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WO1995001920A1 - Recipient pour produits pharmaceutiques - Google Patents

Recipient pour produits pharmaceutiques Download PDF

Info

Publication number
WO1995001920A1
WO1995001920A1 PCT/GB1994/001490 GB9401490W WO9501920A1 WO 1995001920 A1 WO1995001920 A1 WO 1995001920A1 GB 9401490 W GB9401490 W GB 9401490W WO 9501920 A1 WO9501920 A1 WO 9501920A1
Authority
WO
WIPO (PCT)
Prior art keywords
lid
container
neck
contents
access aperture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB1994/001490
Other languages
English (en)
Inventor
Dallas Burston
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DALLAS BURSTON ASHBOURNE Ltd
Original Assignee
DALLAS BURSTON ASHBOURNE Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DALLAS BURSTON ASHBOURNE Ltd filed Critical DALLAS BURSTON ASHBOURNE Ltd
Priority to AU71288/94A priority Critical patent/AU7128894A/en
Publication of WO1995001920A1 publication Critical patent/WO1995001920A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D50/00—Closures with means for discouraging unauthorised opening or removal thereof, with or without indicating means, e.g. child-proof closures
    • B65D50/02—Closures with means for discouraging unauthorised opening or removal thereof, with or without indicating means, e.g. child-proof closures openable or removable by the combination of plural actions
    • B65D50/06—Closures with means for discouraging unauthorised opening or removal thereof, with or without indicating means, e.g. child-proof closures openable or removable by the combination of plural actions requiring the combination of different actions in succession
    • B65D50/061—Closures with means for discouraging unauthorised opening or removal thereof, with or without indicating means, e.g. child-proof closures openable or removable by the combination of plural actions requiring the combination of different actions in succession being disengageable from container only after rotational alignment of closure, or other means inhibiting removal of closure, with container, e.g. tortuous path type

