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WO1996001324A3 - Nouveau site interne d'entree des ribosomes, vecteur le contenant et utilisation therapeutique - Google Patents

Nouveau site interne d'entree des ribosomes, vecteur le contenant et utilisation therapeutique Download PDF

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Publication number
WO1996001324A3
WO1996001324A3 PCT/FR1995/000894 FR9500894W WO9601324A3 WO 1996001324 A3 WO1996001324 A3 WO 1996001324A3 FR 9500894 W FR9500894 W FR 9500894W WO 9601324 A3 WO9601324 A3 WO 9601324A3
Authority
WO
WIPO (PCT)
Prior art keywords
internal ribosome
ribosome entry
entry site
vector containing
containing same
Prior art date
Application number
PCT/FR1995/000894
Other languages
English (en)
Other versions
WO1996001324A2 (fr
Inventor
Clarisse Berlioz
Sandrine Jacquemoud
Christophe Torrent
Jean-Luc Darlix
Original Assignee
Inst Nat Sante Rech Med
Clarisse Berlioz
Sandrine Jacquemoud
Christophe Torrent
Darlix Jean Luc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Nat Sante Rech Med, Clarisse Berlioz, Sandrine Jacquemoud, Christophe Torrent, Darlix Jean Luc filed Critical Inst Nat Sante Rech Med
Priority to EP95925007A priority Critical patent/EP0769062A2/fr
Priority to US08/600,999 priority patent/US5925565A/en
Priority to AU29295/95A priority patent/AU707874B2/en
Priority to JP8503707A priority patent/JPH10503644A/ja
Publication of WO1996001324A2 publication Critical patent/WO1996001324A2/fr
Publication of WO1996001324A3 publication Critical patent/WO1996001324A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13051—Methods of production or purification of viral material
    • C12N2740/13052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/90—Vectors containing a transposable element
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y10S977/802—Virus-based particle
    • Y10S977/803—Containing biological material in its interior
    • Y10S977/804—Containing nucleic acid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/92—Detection of biochemical

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention a pour objet un nouveau site interne d'entrée des ribosomes et une nouvelle région d'encapsidation d'un rétrotransposon et notamment des VL30 murins. Elle concerne également un vecteur et une cellule eucaryote les contenant ainsi que leur usage thérapeutique ou prophylactique.
PCT/FR1995/000894 1994-07-05 1995-07-05 Nouveau site interne d'entree des ribosomes, vecteur le contenant et utilisation therapeutique WO1996001324A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP95925007A EP0769062A2 (fr) 1994-07-05 1995-07-05 Nouveau site interne d'entree des ribosomes, vecteur le contenant et utilisation therapeutique
US08/600,999 US5925565A (en) 1994-07-05 1995-07-05 Internal ribosome entry site, vector containing it and therapeutic use
AU29295/95A AU707874B2 (en) 1994-07-05 1995-07-05 New internal ribosome entry site, vector containing it and therapeutical use
JP8503707A JPH10503644A (ja) 1994-07-05 1995-07-05 新規な内部リボソーム侵入部位、これを含むベクター、および治療への使用

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR94/08300 1994-07-05
FR9408300A FR2722208B1 (fr) 1994-07-05 1994-07-05 Nouveau site interne d'entree des ribosomes, vecteur le contenant et utilisation therapeutique

Publications (2)

Publication Number Publication Date
WO1996001324A2 WO1996001324A2 (fr) 1996-01-18
WO1996001324A3 true WO1996001324A3 (fr) 1996-02-29

Family

ID=9465025

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1995/000894 WO1996001324A2 (fr) 1994-07-05 1995-07-05 Nouveau site interne d'entree des ribosomes, vecteur le contenant et utilisation therapeutique

Country Status (7)

Country Link
US (1) US5925565A (fr)
EP (1) EP0769062A2 (fr)
JP (1) JPH10503644A (fr)
AU (1) AU707874B2 (fr)
CA (1) CA2194155A1 (fr)
FR (1) FR2722208B1 (fr)
WO (1) WO1996001324A2 (fr)

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