[go: up one dir, main page]

WO1996011269B1 - Ligands tie-2, peocedes de production et utilisations de ces ligands - Google Patents

Ligands tie-2, peocedes de production et utilisations de ces ligands

Info

Publication number
WO1996011269B1
WO1996011269B1 PCT/US1995/012935 US9512935W WO9611269B1 WO 1996011269 B1 WO1996011269 B1 WO 1996011269B1 US 9512935 W US9512935 W US 9512935W WO 9611269 B1 WO9611269 B1 WO 9611269B1
Authority
WO
WIPO (PCT)
Prior art keywords
ligand
tie
nucleic acid
receptor
human
Prior art date
Application number
PCT/US1995/012935
Other languages
English (en)
Other versions
WO1996011269A2 (fr
WO1996011269A9 (fr
Filing date
Publication date
Priority claimed from US08/319,932 external-priority patent/US5643755A/en
Priority claimed from US08/348,492 external-priority patent/US5879672A/en
Priority claimed from US08/373,579 external-priority patent/US5650490A/en
Priority claimed from US08/418,595 external-priority patent/US5814464A/en
Priority to CZ19971025A priority Critical patent/CZ292453B6/cs
Priority to AU41295/96A priority patent/AU711111B2/en
Priority to DE69520149T priority patent/DE69520149T2/de
Priority to HK98105155.3A priority patent/HK1005944B/xx
Priority to MX9702530A priority patent/MX9702530A/es
Priority to US08/817,318 priority patent/US6433143B1/en
Priority to EP95939501A priority patent/EP0784683B1/fr
Priority to AT95939501T priority patent/ATE199259T1/de
Priority to NZ296638A priority patent/NZ296638A/xx
Priority to CA2202028A priority patent/CA2202028C/fr
Priority to PL95319586A priority patent/PL184642B1/pl
Priority to ES95939501T priority patent/ES2154354T3/es
Application filed filed Critical
Priority to HU9800160A priority patent/HU221422B1/hu
Priority to JP51267296A priority patent/JP4054375B2/ja
Priority to DK95939501T priority patent/DK0784683T3/da
Priority to EP96910769A priority patent/EP0821728B1/fr
Priority to DE69633121T priority patent/DE69633121T2/de
Priority to CA2216963A priority patent/CA2216963C/fr
Priority to AT96910769T priority patent/ATE273384T1/de
Priority to AU53871/96A priority patent/AU715621B2/en
Priority to PCT/US1996/004806 priority patent/WO1996031598A1/fr
Priority to JP53053796A priority patent/JP4122056B2/ja
Priority to HK98109175.1A priority patent/HK1008230B/en
Publication of WO1996011269A2 publication Critical patent/WO1996011269A2/fr
Publication of WO1996011269A9 publication Critical patent/WO1996011269A9/fr
Publication of WO1996011269B1 publication Critical patent/WO1996011269B1/fr
Priority to NO19971557A priority patent/NO322643B1/no
Priority to FI971406A priority patent/FI120313B/fi
Priority to US09/442,717 priority patent/US6627415B1/en
Priority to GR20010400568T priority patent/GR3035717T3/el

Links

Abstract

Cette invention se rapporte à une molécule d'acide nucléique isolée codant un ligand TIE-2 humain. Cette invention se rapporte en outre à un corps récepteur qui fixe spécifiquement un ligand TIE-2 humain, et à un anticorps qui fixe spécifiquement un ligand TIE-2 humain, ainsi qu'à un antagoniste de ligand TIE-2 humain. Cette invention se rapporte également à des compositions thérapeutiques et à un procédé pour bloquer la croissance des vaisseaux sanguins, à un procédé pour promouvoir la néovascularisation, à un procédé pour promouvoir la croissance ou la différenciation d'une cellule exprimant le récepteur de TIE-2, à un procédé pour bloquer la croissance ou la différenciation d'une cellule exprimant le récepteur de TIE-2, ainsi qu'à un procédé pour atténuer ou empêcher la croissance de tumeurs chez l'homme.
PCT/US1995/012935 1994-10-07 1995-10-06 Ligands tie-2, peocedes de production et utilisations de ces ligands WO1996011269A2 (fr)

Priority Applications (27)