Definitions

  • This invention relates to containers and is particularly, but not exclusively, concerned with containers incorporating a facility for dispensing the container contents in a controlled incremental discharge.
  • 'containei' is used herein to embrace any form of enclosure or hollow vessel, for storage purposes - whether with or without any controlled discharge or dispensing features.
  • 'dispense/' is used herein to embrace any device or contrivance for the controlled egress, discharger or re-disposition of contents from an enclosure or vessel, such as a container.
  • an integrated container and dispenser may typically combine an enclosure with a controlled access device, whereby the container contents may be disgorged or output progressively in some manner to a greater or lesser degree controlled - and even predetermined, eg in a 'one-shot' dispenser.
  • Pharmaceutical containers may fulfil the role of pharmaceutical product dispensers.
  • a diversity of containers have been used for pharmaceutical products - for example, in multiple, discrete, solid element form, specifically, tablets or capsules.
  • the tab must be physically removed (by pulling and severing) to enable operation of the cap.
  • This very locking tab removal provides a visual indication that access has been attempted.
  • the strip may also provide additional security, or entry deterrent - inhibiting dislodgement of the cap, for example upon casual impact or contact.
  • the strip may also afford a supplementary (external) seal for the container - for example in addition to any sealing provision between the cap (inner) and the container (outer) contact surfaces.
  • Such child resistance may, for example, comprise a supplementary 'interlock' between the container body and cap, which must be over-ridden or 'unlocked' before prising the cap from the body.
  • the interlock may utilise an interactive threaded coupling, such as a bayonet pin and socket, holding the cap 'captive' to the body, but allowing free relative rotation, and requiring a certain cap and body pre-alignment to disengage the cap and body threads.
  • regulatory constraints may require provision of both tamper evident and child proof/resistant container packaging for certain 'sensitive' products such as pharmaceuticals - whose unsanctioned or unsupervised consumption may have adverse, or even fatal, health consequences.
  • child resistant features may not prove a deterrent to a determined inquisitive child, without conventional mechanical pre-conceptions of what means might be tried to remove the cap. Indeed, they may even represent a challenge.
  • a disadvantage of some known containers and their various individual locking and security provisions is that their implementation or operation may require more grip, dexterity or force, than, say, a frail, elderly or infirm person can effectively expend or deploy. This can represent a deterrent to an intended user.
  • a container comprising a hollow body enclosure defining a storage region - for example for pharmaceutical products, such as those in multiple, discrete elemental form, ie tablets or capsules, a discharge access in the body, a lid or closure cap beatable over the body access to seal off the access, the closure cap being lockable to the body when located over the body access, by relative rotary movement of the cap and body, to selectively and alternatively hold the lid captive and release the lid for pivot movement about one end thereof, exposing the discharge access, to allow egress of the container contents.
  • pharmaceutical products such as those in multiple, discrete elemental form, ie tablets or capsules
  • a pharmaceutical product container comprising a flat-pack body surmounted by a combination rotary and lift-off lid or closure cap of complementary flat-pack profile.
  • Figure 1 shows a perspective view of a container with a top lid closed
  • Figure 2 shows a perspective view of the container of Figure 1 , with the top lid open;
  • Figure 3 shows a side end elevation of the container shown in Figure 1 ;
  • Figure 4 shows and opposite side end elevation to that shown in Figure 3;
  • Figure 5 shows a top (upper plan) view of the container shown in Figures 1 through 4;
  • Figure 6 shows a base (underside plan) view of the container shown in Figures 1 through 5;
  • Figure 7 shows a front face elevation of the container shown in Figures 1 through 6;
  • Figure 8 shows a rear face elevation of the container shown in Figures 1 through 7
  • Figure 9 shows a scrap section of the lid and integral base neck mounting collar for the container of Figures 1 through 8 in alternative open/closed and assembled/pre- assembled conditions
  • Figure 10 shows a top (upper plan) view of the body of the container shown in Figures 1 through 9, with the lid removed;
  • Figure 11 shows a sectional (side) view of the container shown in Figures 1 through 8, with the lid closed upon the body;
  • Figure 12 shows an end section corresponding to side section of Figure 11.
  • a container 20 is of generally rectangular profile, with a base or body 21 , surmounted by a hinged lid 21.
  • an upstanding cylindrical neck 28 Surmounting the container body 21 is an upstanding cylindrical neck 28, with an access aperture 29 to the interior of the container 20. This is primarily used for discharging the container contents in a controlled manner, but may also be used for filling or replenishing in certain circumstances.
