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WO1996040003A1 - Dispositif d'expansion de tissus - Google Patents

Dispositif d'expansion de tissus Download PDF

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Publication number
WO1996040003A1
WO1996040003A1 PCT/US1996/007689 US9607689W WO9640003A1 WO 1996040003 A1 WO1996040003 A1 WO 1996040003A1 US 9607689 W US9607689 W US 9607689W WO 9640003 A1 WO9640003 A1 WO 9640003A1
Authority
WO
WIPO (PCT)
Prior art keywords
expander
tissue expander
tissue
implant
base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1996/007689
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English (en)
Inventor
Walter J. Ledergerber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to AU58768/96A priority Critical patent/AU5876896A/en
Publication of WO1996040003A1 publication Critical patent/WO1996040003A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/12—Mammary prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/02—Devices for expanding tissue, e.g. skin tissue

Definitions

  • This invention relates to implantable prosthetic devices. More particularly, it relates to implantable tissue expanders for use in plastic and reconstructive surgery to stretch tissue in order to augment a soft tissue deficit, cover an ablative defect, or reconstruct a portion of the body.
  • Implantable prosthetic devices have been used in numerous locations in the body. The most common use has been for restoring or improving upon normal body contour or augmenting as well as reconstruction of the female breast.
  • the most common breast prosthesis is similar to that disclosed in U.S. Patent No. 3,293,663 to Cronin, in which there is a flexible elastomeric container, typically silicone, which is filled with a soft gel, typically silicone gel or a saline solution or a combination of both.
  • a tissue expander is surgically implanted beneath tissue to be stretched and is filled at appropriate intervals with biocompatible fluid. After sufficient stretch has been achieved the tissue expander is removed and the newly available tissue used to cover a soft tissue defect or used to create a replacement body part.
  • a breast tissue expander may be made convertible to a definitive, long-term, augmentative prosthesis, also known as an "implant" .
  • a soft tissue expander which is a temporary implant into the body, utilizes structures having differential and directional expansion capability to project the expander or implant in the desired directions .
  • an expander or implant has an exterior surface defining a volume, the exterior surface including a base portion, a first wall and a second wall, wherein the second wall is relatively thinner than the first wall.
  • a fill port which may be integrally molded into the expander, is included. As the expander is inflated, differential expansion occurs with the relatively thin second wall section expanding more than that of the first wall section.
  • the base may include ribs or other molded-in structures to increase structural integrity. Additionally, the base may include "toes" or other structures which project out from the base, such as flanges, which are adapted to provide a broader base or footprint to the expander. The expander enjoys increased base and dimensional stability as a consequence.
  • Additional directional expansion may be achieved through use of optional bellows molded into a portion of the expander shell wall. As the expander is inflated, the bellows provide a projection beyond that provided by the basic expander. Limiting rings may be used, such as surrounding the bellows at the bellow base which mates to the expander.
  • Molded-in geometric patterns may be employed to present varying textured surfaces to the internal or external surfaces of the implant or expander. This results in increased soft tissue purchase by virtue of unique surface topography and assists in obtaining differential expansion by virtue of the differential purchase resulting from the different molded-in patterns. Textured surfaces also have the effect of weakening periprosthetic scar tissue.
  • compressive structures may be beneficially used on the surface of the implant or in the interior of the implant .
  • a tissue expander uses multiple chambers wherein the chambers are in fluid communication.
  • one of the chambers is adapted for placement behind a muscle, such as the pectoralis muscle if the expander is used for breast reconstruction.
  • Fig. 1 is a cross-sectional view of a telescoping projection element of an implant or expander.
  • Fig. 2 is a cross-sectional view of an implant or expander including a telescoping projection element, where the apical portion of the expansion element is an expansion chamber.
  • Fig. 3 is a cross-sectional view of an implant having variable wall thickness.
  • Fig. 4 is a cross-sectional view of Fig. 3 at line A- A.
  • Fig. 5 is a cross-sectional view of an expander including a bellows expansion member.
  • Fig. 6 is a cross-section of a pressure accommodation element.
  • Fig. 7 is a cross-section of an expander having a base including integral ribs .
  • Fig. 8 is a cross-section of Fig. 7 at A-A.
  • Fig. 9 is a cross-sectional view of a multi-chambered expander.
  • Fig. 10 is a cross-sectional view of a textured covering for use on the implant or expander.