Application Number Priority Date Filing Date Title
DK95939501T DK0784683T3 (da) 1994-10-07 1995-10-06 TIE-2-ligander, fremgangsmåder til dannelse af disse og anvendelser deraf
JP51267296A JP4054375B2 (ja) 1994-10-07 1995-10-06 Ｔｉｅ−２リガンド、その作製方法および使用方法
HU9800160A HU221422B1 (en) 1994-10-07 1995-10-06 Tie-2 ligands, recombinant methods of making and uses thereof
EP95939501A EP0784683B1 (fr) 1994-10-07 1995-10-06 Ligands tie-2, procedes de production et utilisations de ces ligands
AT95939501T ATE199259T1 (de) 1994-10-07 1995-10-06 Tie-2 ligande, verfahren zu ihrer herstellung, und ihre anwendungen
DE69520149T DE69520149T2 (de) 1994-10-07 1995-10-06 Tie-2 ligande, verfahren zu ihrer herstellung, und ihre anwendungen
HK98105155.3A HK1005944B (en) 1994-10-07 1995-10-06 Tie-2 ligands, methods of making and uses thereof
MX9702530A MX9702530A (es) 1994-10-07 1995-10-06 Ligandos tie-2, metodos de preparacion y usos de los mismos.
US08/817,318 US6433143B1 (en) 1994-10-07 1995-10-06 Tie-2 ligands
CZ19971025A CZ292453B6 (cs) 1994-10-07 1995-10-06 Izolovaná molekula nukleové kyseliny kódující TIE-2 ligand a její použití
AU41295/96A AU711111B2 (en) 1994-10-07 1995-10-06 Tie-2 ligands, methods of making and uses thereof
NZ296638A NZ296638A (en) 1994-10-07 1995-10-06 Ligands which bind to tie-2 (tyrosine kinase with ig and egf homology domains) receptors
CA2202028A CA2202028C (fr) 1994-10-07 1995-10-06 Ligands tie-2, peocedes de production et utilisations de ces ligands
PL95319586A PL184642B1 (pl) 1994-10-07 1995-10-06 Izolowana czasteczka kwasu nukleinowego kodujaca ligand TIE-2, wektor zawierajacy izolowana czasteczke kwasu nukleinowego, izolowany i oczyszczony ligand TIE-2, uklad gospodarz-wektor, sposób wytwarzania izolowanego i oczyszczonego ligandu TIE-2, przeciwcialo, cialo ligandu, koniugat, kompozycja farmaceutyczna, zastosowanie przeciwciala, zastosowanie izolowanego i oczyszczonego ligandu, sposób in vitro podtrzymywania w hodowli ekspresji receptora TIE-2, sposób identyfikacji antagonisty receptora TIE-2, cialo receptora, izolowana czasteczka kwasu nukleinowego kodujaca cialo receptora, wektor zawierajacy izolowana czasteczke kwasu nukleinowego kodujaca cialo receptora, kompozycja farmaceutyczna zawierajaca cialo receptora PL
ES95939501T ES2154354T3 (es) 1994-10-07 1995-10-06 Ligandos tie-2, metodos para obtenerlos y sus usos.
EP96910769A EP0821728B1 (fr) 1995-04-06 1996-04-05 Ligands tie-2, procedes d'obtention de ces ligands et leurs utilisations
PCT/US1996/004806 WO1996031598A1 (fr) 1995-04-06 1996-04-05 Ligands tie-2, procedes d'obtention de ces ligands et leurs utilisations
JP53053796A JP4122056B2 (ja) 1995-04-06 1996-04-05 Ｔｉｅ−２リガンド、その作製方法および使用方法
HK98109175.1A HK1008230B (en) 1995-04-06 1996-04-05 Tie-2 ligands, methods of making and uses thereof
DE69633121T DE69633121T2 (de) 1995-04-06 1996-04-05 Tie-2 liganden, herstellungsverfahren und verwendung
AU53871/96A AU715621B2 (en) 1995-04-06 1996-04-05 TIE-2 ligands, methods of making and uses thereof
CA2216963A CA2216963C (fr) 1995-04-06 1996-04-05 Ligands tie-2, procedes d'obtention de ces ligands et leurs utilisations
AT96910769T ATE273384T1 (de) 1995-04-06 1996-04-05 Tie-2 liganden, herstellungsverfahren und verwendung
NO19971557A NO322643B1 (no) 1994-10-07 1997-04-04 Isolert nukleinsyremolekyl som koder for TIE-2-ligand, TIE-2-ligand, fremgangsmate ved fremstilling og anvendelse derav, samt antistoff mot TIE-2-liganden.
FI971406A FI120313B (fi) 1994-10-07 1997-04-04 TIE-2-ligandit, niiden valmistusmenetelmät ja käytöt
US09/442,717 US6627415B1 (en) 1995-04-06 1999-11-18 TIE-2 ligands, methods of making and uses thereof
GR20010400568T GR3035717T3 (en) 1994-10-07 2001-04-06 Tie-2 ligands, methods of making and uses thereof