  • the container 20 incorporates various significant features, including:
  • VII discrete base insert - enabling rapid container filling when inverted, before insertion of the base element;
  • VIII base storage region - at the underside of the container bottom or floor is a supplementary recess into which a multiple folded patient information leaflet may be inserted, restrained or entrained by a sprung clip, or even the resilience of the leaflet paper or card;
  • IX improved internal seal and thus moisture vapour transmission (MVT) inhibition performance (thus preserving the container contents against degradation), without attendant stiffness in lid removal;
  • the lid 22 is mounted as a 'flip-top' to the base 21 - that is it is hinged or pivoted, from one end extremity, with respect to the base 21.
  • the lid 22 and body 21 are mutually entrained - or held captive to one another - by a collar 39 and depending lateral arm 35 integrally moulded with the lid 22 and mounted around the upstanding neck 28 on the upper end of the body 21.
  • Figure 9 shows both the opened out and closed - and assembled and pre-assembled - conditions of the lid 22 and integrally moulded arm 35 and collar 39 about a mutually entraining reduced wall section, forming a hinge or pivot region 36.
  • the integrated lid 22 assembly is actually moulded in the opened out condition - which therefore also represents the 'relaxed' (open) condition of the lid 22 when mounted upon the upstanding neck 28 of the body 21.
  • the lid 22 can thus be mounted upon the neck 28 of the body 21 in the opened out condition - and, in order to close the lid 22, the collar 39 and arm 35 are folded inwards about the waisted hinge region 36 and tucked inside the outer shell 51 , as indicated by arcuate arrow 61.
  • the lid collar 39 partially enshrouds the internal depending neck 33 - with the neck 28 of the body 21 intervening there-between, as shown in Figures 9, 11 and 12.
  • Closure of the lid upon the neck 28, requires it be folded against the natural resilience of the hinge 36 - and similarly, when the lid 22 is released from the neck 28 it has a natural tendency to spring open.
  • FIG. 9 To the right hand side of Figure 9 is depicted the integrated moulding of the opposite end of the lid 22 from the mounting collar 39, to form an internal latching web 47 with a bayonet style latching element 38 for engaging (and thus locking) the lid 22 upon the threads 32 of the neck 28, as shown more clearly in Figures 2 and 11.
  • the latching web 47 is first tucked under the outer shell of the lid 22, by folding inwards as indicated by arcuate arrow 62, and latched upon an internal projection 49 on the underside of the lid shell 51.
  • the lid 22 - eg single-handedly - one end thereof may incorporate an integrally - moulded finger/thumb recess (not shown).
  • discrete elements may jam together in the neck 28 and may prove difficult to dislodge - encouraging the user to shake, strike or vibrate the container 20 in an attempt to re-orientate and re-dispose the elements. Even if this 'informal- empirical' tactic works, there is a tendency for the contents to disgorge suddenly in an uncontrolled outflow.
  • the cross-sectional shape of the access aperture 29 and the axial extent of the neck 28 and the degree of taper of the shoulders 27 are selected to promote a controlled release, discharge or passage of the container contents.
  • the body volume capacity is greater (but not unduly) than that of the maximum intended contents - that is there remains a predetermined minimum free 'head-space' above the contents, even when the container is full.
  • a head-space allows free re-disposition of the contents and thus the opportunity for individual elements to separate from the inter-nested bulk. Nevertheless, in order to restrain such contents movement and thus obviate any consequential damage (eg tablet chipping or fragmentation), during initial packing and transit, a resilient foam packing element or plug may be inserted after filing.
  • a multiple sealing arrangement is associated with the inter-fitting lid 22 and neck 28 profiles.
  • a seal may be effected between the top edge of the neck 28 and the inner face of the lid 22 (ie the underside of the shell 51) - although the contact region is a marginal (annular) peripheral one.
  • the effectiveness, if any, of such a seal depends upon the downward clamping force exerted between the lid 22 and body 21 , upon the rotary inter-locking action described elsewhere.
  • the interior of the lid 22 incorporates a depending seal collar 33 with an external peripheral protruding annular seal rim 34, which inter-fits with a complementary profiled groove 31 on the internal circumference of the upper end of the neck 28 of the body 21 when the lid is in place - as depicted in Figures 11 and 12.
  • Such a seal relies upon a radially tight inter-fitting of lid collar 33 and the body neck 28 - which is independent of the degree of clamping or locking of the lid 22 upon the body 21, but which extends over a larger mutual surface contact area then, say, the neck rim seal.
  • the multiple inter-engaging contours promote a secure, tight inter-fitting seal action - without requiring the lid 22 to fit unduly tightly, ie to the extent of inhibiting lid 22 separation and removal.
