WO1996009035A1

WO1996009035A1 - Hydrating compositions for hygiene and personal cleaning

Info

Publication number: WO1996009035A1
Application number: PCT/BR1995/000039
Authority: WO
Inventors: Israel Henrique Stokfisz Feferman; Maurício CELLA E SANTOS; Silvana Masiero
Original assignee: Johnson and Johnson Consumer Products Inc; Johnson and Johnson Consumer Companies LLC
Current assignee: Kenvue Brands LLC
Priority date: 1994-09-23
Filing date: 1995-09-22
Publication date: 1996-03-28
Anticipated expiration: 1997-03-23
Also published as: ZA957901B; AU3559395A; CA2200714A1; CO4440438A1; UY24042A1

Abstract

The invention refers to hydrating compositions for personal cleaning and hygiene, characterized by comprising a cleaning agent and a hydrating agent, and by providing a trans-epidermal water loss value approximately equal or lesser than that of the skin per se. The compositions of the invention have an effective simultaneous cleaning and hydrating action as well as a cosmetically acceptable foaming, suave action on the skin and eyes and biodegradability.

Description

Title: "HYDRATING COMPOSITIONS FOR HYGIENE AND PERSONAL CLEAN¬ ING"

The present invention refers to compositions for personal cleaning and hygiene, especially hydrating toilet soaps, comprising a system balanced with cleaning and hydrat¬ ing agents. Advantageously, the compositions of this invention have a suave action on the eyes and skin, and are biodegradable.

In a more specific way, without excluding other em- bodiments, the compositions of the present invention are in liquid form, that is to say, they are easy and pleasant to use, being also adaptable to be employed in flexible tubes, commercial, household and hospital dispensers, and the like.

Unexpectedly the use of the compositions of the in- vention is intended for washing and personal body hygiene, be¬ sides skin and hair cleaning, effective skin hydration, unlike a feeling of hydration created, for instance, by occlusive products, which only prevent water from drainig out of the skin, as widely known in the prior art. The compositions of the present invention provides, in an unusual manner, personal cleaning and hygiene, effective skin hydration, a good foaming, biodegradability and a suave action on the skin and eyes, which makes its use advantageous for children and people having sensible skin. Background of the Invention

Under normal conditions, the human healthy skin is covered by a layer of fatty substances which actuate as a bar¬ rier against aggressions from the environment. Within a dy¬ namic balance with the moistness of this environment, such a barrier allows the water contained therein to evaporate to some extent.

During the washing, in contact with either soap or detergent substances in general, this superficial layer is partly removed, whereby the evaporation rate increases, thus causing the skin to dry up. Further as a result of the re- moval of the superficial fatty layer, there is the direct action of the components of the formulation of soap or deter¬ gents on the skin, often causing redness, wrinkling and even wounds in cases of greater sensitivity and/or long exposition. The technique itself of using compositions for per- sonal cleaning and hygiene, namely the washing, favours the drying of the sking, that is to say, one spreads and rubs the composition on the skin with some water, forming foam, and then rinses it with running water. Under these conditions, the superficial fatty material is removed by the rinsing water to- gether with the cleaning product, thus leaving the washed sur¬ face unprotected. Therefore, even toilet soaps having hight glycerin or polyol contents, which are traditionally consid¬ ered hydrating substances, have not succeeded in preventing the skin from becoming dryer and more sensible, because they do not remain on the skin.

It is known that the addition of emollient sub¬ stances to personal cleaning compositions aims at mitigating such effects of drying and sensibility, but the use thereof is compulsorily limited, because they are antifoaming and do not actually cause hydration.

This kind of problem does not occur with lotions, creams and other products intended especially for hydrating the skin, since they are applied onto the skin and remain thereon in prolonged contact. Therefore, they are not pro- ducts such as those of the present invention, which are also inteded for body cleaning and hygiene.