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US08/319,932 US5643755A (en) 1994-10-07 1994-10-07 Nucleic acid encoding tie-2 ligand
US08/319,932 1994-10-07
US08/330,261 US5521073A (en) 1994-10-07 1994-10-27 TIE-2 ligand, and method of making
US08/330,261 1994-10-27
US08/348,492 US5879672A (en) 1994-10-07 1994-12-02 Tie-2 ligand 1
US08/348,492 1994-12-02
US35350394A 1994-12-09 1994-12-09
US08/353,503 1994-12-09
US08/373,579 1995-01-17
US08/373,579 US5650490A (en) 1994-10-07 1995-01-17 Tie-2 ligand 2
US08/418,595 US5814464A (en) 1994-10-07 1995-04-06 Nucleic acids encoding TIE-2 ligand-2
US08/418,595 1995-04-06

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US08/418,595 Continuation US5814464A (en) 1994-10-07 1995-04-06 Nucleic acids encoding TIE-2 ligand-2

Related Child Applications (5)

Application Number Title Priority Date Filing Date
US08/817,318 A-371-Of-International US6433143B1 (en) 1994-10-07 1995-10-06 Tie-2 ligands
PCT/US1996/004806 Continuation WO1996031598A1 (fr) 1995-04-06 1996-04-05 Ligands tie-2, procedes d'obtention de ces ligands et leurs utilisations
US10/179,615 Division US7063840B2 (en) 1994-10-07 2002-06-24 TIE-2 ligands, methods of making and uses thereof
US10/179,820 Division US20030166858A1 (en) 1999-09-16 2002-06-24 TIE-2 ligands, methods of making and uses thereof
US10/179,744 Division US20020173627A1 (en) 1999-09-16 2002-06-24 TIE-2 ligands, methods of making and uses thereof

Publications (3)

Publication Number Publication Date
WO1996011269A2 WO1996011269A2 (fr) 1996-04-18
WO1996011269A9 WO1996011269A9 (fr) 1996-06-06
WO1996011269B1 true WO1996011269B1 (fr) 1996-08-22

Family

ID=27559710

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/012935 WO1996011269A2 (fr) 1994-10-07 1995-10-06 Ligands tie-2, peocedes de production et utilisations de ces ligands

Country Status (22)

Country Link
US (4) US5814464A (fr)
EP (1) EP0784683B1 (fr)
JP (1) JP4054375B2 (fr)
CN (1) CN1230536C (fr)
AT (1) ATE199259T1 (fr)
AU (1) AU711111B2 (fr)
CA (1) CA2202028C (fr)
CZ (1) CZ292453B6 (fr)
DE (1) DE69520149T2 (fr)
DK (1) DK0784683T3 (fr)
ES (1) ES2154354T3 (fr)
FI (1) FI120313B (fr)
GR (1) GR3035717T3 (fr)
HU (1) HU221422B1 (fr)
IL (4) IL115517A (fr)
MX (1) MX9702530A (fr)
NO (1) NO322643B1 (fr)
NZ (1) NZ296638A (fr)
PL (1) PL184642B1 (fr)
PT (1) PT784683E (fr)
WO (1) WO1996011269A2 (fr)
ZA (1) ZA958444B (fr)