  • the wall thickness and material are selected to afford the necessary rigidity or semi- rigidity and resilient deformability, according the local requirements.
  • the upper end of the neck 28 of the body 21 incorporates a diametrically- opposed pair of recesses or gaps 37 in the outer circumferential thread 32, which allows introduction and removal of a thread running element 38 within the lid 22.
  • a thread running element 38 is engaged within or disengaged form the thread 32 of the body 22.
  • the lid may be opened or closed.
  • the four quadrant alignment conditions - or relative lid 22 and body 21 positions - represent the lid 22 at right angles to the body 21.
  • the lid 22 aligned with the body 21 and the respective thread runner 38 and thread 32 inter-engaged, the lid 22 is effectively locked closed - and cannot be opened until it has been turned relative to the body 22 fairly precisely through 90 degrees, or at right angles thereto.
  • an internal mechanical 'user feel' position indexing facility is provided.
  • the lower end of the neck 28 of the body 21 at the region embraced by the collar 39 or neck band of the lid 21, incorporates a series of (in this case 4) equi- angulariy-spaced index protrusions 53, which are receivable in a corresponding (but unshown) array of recesses in the internal face of the collar 39.
  • index protrusions 53 are receivable in a corresponding (but unshown) array of recesses in the internal face of the collar 39.
  • a supplementary visual indication - for example markings (such as moulded arrow heads) on the lid and body which must be brought into alignment - may also be provided to facilitate the lid unlocking and locking actions.
  • the retaining collar 39 In order to mount the lid 22 upon the neck 28 of the body 22, the retaining collar 39 must be located and pressed downwardly over the neck 28, until it reaches the lower shoulder 47 of the neck 28 to which its internal profile 46 is complementary, providing a snug, but relatively rotatable fit. Removal of the collar 39 is inhibited by inter-engagement of a wedge profile internal shoulder 44 at the upper end of thereof (as more readily appreciated from Figure 9) with a complementary wedge shoulder at the mid-section external periphery of the neck 28. In this way, the collar 39, and thus the integral arm 35 and remainder of the hinged lid
  • the rectangular profile lends itself more readily to handling, than, say a conventional cylindrical barrel container.
  • the rectangular body 21 is more ergonomic to grip when seeking to remove the lid 22 - by a relative twisting or turning action.
  • the extended radial profile of the body 21 about the container twist axis provides greater turning moment or leverage about the container axis.
  • the side walls the container body contours are embody a shallow curve with progressively more rounding towards the comers. Such corner rounding also features on upper edges of the lid 21.
  • the same cross-sectional size and shape lid and body configuration may readily be employed for bodies of different length - ie shallow and deep - in order to achieve volumetric capacity variations.
  • a progressive range typically three or four, containers with capacity for a specified number of tablets or capsules, each of a prescribed dosage, and collectively representing a treatment regime at a prescribed consumption rate. For example, a one or two week treatment at one tablet/capsule per day, may be held in a single container.
  • the generally rectangular overall profile of the container 20 lends itself to packing - ie one container nesting against another - without undue wasted space, particularly when compared with conventional cylindrical container configurations.
  • a tray of such containers may simply be shrink- wrapped in plastics film, and stacked in tiers with other such shrink-wrapped trays.
  • containers of such profile are more readily stored and displayed ready for filling or dispensing pre-filled upon the shelves of a pharmacist or dispenser.
  • Label - Identification Profile The relatively flat side surfaces of the container lend themselves to the application and display of (impersonal - supplier issued) product content and (personalised for the recipient) use label information.
  • Such information is a combination of pre-prepared (impersonal, product-specific) manufacturers' product identification, both brand and generic, and technical specification or formulation and product licence number, brand or trade mark and manufacturer or supplier's identity and address - together with (personalised, patient and product specific) prescription information personalised at the point of dispensing, typically with the name of the recipient patient, and consumption directions, ie number and frequency of tablets, produced at the point of issue or dispensing.
  • pre-filled, sealed containers from the manufacturer can readily be identified by a large clear label area - assisting in minimising dispensing errors to the individual patient recipient.
  • the distinctive container profile and prominent label identification area assist in avoiding patient consumption errors - and promoting patient 'compliance' (ie taking only the medication prescribed, when appropriate and for a full course of treatment).