The compositions of the invention manage to combine in an unusual way the simultaneous action of cleaning and hy¬ drating the skin effectively, through a balanced system of cleaning and hydrating agents, which, in the face of the prior art, could not be regarded as presenting such properties. In addition, a cosmetically acceptable foaming, a suave action on the skin and eyes and biodegradability are obtained. The prior art mentions formulations of products for personal cleaning and hygiene, but they are different from the present invention, namely: patent document EP 0330369 discloses skin- conditioning liquid compositions, based on silicone emulsions and high glycerine contents, which are spread over the the skin so as to form a superficial layer, in order to be effec¬ tive. This type of product, different from that of the in¬ vention, is not intended for skin cleaning.

- Patent Documents GB 1427341 and GB 2005297 dis- close the composition of a creamy toilet soap having high glycerin contents (maximum of 50% and 20%, respectively) for personal washing, which aims at preventing the composition from drying at the discharge nozzle of the dispenser and pro¬ viding it with storage stability. This document does not seek or foresee that effective hydration of the skin will take place through the use of the disclosed soap.

- US Pat 4312771 discloses a liquid soap composition containing from 9 to 11 parts by weight of glycerine and/or glycol propylene such that the quite stable viscosity obtained will always be the highest possible at room temperature. The formulation disclosed simultaneously does not seek or foresee that effective skin hydration occurs.

- Patent Document EP 0485212 discloses a liquid de¬ tergent composition for personal washing comprising up to 15% hydrating agent (for example, glycerol), which aims at obtain¬ ing foam in an adequate amount, in spite of the presence of emollients mentioned as being intrinsically antifoaming. The formulation disclosed do not seek or foresee that effective skin hydration will occur. In view of the non-existence of a composition for simultaneous personal cleaning and hygiene with effective hy¬ dration effect in the prior art, the present invention has been developed, which deals with compositions for personal cleaning and hygiene, characterized by comprising a cleaning agent and a hydrating agent in a balanced combination and by providing a value of transepidermal water loss approximately equal or lesser than that of the skin per se.

The measurement of trans-epidermal water-vapor loss (TEWL) allows one to stimulate the water flow through the stratum corneum of the skin, and this technique has been widely used for determining the barrier function of the skin against the aggression of detergents and evaluating body cleaning products, especially as regards hydration. The publi- cations mentioned below illustrate, by way of non-limiting ex¬ ample, the above statements:

Finkaj, M.B. and Crowe, D.M. "The use of evaporimetry to evaluate soap induced irritation on the face. Bioeng. Skin", _4 , 311-321 (1988); - Kajs, M.T. and Gartstein, V. "Review of the in¬ strumental assesment of skin: Effects of cleansing products" J.Soc.Cosm. £2_ , 249-271 (1991);

- Wilson, D. , Berardesca, E. and Maibach, H. I. "In- vivo trans-epidermal water loss and skin surface hydration in assesment of mistrurization and soap effects. Int." J.Cosm. Sci. 10(5), 201-211 (1988);

Rothman, S. "Physiology and biochemistry of the skin". The University of Chicago Press, Chicago (1954);

- Leveque, J.L., Garson, J. C. and de Rigal, J. "Trans-epidermal water loss from dry and normal skin" J. Soc.

Cosm. Chem. 3fJ , 333 (1979);

- Van de Valg, P. G. M., Nater, J. P. and Belumink, E. "Skin irritance of surfactants as assessed by water vapor loss measurements." J. of Invest. Dermatol. 82(3) 291-293 (1984);

- Batt, M. D. and Fairhurst, E. "Hydration of the stratum corneum. Int." J. Cosm. Sci. 8_ , 253-264 (1986).

The cleaning agent used in the present invention comprises a surfactant, either in isolation or in combination with an emollient agent.

Surfactants, emollients and hydrating agents, men¬ tioned as being components of the compositions of the present invention, are in isolation products known to those skilled in that art, and information about them can be found, for in- stance, in publications such as:

- CTFA Cosmetic Ingredient Handbook - NIKITAKIS, J. M. Editor, - The Cosmetic, Toiletry and Fragrance Association Inc. USA - 1st. edition, 1988. - Harry's Cosmeticology - WINKINSON, J. B. and

MOORE, R. J., editors - Langman Scientific and Technical, USA, 7th ed. , 1982.

