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WO1994023034A3 - Sous-unites de recepteurs du facteur de croissance i semblables a l'insuline, et procedes d'utilisation - Google Patents

Sous-unites de recepteurs du facteur de croissance i semblables a l'insuline, et procedes d'utilisation Download PDF

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Publication number
WO1994023034A3
WO1994023034A3 PCT/US1994/003708 US9403708W WO9423034A3 WO 1994023034 A3 WO1994023034 A3 WO 1994023034A3 US 9403708 W US9403708 W US 9403708W WO 9423034 A3 WO9423034 A3 WO 9423034A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor subunits
methods
growth factor
variant insulin
insulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1994/003708
Other languages
English (en)
Other versions
WO1994023034A2 (fr
Inventor
Diane Prager
Shlomo Melded
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cedars Sinai Medical Center
Original Assignee
Cedars Sinai Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cedars Sinai Medical Center filed Critical Cedars Sinai Medical Center
Priority to JP6522465A priority Critical patent/JPH08508409A/ja
Priority to EP94914036A priority patent/EP0694069A1/fr
Publication of WO1994023034A2 publication Critical patent/WO1994023034A2/fr
Publication of WO1994023034A3 publication Critical patent/WO1994023034A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne de nouvelles sous-unités de récepteurs de IGF-I, caractérisées par une fonction modifiée de récepteurs de IGF-I, de nouvelles séquences d'acide polynucléique qui codent ces sous-unités de récepteurs, et diverses applications pour leur utilisation.
PCT/US1994/003708 1993-04-06 1994-04-05 Sous-unites de recepteurs du facteur de croissance i semblables a l'insuline, et procedes d'utilisation Ceased WO1994023034A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP6522465A JPH08508409A (ja) 1993-04-06 1994-04-05 変異インスリン様増殖因子▲ｉ▼受容体サブユニットおよびそれらの使用方法
EP94914036A EP0694069A1 (fr) 1993-04-06 1994-04-05 Sous-unites de recepteurs du facteur de croissance i semblables a l'insuline, et procedes d'utilisation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4454093A 1993-04-06 1993-04-06
US08/044,540 1993-04-06

Publications (2)

Publication Number Publication Date
WO1994023034A2 WO1994023034A2 (fr) 1994-10-13
WO1994023034A3 true WO1994023034A3 (fr) 1994-11-24

Family

ID=21932954

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/003708 Ceased WO1994023034A2 (fr) 1993-04-06 1994-04-05 Sous-unites de recepteurs du facteur de croissance i semblables a l'insuline, et procedes d'utilisation

Country Status (4)

Country Link
US (1) US5942412A (fr)
EP (1) EP0694069A1 (fr)
JP (1) JPH08508409A (fr)
WO (1) WO1994023034A2 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6340674B1 (en) 1993-03-26 2002-01-22 Thomas Jefferson University Method of inhibiting the proliferation and causing the differentiation of cells with IGF-1 receptor antisense oligonucleotides
US6696548B2 (en) * 1993-12-03 2004-02-24 St. Jude Children's Research Hospital Antibodies for recognition of alk protein tyrosine/kinase receptor
AUPM672594A0 (en) * 1994-07-08 1994-08-04 Royal Children's Hospital Research Foundation A method for the prophylaxis and/or treatment of proliferative and/or inflammatory skin disorders
CA2235695A1 (fr) * 1995-11-14 1997-05-22 Thomas Jefferson University Methode pour provoquer une resistance a la croissance de tumeurs au moyen d'un recepteur de igf-1 soluble
US6900186B1 (en) 1999-06-21 2005-05-31 Murdock Children's Research Institute Method for the prophylaxis and/or treatment of medical disorders
WO2003100008A2 (fr) * 2002-05-24 2003-12-04 Schering Corporation Anticorps anti-igfr humain neutralisant
CA2524305C (fr) * 2003-05-01 2015-12-08 Imclone Systems Incorporated Anticorps entierement humains diriges contre le recepteur du facteur de croissance 1 de type insuline
CA2545755A1 (fr) 2003-11-12 2005-05-26 Schering Corporation Systeme de plasmide pour l'expression multigenique
AR046639A1 (es) * 2003-11-21 2005-12-14 Schering Corp Combinaciones terapeuticas de anticuerpo anti- igfr1
MX2007006640A (es) * 2004-12-03 2007-06-19 Schering Corp Biomarcadores para la preseleccion de pacientes para la terapia con anti-receptor 1 del factor de crecimiento similar a la insulina.
US20060233810A1 (en) * 2005-04-15 2006-10-19 Yaolin Wang Methods and compositions for treating or preventing cancer
CA2611149A1 (fr) * 2005-06-15 2006-12-28 Schering Corporation Formulation d'anticorps stable
CN101500597A (zh) 2005-06-17 2009-08-05 伊姆克罗尼系统公司 治疗转移性骨癌的受体拮抗剂
KR101353706B1 (ko) * 2006-02-03 2014-02-18 유니버시티 오브 워싱톤 전립선 암 치료용 보강제로서의 ⅰｇｆ-ⅰｒ 길항제
US20100316639A1 (en) 2009-06-16 2010-12-16 Genentech, Inc. Biomarkers for igf-1r inhibitor therapy

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
D. PRAGER ET AL.;: "Human insulin-like growth factor receptor function in pituitary cells is suppressed by a dominant negative mutant", J. CLIN. INVEST., vol. 90, 1992, pages 2117 - 2122 *
H. YAMASAKI ET AL.;: "Human insulin-like growth factor I receptor 950 tyrosine is required for somatotroph growth factor signal transduction", J. BIOL. CHEM., vol. 267, 1992, pages 20953 - 20958 *
H. YAMASAKI ET AL.;: "Structure-function of the human insulin-like growth factor-I receptor: a discordance of somatotroph internalization and signaling", MOL. ENDOCRINOL., vol. 7, 1993, pages 681 - 685 *

Also Published As

Publication number Publication date
JPH08508409A (ja) 1996-09-10
US5942412A (en) 1999-08-24
WO1994023034A2 (fr) 1994-10-13
EP0694069A1 (fr) 1996-01-31

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