  • the present invention is based upon the previously disclosed method of liquid silicone molding of textured implants (my U.S. Patent #5,354,338) , directional expansion of implants and varying wall thickness (my U.S. Patent #4,955,907) , pressure adaptive structures, (my U.S. Patent #5,383,929) as well as novel elements disclosed herein and methods of manufacture of the combination of elements.
  • implant is used broadly to include any foreign object which is inserted into the body.
  • An expander is an object which is an implant because it is placed within the body.
  • An expander is ordinarily placed within the body, and over time, such as a matter of weeks or a few months, is gradually inflated so as to expand and move adjacent soft tissues. After expansion, the expander may be removed from the body and the space filled with another implant, or optionally, the expander may be converted into a permanent implant in the body. In the latter case, this may involve changing the fluid in the implant/expander, such as from saline to a gel or a triglyceribe or other biocompatible fluid.
  • implant and expander are used interchangeably herein.
  • Fig. 1 shows a cross-section of a telescoping projection element which may be configured as the mammary prosthesis 10 proper or may be configured as a projection element of a more complex implant or expander.
  • Toroid elements 12 may be solid or fluid-filled and serve to restrict horizontal displacement of the shell, yet permit vertical expansion.
  • the apical portion 14 of the expansion chamber 16 is made thin in order to permit preferential dilation of this region.
  • the apical portion 14 is thin relative to other first wall portions 22.
  • the fill port 18 serves to permit input of expansion fluid, which causes the expander to increase in volume, and to undergo differential expansion in the relatively thin wall, apical areas 14.
  • a base region 20 is relatively thick and provides stability to the implant 10 when inserted in the body.
  • sheet teflon (PTFEe) 24 may be used to cover the toroidal regions 12.
  • Fig. 2 shows a cross-section of an implant 30 consisting of a stack of either hollow or solid toroid elements 32 held in apposition by a projection element 34 that traverses the central opening 36 of each toroid element 32 and which by virtue of the enlarged top and bottom portions serves to maintain all elements of the implant in intimate contact.
  • the apical portion 38 of the projection element is an expansion chamber which may be filled through the bottom or top piece fluid port 40.
  • the surfaces of the toroid elements are protected by a covering of PTFEe sheets 42 which are sewn or otherwise affixed to each other at the greater periphery.
  • the tube is shown covered by tubular PTFEe to minimize friction.
  • the apical portion 38 is relatively thin walled compared to first wall portions 44 or the based 46.
  • a biocompatible covering 48 may be added onto the implant 30.
  • Figs. 3 and 4 show a cross-sectional and cut-away view at A-A of a preferred embodiment of a liquid silicon elastomer injection molded tissue expander. This structure is superimposed upon the "male" positive portion of the injection mold which produces the product. The "male" positive portion of the mold necessarily is supported by support column 50, shown in phantom.
  • the tissue expander 52 has continuously variable or varying wall thicknesses, however in the preferred embodiment shown, there is a single, first thick region 54 of the implant incorporating substantially the smaller pole of the expander as well as extending to the "toe" 56 region of the base 58 and in the opposite direction from the smaller pole toward, and incorporating, the region of the fill port 60.
  • the thin region 62 incorporates substantially the larger pole of the expander.
  • the "toe” region 56 is a molded flange-like extension of the integrally molded base 58 portion of the expander and is more generally described as an extension of any thickened portion of an expander.
  • the functions of the "toe” region include: as an anchoring mechanism for the thick region of the expander as collagen matrix collects in space 64 which is defined as the recess between the "toe” (flange) 56 and the outer surface of the expander shell. Maturation of scar tissue results in increased tensile strength of the scar in space 64, which by shortening along the long circular axis of the scar, results in firm anchoring of the "toe" (flange) to the immediately adjacent tissues of the body.
  • the textured surface topography of the base region as well as all other texturized surface portions of the expander help to cause firm adherence between the expander and enveloping scar, as well as to disorganize scar, and thus weaken it.
  • the "toe" (flange) 56 region assists greatly in maintaining dimensional as well as positional relationships. Upon surgical explantation of the tissue expander 52 the surgeon often reshapes the interior of the cavity created by the expander.
  • the "toe” region having formed a firm scar band in the region of the space 64, allows the surgeon the flexibility of conveniently creating more laxity of the wall of the cavity created by the expander by simply excising the scar band to the extent desired.
  • the surgeon can limit the further stretching of the involved region of the cavity. It will be appreciated that the volume of scar and therefore the total tension in that scar is a direct function of the size/volume of space 64.
