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WO1996011680A3 - Use of gaba agonists in the treatment of emesis - Google Patents

Use of gaba agonists in the treatment of emesis Download PDF

Info

Publication number
WO1996011680A3
WO1996011680A3 PCT/EP1995/004025 EP9504025W WO9611680A3 WO 1996011680 A3 WO1996011680 A3 WO 1996011680A3 EP 9504025 W EP9504025 W EP 9504025W WO 9611680 A3 WO9611680 A3 WO 9611680A3
Authority
WO
WIPO (PCT)
Prior art keywords
emesis
treatment
gaba agonists
agonists
gaba
Prior art date
Application number
PCT/EP1995/004025
Other languages
French (fr)
Other versions
WO1996011680A2 (en
Inventor
David Edmund Bays
Charanjit Bountra
Original Assignee
Glaxo Group Ltd
David Edmund Bays
Charanjit Bountra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd, David Edmund Bays, Charanjit Bountra filed Critical Glaxo Group Ltd
Priority to AU37458/95A priority Critical patent/AU3745895A/en
Publication of WO1996011680A2 publication Critical patent/WO1996011680A2/en
Publication of WO1996011680A3 publication Critical patent/WO1996011680A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to the use of selected GABA agonists having an agonist action at GABAB receptors in the treatment of emesis.
PCT/EP1995/004025 1994-10-14 1995-10-12 Use of gaba agonists in the treatment of emesis WO1996011680A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU37458/95A AU3745895A (en) 1994-10-14 1995-10-12 Use of gaba antagonists in the treatment of emesis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9420784A GB9420784D0 (en) 1994-10-14 1994-10-14 Medicaments

Publications (2)

Publication Number Publication Date
WO1996011680A2 WO1996011680A2 (en) 1996-04-25
WO1996011680A3 true WO1996011680A3 (en) 1996-06-27

Family

ID=10762886

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1995/004025 WO1996011680A2 (en) 1994-10-14 1995-10-12 Use of gaba agonists in the treatment of emesis

Country Status (3)

Country Link
AU (1) AU3745895A (en)
GB (1) GB9420784D0 (en)
WO (1) WO1996011680A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE41920E1 (en) 1996-07-24 2010-11-09 Warner-Lambert Company Llc Isobutylgaba and its derivatives for the treatment of pain

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999008670A1 (en) * 1997-08-20 1999-02-25 Guglietta, Antonio Gaba analogs to prevent and treat gastrointestinal damage
US6127418A (en) * 1997-08-20 2000-10-03 Warner-Lambert Company GABA analogs to prevent and treat gastrointestinal damage
EP0974351A3 (en) * 1998-04-24 2000-12-13 Jouveinal Medicament for preventing and treating gastrointestinal damage
US7309719B1 (en) * 1998-05-15 2007-12-18 Warner Lambert Company, Llc Stabilized pharmaceutical preparation of gamma-aminobutyric acid derivatives and process for preparing the same
EP1031350A1 (en) * 1999-02-23 2000-08-30 Warner-Lambert Company Use of a gabapentin-analog for the manufacture of a medicament for preventing and treating visceral pain
US7319095B2 (en) 1999-12-09 2008-01-15 Astrazeneca Ab Use of GABAB receptor agonists
SE9904507D0 (en) 1999-12-09 1999-12-09 Astra Ab New compounds
SE9904508D0 (en) 1999-12-09 1999-12-09 Astra Ab New compounds
AR033779A1 (en) 2001-06-08 2004-01-07 Astrazeneca Ab USEFUL COMPOUNDS IN REFLUX DISEASE
US20050090554A1 (en) * 2003-09-12 2005-04-28 John Devane Treatment of gastroparesis and nonulcer dyspepsia with GABAB agonists
WO2017046117A1 (en) 2015-09-15 2017-03-23 Abbvie Inc. Substituted isoxazolopyridazinones and isothiazolopyridazinones and methods of use
WO2018048868A1 (en) * 2016-09-07 2018-03-15 The Children's Hospital Of Philadelphia Nonselective metabotropic glutamate receptor activators for treatment of anorexia nervosa and binge eating disorder
CN111603560A (en) * 2020-06-22 2020-09-01 泉州台商投资区秋鑫茶业有限公司 Application of tea gamma-aminobutyric acid in tumor radiotherapy

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3896149A (en) * 1972-06-07 1975-07-22 Sakai Chemical Industry Co Novel pyrrolidone derivatives and manufacturing the same
EP0082369A1 (en) * 1981-12-19 1983-06-29 MERCK PATENT GmbH Imidazo (4,5-c) pyridines, pharmaceutical compositions containing them and process for their preparation
GB2185483A (en) * 1986-01-21 1987-07-22 Nippon Shinyaku Co Ltd Pyroglutamide derivatives
US4952573A (en) * 1988-03-23 1990-08-28 Laboratoirs Alcon S.A. Compounds having GABA like activity, and use of same in tissue irrigating solutions
US5182290A (en) * 1991-08-27 1993-01-26 Neurogen Corporation Certain oxazoloquinolinones; a new class of GABA brain receptor ligands
WO1993011138A1 (en) * 1991-12-02 1993-06-10 John Wyeth & Brother Limited Amine derivatives containing a phosphonic, phosphonous or phosphinic acid moiety
WO1993022314A1 (en) * 1992-04-30 1993-11-11 Neurogen Corporation Certain aryl and cycloalkyl fused imidazopyrazinediones; a new class of gaba brain receptor ligands
US5281747A (en) * 1989-05-13 1994-01-25 Ciba-Geigy Corporation Substituted aminoalkylphosphinic acids
WO1994025016A1 (en) * 1993-04-23 1994-11-10 Glaxo Group Limited Novel medical use for gaba agonists

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3896149A (en) * 1972-06-07 1975-07-22 Sakai Chemical Industry Co Novel pyrrolidone derivatives and manufacturing the same
EP0082369A1 (en) * 1981-12-19 1983-06-29 MERCK PATENT GmbH Imidazo (4,5-c) pyridines, pharmaceutical compositions containing them and process for their preparation
GB2185483A (en) * 1986-01-21 1987-07-22 Nippon Shinyaku Co Ltd Pyroglutamide derivatives
US4952573A (en) * 1988-03-23 1990-08-28 Laboratoirs Alcon S.A. Compounds having GABA like activity, and use of same in tissue irrigating solutions
US5281747A (en) * 1989-05-13 1994-01-25 Ciba-Geigy Corporation Substituted aminoalkylphosphinic acids
US5182290A (en) * 1991-08-27 1993-01-26 Neurogen Corporation Certain oxazoloquinolinones; a new class of GABA brain receptor ligands
WO1993011138A1 (en) * 1991-12-02 1993-06-10 John Wyeth & Brother Limited Amine derivatives containing a phosphonic, phosphonous or phosphinic acid moiety
WO1993022314A1 (en) * 1992-04-30 1993-11-11 Neurogen Corporation Certain aryl and cycloalkyl fused imidazopyrazinediones; a new class of gaba brain receptor ligands
WO1994025016A1 (en) * 1993-04-23 1994-11-10 Glaxo Group Limited Novel medical use for gaba agonists

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"Baclofen for intractable vomiting in muscular dystrophy", LANCET, pages 227, XP000563383 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE41920E1 (en) 1996-07-24 2010-11-09 Warner-Lambert Company Llc Isobutylgaba and its derivatives for the treatment of pain

Also Published As

Publication number Publication date
AU3745895A (en) 1996-05-06
WO1996011680A2 (en) 1996-04-25
GB9420784D0 (en) 1994-11-30

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