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WO1995033494B1 - Emulsions of paramagnetic contrast agents for magnetic resonance imaging (mri), containing an organic chelator having an unsaturated aliphatic group - Google Patents

Emulsions of paramagnetic contrast agents for magnetic resonance imaging (mri), containing an organic chelator having an unsaturated aliphatic group

Info

Publication number
WO1995033494B1
WO1995033494B1 PCT/US1995/006818 US9506818W WO9533494B1 WO 1995033494 B1 WO1995033494 B1 WO 1995033494B1 US 9506818 W US9506818 W US 9506818W WO 9533494 B1 WO9533494 B1 WO 9533494B1
Authority
WO
WIPO (PCT)
Prior art keywords
unsaturated aliphatic
aliphatic group
emulsions
mri
contrast agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1995/006818
Other languages
French (fr)
Other versions
WO1995033494A1 (en
Filing date
Publication date
Priority claimed from US08/252,830 external-priority patent/US5571498A/en
Application filed filed Critical
Priority to AU26931/95A priority Critical patent/AU2693195A/en
Publication of WO1995033494A1 publication Critical patent/WO1995033494A1/en
Publication of WO1995033494B1 publication Critical patent/WO1995033494B1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Abstract

Emulsions of paramagnetic contrast agents and processes of making and using them are disclosed. The emulsions contain water, a dispersed oil phase and a complex of a paramagnetic metal ion and an organic chelator having a C10-C30 unsaturated aliphatic group. The emulsions are very stable and therapeutically acceptable for intravenous administration to enhance MRI.

Claims

57
AMENDED CLAIMS
[received by the International Bureau on 19 December 1995 (19.12.95); original claim 1 cancelled; original claims 16 and 18 amended; remaining claims unchanged (2 pages)]
2. A physiologically acceptable emulsion for enhancement of MRI imaging comprising water, a dispersed oil phase and a complex of a paramagnetic metal ion and an organic chelator having the formula
Figure imgf000003_0001
wherein from 2 to 5 M groups are hydroxyl, n=0 to 2, and at least one remaining M group is NR^, each R, is a C10-
C3o unsaturated aliphatic group and R2 is hydrogen, hydroxyl or a C^^ alkyl.
58
16. A physiologically acceptable emulsion for intravenous administration and enhancement of MRI imaging comprising water, a dispersed oil phase and a paramagnetic metal complex having a Cjo-Cjo unsaturated aliphatic group of claim 1, said emulsion having an average particle size less than about 1 micron.
17. The physiologically acceptable emulsion of claim 16 having an average particle size on the order of about 0.2 to about 0.4 micron.
18. A physiologically acceptable emulsion for enhancement of MRI imaging comprising water, a dispersed oil phase selected from the group consisting of an oil and fluorochemical, and mixtures thereof, a surfactant, and a complex of a paramagnetic metal ion and an organic chelator having the formula
Figure imgf000004_0001
wherein from 2 to 5 M groups are hydroxyl, n=0 to 2 and at least one remaining M group is NR^, each j is a C^-C^ unsaturated aliphatic group and Rj is hydrogen, hydroxyl or a
Figure imgf000004_0002
alkyl.
PCT/US1995/006818 1994-06-02 1995-05-31 Emulsions of paramagnetic contrast agents for magnetic resonance imaging (mri), containing an organic chelator having an unsaturated aliphatic group Ceased WO1995033494A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU26931/95A AU2693195A (en) 1994-06-02 1995-05-31 Emulsions of paramagnetic contrast agents for magnetic resonance imaging (mri), containing an organic chelator having an unsaturated aliphatic group

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/252,830 US5571498A (en) 1994-06-02 1994-06-02 Emulsions of paramagnetic contrast agents for magnetic resonance imaging (MRI).
US08/252,830 1994-06-02

Publications (2)

Publication Number Publication Date
WO1995033494A1 WO1995033494A1 (en) 1995-12-14
WO1995033494B1 true WO1995033494B1 (en) 1996-01-25

Family

ID=22957731

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/006818 Ceased WO1995033494A1 (en) 1994-06-02 1995-05-31 Emulsions of paramagnetic contrast agents for magnetic resonance imaging (mri), containing an organic chelator having an unsaturated aliphatic group

Country Status (4)

Country Link
US (1) US5571498A (en)
AU (1) AU2693195A (en)
IL (1) IL113897A0 (en)
WO (1) WO1995033494A1 (en)

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US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
DE19948651B4 (en) * 1999-09-29 2006-10-05 Schering Ag Galenic formulations containing para and diamagnetic perfluorinated compounds, their preparation and use
DE10105014C2 (en) * 2001-01-26 2003-03-27 Schering Ag New process for the production of DTPA monoamides
US6677483B2 (en) 2001-01-26 2004-01-13 Schering Ag Process for the production of monoamides of DTPA
US7179449B2 (en) 2001-01-30 2007-02-20 Barnes-Jewish Hospital Enhanced ultrasound detection with temperature-dependent contrast agents
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