Families Citing this family (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681714A (en) * 1992-07-30 1997-10-28 Mount Sinai Hospital Corporation Nucleic acid encoding tek receptor tyrosine kinase
US6130071A (en) * 1997-02-05 2000-10-10 Helsinki University Licensing, Ltd. Vascular endothelial growth factor C (VEGF-C) ΔCys156 protein and gene, and uses thereof
US6245530B1 (en) 1995-08-01 2001-06-12 Ludwig Institute For Cancer Research Receptor ligand
US6645933B1 (en) 1995-08-01 2003-11-11 Helsinki University Licensing Ltd. Oy Receptor ligand VEGF-C
US6221839B1 (en) 1994-11-14 2001-04-24 Helsinki University Licensing Ltd. Oy FIt4 ligand and methods of use
US6818220B1 (en) 1994-11-14 2004-11-16 Licentia Ltd. Vascular endothelial growth factor C (VEGF-C) protein and gene mutants thereof, and uses thereof
US6403088B1 (en) 1995-08-01 2002-06-11 Helsinki University Licensing, Ltd. Antibodies reactive with VEGF-C, a ligand for the Flt4 receptor tyrosine kinase (VEGFR-3)
AU755337B2 (en) * 1995-04-06 2002-12-12 Regeneron Pharmaceuticals, Inc. New uses of tie-2 ligands
DE69633121T2 (de) * 1995-04-06 2005-07-28 Regeneron Pharmaceuticals, Inc. Tie-2 liganden, herstellungsverfahren und verwendung
US7727761B2 (en) 1995-08-01 2010-06-01 Vegenics Limited Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof
US6361946B1 (en) 1997-02-05 2002-03-26 Licentia Ltd Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof
EP0853668B2 (fr) 1995-09-29 2013-03-06 Vegenics Pty Ltd Genes regules et leurs utilisations
US7063965B2 (en) * 1996-04-05 2006-06-20 Regeneron Pharmaceuticals, Inc. Nucleic acid encoding TIE-2 ligand
DE19623850A1 (de) * 1996-06-14 1997-12-18 Wacker Chemie Gmbh Homogenisierung von Dispersionen
US5851797A (en) * 1996-06-19 1998-12-22 Regeneron Pharmaceuticals, Inc. Tie ligand-3, methods of making and uses thereof
IL127623A0 (en) 1996-06-19 1999-10-28 Regeneron Pharma Tie-2 receptor ligands (tie ligand-3; tie ligand-4) and their uses
US6846914B2 (en) 1996-06-19 2005-01-25 Regeneron Pharmaceuticals, Inc. Tie-2 ligand-3
US6265564B1 (en) 1996-08-02 2001-07-24 Regeneron Pharmaceuticals, Inc. Expressed ligand-vascular intercellular signalling molecule
ES2251740T3 (es) 1996-08-23 2006-05-01 Ludwig Institute For Cancer Research Factor de crecimiento de celulas de endotelio vascular d recombinante (vegf-d).
US7125714B2 (en) 1997-02-05 2006-10-24 Licentia Ltd. Progenitor cell materials and methods
US5972338A (en) * 1997-09-19 1999-10-26 Genentech, Inc. Tie ligands homologues
US6057435A (en) * 1997-09-19 2000-05-02 Genentech, Inc. Tie ligand homologues
US6350450B1 (en) 1997-09-19 2002-02-26 Genentech, Inc. TIE ligand homologue antibody
US6348350B1 (en) 1997-09-19 2002-02-19 Genentech, Inc. Ligand homologues
US6030831A (en) * 1997-09-19 2000-02-29 Genetech, Inc. Tie ligand homologues
IL136830A0 (en) * 1997-12-19 2001-06-14 Regeneron Pharma Receptor tyrosine kinase, ar-1
WO1999032515A2 (fr) * 1997-12-19 1999-07-01 Zymogenetics, Inc. Homologue de l'angiopoietine, adn le codant et procede de production dudit homologue
WO1999040193A1 (fr) * 1998-02-04 1999-08-12 Zymogenetics, Inc. Zapo3 homologue d'angiopoietine, adn le codant et sa methode de production
DE69942334D1 (de) 1998-03-02 2010-06-17 Massachusetts Inst Technology Poly-zinkfinger-proteine mit verbesserten linkern
IL138216A0 (en) * 1998-03-02 2001-10-31 Millennium Pharm Inc Novel fdrg protein and nucleic acid molecules and uses therefor
US7488590B2 (en) * 1998-10-23 2009-02-10 Amgen Inc. Modified peptides as therapeutic agents