Unless otherwise stated, the percentages given below refer to the weight of the composition. Preferably, the amount of the cleaning agent in the present invention is of from 9 to 19% by weight of the compo¬ sition.

Advantageously the surfactant of the cleaning agent of the present invention is chosed from the anionic, amphoteric or non-ionic surfactants, preferably a mixture thereof. Within the composition of the invention the contents thereof may vary preferably from 9% to 19%, and more prefera¬ bly range from 11 to 17%% by weight of the composition. When a mixture of anionic, amphoteric and non-ionic surfactants is used, the percentages thereof, preferably can vary from about 2.5% to 5%, 3.5% to 7.0% and 5.5% to 11.f%, respectively, by weight of the composition.

Preferably the anionic surfactants are chosen from the alkyl ether sulfates, the sulphosuccynates and the acylisotianates, as for instance, triglycerylether sodium sulphate.

Preferably the amphoteric surfactants are chosen from the alkyl imidazolins and the alkyl aminoacids such as betains, cocoamidopropylbetain and cocoanphocarboxylglycinate. Preferably the non-ionic surfactants are chosen from the alcanolamides and the derivatives of polyethylene glycol, as for instance, polyethylene glycol laurate sorbitan, lauryl poliglycose and laurylether sodium carboxylate.

Ready-for-use compositions comprising the cited surfactants are available on the market.

The emollient agent, component of the cleaning agent of the present invention, can be defined as one or more ingre¬ dients that help to maintain the skin soft, suave and flexi¬ ble. Preferably an amount ranging from about 0.5% to 10%, more preferably from 1.0% to 5% by weight of such a component is used, based on the weight of the composition.

Preferably the emollient agent is a mixture of etoxylated and propoxylated cethyl alcohol and ethoxylated lanonin.

The hydrating agent of the present invention is preferably chosen from the list made up of polyhydric alcohols (for example, glycerol, sorbitol, manitol, xilitol, polyethylene glycol, 1,2,6-hexanotriol, inositol), alkylene glycols (for example 1,3-buthylene glycol, diethylene glycol, triethylene glycol) and derivatives of the glutamic acid (for example, sodic pyroglutanate) or mixtures thereof. More pref¬ erably the hydrating agent is either glycerol or sorbitol, ei¬ ther individually or in mixture with each other or with one or more hydrating agents. Also preferably the contents of the hy¬ drating agent in the compositions of the invention range from 5% to 25%, more preferably from about 18% to 23% by weight of the composition.

Carriers such as water can be used in the compos- itions of the invention in the amounts usually employed in the art. The use of such components as well as their specificity are well known by those skilled in the branch of the compos¬ itions of the present invention.

The compositions of the invention can also contain, optionally, without departing from the scope of the invention, a wide variety of additives known by those skilled in the art, for instance perfumes, dyes, preserving agents, thickeners, opacifiers, antioxidants, hydrating agents, stabilizers, disinfectants, emulsifiers, etc., taking into account the ad- ditional specific needs or properties which one desires to reach. Determining the TEWL

In determining the TEWL a vaporimeter from the Swedish Firm ServoMed is used in a climatized at 20°C and with an average relative humiditys of 45°C. The tests are made over the volar region of the panelists, as indicated in figure 1. Line M delimits the two regions C and T; C being the control region for non-treated skin and T the region of application of the composition under test. An amount of 4g of product to be tested is applied to region T during 30 seconds, with light and circular move¬ ments, and then a careful rinsing with running water (2 litres/min) is made during 1 minute. This application cycle is repeated 4 times. The application place is dried with a light pressure of the absorbent paper. After eight minutes of rest of the panelist, readings of the value of the water-vapor flow is made each 2 minutes alternately at regions T and C. The difference between such readings is the TEWL value, given in gm —^? —^■1, which is plotted with respect to the time and shown in figure 2.

