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WO1996011562A3 - Human checkpoint gene and gene for antisense rna thereof - Google Patents

Human checkpoint gene and gene for antisense rna thereof Download PDF

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Publication number
WO1996011562A3
WO1996011562A3 PCT/US1995/012445 US9512445W WO9611562A3 WO 1996011562 A3 WO1996011562 A3 WO 1996011562A3 US 9512445 W US9512445 W US 9512445W WO 9611562 A3 WO9611562 A3 WO 9611562A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene
rap
antisense rna
human
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1995/012445
Other languages
French (fr)
Other versions
WO1996011562A2 (en
Inventor
Dan Canaani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ramot at Tel Aviv University Ltd
Original Assignee
Ramot at Tel Aviv University Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ramot at Tel Aviv University Ltd filed Critical Ramot at Tel Aviv University Ltd
Priority to US08/817,436 priority Critical patent/US5882880A/en
Priority to AU37306/95A priority patent/AU3730695A/en
Publication of WO1996011562A2 publication Critical patent/WO1996011562A2/en
Publication of WO1996011562A3 publication Critical patent/WO1996011562A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A human radiation protecting checkpoint (RAP-1) gene and the RAP-1 protein encoded by the gene are claimed. RAP-1 is believed to be involved in the regulation of cell cycle progression and/or programmed cell death (apoptosis). A human antisense RNA which can bind to the mRNA of the human RAP-1 protein, as well as the DNA from which the antisense RNA is transcribed are also claimed. Additionally, a method for isolating DNA damage-monitoring checkpoint genes is described. The use of the DNA and RNA sequences and of the protein of the invention for the early detection, prevention and/or treatment of cancer, AIDS and other diseases is also disclosed.
PCT/US1995/012445 1994-10-11 1995-10-11 Human checkpoint gene and gene for antisense rna thereof Ceased WO1996011562A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US08/817,436 US5882880A (en) 1994-10-11 1995-10-11 Human checkpoint gene and gene for antisense RNA thereof
AU37306/95A AU3730695A (en) 1994-10-11 1995-10-11 Human checkpoint gene and gene for antisense RNA thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL111238 1994-10-11
IL11123894A IL111238A (en) 1994-10-11 1994-10-11 Human checkpoint gene and gene for antisense rna thereof

Publications (2)

Publication Number Publication Date
WO1996011562A2 WO1996011562A2 (en) 1996-04-25
WO1996011562A3 true WO1996011562A3 (en) 1996-10-24

Family

ID=11066634

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/012445 Ceased WO1996011562A2 (en) 1994-10-11 1995-10-11 Human checkpoint gene and gene for antisense rna thereof

Country Status (3)

Country Link
AU (1) AU3730695A (en)
IL (1) IL111238A (en)
WO (1) WO1996011562A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5882880A (en) * 1994-10-11 1999-03-16 Ramot University Authority For Applied And Industrial Development Ltd. Human checkpoint gene and gene for antisense RNA thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993023571A1 (en) * 1992-05-12 1993-11-25 Fred Hutchinson Cancer Research Center Human cell cycle checkpoint genes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993023571A1 (en) * 1992-05-12 1993-11-25 Fred Hutchinson Cancer Research Center Human cell cycle checkpoint genes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL "yr12d06.r1 Soares fetal liver spleen 1NFLS Homo sapiens cDNA clone IMAGE:205067 5', mRNA sequence.", XP002005781 *
JEGGO, P. A. ET AL: "Cloning human DNA repair genes", INT. J. RADIAT. BIOL. (1994), 66(5), 573-7 CODEN: IJRBE7;ISSN: 0955-3002, 1994, XP002005780 *
KUERBITZ, STEVEN J. ET AL: "Wild-type p53 is a cell cycle checkpoint determinant following irradiation", PROC. NATL. ACAD. SCI. U. S. A. (1992), 89(16), 7491-5 CODEN: PNASA6;ISSN: 0027-8424, 1992, XP002005779 *

Also Published As

Publication number Publication date
WO1996011562A2 (en) 1996-04-25
AU3730695A (en) 1996-05-06
IL111238A0 (en) 1994-12-29
IL111238A (en) 2003-05-29

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