WO1996014570A9 - Dispositif d'echantillonnage autonome generateur de signaux et ses modes d'utilisation - Google Patents
Dispositif d'echantillonnage autonome generateur de signaux et ses modes d'utilisationInfo
- Publication number
- WO1996014570A9 WO1996014570A9 PCT/US1995/013147 US9513147W WO9614570A9 WO 1996014570 A9 WO1996014570 A9 WO 1996014570A9 US 9513147 W US9513147 W US 9513147W WO 9614570 A9 WO9614570 A9 WO 9614570A9
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sampling
- lower housing
- sample
- signal generating
- nutrient
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 22
- 238000005070 sampling Methods 0.000 title claims description 64
- 239000000203 mixture Substances 0.000 claims abstract description 30
- 108060001084 Luciferase Proteins 0.000 claims abstract description 28
- 239000005089 Luciferase Substances 0.000 claims abstract description 27
- IGXWBGJHJZYPQS-SSDOTTSWSA-N D-Luciferin Chemical compound OC(=O)[C@H]1CSC(C=2SC3=CC=C(O)C=C3N=2)=N1 IGXWBGJHJZYPQS-SSDOTTSWSA-N 0.000 claims abstract description 25
- CYCGRDQQIOGCKX-UHFFFAOYSA-N Dehydro-luciferin Natural products OC(=O)C1=CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 CYCGRDQQIOGCKX-UHFFFAOYSA-N 0.000 claims abstract description 25
- BJGNCJDXODQBOB-UHFFFAOYSA-N Fivefly Luciferin Natural products OC(=O)C1CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 BJGNCJDXODQBOB-UHFFFAOYSA-N 0.000 claims abstract description 25
- DDWFXDSYGUXRAY-UHFFFAOYSA-N Luciferin Natural products CCc1c(C)c(CC2NC(=O)C(=C2C=C)C)[nH]c1Cc3[nH]c4C(=C5/NC(CC(=O)O)C(C)C5CC(=O)O)CC(=O)c4c3C DDWFXDSYGUXRAY-UHFFFAOYSA-N 0.000 claims abstract description 25
- 239000000463 material Substances 0.000 claims abstract description 24
- 241000894006 Bacteria Species 0.000 claims abstract description 22
- 231100000331 toxic Toxicity 0.000 claims abstract description 19
- 230000002588 toxic effect Effects 0.000 claims abstract description 19
- 239000012530 fluid Substances 0.000 claims description 51
- 238000012360 testing method Methods 0.000 claims description 35
- 239000000126 substance Substances 0.000 claims description 34
- 239000003708 ampul Substances 0.000 claims description 24
- 238000005406 washing Methods 0.000 claims description 18
- 230000001580 bacterial effect Effects 0.000 claims description 17
- 238000000926 separation method Methods 0.000 claims description 16
- 238000011109 contamination Methods 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 12
- 239000011521 glass Substances 0.000 claims description 9
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 8
- 239000012528 membrane Substances 0.000 claims description 7
- 239000002250 absorbent Substances 0.000 claims description 5
- 230000002745 absorbent Effects 0.000 claims description 5
- 238000005415 bioluminescence Methods 0.000 claims description 4
- 230000029918 bioluminescence Effects 0.000 claims description 4
- 229910001629 magnesium chloride Inorganic materials 0.000 claims description 4
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 3
- 238000011069 regeneration method Methods 0.000 claims description 2
- 235000015097 nutrients Nutrition 0.000 claims 2
- 230000006835 compression Effects 0.000 claims 1
- 238000007906 compression Methods 0.000 claims 1
- 230000008929 regeneration Effects 0.000 claims 1
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 12
- 238000004806 packaging method and process Methods 0.000 description 10
- 230000004888 barrier function Effects 0.000 description 9
- 239000012620 biological material Substances 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 8
- 241000894007 species Species 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- 235000013305 food Nutrition 0.000 description 5
- 229910001385 heavy metal Inorganic materials 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- 241000588724 Escherichia coli Species 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- -1 porex Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 230000034994 death Effects 0.000 description 3
- 231100000517 death Toxicity 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000004020 luminiscence type Methods 0.000 description 3
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 3
- 229910052753 mercury Inorganic materials 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 3
- 235000019345 sodium thiosulphate Nutrition 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 241000186781 Listeria Species 0.000 description 2
- 241000607142 Salmonella Species 0.000 description 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000001627 detrimental effect Effects 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 235000013410 fast food Nutrition 0.000 description 2