  • the "toe" region 56 thus helps greatly in configuration angulation of the cavity margin.
  • Variably rounded peripheries of the base of a cavity can be engineered by varying base 58 thickness, expander wall 54 and 62 thickness, "toe" (flange) 56 thickness and length, differential expansion capability, degree of purchase at the tissue/expander interface, and volume/pressure relationships generated within the expander.
  • the injection fill port 60 of the expander is directly molded-in and thus incorporated into the molded shell structure of the tissue expander.
  • the fill port 60 is incorporated as a thickened cup-like region 66 of the molded integral tissue expander shell.
  • This structure is fully disclosed in an application filed simultaneously with the present application, entitled "Injection Port for Implantable Tissue Expander.”
  • the position of the fill port 60 relative to any other structural element of the tissue expander is highly variable.
  • the void in the base created by the support column is patched with a separately molded silicone elastomer patch.
  • Fig. 4 shows the cross-sectional detail of Fig 3 at line A-A.
  • the first wall 54 would be relatively thick, such as from 0.020 to 0.100 inches, and may have a thickness of approximately 0.030 inches.
  • the second wall 62 would be relatively thinner, such as from 0.005 to 0.050 inches and would, for example, have a thickness of 0.020 inches.
  • the base portion 58 may be of a different thickness, preferable relatively thick compared to the first wall 54 and second wall 62, and could be, for example, 0.050 inches thick.
  • Fig. 5 shows the "bellows" 70 structure as incorporated within the thin region 62 in this preferred embodiment but may be incorporated in any region of an expander where differential and directional expandability is required.
  • the limiting ring 72 which may be a separately molded silicone elastomer or another suitable material, restricts the expansion of the lesser diameter of the "bellows” 70 resulting in directional expansion of the bellows along an axis perpendicular to the plane of the limiting ring and away from the center of the expander lumen.
  • the degree of directionality of expansion of the - bellows is greater than is otherwise possible.
  • Fig. 6 is a cross-sectional view of a compressive structure 70 which may optionally be inserted into a chamber, such as at 66 on Fig. 5.
  • the pressure accommodation element may be affixed to the outer and/or inner surfaces of the shell or may be permitted to float freely within the saline or gel matrix within.
  • Fig. 6 is included to clarify the text pertaining to the comprehensive description of the invention. It must be clarified here that this structure is molded separately and adhesively secured to the internal surface of the expander not at the time of molding the expander shell, but rather at a later manufacturing step.
  • a shell 72 preferably includes an evaginated insert 74 which contains gas or fluid. Optionally, openings 76 in the shell 72 permit flow to the insert 74.
  • the Pressure Adaptive Structure may be adhesively attached to the interior of the base of this embodiment .
  • the pressure adaptive structure illustrated in Fig. 6 is only one of many configurations of gas-filled structures well-suited to serve the function of a "continuous" expanding structure within the tissue expander.
  • a curled sealed tubular gas- impervious structure, or a toroidal structure with the same characteristics would likewise suit the requirements for this structure : the ability to contain a biocompatible gas within the structure, which under the increased pressure exerted by the fluid during periodic augmentative filling causes the expander to partially collapse and in so doing compresses the gas substantially.
  • the consequent increased pressure generated within the lumen of the pressure adaptive structure continues to exert outward pressure on the fluid in the lumen of the expander proper.
  • the pressure inside the pressure adaptive structure and the pressure inside the lumen of the tissue expander proper are in equilibrium, however the gas-filled pressure adaptive structure exercises the necessary recoil needed to continue the expansion of the entire tissue expander in order to overcome the resistance offered by the tissues undergoing expansion.
  • Fig. 7 is a cross-section of an expander 80 having a base including integral ribs.
  • Fig. 8 is a cross-section of Fig. 7 at A-A.
  • reinforcing ribs 82, 84 are integrally formed in the base 58 of the implant/expander 80. This provides relative rigidity to the structure.
  • the ribs may be formed in any direction, or in any pattern or configuration to achieve the desired rigidity.
  • longitudinal ribs 82 run into the plane of Fig. 7 and traverse ribs 84 run parallel to the plane of Fig. 7.
  • Fig. 9 is a cross-sectional view of a multi-chambered expander 90. While two chambers are shown in Fig. 9, more chambers 92 may be used consistent with the inventive concept.
  • the first chamber comprises a relatively large chamber, and may incorporate a first relatively thick walled portion 94, and a second relatively thin walled portion 96.
  • the second chamber, or pumping chamber 98 is in fluid communication with the first chamber 92, such as at tube or passageway 100.