  • the overall container configuration is volumetrically-efficient - that is the effective or usable storage capacity is a good proportion of the outer volume.
  • the container may be filled in production, either through the mouth 29, using proprietary filling/counting/weighing equipment, before the lid is fitted - or by inverting the container before the base element 41 is installed.
  • the lid assembly 22 may be mounted upon the body 21 , and indeed locked in position thereupon.
  • the container 20 may be moulded from synthetic plastics materials, with appropriate characteristics, using conventional techniques.
  • the body 21 could be moulded from, say, white, high density polyethylene, the lid or closure cap from, say, white polypropylene and the base also of white polyethylene.
  • the lid 22 and body 21 of the container 20 are initially sealed, entrained or tethered together - or simply mutually restrained (ie from relative rotation necessary to unlock the lid) - by a lateral locking strip 23 along one of the longer side walls.
  • This strip 23 may be integrally-moulded with the lid 22 with a pre-formed weakening line to facilitate subsequent separation and detachment.
  • the strip 23 may optionally inco ⁇ orate a thread blocking element which inhibits co- operative action of the threads on the lid 22 and neck 28 of the body 21.
  • the strip 23 may thus be present initially upon the lid 22 - which is installed by the initial moulding process, and before insertion of the base 41 , so that the lid 22 and body 21 are initially integrated by the strip 23.
  • the container 20 can be filled from the base end by upturning and the base 41 subsequently installed.
  • the base 41 is a one-way fit in the interior base periphery of the body 21 , with inter-engaging complementary detent ribs and recesses 42, 43.
  • one end of the locking strip has a slightly protruding end pull tab 24, whereby the strip 23 can be prised away from both the lid 22 and body 21 (and indeed separated altogether there-from and disposed of) - enabling relative (unlocking) rotation there-between, and thus access to the container contents, through the access aperture or mouth 29.
  • This strip 23 thus provides a form of tamper-evident seal - removal of, or even interference with, which provides a readily visible indication that the container contents may have be interfered with.
  • Such a tamper evident feature is primarily for peace-of-mind and security to the customer or recipient upon the initial presentation of the container 20.
  • a lateral locking tab could in some form remain a permanent additional security feature, for example in child-resistance.
  • the dispensing - ie controlled discharge - capabilities of the container 20 may be enhanced, for example to include some form of quantity or flow regulation - and even measurement.
  • the lid 22 could form an intermediary reception ladle - with the container contents first being disgorged by careful tipping over into the upturned inner crater or 'cradle' of the lid.
  • Such a lid cradle might be of a prescribed volume or capacity - so that when full, its contents represent a prescribed dosage (of a pharmaceutical container contents).
  • Dispensing control may feature more importantly with flowing bulk container ingredients - ie powders and liquids.
  • valve assembly may be included - for example with the valve elements embodied in the lid and body (neck or spout) structures.
  • the valve operation may rely upon the relative lid and body rotation previously described to open and close the valve, ie by aligning respective access apertures or tightening or releasing an intervening seal element - and indeed supplemental movements.
  • OPD One Pack Dispensing
  • a container according to the invention lend itself to OPD or One Pack Dispensing requirements. That is the container contents are self-contained as a complete course of treatment and thus can be dispensed as an entire intact - and (tamper evident) sealed - pack.
  • the size, proportions and configuration of the container may vary considerably and may be adapted to suit particular purposes - ie contents nature, bulk storage capacity and dispensing or controlled discharge requirements.
  • the lid or cap seals may be improved for security of liquid retention and the access opening reduced to facilitate a controlled outflow of liquid contents.
  • a funnel, mouth or spout may be provided - say, in the neck profile.
  • the neck 28 is co-axial with the container - or the container axis of symmetry, a laterally- offset neck position could be adopted without undermining the flip-top leverage action, as indeed could non-symmetrical body profiles and lid/body relative configurations.
  • lid and body do not have to conform identically in profile.
  • a deliberately enlarge lid could be provided to facilitate gripping and removal. Individual Roles of Lid and Body - other environments.
  • lid and body have been hitherto described as a co-operative, integrated whole, they may fulfil separate, independent roles. That is to say a given lid could be mounted upon disparate containers, provided the immediate neck configuration remained in common.
  • a sealing closure door for an appliance with an activity chamber such as a washing machine may usefully embody the integrated flip-latch and turn-locking facilities disclosed.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Closures For Containers (AREA)

