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WO1996007415B1 - Protection du myocarde a l'aide de benzothiazepinones - Google Patents

Protection du myocarde a l'aide de benzothiazepinones

Info

Publication number
WO1996007415B1
WO1996007415B1 PCT/CA1995/000514 CA9500514W WO9607415B1 WO 1996007415 B1 WO1996007415 B1 WO 1996007415B1 CA 9500514 W CA9500514 W CA 9500514W WO 9607415 B1 WO9607415 B1 WO 9607415B1
Authority
WO
WIPO (PCT)
Prior art keywords
represents hydrogen
methyl
compound
reperfusion
myocardial protection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA1995/000514
Other languages
English (en)
Other versions
WO1996007415A1 (fr
Filing date
Publication date
Priority claimed from US08/303,826 external-priority patent/US5580867A/en
Application filed filed Critical
Priority to EP95930352A priority Critical patent/EP0779811A1/fr
Priority to JP8509064A priority patent/JPH10505350A/ja
Priority to KR1019970701573A priority patent/KR970705396A/ko
Priority to BR9508907A priority patent/BR9508907A/pt
Priority to AU33781/95A priority patent/AU3378195A/en
Publication of WO1996007415A1 publication Critical patent/WO1996007415A1/fr
Publication of WO1996007415B1 publication Critical patent/WO1996007415B1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Abstract

On obtient une protection du myocarde en administrant à un patient une quantité efficace d'un dérivé de la benzothiazépine. Ce type de dérivés de la benzothiazépine présente la formule chimique générale (I), où R1 représente hydrogène ou méthyle, R2 représente hydrogène ou acétyle, R3 représente hydrogène ou méthyle et R4 représente hydrogène ou un halogène, à condition que R1 ne puisse représenter méthyle quand R2 représente acétyle, R3 méthyle et R4 hydrogène. Ces composés se prêtent aussi au traitement d'autres états cliniques, tel que l'angor stable et instable, les infarctus du myocarde ne produisant pas d'onde Q, les ischémies et reperfusions suivant un traumatisme cérébral, ainsi qu'à la préservation d'organe greffés, etc.
PCT/CA1995/000514 1994-09-09 1995-09-11 Protection du myocarde a l'aide de benzothiazepinones Ceased WO1996007415A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP95930352A EP0779811A1 (fr) 1994-09-09 1995-09-11 Protection du myocarde a l'aide de benzothiazepinones
JP8509064A JPH10505350A (ja) 1994-09-09 1995-09-11 ベンゾチアゼピノンを用いる心筋の保護
KR1019970701573A KR970705396A (ko) 1994-09-09 1995-09-11 벤조티아제피논류를 이용한 심근의 보호
BR9508907A BR9508907A (pt) 1994-09-09 1995-09-11 Proteçãodo miocárdio usando benzotiazepinonas
AU33781/95A AU3378195A (en) 1994-09-09 1995-09-11 Myocardial protection using benzothiazepinones

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/303,826 US5580867A (en) 1994-09-09 1994-09-09 Myocardial protection during ischemia and reperfusion
US08/303,826 1994-09-09

Publications (2)

Publication Number Publication Date
WO1996007415A1 WO1996007415A1 (fr) 1996-03-14
WO1996007415B1 true WO1996007415B1 (fr) 1996-04-11

Family

ID=23173874

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1995/000514 Ceased WO1996007415A1 (fr) 1994-09-09 1995-09-11 Protection du myocarde a l'aide de benzothiazepinones

Country Status (8)

Country Link
US (1) US5580867A (fr)
EP (1) EP0779811A1 (fr)
JP (1) JPH10505350A (fr)
KR (1) KR970705396A (fr)
AU (1) AU3378195A (fr)
BR (1) BR9508907A (fr)
CA (1) CA2198862A1 (fr)
WO (1) WO1996007415A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL157437A0 (en) * 2003-07-14 2004-03-28 Superseal Ltd Superseal Ltd Hydrophobic aggregate and applications thereof
JP2010520237A (ja) * 2007-02-28 2010-06-10 メルク・シャープ・エンド・ドーム・コーポレイション ナトリウムチャネル遮断薬としての置換ベンゾジアゼピノン、ベンゾオキサアゼピノン及びベンゾチアゼピノン

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58113185A (ja) * 1981-12-28 1983-07-05 Hamari Yakuhin Kogyo Kk 新規ベンゾチアゼピン誘導体およびその製造法
US4520112A (en) * 1983-03-09 1985-05-28 The Johns Hopkins University Assay method for organic calcium antagonist drugs and a kit for such an assay
US4585768A (en) * 1984-04-10 1986-04-29 Tanabe Seiyaku Co., Ltd. 1,5-benzothiazepine derivatives and processes for preparing the same
JPS62161776A (ja) * 1986-01-07 1987-07-17 Tanabe Seiyaku Co Ltd １，５−ベンゾチアゼピン誘導体の製法
FR2597097B1 (fr) * 1986-04-15 1988-12-02 Synthelabo Derives de benzothiazepine-1, 5, leur preparation et leur application en therapeutique
US4902684A (en) * 1988-06-20 1990-02-20 E. R. Squibb & Sons, Inc. Benzazepine and benzothiazepine derivatives
US4950663A (en) * 1989-02-15 1990-08-21 Louis Dumont Antihypertensive composition

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