ATE556090T1 (de) 1998-11-10 2012-05-15 Ludwig Inst Cancer Res Verkürzter, von blutplättchen abstammender wachstumsfaktor d, dafür kodierendes dns und deren verwendung
AU776393B2 (en) 1998-12-23 2004-09-09 Regeneron Pharmaceuticals, Inc. Method of enhancing the biological activity of ligands
AU3359600A (en) * 1999-03-02 2000-09-21 Regeneron Pharmaceuticals, Inc. Angiopoietin-related protein and nucleic acids
US6455035B1 (en) 1999-03-26 2002-09-24 Regeneron Pharmaceuticals, Inc. Angiopoietins and methods of use thereof
HK1045700B (zh) 1999-04-28 2007-07-27 德克萨斯大学董事会 用於通过选择性抑制vegf来治疗癌症的组合物和方法
US6703020B1 (en) 1999-04-28 2004-03-09 Board Of Regents, The University Of Texas System Antibody conjugate methods for selectively inhibiting VEGF
PT1187918E (pt) * 1999-06-07 2006-08-31 Immunex Corp Antagonistas de tek
US6521424B2 (en) 1999-06-07 2003-02-18 Immunex Corporation Recombinant expression of Tek antagonists
DE60043322D1 (de) 1999-06-15 2009-12-24 Genentech Inc Sekretierte und Transmembran-Polypeptide sowie Nukleinsäuren zu deren Kodierung
US6689035B1 (en) 2000-04-11 2004-02-10 Gerber Scientific Products, Inc. Method and apparatus for designing and creating a package
JP2004537260A (ja) 2000-12-07 2004-12-16 サンガモ バイオサイエンシーズ， インコーポレイテッド ジンクフィンガータンパク質による血管新生の調節
US7067317B2 (en) 2000-12-07 2006-06-27 Sangamo Biosciences, Inc. Regulation of angiogenesis with zinc finger proteins
US7205275B2 (en) * 2001-10-11 2007-04-17 Amgen Inc. Methods of treatment using specific binding agents of human angiopoietin-2
US7658924B2 (en) * 2001-10-11 2010-02-09 Amgen Inc. Angiopoietin-2 specific binding agents
US7138370B2 (en) * 2001-10-11 2006-11-21 Amgen Inc. Specific binding agents of human angiopoietin-2
US7521053B2 (en) * 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
AU2006228095B2 (en) * 2001-10-11 2010-11-04 Amgen Inc. Angiopoietin-2 specific binding agents
US20050123925A1 (en) 2002-11-15 2005-06-09 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US7052695B2 (en) 2001-10-25 2006-05-30 Regeneron Pharmaceuticals, Inc. Angiopoietins and methods of treating hypertension
JP4242590B2 (ja) 2002-01-11 2009-03-25 俊一 塩澤 慢性関節リウマチの疾患感受性遺伝子、及びその利用
US7427594B1 (en) * 2002-02-26 2008-09-23 The Trustees Of The University Of Pennsylvania Methods and pharmaceuticals compositions for treating coronary artery disease, ischemia,and vascular disease using angiopoietins
US7081443B2 (en) 2002-05-21 2006-07-25 Korea Advanced Institutes Of Science And Technology (Kaist) Chimeric comp-ang1 molecule
US20040115640A1 (en) * 2002-12-11 2004-06-17 Isis Pharmaceuticals Inc. Modulation of angiopoietin-2 expression
US7479270B2 (en) 2002-07-23 2009-01-20 Vegenics Limited Methods and compositions for activating VEGF-D and VEGF-C
WO2004045531A2 (fr) 2002-11-14 2004-06-03 Cornell Research Foundation, Inc. Protection du myocarge cardiaque
DK1648998T3 (en) 2003-07-18 2015-01-05 Amgen Inc Specific binding agents for hepatocyte growth factor
CN1323723C (zh) * 2003-12-26 2007-07-04 上海新世界基因技术开发有限公司 Tie2受体介导的靶向性肿瘤基因治疗的基因转移系统
US8298532B2 (en) 2004-01-16 2012-10-30 Regeneron Pharmaceuticals, Inc. Fusion polypeptides capable of activating receptors
US20060024302A1 (en) 2004-03-05 2006-02-02 Ludwig Institute For Cancer Research Chimeric anti-VEGF-D antibodies and humanized anti-VEGF-D antibodies and methods of using same
NZ552956A (en) * 2004-07-20 2010-03-26 Genentech Inc Inhibitors of angiopoietin-like 4 protein (ANGPTL4), combinations, and their use for treating cancer
US8604185B2 (en) 2004-07-20 2013-12-10 Genentech, Inc. Inhibitors of angiopoietin-like 4 protein, combinations, and their use
