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WO1996040277A3 - Spray dried polymeric microparticles containing imaging agents - Google Patents

Spray dried polymeric microparticles containing imaging agents Download PDF

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Publication number
WO1996040277A3
WO1996040277A3 PCT/US1996/008378 US9608378W WO9640277A3 WO 1996040277 A3 WO1996040277 A3 WO 1996040277A3 US 9608378 W US9608378 W US 9608378W WO 9640277 A3 WO9640277 A3 WO 9640277A3
Authority
WO
WIPO (PCT)
Prior art keywords
microparticles
imaging
polymer
spray dried
microspheres
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1996/008378
Other languages
French (fr)
Other versions
WO1996040277A2 (en
Inventor
Edith Mathiowitz
Jules S Jacob
Donald E Chickering Iii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brown University Research Foundation Inc
Original Assignee
Brown University Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brown University Research Foundation Inc filed Critical Brown University Research Foundation Inc
Priority to AU63780/96A priority Critical patent/AU6378096A/en
Publication of WO1996040277A2 publication Critical patent/WO1996040277A2/en
Publication of WO1996040277A3 publication Critical patent/WO1996040277A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Methods are provided for the synthesis of synthetic polymeric delivery systems consisting of microparticles which contain a diagnostic imaging agent using spray drying of dilute synthetic polymer solutions, typically between 0.2 and 20 w/v% polymer. In a preferred embodiment, the imaging agent is a gas, the polymer is biodegradable, the polymer solution is saturated with gas and formed into an emulsion, then spray dried. Microparticles produced by this method typically have an average diameter of between about one to seven microns, and therefore freely pass through the pulmonary capillaries. Additional, or alternative, imaging agents can be incorporated within the microparticles. Larger microparticles can also be manufactured for administration to mucosal membranes or oral administration. Adhesion of these microparticles can be enhanced through the selection of bioadhesive polymers. Targeting can also be achieved by selection of the polymer or incorporation within or coupling to the polymer of ligands which specifically bind to particular tissue types or cell surface molecules. Additionally, ligands may be attached to the microspheres which affect the charge, lipophilicity or hydrophilicity of the particle. The polymeric microparticles are useful in a variety of diagnostic imaging procedures including ultrasound imaging, magnetic resonance imaging, fluoroscopy, X-ray, and computerized tomography. The microspheres may be used in a variety of imaging applications including cardiology applications, as well as for organ and peripheral vein imaging.
PCT/US1996/008378 1995-06-07 1996-06-03 Spray dried polymeric microparticles containing imaging agents Ceased WO1996040277A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU63780/96A AU6378096A (en) 1995-06-07 1996-06-03 Spray dried polymeric microparticles containing imaging agen ts

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48777595A 1995-06-07 1995-06-07
US487,775 1995-06-07

Publications (2)

Publication Number Publication Date
WO1996040277A2 WO1996040277A2 (en) 1996-12-19
WO1996040277A3 true WO1996040277A3 (en) 1997-05-01

Family

ID=23937074

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/008378 Ceased WO1996040277A2 (en) 1995-06-07 1996-06-03 Spray dried polymeric microparticles containing imaging agents

Country Status (2)

Country Link
AU (1) AU6378096A (en)
WO (1) WO1996040277A2 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7306787B2 (en) 1997-09-29 2007-12-11 Nektar Therapeutics Engineered particles and methods of use
US7368102B2 (en) 2001-12-19 2008-05-06 Nektar Therapeutics Pulmonary delivery of aminoglycosides
US7442388B2 (en) 2000-05-10 2008-10-28 Weers Jeffry G Phospholipid-based powders for drug delivery
US7628978B2 (en) 1997-09-29 2009-12-08 Novartis Pharma Ag Stabilized preparations for use in metered dose inhalers
US9439862B2 (en) 2000-05-10 2016-09-13 Novartis Ag Phospholipid-based powders for drug delivery
US9554993B2 (en) 1997-09-29 2017-01-31 Novartis Ag Pulmonary delivery particles comprising an active agent

