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WO1994012881A3 - A method for detecting growing cells using translationally controlled tumor protein p21 - Google Patents

A method for detecting growing cells using translationally controlled tumor protein p21 Download PDF

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Publication number
WO1994012881A3
WO1994012881A3 PCT/EP1993/003314 EP9303314W WO9412881A3 WO 1994012881 A3 WO1994012881 A3 WO 1994012881A3 EP 9303314 W EP9303314 W EP 9303314W WO 9412881 A3 WO9412881 A3 WO 9412881A3
Authority
WO
WIPO (PCT)
Prior art keywords
tumor protein
growing cells
controlled tumor
translationally controlled
detecting growing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1993/003314
Other languages
French (fr)
Other versions
WO1994012881A2 (en
Inventor
Denis F Hochstrasser
Graham J Hughes
Ron D Appel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to AU56946/94A priority Critical patent/AU5694694A/en
Publication of WO1994012881A2 publication Critical patent/WO1994012881A2/en
Publication of WO1994012881A3 publication Critical patent/WO1994012881A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5748—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

This invention relates to a novel method for detecting growing cells including cancer cells based upon elevated expression of a gene designated Translationally Controlled Tumor Protein p21. The invention provides for direct and indirect methods of quantifying this marker including immunoassays and nucleic acid hybridization assays.
PCT/EP1993/003314 1992-12-02 1993-11-26 A METHOD FOR DETECTING GROWING CELLS USING TRANSLATIONALLY CONTROLLED TUMOR PROTEIN p21 Ceased WO1994012881A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU56946/94A AU5694694A (en) 1992-12-02 1993-11-26 A method for detecting growing cells using translationally controlled tumor protein p21

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99030292A 1992-12-02 1992-12-02
US07/990,302 1992-12-02

Publications (2)

Publication Number Publication Date
WO1994012881A2 WO1994012881A2 (en) 1994-06-09
WO1994012881A3 true WO1994012881A3 (en) 1994-07-21

Family

ID=25536002

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1993/003314 Ceased WO1994012881A2 (en) 1992-12-02 1993-11-26 A METHOD FOR DETECTING GROWING CELLS USING TRANSLATIONALLY CONTROLLED TUMOR PROTEIN p21

Country Status (2)

Country Link
AU (1) AU5694694A (en)
WO (1) WO1994012881A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458939B1 (en) * 1996-03-15 2002-10-01 Millennium Pharmaceuticals, Inc. Compositions and methods for the diagnosis, prevention, and treatment of neoplastic cell growth and proliferation
US5914238A (en) 1996-06-05 1999-06-22 Matritech, Inc. Materials and methods for detection of breast cancer
US5952194A (en) * 1996-08-01 1999-09-14 Heska Corporation Flea nucleic acid sequences and uses thereof
US5858683A (en) * 1996-08-30 1999-01-12 Matritech, Inc. Methods and compositions for the detection of cervical cancer
DE19829473C2 (en) * 1998-07-01 2000-08-10 Magnus Von Knebel Doeberitz Ch Procedure for early diagnosis of carcinomas
US20030232056A1 (en) 1999-09-10 2003-12-18 Corixa Corporation Compositions and methods for the therapy and diagnosis of ovarian cancer
US7691567B2 (en) 2000-10-30 2010-04-06 Board Of Regents, The University Of Texas System Methods and compositions relating to fortilin, an anti-apoptotic molecule, and modulators of fortilin
FR2820757A1 (en) * 2001-02-13 2002-08-16 Molecular Engines Lab SEQUENCES INVOLVED IN THE PHENOMENA OF TUMOR DEPRESSION, TUMOR REVERSION, APOPTOSIS AND / OR VIRUS RESISTANCE AND THEIR USE AS MEDICAMENTS
FR2822475B1 (en) * 2002-03-20 2005-12-30 Molecular Engines Lab SEQUENCES INVOLVED IN THE PHENOMENA OF TUMOR DEPRESSION, TUMOR REVERSION, APOPTOSIS AND / OR VIRUS RESISTANCE AND THEIR USE AS MEDICAMENTS
US7482116B2 (en) 2002-06-07 2009-01-27 Dna Genotek Inc. Compositions and methods for obtaining nucleic acids from sputum
WO2004065572A2 (en) * 2003-01-23 2004-08-05 Molecular Engines Laboratories Proteic binding partners of tctp and methods of modulating tumor reversion or cell apoptosis
KR20060112709A (en) * 2003-07-14 2006-11-01 가부시키가이샤 피리오독크 How to diagnose endometriosis-related diseases
JP4362478B2 (en) 2003-07-14 2009-11-11 独立行政法人科学技術振興機構 Method for determining endometriosis-related diseases
WO2007048978A2 (en) * 2005-10-28 2007-05-03 Biomerieux Sa Method for detecting cancer
MX347611B (en) 2011-06-19 2017-05-04 Abogen Inc DEVICES, SOLUTIONS AND METHODS FOR SAMPLE COLLECTION.
CA2947704A1 (en) * 2014-04-10 2015-10-15 Dna Genotek Inc. Method and system for microbial lysis using periodates

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0177814A2 (en) * 1984-09-19 1986-04-16 Cetus Corporation Peptide antibodies and their use in detecting oncogene products
WO1990010233A1 (en) * 1989-03-03 1990-09-07 Board Of Regents, The University Of Texas System A diagnostic protein marker for bladder cancer
EP0505012A2 (en) * 1985-03-28 1992-09-23 F. Hoffmann-La Roche Ag Means for amplifying nucleic acid sequences

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0177814A2 (en) * 1984-09-19 1986-04-16 Cetus Corporation Peptide antibodies and their use in detecting oncogene products
EP0505012A2 (en) * 1985-03-28 1992-09-23 F. Hoffmann-La Roche Ag Means for amplifying nucleic acid sequences
WO1990010233A1 (en) * 1989-03-03 1990-09-07 Board Of Regents, The University Of Texas System A diagnostic protein marker for bladder cancer

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHITPATIMA, S. TIM ET AL: "Nucleotide sequence of a major messenger RNA for a 21 kilodalton polypeptide that is under translational control in mouse tumor cells", NUCLEIC ACIDS RES., 16(5, PT. B), 2350, 1988 *
GARY E. GALLICK ET AL.: "Expression of p21ras in fresh primary and metastatic human colorectal tumors", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 82, no. 6, March 1985 (1985-03-01), WASHINGTON US, pages 1795 - 1799 *
GROSS, BURCKHARD ET AL: "cDNA sequence coding for a translationally controlled human tumor protein", NUCLEIC ACIDS RES., 17(20), 8367, 1989 *
PAY, ANIKO ET AL: "An alfalfa cDNA encodes a protein with homology to translationally controlled human tumor protein", PLANT MOL. BIOL., 19(3), 501-3, 1992 *

Also Published As

Publication number Publication date
WO1994012881A2 (en) 1994-06-09
AU5694694A (en) 1994-06-22

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