KR101017301B1 (ko) 2004-12-21 2011-02-28 메드임뮨 리미티드 앤지오포이에틴-2에 대한 항체 및 그의 용도
WO2006074426A2 (fr) * 2005-01-07 2006-07-13 Emory University Antagonistes de cxcr4 pour le traitement de l'infection due au vih
JP4657757B2 (ja) * 2005-02-23 2011-03-23 株式会社膠原病研究所 肺高血圧症発症関連遺伝子を用いた肺高血圧症の診断および治療
JP2006325528A (ja) * 2005-05-27 2006-12-07 Institute For Rheumatic Diseases Co Ltd 糖尿病性網膜症の診断および予防
JP4657857B2 (ja) * 2005-08-25 2011-03-23 株式会社膠原病研究所 メタボリックシンドロームの診断および予防
AU2006324477A1 (en) * 2005-12-15 2007-06-21 Medimmune Limited Combination of angiopoietin-2 antagonist and of VEGF-A, KDR and/or Flt1 antagonist for treating cancer
AR059066A1 (es) * 2006-01-27 2008-03-12 Amgen Inc Combinaciones del inhibidor de la angiopoyetina -2 (ang2) y el inhibidor del factor de crecimiento endotelial vascular (vegf)
BRPI0711358A2 (pt) 2006-05-09 2011-09-27 Pfizer Prod Inc derivados do ácido cicloalquilamino e suas composições farmacêuticas
NZ583282A (en) 2007-08-21 2012-09-28 Amgen Inc Human c-fms antigen binding proteins
US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
US9266967B2 (en) 2007-12-21 2016-02-23 Hoffmann-La Roche, Inc. Bivalent, bispecific antibodies
US8227577B2 (en) * 2007-12-21 2012-07-24 Hoffman-La Roche Inc. Bivalent, bispecific antibodies
US8454960B2 (en) 2008-01-03 2013-06-04 The Scripps Research Institute Multispecific antibody targeting and multivalency through modular recognition domains
AU2008346734A1 (en) 2008-01-03 2009-07-16 The Scripps Research Institute Antibody targeting through a modular recognition domain
US8557243B2 (en) 2008-01-03 2013-10-15 The Scripps Research Institute EFGR antibodies comprising modular recognition domains
US8557242B2 (en) 2008-01-03 2013-10-15 The Scripps Research Institute ERBB2 antibodies comprising modular recognition domains
US8574577B2 (en) 2008-01-03 2013-11-05 The Scripps Research Institute VEGF antibodies comprising modular recognition domains
US8507656B2 (en) 2008-01-28 2013-08-13 Medimmune Limited Stabilized angiopoietin-2 antibodies and uses thereof
JO2913B1 (en) 2008-02-20 2015-09-15 امجين إنك, Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses
EP2671891A3 (fr) 2008-06-27 2014-03-05 Amgen Inc. Inhibition d'ang-2 pour traiter la sclérose en plaques
US8268314B2 (en) 2008-10-08 2012-09-18 Hoffmann-La Roche Inc. Bispecific anti-VEGF/anti-ANG-2 antibodies
US8133979B2 (en) 2008-12-16 2012-03-13 Hoffmann-La Roche Inc. Antibodies against human angiopoietin 2
EP2414391B1 (fr) * 2009-04-02 2018-11-28 Roche Glycart AG Anticorps multispécifiques renfermant des anticorps complets et des fragments fab monocaténaires
PT2417156E (pt) 2009-04-07 2015-04-29 Roche Glycart Ag Anticorpos trivalentes, biespecíficos
US9676845B2 (en) 2009-06-16 2017-06-13 Hoffmann-La Roche, Inc. Bispecific antigen binding proteins
US20120189635A1 (en) 2009-07-29 2012-07-26 Regeneron Pharmaceuticals, Inc. Methods for Treating or Preventing Malaria by Administering an Antibody that Specifically Binds Angiopoietin-2 (Ang-2)
US8980268B2 (en) 2009-07-29 2015-03-17 Regeneron Pharamceuticals, Inc. Methods for treating cancer by administering an anti-Ang-2 antibody
JO3182B1 (ar) 2009-07-29 2018-03-08 Regeneron Pharma مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2
CA2781519A1 (fr) 2009-09-16 2011-03-24 Genentech, Inc. Complexes proteiques contenant une super-helice et/ou une attache et leurs utilisations
WO2011038139A1 (fr) 2009-09-23 2011-03-31 Amgen Inc. Traitement du cancer de l'ovaire au moyen d'un agent de liaison spécifique de l'angiopoïétine-2 humaine en association avec un taxane