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2247151C (en) * 1996-03-05 2008-05-20 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
BR9712683A (en) 1996-10-28 1999-10-19 Nyomed Imaging A S Diagnostic and / or therapeutically active targetable agent, combined formulation, process for preparing and using it, combined formulation, and processes for generating enhanced images of a human or non-human animal body and for in vitro targeting investigation by an agent.
US6261537B1 (en) 1996-10-28 2001-07-17 Nycomed Imaging As Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors
US6331289B1 (en) 1996-10-28 2001-12-18 Nycomed Imaging As Targeted diagnostic/therapeutic agents having more than one different vectors
WO1998018498A2 (en) * 1996-10-28 1998-05-07 Marsden, John, Christopher Improvements in or relating to diagnostic/therapeutic agents
DE19813174A1 (en) * 1998-03-25 1999-05-27 Schering Ag Gas-filled microparticles, used for administering biologically active substances
WO2004105802A1 (en) * 2003-05-27 2004-12-09 Philips Intellectual Property & Standards Gmbh Tracer for medical imaging
GB2519738A (en) * 2013-09-06 2015-05-06 Biocompatibles Uk Ltd Radiopaque polymers
CN106668880B (en) * 2014-10-31 2019-11-22 苏州大学 Application of Ultrasound/Magnetic Resonance Dual Mode Contrast Agent

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0458745A1 (en) * 1990-05-18 1991-11-27 BRACCO International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
EP0458079A2 (en) * 1990-04-26 1991-11-27 Hoechst Aktiengesellschaft Ultrasonic contrast agent, its preparation and application as diagnostic or therapeutic
WO1992017514A1 (en) * 1991-04-05 1992-10-15 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
WO1992018164A1 (en) * 1991-04-10 1992-10-29 Delta Biotechnology Limited Preparation of diagnostic agents
EP0535387A1 (en) * 1991-09-03 1993-04-07 Hoechst Aktiengesellschaft Echographique particle, preparation and application
WO1994008627A1 (en) * 1992-10-10 1994-04-28 Andaris Limited Preparation of further diagnostic agents

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0458079A2 (en) * 1990-04-26 1991-11-27 Hoechst Aktiengesellschaft Ultrasonic contrast agent, its preparation and application as diagnostic or therapeutic
EP0458745A1 (en) * 1990-05-18 1991-11-27 BRACCO International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
WO1992017514A1 (en) * 1991-04-05 1992-10-15 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
WO1992018164A1 (en) * 1991-04-10 1992-10-29 Delta Biotechnology Limited Preparation of diagnostic agents
EP0535387A1 (en) * 1991-09-03 1993-04-07 Hoechst Aktiengesellschaft Echographique particle, preparation and application
WO1994008627A1 (en) * 1992-10-10 1994-04-28 Andaris Limited Preparation of further diagnostic agents

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7306787B2 (en) 1997-09-29 2007-12-11 Nektar Therapeutics Engineered particles and methods of use
US7628978B2 (en) 1997-09-29 2009-12-08 Novartis Pharma Ag Stabilized preparations for use in metered dose inhalers
US9554993B2 (en) 1997-09-29 2017-01-31 Novartis Ag Pulmonary delivery particles comprising an active agent
US7442388B2 (en) 2000-05-10 2008-10-28 Weers Jeffry G Phospholipid-based powders for drug delivery
US9439862B2 (en) 2000-05-10 2016-09-13 Novartis Ag Phospholipid-based powders for drug delivery
US7368102B2 (en) 2001-12-19 2008-05-06 Nektar Therapeutics Pulmonary delivery of aminoglycosides
US9421166B2 (en) 2001-12-19 2016-08-23 Novartis Ag Pulmonary delivery of aminoglycoside

Also Published As

Publication number Publication date
AU6378096A (en) 1996-12-30
WO1996040277A2 (en) 1996-12-19

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