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WO1995030001A3 - Novel p-selectin ligand protein - Google Patents

Novel p-selectin ligand protein Download PDF

Info

Publication number
WO1995030001A3
WO1995030001A3 PCT/US1995/004968 US9504968W WO9530001A3 WO 1995030001 A3 WO1995030001 A3 WO 1995030001A3 US 9504968 W US9504968 W US 9504968W WO 9530001 A3 WO9530001 A3 WO 9530001A3
Authority
WO
WIPO (PCT)
Prior art keywords
selectin ligand
selectin
ligand protein
novel
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1995/004968
Other languages
French (fr)
Other versions
WO1995030001A2 (en
WO1995030001A9 (en
Inventor
Glenn R Larsen
Dianne S Sako
Xiao-Jia Chang
Geertruida M Veldman
Dale Cumming
Ravindra Kumar
Gray D Shaw
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Institute LLC
Original Assignee
Genetics Institute LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Institute LLC filed Critical Genetics Institute LLC
Priority to AU23613/95A priority Critical patent/AU2361395A/en
Publication of WO1995030001A2 publication Critical patent/WO1995030001A2/en
Publication of WO1995030001A9 publication Critical patent/WO1995030001A9/en
Publication of WO1995030001A3 publication Critical patent/WO1995030001A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.
PCT/US1995/004968 1994-04-28 1995-04-24 Novel p-selectin ligand protein Ceased WO1995030001A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU23613/95A AU2361395A (en) 1994-04-28 1995-04-24 Novel P-selectin ligand protein

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US23539894A 1994-04-28 1994-04-28
US08/235,398 1994-04-28
US31630594A 1994-09-30 1994-09-30
US08/316,305 1994-09-30

Publications (3)

Publication Number Publication Date
WO1995030001A2 WO1995030001A2 (en) 1995-11-09
WO1995030001A9 WO1995030001A9 (en) 1995-12-14
WO1995030001A3 true WO1995030001A3 (en) 1996-01-11

Family

ID=26928869

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/004968 Ceased WO1995030001A2 (en) 1994-04-28 1995-04-24 Novel p-selectin ligand protein

Country Status (2)

Country Link
AU (1) AU2361395A (en)
WO (1) WO1995030001A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464778A (en) * 1989-03-08 1995-11-07 Board Of Regents Of The University Of Oklahoma Glycoprotein ligand for P-selectin and methods of use thereof
US6309639B1 (en) 1991-02-05 2001-10-30 The Board Of Regents Of The University Of Oklahoma Method for inhibiting an inflammatory response using antibodies to P-selectin glycoprotein ligand
US6124267A (en) * 1991-02-05 2000-09-26 Southpac Trust Internationals, Inc. O-glycan inhibitors of selectin mediated inflammation derived from PSGL-1
DE69332881T2 (en) * 1992-05-05 2004-01-29 Aeres Biomedical Ltd ANTIBODIES AGAINST P-SELECTIN AND THEIR USE
US6277975B1 (en) 1992-10-23 2001-08-21 Genetics Institute, Inc. Fusions of P-selectin ligand protein and polynucleotides encoding same
CZ401497A3 (en) * 1995-06-14 1998-07-15 The General Hospital Corporation P-selectin ligands and related molecules and processes
ES2208759T3 (en) * 1995-08-03 2004-06-16 Board Of Regents Of The University Of Oklahoma O-GLICANS INHIBITORS OF THE INFLAMMATION MEDIATED BY SELECTINE.
AU770883B2 (en) * 1996-08-30 2004-03-04 Genetics Institute, Llc P-selectin ligand proteins
US5728568A (en) * 1996-11-22 1998-03-17 Genetics Institute, Inc. Human GDP-mannose 4,6 dehydratase
AU2975599A (en) * 1998-02-27 1999-09-15 Genetics Institute Inc. P-selectin ligand protein including tetrameric fusion proteins
AU2000274809A1 (en) * 2000-09-12 2002-03-26 Genetics Institute Llc Inhibition of stenosis or restenosis by p-selectin antagonists
JP7244422B2 (en) 2017-01-11 2023-03-22 ブリストル－マイヤーズ スクイブ カンパニー PSGL-1 antagonists and uses thereof
SG11201907848YA (en) 2017-03-14 2019-09-27 Five Prime Therapeutics Inc Antibodies binding to vista at acidic ph
MX2020009786A (en) 2018-03-21 2020-10-12 Five Prime Therapeutics Inc ANTIBODIES BINDING TO SUPPRESSOR OF T CELL ACTIVATION CONTAINING THE IMMUNOGLOBULIN VARIABLE DOMAIN (VISTA) AT ACID PH.
US12091462B2 (en) 2018-07-11 2024-09-17 Five Prime Therapeutics, Inc. Antibodies binding to vista at acidic pH

