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WO1996041594A1 - Membrane de recouvrement - Google Patents

Membrane de recouvrement Download PDF

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Publication number
WO1996041594A1
WO1996041594A1 PCT/DE1996/000630 DE9600630W WO9641594A1 WO 1996041594 A1 WO1996041594 A1 WO 1996041594A1 DE 9600630 W DE9600630 W DE 9600630W WO 9641594 A1 WO9641594 A1 WO 9641594A1
Authority
WO
WIPO (PCT)
Prior art keywords
covering
bone
soft tissue
tissue
cover membrane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE1996/000630
Other languages
German (de)
English (en)
Inventor
Axel Kirsch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to BR9609157A priority Critical patent/BR9609157A/pt
Priority to EP96909032A priority patent/EP0830115A1/fr
Priority to JP9502465A priority patent/JPH11507281A/ja
Priority to AU52695/96A priority patent/AU700349B2/en
Publication of WO1996041594A1 publication Critical patent/WO1996041594A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
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    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/005—Ingredients of undetermined constitution or reaction products thereof
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    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
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    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A61F2002/30064—Coating or prosthesis-covering structure made of biodegradable material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
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    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30317—The prosthesis having different structural features at different locations within the same prosthesis
    • A61F2002/30322—The prosthesis having different structural features at different locations within the same prosthesis differing in surface structures
    • A—HUMAN NECESSITIES
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A61F2002/30878—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
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    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Definitions