AR080793A1 (es) 2010-03-26 2012-05-09 Roche Glycart Ag Anticuerpos biespecificos
TWI426920B (zh) * 2010-03-26 2014-02-21 Hoffmann La Roche 雙專一性、雙價抗－ｖｅｇｆ／抗－ａｎｇ－２抗體
US20120100166A1 (en) 2010-07-15 2012-04-26 Zyngenia, Inc. Ang-2 Binding Complexes and Uses Thereof
CA2807278A1 (fr) 2010-08-24 2012-03-01 F. Hoffmann - La Roche Ag Anticorps bispecifiques comprenant un fragment fv stabilise par bisulfure
JP5766296B2 (ja) 2010-12-23 2015-08-19 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ポリペプチド−ポリヌクレオチド複合体、およびエフェクター成分の標的化された送達におけるその使用
MX342034B (es) 2011-02-28 2016-09-12 Hoffmann La Roche Proteinas monovalentes que se unen a antigenos.
CA2825081A1 (fr) 2011-02-28 2012-09-07 Birgit Bossenmaier Proteines de liaison a un antigene
ES2704038T3 (es) 2011-05-24 2019-03-13 Zyngenia Inc Complejos multiespecíficos multivalentes y monovalentes y sus usos
JP6069312B2 (ja) 2011-06-29 2017-02-01 アムジェン インコーポレイテッド 腎細胞癌の治療における生存の予測バイオマーカー
WO2013112438A1 (fr) 2012-01-23 2013-08-01 Regeneron Pharmaceuticals, Inc. Formulations stabilisées contenant des anticorps anti-ang2
RU2644341C2 (ru) 2012-02-10 2018-02-08 Дженентек, Инк. Одноцепочечные антитела и другие гетеромультимеры
AR090263A1 (es) 2012-03-08 2014-10-29 Hoffmann La Roche Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma
WO2013134516A1 (fr) 2012-03-08 2013-09-12 Medimmune, Llc Procédés de traitement par des anticorps anti-angiopoïétine-2
HRP20190817T1 (hr) 2012-03-30 2019-06-28 Boehringer Ingelheim International Gmbh Ang2-vezujuće molekule
HK1207864A1 (en) 2012-06-27 2016-02-12 F. Hoffmann-La Roche Ag Method for selection and production of tailor-made highly selective and multi-specific targeting entities containing at least two different binding entities and uses thereof
WO2014001325A1 (fr) 2012-06-27 2014-01-03 F. Hoffmann-La Roche Ag Méthode de fabrication de conjugués d'anticorps à région fc comprenant au moins une entité de liaison qui se lie spécifiquement à une cible et leurs utilisations
AU2013288641B2 (en) 2012-07-13 2017-07-06 Roche Glycart Ag Bispecific anti-VEGF/anti-ANG-2 antibodies and their use in the treatment of ocular vascular diseases
WO2014108854A1 (fr) 2013-01-09 2014-07-17 Fusimab Ltd. Anticorps anti-hgf et anti-ang2 monospécifiques, et anticorps anti-hgf/anti-ang2 bispécifiques
CN105451767B (zh) 2013-03-15 2019-10-18 泽恩格尼亚股份有限公司 多价和单价多特异性复合物及其用途
EP3055329B1 (fr) 2013-10-11 2018-06-13 F. Hoffmann-La Roche AG Anticorps à chaîne variable légère commune échangés dans un domaine multispécifique
US10670611B2 (en) 2014-09-26 2020-06-02 Somalogic, Inc. Cardiovascular risk event prediction and uses thereof
EP3207059A1 (fr) 2014-10-17 2017-08-23 Amgen Inc. Anticorps dirigés contre l'angiopoïétine 1 et l'angiopoïétine 2 pour thérapies oculaires
JP6721590B2 (ja) 2014-12-03 2020-07-15 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 多重特異性抗体
CN113957043A (zh) 2015-03-04 2022-01-21 迈索布拉斯特国际有限公司 间充质干细胞的细胞培养方法
WO2016209972A1 (fr) 2015-06-26 2016-12-29 Amgen Inc. Biomarqueur de survie dans le traitement d'un carcinome à cellules rénales avec un inhibiteur de vegfr et un inhibiteur d'ang2
DK3389636T3 (da) 2015-12-16 2022-09-19 Regeneron Pharma Sammensætninger og fremgangsmåder til fremstilling af proteinmikropartikler
JP7174691B2 (ja) 2016-08-23 2022-11-17 メディミューン リミテッド 抗ｖｅｇｆ－ａおよび抗ａｎｇ２抗体ならびにそれらの使用
CA3233933A1 (fr) 2017-01-30 2018-08-02 Regeneron Pharmaceuticals, Inc. Procede permettant de reduire la charge microbienne en chromatographie
EP3694890A4 (fr) 2017-10-12 2021-11-03 Immunowake Inc. Protéine de fusion à chaîne légère d'anticorps vegfr