  • the second chamber 98 is adapted for disposition between the ribs 102 and the pectoralis muscle 104.
  • a base portion 106 is integral to the second chamber 98.
  • texturization 108 may be formed over the surface of the implant, such as over the exterior disposed face of the implant, and on the exterior portion of the base 108 directed towards the chest wall.
  • a fill port 110 is provided. It will be appreciated that the pumping function of the second chamber 98 in combination with pectoralis muscle 104 could also be preformed by a mechanical pump integrated into the system.
  • Fig. 10 is a cross-sectional view of a textured covering for use on the implant or expander.
  • the 'nested hexcels' structural pattern 112 may be attached to or part of the implant.
  • the textured covering may form the entirety or only a portion of the covering of the implant .
  • the hexcel with the largest perimeter 114 in this configuration is also the tallest and delimits hexagonal pools of biologic materials and tissues at the interface between the implant and the body cavity. As scar tissue forms it is forced into concentric, nested rings of scar tissue which do not communicate freely and thus do not contribute to an integral circumferential scar capsule.
  • the height of these nested hexcels structures may be varied. Also, the number, diameter or perimeter of the hexcel structures as well as their wall thickness and shapes and characteristics may be varied. It will be further appreciated that a great number of geometric patterns may be utilized for the purposes described here, including square and circular patterns.
  • the surface may easily be texturized with any desired form or pattern, whether predictable or random.
  • the tissue expander is made of liquid silicone elastomer supplied by NuSil Technology of Carpinteria, California and described in product literature as Liquid Silicone Rubber MED-4840.
  • the product is described as a two part system which is Platinum cured.
  • the pre-mixed liquid parts A and B are injected into a preheated mold which is then heated further to 275-320 degrees Fahrenheit. Curing time ranges between 5-10 minutes.
  • the molded product is removed from the mold and further vulcanized for 20-45 minutes in a separate oven at 275-375 degrees Fahrenheit. Molded voids in the shell are then patched with a silicone elastomer molded component.
  • the tissue expander thus molded results in a variably textured and contoured shape with continuously variable wall thickness.
  • the tissue expander may be molded with an integral chamber-like fill port incorporated directly into the whole structure at the time of molding.
  • a fill port may be molded separately and during a later stage of manufacture be made adherent to the shell-like expander structure either totally on the smooth internal surface of the shell-like structure or with a portion of the fill port projecting through the shell-like structure.
  • FIGs. 3 and 5 Illustrated in Figs. 3 and 5 are two preferred embodiments of a molding tool positive with a product of the molding process superimposed on the tool.
  • Fig. 3 illustrates the case where a single void in the shell-like structure results from the molding process as a result of the presence of supporting column 50. This void is sized so as to accept a separately molded fill port which is adhesively attached to the shell-like expander.
  • Fig. 5 illustrates the case where a fully integrated fill port or other appended structure is molded directly into the expander proper.
  • a single resultant void is created at the region where supporting column 50 is attached to the positive portion of the molding structure.
  • this void requires patching with a special silicone elastomer patch created specifically for this purpose.
  • there are two "female" portions of the mold which serve to texturize the outer surface of the molded product. These female mold elements slide up and down guide shafts to fully enclose the positive mold element, or may slide in a plane substantially perpendicular to the axis of column.
  • the variably dimensioned void between the positive (male) and “female” portions of the mold serve to define the variable wall thickness of the final molded silicone elastomer product.
  • Unique texturing of the mold as per U.S. Patent #5,354,338 is transferred to molded product in accordance with engineering specifications. Thin 62 and thick 54 regions of the wall of the balloon-like expander shell enable differential expansion, the thin region enhancing expansion, the thick regions inhibiting it.
  • An additional preferred embodiment feature permitting especially advantageous directional expansion of a portion of a molded product is the bellows-like structure 70 molded directly into the "larger pole" apex of the tissue expander.
  • a further preferred embodiment of a tissue expander is the inclusion of a gas-filled pressure adaptive structure (Fig. 6) within the lumen of the tissue expander as per my U.S. Patent #5,383,929. This structure is indicated in Figure 6, "pressure adaptive" structure and is adhesively attached to the interior surface of thick region.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Public Health (AREA)
  • Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Prostheses (AREA)