  • the invention relates to a covering membrane made of body-compatible, possibly at least partially resorbable membrane material for temporarily covering a recess in the body's own bone tissue filled with bone building material, in particular hydroxyapatite granules.
  • bone building material which is usually made from a mis ⁇ chung from bone substitute material, such as hydroxyapatite granules, and the body's own bone particles, or also from bone substitute material or body's own bone particles alone.
  • bone building material which is usually made from a mis ⁇ chung from bone substitute material, such as hydroxyapatite granules, and the body's own bone particles, or also from bone substitute material or body's own bone particles alone.
  • EP 0 475 477 discloses a covering membrane of the type described above, in which the covering membrane is essentially completely resorbable, but there is the possibility that the covering membrane is resorbed so quickly that the bony growth of the bone-building material and so that the healing of the bone defect and the lost periodontal tissue or the dental cement can, under unfavorable circumstances, be disturbed by the inflammatory process accompanying any resorption of foreign tissue.
  • the US 48 16 339 shows a cover membrane made of several layers, these layers not consisting of resorbable membrane material, but of polytetrafluoroethylene-containing materials.
  • the multilayer structure serves to optimize the waxing properties, but the lack of resorption of the membrane material can lead to long-term problems.
  • a cover membrane of the gate Described in accordance with the invention, in which the fact that the membrane material can be more quickly absorbed from the side facing away from the body's own bone than from the side facing towards the body's own bone largely ensures that the bony growth of the bone building material and thus the healing of the bone defect essentially undisturbed by the inflammation process accompanying any resorption of foreign tissue.
  • the generic cover membrane has proven itself. However, it has turned out to be desirable to give the soft or connective tissue surrounding the bone defect site the possibility of rapidly growing on the covering membrane, so that a good connection between the soft tissue and the bone that is later restored is ensured. This is particularly, but not exclusively, of particular importance if the covering membrane is to remain in the body.
  • the invention is based on the object of developing the generic covering membrane in such a way that a flawless stabilizing and relative movement-avoiding connection of the soft tissue surrounding the bone defect site or of the collagen structures that result from the predeterminated granulation tissue, which after bleeding into the bone defect parts this fills, and the cover membrane is guaranteed.
  • this object is achieved in that the side of the covering membrane facing the soft tissue and / or the bone tissue (each) has a retention support device for improving the retention of the soft tissue or the (respective) collagen structure (s) on the covering membrane /exhibit.
  • the invention also provides for the retention support device (s) to have at least one mechanical retention aid.
  • the invention further provides that the mechanically active retention aid (s) is / are at least partially designed for positive engagement by soft tissue and / or collagen structure (s).
  • the mechanical retention aid (s) is / are at least partially formed by projections and / or depressions in the covering membrane of the covering device.
  • the invention also provides that the mechanical retention aid (s) is / are at least partially formed by uneven surfaces of the covering membrane of the covering device.
  • the invention provides that the mechanical retention aids are at least partially formed by a tissue and / or knitted structure of the surface of the covering membrane of the covering device facing the soft tissue or the bone tissue.
  • the invention also provides that the retention support devices are / are formed at least partially by appropriate selection of the chemical composition and / or the morphological structure of the material of the covering membrane in the area of the covering membrane facing the soft tissue or the bone tissue.
  • the invention is characterized by at least two layers of different structure and / or composition, the layer facing the soft tissue being the Retention support device (s) has / have.
  • the invention is also characterized by open micropores provided in the soft tissue and / or the layer facing the bone tissue.
  • the invention is characterized by chemically and / or physically acting molecular docking aids for the soft tissue or the collagen structure (s) provided in the area facing the soft tissue and / or the area facing the bone tissue.
  • the invention is based on the surprising finding that it is possible to effectively promote the adhesion of the connective or soft tissue or the collagen structures which sprout into the bone defect site by virtue of the fact that the soft or connective tissue or the bone defect parts facing surface of the covering membrane is formed in such a way that retention support devices are provided for improving the growth of the respective tissue or the respective collagen structures, whereby a reliable stabilizing connection with the covering membrane is ensured.
  • retention support devices can be, for example, mechanically acting devices for preferably interlocking gripping through soft or connective tissue or collagen structures.
  • chemical, ie molecularly acting, docking aids can also be provided, which may be formed by a corresponding special “special layer” of the cover membrane, which, for. B. facing the connective tissue.
  • a corresponding special “special layer” of the cover membrane which, for. B. facing the connective tissue.
  • the base layer can be designed in such a way that there is a particularly good cell-occlusive and / or mechanically supportive effect.
  • FIG. 1 shows a first embodiment of a cover membrane according to the invention in section perpendicular to the membrane plane;
  • FIG. 2 in a representation corresponding to FIG. 1, a further exemplary embodiment of a cover membrane according to the invention.
  • Fig. 3 shows another embodiment of a
  • the surface facing the connective or soft tissue lying at the top of the drawing has a covering membrane 18, projections 36 and depressions 38, which are each designed so that they form through collagen structures of the connective tissue that grows from above ⁇ can be encompassed, whereby the retention of Connective tissue on the cover membrane 18 is improved.
  • the covering membrane 18 is constructed from a base layer 40, which faces the bone, and a cover layer 42, the latter having open micropores 44, which are also suitable for the ingrowth of collagen structures.
  • the covering membrane 18 has a backing layer 46 on the side of the base layer 40 facing away from the covering layer 42, ie facing the bone defect site, which is also provided with open micropores 44, which are used to ingrow collagen structures from the bone defect site are suitable.
  • the layers 42 and 46 preferably have such a resorption genetics that there is a resorption time of about 6 to 12 weeks in periodontal surgery and a resorption time of about 6 to 9 months in bone surgery.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cardiology (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention concerne une membrane de recouvrement (18) réalisée dans un matériau membranaire compatible avec l'organisme, éventuellement résorbable au moins en partie, servant à recouvrir provisoirement une cavité de tissu osseux endogène, remplie d'un matériau ostéogénique osseuse, notamment de l'apatite d'hydroxyle sous forme de granulés. Cette membrane de recouvrement (18) se caractérise en ce que son côté qui fait face au tissu mou et/ou au tissu osseux comporte une dispositif favorisant la rétention (36, 38, 42, 44, 46), servant à améliorer la rétention du tissu mou ou de la structure collagène au niveau de la membrane de recouvrement (18).
PCT/DE1996/000630 1995-06-08 1996-04-03 Membrane de recouvrement Ceased WO1996041594A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
BR9609157A BR9609157A (pt) 1995-06-08 1996-04-03 Membrana de cobertura
EP96909032A EP0830115A1 (fr) 1995-06-08 1996-04-03 Membrane de recouvrement
JP9502465A JPH11507281A (ja) 1995-06-08 1996-04-03 被覆膜
AU52695/96A AU700349B2 (en) 1995-06-08 1996-04-03 Cover diaphragm

