatomy 0.000 claims description 2
- 230000006870 function Effects 0.000 claims 2
- 238000005259 measurement Methods 0.000 claims 1
- 230000011664 signaling Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 description 11
- 238000011161 development Methods 0.000 description 5
- 208000010125 myocardial infarction Diseases 0.000 description 5
- 230000000747 cardiac effect Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 206010020772 Hypertension Diseases 0.000 description 2
- 206010061216 Infarction Diseases 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
- 230000006793 arrhythmia Effects 0.000 description 2
- 206010003119 arrhythmia Diseases 0.000 description 2
- 230000002526 effect on cardiovascular system Effects 0.000 description 2
- 210000003414 extremity Anatomy 0.000 description 2
- 230000007574 infarction Effects 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 230000002746 orthostatic effect Effects 0.000 description 2
- BQENDLAVTKRQMS-SBBGFIFASA-L Carbenoxolone sodium Chemical compound [Na+].[Na+].C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C([O-])=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](OC(=O)CCC([O-])=O)C1(C)C BQENDLAVTKRQMS-SBBGFIFASA-L 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 206010027727 Mitral valve incompetence Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000037273 Pathologic Processes Diseases 0.000 description 1
- 208000008784 apnea Diseases 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000001772 blood platelet Anatomy 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 230000002802 cardiorespiratory effect Effects 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000002847 impedance measurement Methods 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000004081 narcotic agent Substances 0.000 description 1
- 210000003540 papillary muscle Anatomy 0.000 description 1
- 230000009054 pathological process Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000009979 protective mechanism Effects 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000002861 ventricular Effects 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6802—Sensor mounted on worn items
- A61B5/681—Wristwatch-type devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
Definitions
- This invention relates to the medical technique and is used as an indicator for health control, in cases of the origination of the following diseases and in the process of their treatment.
- Patent FRANCE 35484 A6lb "A rheoplethsmographic device”. 19.10.70.
- Patent ISRAEL 71468 A61b Apnea monitoring method and apparatus. 8.4.84.
- All the mentioned methods are a posteriori ones, i.e., determine the fact of already occurred infarction or determine the organical cardio-vascular changes by way of traumatic intravascular influence (introduction of contrast substances or a catheter) ; - A part of these methods is intended for impedance determination of some blood parameters by way of taking test blood samples;
- Medical information about the state of organism is derived from information, which is included in changes curves of the there channel E.C., of a part of the body by means of specific processing of the results of measuring of, these curves against of background of the noise.
- the device will be done in the form of a "clock" (Fig. 1) for its permanent use on a hand wrist.
- Fig. 2 Functional scheme of the device is shown on Fig. 2. Electrical signals from sensors (1) , against of the background of high-frequency tension is created by a generator (3) , is taken from measuring bridge (2) measuring system (4) .
- the micro-processor (5) receives the signals in digital form after analog -digital converter (5) in the processing of programs, registered in permanent memory (7). The results of the processing appear on the digital indicator (8) of the device if the "danger" is surpassing the threshold for alarm (9) .
- the principal method of obtaining the medical information by measuring E.C. of a body is shown on an example of indication of the cardio-vascular state, with the purposes of preventing an myocardial infarction.
- the increase of the E.C. basic component (Fig. 1) is caused by the increase in blood viscosity due to the increase of thrombocytes adhesiveness, growth of plasmic fibrogen and hematokrit.
- hypermolesteria the increase of the lipoproteins by more than 180 g/dl and triglycerides by more than 150 mg/dl.
- FIG 1. The increase of the E.C. Basic Component 2.
- FIG. 2 The increase in time of restoring the E.C. Basic component during the orthostatic test.
- FIG. 3 The increase in the forefront steepness of the E.C. pulse component in the case of hypertension. 4.
- the change of E.C. pulse components is causing the appearance of "spikes" on the smooth surfaces (Fig. 4) .
- the change of form is expressed in the appearance of an additional great "tooth” in a systolic part of the pulse component. This effect comes as result of the mitral regurgitation due to the ischemia of the cardiac papillary muscles (holosystolic noise) .
- FIG. 4. The change of the E.C. pulse component form.
- the arrhythmia of the E.C. pulse component (change in periodicity) or the increase in the frequency of the arrhythmia in case of development of cardiac ventricular arrhythmi .
- FIG. 5 The increase in the amplitude and frequency of the E.C. respiratory component.
- the alarm signal (a possibility of myocardial infarction) is given on the basis of a simultaneous registration of all the signs or, at least, of the majority of them.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Physics & Mathematics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
L'appareil de l'invention permet de contrôler la conductivité électrique d'une personne et détermine les états physiologiques ou pathologiques, et peut éventuellement déclencher une alarme lorsque des états graves sont indiqués.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL111535941106 | 1994-11-06 | ||
| IL11153594A IL111535A0 (en) | 1994-11-06 | 1994-11-06 | Universal indicator for physiological and pathological conditions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1996014791A2 true WO1996014791A2 (fr) | 1996-05-23 |
Family
ID=11066732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1995/014549 WO1996014791A2 (fr) | 1994-11-06 | 1995-11-06 | Indicateur universel pour etats physiologiques et pathologiques |
Country Status (2)
| Country | Link |
|---|---|
| IL (1) | IL111535A0 (fr) |
| WO (1) | WO1996014791A2 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999065390A1 (fr) | 1998-06-17 | 1999-12-23 | Nimeda Ltd. | Surveillance non-invasive de parametres physiologiques |
-
1994
- 1994-11-06 IL IL11153594A patent/IL111535A0/xx unknown
-
1995
- 1995-11-06 WO PCT/US1995/014549 patent/WO1996014791A2/fr active Application Filing
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999065390A1 (fr) | 1998-06-17 | 1999-12-23 | Nimeda Ltd. | Surveillance non-invasive de parametres physiologiques |
Also Published As
| Publication number | Publication date |
|---|---|
| IL111535A0 (en) | 1995-01-24 |
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