- 239000011888 foil Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 230000003472 neutralizing effect Effects 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 108090000363 Bacterial Luciferases Proteins 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 229920004934 Dacron® Polymers 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241001646716 Escherichia coli K-12 Species 0.000 description 1
- 241000206602 Eukaryota Species 0.000 description 1
- 229920002444 Exopolysaccharide Polymers 0.000 description 1
- 108090000157 Metallothionein Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 241001148064 Photorhabdus luminescens Species 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 229920000297 Rayon Polymers 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 102000005936 beta-Galactosidase Human genes 0.000 description 1
- 108010005774 beta-Galactosidase Proteins 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000005388 borosilicate glass Substances 0.000 description 1
- 229910052793 cadmium Inorganic materials 0.000 description 1
- BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 235000013351 cheese Nutrition 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 231100000463 ecotoxicology Toxicity 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 239000002440 industrial waste Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 231100000719 pollutant Toxicity 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 239000005297 pyrex Substances 0.000 description 1
- 239000002964 rayon Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 238000011012 sanitization Methods 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- AXVOAMVQOCBPQT-UHFFFAOYSA-N triphos Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)CCP(C=1C=CC=CC=1)CCP(C=1C=CC=CC=1)C1=CC=CC=C1 AXVOAMVQOCBPQT-UHFFFAOYSA-N 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 238000013022 venting Methods 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
Definitions
- the luciferase gene may be cloned behind a promoter that is activated by various substances, for example, heavy metals. Upon the addition of a sample containing activating toxic material, for example, heavy- metals, luciferase will be produced providing a detectable signal. Construction of a bacterial plas id may be done as is known in the art and as set forth in Molecular Cloning, a Laboratory Manual Second Edition, Sambrook et al . , incorporated herein by reference. Heavy metal inducible promoters and/or bacterial bioluminescent sensor strategies are disclosed in the following publications: Abstracts of the American Society for Microbiology, 93 general Meeting 16-20 May 1993, Atlanta Georgia; Abstract No.
Abstract
L'invention concerne un dispositif autonome générateur de signaux et ses modes d'utilisation. Le dispositif et ses modes d'utilisation peuvent détecter la présence de matières biologiques ou toxiques, et peut faire appel, entre autres compositions, à une composition de luciférine/luciférase, à des milieux indicateurs de nutriment ou à des bactéries bioluminescentes pour émettre un signal indiquant la présence de matière biologique ou toxique.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33685194A | 1994-11-07 | 1994-11-07 | |
| US08/336,851 | 1994-11-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1996014570A1 WO1996014570A1 (fr) | 1996-05-17 |
| WO1996014570A9 true WO1996014570A9 (fr) | 1996-09-19 |
Family
ID=23317948
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1995/013147 WO1996014570A1 (fr) | 1994-11-07 | 1995-10-17 | Dispositif d'echantillonnage autonome generateur de signaux et ses modes d'utilisation |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO1996014570A1 (fr) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5827675A (en) * | 1995-07-12 | 1998-10-27 | Charm Sciences, Inc. | Test apparatus, system and method for the detection of test samples |
| TW491892B (en) * | 1996-11-07 | 2002-06-21 | Srl Inc | Apparatus for detecting microorganism |
| GB9626101D0 (en) * | 1996-12-16 | 1997-02-05 | Celsis Int Plc | Assay device |
| DE19726268A1 (de) * | 1997-06-20 | 1999-01-21 | Connex Ges Zur Optimierung Von | Vorrichtung zur Aufnahme und Untersuchung von Proben |
| WO1999031218A1 (fr) * | 1997-12-16 | 1999-06-24 | Celsis International Plc | Dispositif de dosage et de prelevement d'echantillon |
| DE69940067D1 (de) * | 1998-08-14 | 2009-01-22 | Biocontrol Systems Inc | Ger einheiten die zielmaterialbindende farbstoffe gebrauchen |