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19520867.6 1995-06-08
DE19520867A DE19520867C2 (de) 1995-06-08 1995-06-08 Abdeckmembran

Publications (1)

Publication Number Publication Date
WO1996041594A1 true WO1996041594A1 (fr) 1996-12-27

Family

ID=7763879

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1996/000630 Ceased WO1996041594A1 (fr) 1995-06-08 1996-04-03 Membrane de recouvrement

Country Status (9)

Country Link
EP (1) EP0830115A1 (fr)
JP (1) JPH11507281A (fr)
KR (1) KR100250116B1 (fr)
AU (1) AU700349B2 (fr)
BR (1) BR9609157A (fr)
CA (1) CA2217036A1 (fr)
DE (1) DE19520867C2 (fr)
HU (1) HUP9802830A3 (fr)
WO (1) WO1996041594A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997032616A1 (fr) * 1996-03-04 1997-09-12 Axel Kirsch Membrane de recouvrement, corps moules produits a partir de cette membrane, et procede de production de celle-ci
JP2000510017A (ja) * 1996-05-10 2000-08-08 ジェイ． メドフ，ロバート 移植材料拘束装置
EP2542164A4 (fr) * 2010-03-05 2015-02-25 Univ Case Western Reserve Membrane chirurgicale multicouche

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DE19608250C2 (de) * 1996-03-04 1999-08-05 Kirsch Axel Abdeckmembran und Verfahren zu deren Herstellung
AT405236B (de) * 1997-07-18 1999-06-25 Implantech Medizintechnik Ges Implantat, insbesondere gelenk-prothesenimplantat
DE19830992C2 (de) * 1998-07-10 2000-06-08 Eckhard Binder Formteile, insbesondere Folien, zur Förderung der Neubildung von Knochenmaterial im Kiefer
DE19835251A1 (de) 1998-07-10 2000-03-23 Eckhard Binder Formteile, insbesondere Folien, zur Förderung der Neubildung von Knochenmaterial im Kiefer
ATE290353T1 (de) * 1999-07-28 2005-03-15 Interface Biotech As In vitro heilung von knochen- und/oder knorpelschäden
DE19940977A1 (de) * 1999-08-28 2001-03-01 Lutz Claes Folie aus resorbierbarem Polymermaterial und Verfahren zur Herstellung einer solchen Folie
US6858042B2 (en) 1999-12-15 2005-02-22 Zimmer Orthobiologics, Inc. Preparation for repairing cartilage defects or cartilage/bone defects in human or animal joints
DE102007050440A1 (de) * 2007-10-18 2009-04-23 Alexakis, Antonis, Dr. med. dent. Beschichtetes Granulat zur Neubildung von Knochenmaterial
DE102009020707A1 (de) * 2009-05-11 2010-11-25 Alexakis, Antonis, Dr. med. dent. Beschichtetes Granulat zur Neubildung von Knochenmaterial
US8435305B2 (en) 2010-08-31 2013-05-07 Zimmer, Inc. Osteochondral graft delivery device and uses thereof