Abstract

Dispositif d'expansion (52) de tissus mous présentant un rendement amélioré grâce à l'utilisation d'une expansion différentielle et directionnelle, une capacité d'expansion continue, une base et une stabilité dimensionnelle accrues, l'acquisition accrue de tissu mou grâce à une topographie de surface unique se traduisant par une amélioration du contour d'une cavité après expansion. On peut prévoir des moyens d'expansion destinés à réaliser l'expansion de l'implant dans une direction souhaitée. Dans le mode préféré de réalisation, un dispositif d'expansion ou implant (52) possède une surface extérieure (62) définissant un volume, ladite surface (62) comprenant une partie de base (58), une première paroi (54) et une seconde paroi (62), la seconde paroi (62) étant relativement plus mince que la première. Un orifice de remplissage (60), qui peut être réalisé par moulage intégral dans le dispositif d'expansion (52), est ménagé. Lorsque le dispositif d'expansion (52) est gonflé, une expansion différentielle se produit, la seconde partie de paroi (62) relativement mince se dilatant plus que la première partie de paroi (54). La base (58) peut comporter des nervures (82) ou autres moulées en structures pour accroître l'intégrité structurale. Eventuellement, un soufflet (70) peut être inclus sur la surface extérieure du dispositif d'expansion, ledit soufflet (70) comportant éventuellement une bague de limitation (72). Des structures géométriques moulées en place peuvent être employées pour présenter des surfaces intérieures ou extérieures texturées à l'implant ou au dispositif d'expansion. Des structures compressives peuvent être utilisées sur la surface intérieure ou extérieure de l'implant.
PCT/US1996/007689 1995-06-07 1996-05-24 Dispositif d'expansion de tissus Ceased WO1996040003A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU58768/96A AU5876896A (en) 1995-06-07 1996-05-24 Tissue expander

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47278195A 1995-06-07 1995-06-07
US08/472,781 1995-06-07

Publications (1)

Publication Number Publication Date
WO1996040003A1 true WO1996040003A1 (fr) 1996-12-19

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PCT/US1996/007689 Ceased WO1996040003A1 (fr) 1995-06-07 1996-05-24 Dispositif d'expansion de tissus