A Practical Example of the Embodiment

In order to compare the invention with products of the prior art, the composition A described below has been for- mulated, and its TEWL values (as described previously) were compared with product available on the market such as the com¬ mon bar toilet soap, based on coco and tallow, and the liquid hydrating soap commercialized by NITROGENA. the respective percentage is given by weight of specific active product in the respective formulation (solution) used, the percentages indicated in the "composition A" column being taken on the ba¬ sis of the respective formulations.

COMPONENT FUNCTION COMP.A

- tridecylether anionic sodium sulfate at 30% surfactant 12.60

- cocoamidopropyl- amphoteric betain at 30% surfactant 9.80

- cocoanfocarboxy- amphoteric glycinate at 30% surfactant 7.00

- polyethylene glycol non-ionic laurate sorbitan at 72% surfactant 6.80

- lauryl polyglycose at 50% nnoonn--iioonniicc surfactant 3.40 - laurylether sodium carboxylate at 70% non-ionic surfactant 1.00

- cetylic ethoxylated and propoxylated alcohol at 100% emollient 2.00

- ethoxylated lanolin at 50% hydrating agent 20.00 - water carrier qsp 100

Figure 2 shows the result of the composition of for¬ mulation A with the two other products available on the mar¬ ket. With the teachings of the prior art know so far, it would be possible to foresee that formulation A would provide a lesser increase in TEWL, that is to say, a behaviour similar to that obtained by the liquid toilet soap available commer¬ cially under the name "Neutrogena" . However, one obtains a behaviour indicating that hydration is taking place, since the other conditions of use of the pruduct are maintained. In order to establish the existence of hydration of the skin more surely, the electric resistance of the skin af¬ ter application of formulation A was measured and the value obtained for non-treated skin was compared. It was found that the value obtained with formulation A (0.24 giga Ohms) was lower than that obtained for treated skin (0.26 giga Ohms), thus corroborating the existence of hydration.

The method utilized for determining the electric re¬ sistance of the skin is as follows:

- a cotton disk of about 4 cmr in area, containing 0.8 g of the liquid toilet soap formulation of the invention

^■j is placed on a site of 4 cm rrr in the test volar region T of the panelist, as shown in figure 1, during 4 minuts. The cot¬ ton disk is removed and the region is rinses with running wa¬ ter for 1 minute with water flow of 2 litres/min. The application of a new cotton disk containing liquid toilet soap, followed by washing, as described, is repeated several times, with rest intervals of 40 minutes. After 30 minutes from the last application and rinsing, the panelist remains 30 minutes in an ambient climatized at 20°C and average relative humidity of 45%, when the electric resistance of the skin of site T and of site C of the non-treated skin is measured. For such measurement of the electric resistance of the skin, a Keythley 617 of the American Firm Keythley is used, connected to stainless steel electrodes, one being cylindrical, to be in contact with the panelist's gums, and the other disk with an area of about 3.8 cm , to be in contact with the skin of the desired region, under a pressure of about 23.7 g/cm².

Composition A was used in a practical test with 10 women at the age of from 30 to 50 years, during one week. Com¬ position A was used daily to wash one of the legs, while the usual toilet soap of the panelist was used on the rest of the body. In the beginning and at the end of the study the leg of each panelist was assessed, and the hydrating effect of the product was statistically significant.

Claims

1- Hydrating compositions for personal cleaning and hygiene, characterized by comprising a cleaning agent and a hydrating agent, and by providing a trans-epidermal water loss value approximately equal or lesser than that of the skin per se.

2- Hydrating compositions for personal cleaning and hygiene in accordance with claim 1, characterized in that they are preferably in liquid form. 3- Hydrating compositions for personal cleaning and hygiene in accordance with claim 1, characterized in that the cleaning agent is present preferably in an amount ranging from 9% to 19% by weight.

4- Hydrating compositions for personal cleaning and hygiene in accordance with claim 1, characterized in that said cleaning agent comprises a surfactant, either alone or in con¬ junction with an emollient agent.