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5116964A (en) * 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
WO1995013387A1 (fr) * 1993-11-12 1995-05-18 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Nouvelle tyrosine-kinase receptrice appelee tie-2
US5879672A (en) * 1994-10-07 1999-03-09 Regeneron Pharmaceuticals, Inc. Tie-2 ligand 1
BR9912053A (pt) * 1998-07-13 2001-04-03 Univ Texas Processos de tratamento de câncer utilizando conjugados terapêuticos que se ligam a aminofosfolipìdios

Similar Documents

Publication Publication Date Title
WO1996011269B1 (fr) Ligands tie-2, peocedes de production et utilisations de ces ligands
CA2202028A1 (fr) Ligands tie-2, peocedes de production et utilisations de ces ligands
CA2216963A1 (fr) Ligands tie-2, procedes d'obtention de ces ligands et leurs utilisations
RU97107471A (ru) Tie-2 лиганды, способы их получения и применения
JP3600617B2 (ja) ヒト上皮細胞成長因子レセプターに特異的なモノクローナル抗体及びそれを用いた治療剤
US6399068B1 (en) Method of treatment with a non-antigenic toxin-conjugate and fusion protein of internalizing receptor system
JP3589459B2 (ja) 生物応答調節物質の新規な抗体運送システム
AU618722B2 (en) Recombinant pseudomanas exotoxin: construction of an active immunotoxin with low side effects
DE69129421T2 (de) Interleukin 2 enthaltende rekombinante Immunkonjugate für die Therapie
AU631545B2 (en) Il-2 receptor-specific chimeric antibodies
EP3444277A1 (fr) Nanocorps anti-pd-l1, séquence de codage et utilisation associées
AU6084694A (en) Methods of delivering agents to target cells
US4792447A (en) Anti-immunoglobulin toxin conjugates useful in the treatment of B cell tumors
Ross et al. Increased Toxicity of Diphtheria Toxin for Human Lymphoblastoid Cells following Covalent Linkage to Anti‐(human lymphocyte) Globulin or Its F (ab′) 2 Fragment
CA2097060A1 (fr) Anticorps bifonctionnels et leur methode de preparation
WO1994009149A1 (fr) Anticorps monoclonal
DE69934903T2 (de) Mitogene regulatoren
JPH08501925A (ja) 糖蛋白ｐに対するモノクローナル抗体
WO1989010133A1 (fr) Inhibiteurs de cellules a tiges
AU2002354096B2 (en) Cytotoxic protein and utilization thereof
JPH115749A (ja) 癌治療医薬品組成物
AU673858B2 (en) Monoclonal antibody
CN113321730B (zh) Cldn18.2抗体及其应用
DE69925817T2 (de) Rekombinante onconase und fusionsproteine davon
EP0668923B1 (fr) Anticorps monoclonal