Abstract

Un récipient (2) pour produits pharmaceutiques, se présentant sous la forme de plusieurs élément discrets tels que des comprimés ou des capsules, présente une forme générale de 'boîtier plat', d'un profil rectangulaire en projection verticale et horizontale, et un couvercle (22) à charnière, pouvant être verrouillé sur un corps (21) par un élément de verrouillage rotatif (37, 38); le profil rectangulaire aide à la prise en main, et le couvercle est articulé à une extrémité afin d'en faciliter l'ouverture par le soulèvement de l'extrémité libre opposée; le couvercle ne peut être verrouillé ou déverrouillé que lorsqu'il est tourné vers une position choisie entre quatre positions sur des quarts de cercle, dans lesquelles les éléments de verrouillage sont alignés de façon à pouvoir être libérés.
PCT/GB1994/001490 1993-07-09 1994-07-08 Recipient pour produits pharmaceutiques Ceased WO1995001920A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU71288/94A AU7128894A (en) 1993-07-09 1994-07-08 Pharmaceutical container

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9314472.3 1993-07-09
GB939314472A GB9314472D0 (en) 1993-07-09 1993-07-09 Pharmaceutical container

Publications (1)

Publication Number Publication Date
WO1995001920A1 true WO1995001920A1 (fr) 1995-01-19

Family

ID=10738749

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1994/001490 Ceased WO1995001920A1 (fr) 1993-07-09 1994-07-08 Recipient pour produits pharmaceutiques

Country Status (3)

Country Link
AU (1) AU7128894A (fr)
GB (1) GB9314472D0 (fr)
WO (1) WO1995001920A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003057593A1 (fr) * 2001-12-21 2003-07-17 Nektar Therapeutics Emballage a capsules a membrane etanche

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT304290B (de) * 1970-11-18 1972-12-27 Ernst Feichtinger Dipl Kfm Ing Schnappverschluß für Flaschen
GB1520808A (en) * 1976-10-14 1978-08-09 Glyndon Plastics Ltd Caps and containers
US4449639A (en) * 1982-12-13 1984-05-22 Johnsen & Jorgensen (Plastics) Ltd. Tamper-resistant and child-resistant closures
EP0110796A1 (fr) * 1982-11-18 1984-06-13 M.B.F. Plastiques (Société anonyme) Système de retenue d'un obturateur ou capot par rapport au goulot d'un récipient
EP0500265A1 (fr) * 1991-02-16 1992-08-26 Cope Allman Plastics Limited Fermeture de sécurité
EP0541846A1 (fr) * 1989-12-04 1993-05-19 Joyce Molding Corp. Récipient à l'épreuve des enfants et couvercle basculant pour contenu sec ou liquide

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT304290B (de) * 1970-11-18 1972-12-27 Ernst Feichtinger Dipl Kfm Ing Schnappverschluß für Flaschen
GB1520808A (en) * 1976-10-14 1978-08-09 Glyndon Plastics Ltd Caps and containers
EP0110796A1 (fr) * 1982-11-18 1984-06-13 M.B.F. Plastiques (Société anonyme) Système de retenue d'un obturateur ou capot par rapport au goulot d'un récipient
US4449639A (en) * 1982-12-13 1984-05-22 Johnsen & Jorgensen (Plastics) Ltd. Tamper-resistant and child-resistant closures
EP0541846A1 (fr) * 1989-12-04 1993-05-19 Joyce Molding Corp. Récipient à l'épreuve des enfants et couvercle basculant pour contenu sec ou liquide
EP0500265A1 (fr) * 1991-02-16 1992-08-26 Cope Allman Plastics Limited Fermeture de sécurité

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003057593A1 (fr) * 2001-12-21 2003-07-17 Nektar Therapeutics Emballage a capsules a membrane etanche
JP2005514129A (ja) * 2001-12-21 2005-05-19 ネクター セラピューティクス 湿気のバリアを有するカプセルパッケージ
US8777011B2 (en) 2001-12-21 2014-07-15 Novartis Ag Capsule package with moisture barrier

Also Published As

Publication number Publication date
AU7128894A (en) 1995-02-06
GB9314472D0 (en) 1993-08-25

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