[go: up one dir, main page]

WO1995015376A3 - METHODE DE DETECTION IN VIVO D'INHIBITEURS DE REPONSES ALLERGIQUES INDUITES PAR L'IgE - Google Patents

METHODE DE DETECTION IN VIVO D'INHIBITEURS DE REPONSES ALLERGIQUES INDUITES PAR L'IgE Download PDF

Info

Publication number
WO1995015376A3
WO1995015376A3 PCT/US1994/013660 US9413660W WO9515376A3 WO 1995015376 A3 WO1995015376 A3 WO 1995015376A3 US 9413660 W US9413660 W US 9413660W WO 9515376 A3 WO9515376 A3 WO 9515376A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibitors
allergic responses
vivo assays
mediated allergic
ige mediated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1994/013660
Other languages
English (en)
Other versions
WO1995015376A2 (fr
WO1995015376A9 (fr
Inventor
Jean Pierre Kinet
Beverly Koller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Priority to AU12136/95A priority Critical patent/AU1213695A/en
Publication of WO1995015376A2 publication Critical patent/WO1995015376A2/fr
Publication of WO1995015376A3 publication Critical patent/WO1995015376A3/fr
Publication of WO1995015376A9 publication Critical patent/WO1995015376A9/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0381—Animal model for diseases of the hematopoietic system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Dans les méthodes de détection in vivo d'inhibiteurs de réponses allergiques humaines on utilise des souris transgéniques humanisées dans lesquelles au moins un gène humain codant une chaîne du récepteur de Fc⊂RI remplace l'expression de son homologue murin. Ces méthodes sont particulièrement utiles pour détecter les inhibiteurs des réponses allergiques induites par l'IgE.
PCT/US1994/013660 1993-12-01 1994-12-01 METHODE DE DETECTION IN VIVO D'INHIBITEURS DE REPONSES ALLERGIQUES INDUITES PAR L'IgE Ceased WO1995015376A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU12136/95A AU1213695A (en) 1993-12-01 1994-12-01 (in vivo) assays for inhibitors of ige mediated allergic responses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16050293A 1993-12-01 1993-12-01
US08/160,502 1993-12-01

Publications (3)

Publication Number Publication Date
WO1995015376A2 WO1995015376A2 (fr) 1995-06-08
WO1995015376A3 true WO1995015376A3 (fr) 1995-06-29
WO1995015376A9 WO1995015376A9 (fr) 1995-07-06

Family

ID=22577130

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/013660 Ceased WO1995015376A2 (fr) 1993-12-01 1994-12-01 METHODE DE DETECTION IN VIVO D'INHIBITEURS DE REPONSES ALLERGIQUES INDUITES PAR L'IgE

Country Status (2)

Country Link
AU (1) AU1213695A (fr)
WO (1) WO1995015376A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6111166A (en) * 1994-09-19 2000-08-29 Medarex, Incorporated Transgenic mice expressing human Fcα and β receptors
DE19643427C1 (de) * 1996-10-22 1998-02-12 Bundesrep Deutschland Verfahren zur Bestimmung von Allergenen in der Luft
FR2822161B1 (fr) * 2001-03-15 2003-09-19 Genoway Cellule et animal transgenique modelisant les reponses humaines allergiques mediees par les ige, et leurs utilisations
DE60322426D1 (fr) 2002-12-16 2008-09-04 Genentech Inc
SI24066A (sl) * 2012-05-07 2013-11-29 Univerzitetna klinika za pljuÄŤne bolezni in alergijo Golnik Materiali in metode na nivoju bazofilcev in visokoafinitetnega IgE receptorja povezane z diagnosticiranjem anafilaksije

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DOWBROWIC, D. ET AL.: "Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobin E receptor alpha chain gene", CELL., vol. 75, no. 5, 3 December 1995 (1995-12-03), CAMBRIDGE, NA US, pages 969 - 976 *
GILFILLAN, A.M. ET AL.: "Characterization of mast cell like lines expressing a functional human FcERI alpha subunit", JOURNAL OF CELL BIOLOGY, vol. 115, no. 3 P2, November 1991 (1991-11-01), pages 220A *
HAKIMI J. ET AL.: "The alpha subunit of the human IgE receptor (FcERI) is sufficient for high affinity IgE binding", JOURNAL OF BIOLOGICAL CHEMISTRY. (MICROFILMS), vol. 265, no. 36, 25 December 1990 (1990-12-25), BALTIMORE, MD US, pages 22079 - 22081 *

Also Published As

Publication number Publication date
AU1213695A (en) 1995-06-19
WO1995015376A2 (fr) 1995-06-08

Similar Documents

Publication Publication Date Title
SG52215A1 (en) Cloning and expresssion of humanized monoclonal antibodies against human interleukin-4
FR2700908B1 (fr) Récepteur de télévision à mémoire tampon.
WO2002056670A3 (fr) Sondes d'imagerie activables
EP2128260A3 (fr) Protéines de surperfamille à TGF-béta modifié
DE69600919D1 (de) Anpassungssteuerung für einen echounterdrücker
FI962377A7 (fi) Humanisoituja vasta-aineita ja niiden käyttö
BR9609035A (pt) Anticorpos monoclonais de macaco específicos para formas primatizadas B7.1 e/ou B&.2 humanas composições farmacéuticas
DE69533675D1 (de) Monoklonaler antikörper gegen rhesus d (d7c2)
KR970703100A (ko) 부피가 감소된 식품의 부피를 크게하는 방법(method for increasing the bulk of food having reduced bulk)
WO2005051178A3 (fr) Marqueur pour la neuromyelite optique
FR2705765B1 (fr) Porte de four.
DE69833537D1 (de) Ultraschallsendeimpulse für nicht-lineare Ultraschallbilderzeugung
CY1107339T1 (el) Mu-1, μελος της οικογενειας υποδοχεα κυτοκινης
EP0628811A3 (fr) Procédé de spectroscopie à résonance ultrasonique pour déterminer les modules d'élasticité.
WO1998026054A3 (fr) Produits et procedes en relation avec la pyk2
WO1995024481A3 (fr) Anticorps monoclonaux humanises contre l'interleukine-4 chez l'homme
WO1995015376A3 (fr) METHODE DE DETECTION IN VIVO D'INHIBITEURS DE REPONSES ALLERGIQUES INDUITES PAR L'IgE
FI953579A0 (fi) Menettely hiilivetytuotteiden fysikaalisten ominaisuusarvojen ennustamiseksi
TR199800517A3 (tr) Hümanize anti-hümen fas antikor.
TR199501542A2 (tr) Bagisiklik önleyici aktiviteye sahip monoklonal antikor parcalari.
NO940424L (no) Fremgangsmåte for fraksjonering av havre, samt havreprodukter
ITRM940137A0 (it) Coloranti azoici e prodotti intermedi, loro preparazione e loro impiego come coloranti. (caso 158-5691)
EP0652092A3 (fr) Granulateur.
NO975600D0 (no) Tidlig diagnostisk test
AU4654097A (en) Rdgb-proteins

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU BR CA CZ FI HU JP KR NO NZ

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

AK Designated states

Kind code of ref document: A3

Designated state(s): AU BR CA CZ FI HU JP KR NO NZ

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

COP Corrected version of pamphlet

Free format text: PAGES 9 AND 39,DESCRIPTION,REPLACED BY NEW PAGES BEARING THE SAME NUMBER;AFTER RECTIFICATION OF OBVIOUS ERRORS AS AUTHORIZED BY THE INTERNATIONAL SEARCHING AUTHORITY

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: CA