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991006632A1 (en) * 1989-10-20 1991-05-16 New England Medical Center Hospitals, Inc. Inhibition of padgem-mediated cell binding
WO1992001718A2 (en) * 1990-07-17 1992-02-06 Board Of Regents Of The University Of Oklahoma Functionally active selectin-derived peptides and ligand for gmp-140
WO1992016612A2 (en) * 1991-03-11 1992-10-01 New England Medical Center Hospitals, Inc. Method of inhibiting padgem-mediated interactions using an inhibitor comprising a 2,6 sialic acid component
WO1992019735A1 (en) * 1991-05-06 1992-11-12 Genentech, Inc. GLYCAM-1 (Sgp 50), A SELECTIN LIGAND
WO1994010309A1 (en) * 1992-10-23 1994-05-11 Genetics Institute, Inc. Novel p-selectin ligand protein
WO1994011498A1 (en) * 1992-11-16 1994-05-26 Board Of Regents Of The University Of Oklahoma Glycoprotein ligand for p-selectin and methods of use thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991006632A1 (en) * 1989-10-20 1991-05-16 New England Medical Center Hospitals, Inc. Inhibition of padgem-mediated cell binding
WO1992001718A2 (en) * 1990-07-17 1992-02-06 Board Of Regents Of The University Of Oklahoma Functionally active selectin-derived peptides and ligand for gmp-140
WO1992016612A2 (en) * 1991-03-11 1992-10-01 New England Medical Center Hospitals, Inc. Method of inhibiting padgem-mediated interactions using an inhibitor comprising a 2,6 sialic acid component
WO1992019735A1 (en) * 1991-05-06 1992-11-12 Genentech, Inc. GLYCAM-1 (Sgp 50), A SELECTIN LIGAND
WO1994010309A1 (en) * 1992-10-23 1994-05-11 Genetics Institute, Inc. Novel p-selectin ligand protein
WO1994011498A1 (en) * 1992-11-16 1994-05-26 Board Of Regents Of The University Of Oklahoma Glycoprotein ligand for p-selectin and methods of use thereof

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
C.N. STEININGER ET AL.: "The glycoprotease of Pasteurella haemolytica A1 eliminates binding of myeloid cells to P-selectin but not to E-selectin", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 188, no. 2, 30 October 1992 (1992-10-30), ACADEMIC PRESS, N.Y., US;, pages 760 - 766 *
D. SAKO ET AL.: "Expression cloning of a functional glycoprotein ligand for p-selectin", CELL, vol. 75, no. 6, 17 December 1993 (1993-12-17), CELL PRESS,CAMBRIDGE,MA,US;, pages 1179 - 1186 *
G.R. LARSON ET AL.: "P-selectin and E-selectin", J. BIOL. CHEM., vol. 267, no. 16, 5 June 1992 (1992-06-05), AM. SOC. MOL. BIOL., INC.,BALTIMORE, US;, pages 11104 - 11110 *
K. MAEMURA AND M. FUKUDA: "Poly-N-acetyllactosaminyl O-glycans attached to leukosialin", J. BIOL. CHEM., vol. 267, no. 34, 5 December 1992 (1992-12-05), AM. SOC. BIOCHEM. MOL.BIOL.,INC.,BALTIMORE,US, pages 24379 - 24386 *
K.L. MOORE ET AL.: "The P-selectin glycoprotein ligand from human neutrophils displays sialylated, fucosylated, O-linked poly-N-acetyllactosamine", J. BIOL. CHEM., vol. 269, no. 37, 16 September 1994 (1994-09-16), AM. SOC. BIOCHEM. MOL.BIOL.,INC.,BALTIMORE,US, pages 23318 - 23327 *
K.L.MOORE ET AL.: "Identification of a specific glycoprotein ligand for P-selectin (CD62) on myeloid cells", J. CELL BIOLOGY, vol. 118, no. 2, ROCKEFELLER UNIV. PRESS, N.Y. , US;, pages 445 - 456 *
M.F.A. BIERHUIZEN AND M. FUKUDA: "Expression cloning of a cDNA encoding UDP-Glc:Galbeta1-3-GalNAc-R (GlcNAc to GalNAc) beta1-6GlcNAc transferase by gene transfer into CHO cells expressing polymoma large tumor antigen", PROC. NATL.ACAD SCI., vol. 89, NATL. ACAD SCI.,WASHINGTON,DC,US;, pages 9326 - 9330 *

Also Published As

Publication number Publication date
WO1995030001A2 (en) 1995-11-09
AU2361395A (en) 1995-11-29

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