5- Hydrating compositions for personal cleaning and hygiene in accordance with claim 4, characterized in that said cleaning agent is chosen from the anionic, amphoteric and non- ionic surfactants.

6- Hydrating compositions for personal cleaning and hygiene in accordance with claim 1 or 4, characteized in that said cleaning agent is a mixture of ionic, amphoteric and non- ionic surfactants.

7- Hydrating compositions for personal cleaning and hygiene in accordance with claim 6, characterized in that said ionic surfactant is present preferably in an amount of about 2.5% to 5.0% by weight. 8- Hydrating compositions for personal cleaning and hygiene in accordance with claim 6, characterized in that said amphoteric surfactant is present preferably in an amount of about 3.5% to 7.0% by weight.

9- Hydrating compositions for personal cleaning and hygiene in accordance with claim 6, characterized in that said non-ionic surfactant is present preferably in an amount of about 5.5% to 11.0% by weight.

10- Hydrating compositions for personal cleaning and hygiene in accordance with claim 5 or 6, characterized in that the ionic surfactant is preferably chosen from the group con- sisting of alkyl ether sulfates, sulfosuccinates and acylisothianates..

11- Hydrating compositions for personal cleaning and hygiene in accordance with claim 5 or 6, characterized in that the amphoteric surfactant is preferably chosen from the group consisting of alkylimidazolines and alkylaminoacids.

12- Hydrating compositions for personal cleaning and hygiene in accordance with claim 5 or 6, characterized in that the non-ionic surfactant is preferably chosen from the group consisting of alkalonamides and derivatives of poliethylene glycol.

13- Hydrating compositions for personal cleaning and hygiene in accordance with claim 4, characterized in that said emollient agent is present preferably in an amount of about 0.5% to 10.0% by weight. 14- Hydrating compositions for personal cleaning and hygiene in accordance with claim 4, characterized in that said emollient agent is present preferably in an amount of about 1,0% to 5.0% by weight.

15- Hydrating compositions for personal cleaning and hygiene, characterized in that said emollient agent is prefer¬ ably constituted by a mixture of etoxylated and propoxylated cethyl alcohol and ethoxylated lanolin.

16- Hydrating compositions for personal cleaning and hygiene in accordance with claim 1, characterized in that said hydrating agent is preferably chosen from the group consisting of polyls, alkylene glycols and derivatives of glytanic acid.

17- Hydrating compositions for personal cleaning and hygiene in accordance with claim 1, characterized in that said hydrating agent is preferably glycol or sorbitol, either indi- vidually or in mixture with each other or with other hydrating agents.

18- Hydrating compositions for personal cleaning and hygiene in accordance with claim 1, characterized in tha said hydrating agent is present preferably in an amount of about 5.0% to 25.0% by weight.

19- Hudrating compositions for cleaning and hygiene in accordance with claim 1, characterized in that said hydrat¬ ing agent is present preferably in an amount of about 18.0% to 23.0% by weight.

20- Hydrating compositions for personal cleaning and hygiene in accordance with any one of the preceding claims, characterized by providing value of the electric resistance of the skin lesser than that of the non-treated skin. 21- A composition in accordance with any one of the preceding claims, characterized by comprising the following components with the respective contents and functions defined as follows:

COMPONENT FUNCTION COMP.A

- tridecylether anionic sodium sulfate at 30% surfactant 12.60

- cocoamidopropyl- amphoteric betain at 30% surfactant 9.80

- cocoanfocarboxy- amphoteric glycinate at 30% surfactant 7.00

- polyethylene glycol non-ionic laurate sorbitan at 72% surfactant 6.80

- lauryl polyglycose at 50% non-ionic surfactant 3.40

- laurylether sodium carboxylate at 70% non-ionic surfactant 1.00

- cetylic ethoxylated and propoxylated alcohol at 100% emollient 2.00

- ethoxylated lanolin at 50% hydrating agent 20.00

- water carrier qsp 100

22- A composition characterized in that it is as de¬ scribed in the specification and the example.

23- An invention characterized in that it is as dis¬ closed in the present application.