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DE3531144A1 (de) * 1984-09-25 1986-03-27 TDK Corporation, Tokio/Tokyo Poroeses hydroxyapatitmaterial und seine verwendung
GB2181354A (en) * 1985-10-08 1987-04-23 Finsbury Improvements relating to orthopaedic implants
US4865603A (en) * 1988-02-04 1989-09-12 Joint Medical Products Corporation Metallic prosthetic devices having micro-textured outer surfaces
WO1992011043A1 (fr) * 1990-12-24 1992-07-09 Q-Life Systems, Inc. Surfaces activement steriles
US5152791A (en) * 1989-12-07 1992-10-06 Olympus Optical Co., Ltd. Prosthetic artificial bone having ceramic layers of different porosity
DE4211343A1 (de) * 1992-04-04 1993-10-07 S & G Implants Gmbh Endoprothese
DE4302709C1 (de) * 1993-02-01 1994-07-28 Kirsch Axel Abdeckeinrichtung mit Abdeckmembran
DE4302708A1 (de) * 1993-02-01 1994-08-04 Kirsch Axel Abdeckmembran
WO1995009583A1 (fr) * 1993-10-01 1995-04-13 Lucocer Aktiebolag Implant
DE4414675C1 (de) * 1994-04-27 1995-09-28 Kirsch Axel Abdeckeinrichtung für Knochendefektstellen und Verfahren zu deren Herstellung

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US4430760A (en) * 1981-12-18 1984-02-14 Collagen Corporation Nonstress-bearing implantable bone prosthesis
US4816339A (en) * 1987-04-28 1989-03-28 Baxter International Inc. Multi-layered poly(tetrafluoroethylene)/elastomer materials useful for in vivo implantation
DE69120177T2 (de) * 1990-09-10 1996-10-10 Synthes Ag Membran für Knochenregenerierung
DE69121587T3 (de) * 1990-12-06 2000-05-31 W.L. Gore & Associates, Newark Implantierbare bioresorbierbare artikel

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Publication number Priority date Publication date Assignee Title
DE3531144A1 (de) * 1984-09-25 1986-03-27 TDK Corporation, Tokio/Tokyo Poroeses hydroxyapatitmaterial und seine verwendung
GB2181354A (en) * 1985-10-08 1987-04-23 Finsbury Improvements relating to orthopaedic implants
US4865603A (en) * 1988-02-04 1989-09-12 Joint Medical Products Corporation Metallic prosthetic devices having micro-textured outer surfaces
US5152791A (en) * 1989-12-07 1992-10-06 Olympus Optical Co., Ltd. Prosthetic artificial bone having ceramic layers of different porosity
WO1992011043A1 (fr) * 1990-12-24 1992-07-09 Q-Life Systems, Inc. Surfaces activement steriles
DE4211343A1 (de) * 1992-04-04 1993-10-07 S & G Implants Gmbh Endoprothese
DE4302709C1 (de) * 1993-02-01 1994-07-28 Kirsch Axel Abdeckeinrichtung mit Abdeckmembran
DE4302708A1 (de) * 1993-02-01 1994-08-04 Kirsch Axel Abdeckmembran
WO1995009583A1 (fr) * 1993-10-01 1995-04-13 Lucocer Aktiebolag Implant
DE4414675C1 (de) * 1994-04-27 1995-09-28 Kirsch Axel Abdeckeinrichtung für Knochendefektstellen und Verfahren zu deren Herstellung

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997032616A1 (fr) * 1996-03-04 1997-09-12 Axel Kirsch Membrane de recouvrement, corps moules produits a partir de cette membrane, et procede de production de celle-ci
JP2000510017A (ja) * 1996-05-10 2000-08-08 ジェイ． メドフ，ロバート 移植材料拘束装置
EP2542164A4 (fr) * 2010-03-05 2015-02-25 Univ Case Western Reserve Membrane chirurgicale multicouche

Also Published As

Publication number Publication date
HUP9802830A3 (en) 2000-11-28
AU5269596A (en) 1997-01-09
CA2217036A1 (fr) 1996-12-27
JPH11507281A (ja) 1999-06-29
DE19520867A1 (de) 1996-12-12
EP0830115A1 (fr) 1998-03-25
KR100250116B1 (ko) 2000-06-01
BR9609157A (pt) 1999-05-04
HUP9802830A2 (hu) 1999-06-28
DE19520867C2 (de) 1998-05-20
KR19990022607A (ko) 1999-03-25
AU700349B2 (en) 1999-01-07

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