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WO1994019359A1 - Procede de production de methanediphosphonate - Google Patents

Procede de production de methanediphosphonate Download PDF

Info

Publication number
WO1994019359A1
WO1994019359A1 PCT/JP1994/000283 JP9400283W WO9419359A1 WO 1994019359 A1 WO1994019359 A1 WO 1994019359A1 JP 9400283 W JP9400283 W JP 9400283W WO 9419359 A1 WO9419359 A1 WO 9419359A1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
producing
null
methanediphosphonate
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP1994/000283
Other languages
English (en)
Inventor
Keijiro Takanishi
Hiromi Uchiro
Norio Kawabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Priority to FI944998A priority Critical patent/FI944998A7/fi
Priority to AU61150/94A priority patent/AU674059B2/en
Priority to KR1019940703838A priority patent/KR950701338A/ko
Publication of WO1994019359A1 publication Critical patent/WO1994019359A1/fr
Priority to NO944038A priority patent/NO300547B1/no
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3865—Polyphosphonic acids containing sulfur substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/4043—Esters of poly(thio)phosphonic acids containing sulfur substituents

Definitions

  • V sr ft iffl 53- 9 ⁇ US M ⁇ rv ⁇ Vi H ⁇ -fr sr f I r ⁇ v sr - ⁇ ? J*ft l iStf I J' 11 4 ⁇ sr rv sr -fr
  • V ri * ⁇ > ri rt t ⁇ V ⁇ ⁇ sr sr e 4 rv 1 impart V v_oL ⁇ t ll -S r ⁇ .
  • V. 94- 4 ⁇ ⁇ v. rv a* *J Sv SN W 4 * vjlfl.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Optical Record Carriers And Manufacture Thereof (AREA)
  • Ink Jet Recording Methods And Recording Media Thereof (AREA)

Abstract

L'invention concerne un procédé de production d'un composé de 1-alkylthio ou 1-arylthiométhanediphosphonate qui consiste à provoquer une réaction de couplage représentée par la formule (I) en présence d'un oxyde métallique, dans laquelle quatre groupes R'1 représentent indépendamment alkyle C1-C6 droit ou ramifié; quatre groupes R1 représentent indépendamment un cation pharmacologiquement acceptable, hydrogène ou alkyle C1-C6 droit ou ramifié; et R2 représente alkyle ou aryle. Ce procédé est extrêmement utile au plan économique et industriel car il est d'un rendement considérablement élevé et prévoit une procédure de purification simplifiée par rapport aux procédés classiques.
PCT/JP1994/000283 1993-02-25 1994-02-23 Procede de production de methanediphosphonate Ceased WO1994019359A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
FI944998A FI944998A7 (fi) 1993-02-25 1994-02-23 Menetelmä metaanidifosfonihappoyhdisteen valmistamiseksi
AU61150/94A AU674059B2 (en) 1993-02-25 1994-02-23 Process for producing methanediphosphonate compound
KR1019940703838A KR950701338A (ko) 1993-02-25 1994-02-23 메탄디포스폰산 화합물의 제조방법(Process for producing methanediphosphonate compound)
NO944038A NO300547B1 (no) 1993-02-25 1994-10-24 Fremgangsmåte for fremstilling av en metandifosfonatforbindelse

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP3683293 1993-02-25
JP5/36832 1993-02-25

Publications (1)

Publication Number Publication Date
WO1994019359A1 true WO1994019359A1 (fr) 1994-09-01

Family

ID=12480724

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1994/000283 Ceased WO1994019359A1 (fr) 1993-02-25 1994-02-23 Procede de production de methanediphosphonate

Country Status (7)

Country Link
JP (1) JP2546067B2 (fr)
KR (1) KR950701338A (fr)
CN (1) CN1038033C (fr)
AU (1) AU674059B2 (fr)
FI (1) FI944998A7 (fr)
TW (1) TW346489B (fr)
WO (1) WO1994019359A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0725070A4 (fr) * 1994-08-24 1997-10-22 Toray Industries Procede d'elaboration d'un compose d'acide methanediphosphonique
WO2010026701A1 (fr) * 2008-09-03 2010-03-11 国立大学法人東北大学 Promoteur d'ostéogenèse comprenant l'acide [4-(méthylthio)phénylthio]méthanebisphosphonique ou sel pharmaceutiquement acceptable de celui-ci en tant qu'ingrédient actif

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5942395A (ja) * 1982-07-29 1984-03-08 サノフイ メチレン−ジホスホン酸から誘導された炎症抑制性生成物およびその製造方法
JPH0222285A (ja) * 1988-03-31 1990-01-25 Symphar Sa フェノール置換ジェム―ジホスホネート誘導体、その調製法およびそれを含む医薬組成物
JPH0377894A (ja) * 1989-08-18 1991-04-03 Toray Ind Inc メチレンジホスホン酸化合物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5942395A (ja) * 1982-07-29 1984-03-08 サノフイ メチレン−ジホスホン酸から誘導された炎症抑制性生成物およびその製造方法
JPH0222285A (ja) * 1988-03-31 1990-01-25 Symphar Sa フェノール置換ジェム―ジホスホネート誘導体、その調製法およびそれを含む医薬組成物
JPH0377894A (ja) * 1989-08-18 1991-04-03 Toray Ind Inc メチレンジホスホン酸化合物

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0725070A4 (fr) * 1994-08-24 1997-10-22 Toray Industries Procede d'elaboration d'un compose d'acide methanediphosphonique
WO2010026701A1 (fr) * 2008-09-03 2010-03-11 国立大学法人東北大学 Promoteur d'ostéogenèse comprenant l'acide [4-(méthylthio)phénylthio]méthanebisphosphonique ou sel pharmaceutiquement acceptable de celui-ci en tant qu'ingrédient actif

Also Published As

Publication number Publication date
JP2546067B2 (ja) 1996-10-23
CN1038033C (zh) 1998-04-15
CN1102750A (zh) 1995-05-17
FI944998A0 (fi) 1994-10-24
KR950701338A (ko) 1995-03-23
FI944998L (fi) 1994-10-24
AU674059B2 (en) 1996-12-05
AU6115094A (en) 1994-09-14
TW346489B (en) 1998-12-01
FI944998A7 (fi) 1994-10-24

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