| KR100353617B1 (ko) * | 1999-06-21 | 2002-09-26 | 광주과학기술원 | 발광성 미생물을 이용한 독성물질의 분해도 및 처리공정효율평가 방법 |
| EP1289659B1 (fr) | 2000-06-02 | 2005-01-26 | BioControl Systems, Inc. | Dispositifs autonomes de detection de contaminants biologiques |
| FR2849861B1 (fr) * | 2003-01-09 | 2005-04-15 | Giat Ind Sa | Detecteur biologique |
| US7132249B1 (en) | 2003-05-12 | 2006-11-07 | Charm Sciences, Inc. | Method of determining allergenic food on surfaces |
| US7494781B1 (en) | 2003-05-12 | 2009-02-24 | Charm Sciences, Inc. | Sensitive method for detecting low levels of ATP |
| US7863053B2 (en) | 2003-12-23 | 2011-01-04 | Kimberly-Clark Worldwide, Inc. | Swab-based diagnostic systems |
| US7098040B2 (en) | 2003-12-23 | 2006-08-29 | Kimberly-Clark Worldwide, Inc. | Self-contained swab-based diagnostic systems |
| WO2006069053A2 (fr) | 2004-12-22 | 2006-06-29 | Charm Sciences, Inc. | Dispositif et procede d'echantillonnage |
| TW200714898A (en) | 2005-08-02 | 2007-04-16 | 3M Innovative Properties Co | Apparatus and method for detecting an analyte |
| TW200712487A (en) * | 2005-08-02 | 2007-04-01 | 3M Innovative Properties Co | Apparatus and method for detecting an analyte |
| US8476064B2 (en) | 2006-05-09 | 2013-07-02 | Charm Sciences, Inc. | Inhibition assay method and device for detection of antibiotics |
| US8506898B2 (en) | 2007-07-16 | 2013-08-13 | Perez Forensic Strategies, Llc | Specimen gathering device and method of use |
| JP2012503988A (ja) * | 2008-09-30 | 2012-02-16 | スリーエム イノベイティブ プロパティズ カンパニー | 生物学的検出物品 |
| US8609330B2 (en) | 2008-12-31 | 2013-12-17 | 3M Innovative Properties Company | Live Bioload detection using microparticles |
| WO2010129726A1 (fr) * | 2009-05-06 | 2010-11-11 | 3M Innovative Properties Company | Articles à matrice comprenant un agent d'extraction cellulaire et procédés de biodétection associés |
| WO2010129728A2 (fr) * | 2009-05-06 | 2010-11-11 | 3M Innovative Properties Company | Articles avec structures en couches contenant un agent d'extraction cellulaire et méthodes de biodétection associées |
| WO2010129727A1 (fr) * | 2009-05-06 | 2010-11-11 | 3M Innovative Properties Company | Substrats enduits comprenant un agent extracteur cellulaire et procédés de biodétection associés |
| USD759520S1 (en) | 2015-03-13 | 2016-06-21 | 3M Innovative Properties Company | Handheld luminometer |
| USD758224S1 (en) | 2015-03-13 | 2016-06-07 | 3M Innovative Properties Company | Handheld luminometer |
| US10488249B2 (en) | 2015-03-13 | 2019-11-26 | 3M Innovative Properties Company | Light detection system and method of using same |
| WO2016149017A1 (fr) | 2015-03-13 | 2016-09-22 | 3M Innovative Properties Company | Système de détection de lumière et son procédé d'utilisation |
| CN107430075B (zh) | 2015-03-13 | 2020-11-24 | 3M创新有限公司 | 光检测系统及其使用方法 |
| CN107159345A (zh) * | 2017-07-08 | 2017-09-15 | 孙少朋 | 一种能动手学习7大创新原则和43个发明原理的学习桌 |
| IT202200025407A1 (it) * | 2022-12-13 | 2024-06-13 | Nova Health S R L | Dispositivo e metodo di raccolta per il trasporto e la processazione di campioni biologici in filiera totalmente sterile |
| WO2024127437A1 (fr) * | 2022-12-13 | 2024-06-20 | Nova Health S.R.L. | Dispositif de collecte et procédé de transport et de traitement d'échantillons biologiques dans une chaîne d'approvisionnement totalement stérile |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4207394A (en) * | 1976-01-28 | 1980-06-10 | Mcdonnell Douglas Corporation | Process and apparatus for analyzing specimens for the presence of microorganisms therein |
| CA1103050A (fr) * | 1977-09-28 | 1981-06-16 | Anthony A. Bulich | Methode de detection de substances toxiques dans un liquide |
| JPH02104273A (ja) * | 1988-10-12 | 1990-04-17 | Ricoh Co Ltd | 液体検知装置 |
| US5108889A (en) * | 1988-10-12 | 1992-04-28 | Thorne, Smith, Astill Technologies, Inc. | Assay for determining analyte using mercury release followed by detection via interaction with aluminum |
| EP0572637B1 (fr) * | 1990-12-13 | 2000-03-29 | NASON, Frederic L. | Unite de test de specimens |
| US5188965A (en) * | 1991-03-18 | 1993-02-23 | Difco Laboratories | Reagent source for chemiluminescent reactions, test kit, and method for use |
| GB9114265D0 (en) * | 1991-07-02 | 1991-08-21 | Amersham Int Plc | Sampling device |
| ES2106198T3 (es) * | 1991-11-01 | 1997-11-01 | Univ Birmingham | Dispositivo de analisis. |
| US5313959A (en) * | 1993-04-21 | 1994-05-24 | Becton, Dickinson And Company | Device and method for breaking an ampoule |
| GB9405590D0 (en) * | 1994-03-22 | 1994-05-11 | Celsis Ltd | Assay device |
-
1995
- 1995-10-17 WO PCT/US1995/013147 patent/WO1996014570A1/fr active Application Filing
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