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WO (1) WO1996040003A1 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0872221A1 (fr) * 1997-04-05 1998-10-21 MediSyn Technologies Limited Prothèse mammaire sans couture
FR2794361A1 (fr) * 1999-06-02 2000-12-08 Arnaud Rochebiliere Prothese mammaire
EP1651143A2 (fr) * 2003-07-24 2006-05-03 Compagnie Européenne d'Etude et de Recherche de Dispositifs pour l'Implantation par Laparoscopie Implant de chirurgie plastique a regularite amelioree et procede de fabrication correspondant
EP2689747A1 (fr) * 2008-01-31 2014-01-29 Milux Holding SA Système d'implant mammaire
EP1469799B1 (fr) * 2002-02-01 2014-05-07 Mentor Worldwide LLC Dispositif extenseur de tissus avec protection contre une perforation accidentelle
WO2014168926A1 (fr) * 2013-04-09 2014-10-16 Reconstructive Technologies, Llc Systèmes et procédés pour un expanseur tissulaire
US9017403B2 (en) 2009-07-17 2015-04-28 Peter Forsell Breast implant system
US9399122B2 (en) 2013-04-09 2016-07-26 Reconstructive Technologies, Llc Systems and methods for a tissue expander
US9463087B2 (en) 2014-03-31 2016-10-11 Mentor Worldwide Llc Directional tissue expander
US9700405B2 (en) 2014-03-31 2017-07-11 Mentor Worldwide Llc Directional tissue expander

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3559214A (en) * 1968-10-17 1971-02-02 William J Pangman Compound prosthesis
US3852833A (en) * 1972-05-23 1974-12-10 Thamert O Textil Und Kunststof Breast prosthesis
US4264990A (en) * 1979-01-24 1981-05-05 Hamas Robert S Mammary prosthesis
US4574780A (en) * 1984-11-13 1986-03-11 Manders Ernest K Tissue expander and method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3559214A (en) * 1968-10-17 1971-02-02 William J Pangman Compound prosthesis
US3852833A (en) * 1972-05-23 1974-12-10 Thamert O Textil Und Kunststof Breast prosthesis
US4264990A (en) * 1979-01-24 1981-05-05 Hamas Robert S Mammary prosthesis
US4574780A (en) * 1984-11-13 1986-03-11 Manders Ernest K Tissue expander and method

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0872221A1 (fr) * 1997-04-05 1998-10-21 MediSyn Technologies Limited Prothèse mammaire sans couture
FR2794361A1 (fr) * 1999-06-02 2000-12-08 Arnaud Rochebiliere Prothese mammaire
WO2000074599A1 (fr) * 1999-06-02 2000-12-14 Missana Marie Christine Prothese mammaire
US6916339B1 (en) 1999-06-02 2005-07-12 Marie-Christine Missana Breast prosthesis
EP1469799B1 (fr) * 2002-02-01 2014-05-07 Mentor Worldwide LLC Dispositif extenseur de tissus avec protection contre une perforation accidentelle
EP1651143A2 (fr) * 2003-07-24 2006-05-03 Compagnie Européenne d'Etude et de Recherche de Dispositifs pour l'Implantation par Laparoscopie Implant de chirurgie plastique a regularite amelioree et procede de fabrication correspondant
EP2689747A1 (fr) * 2008-01-31 2014-01-29 Milux Holding SA Système d'implant mammaire
EP3354232A1 (fr) * 2008-01-31 2018-08-01 Milux Holding SA Système d'implant mammaire
US10537420B2 (en) 2008-01-31 2020-01-21 Peter Forsell Breast implant system
EP4046597A1 (fr) * 2008-01-31 2022-08-24 Implantica Patent Ltd Système d'implant mammaire
US9017403B2 (en) 2009-07-17 2015-04-28 Peter Forsell Breast implant system
WO2014168926A1 (fr) * 2013-04-09 2014-10-16 Reconstructive Technologies, Llc Systèmes et procédés pour un expanseur tissulaire
US9399122B2 (en) 2013-04-09 2016-07-26 Reconstructive Technologies, Llc Systems and methods for a tissue expander
US9463087B2 (en) 2014-03-31 2016-10-11 Mentor Worldwide Llc Directional tissue expander
US9700405B2 (en) 2014-03-31 2017-07-11 Mentor Worldwide Llc Directional tissue expander

Also Published As

Publication number Publication date
AU5876896A (en) 1996-12-30

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