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WO1994009833B1 - Wearable, portable, light-weight artificial kidney - Google Patents

Wearable, portable, light-weight artificial kidney

Info

Publication number
WO1994009833B1
WO1994009833B1 PCT/US1993/011352 US9311352W WO9409833B1 WO 1994009833 B1 WO1994009833 B1 WO 1994009833B1 US 9311352 W US9311352 W US 9311352W WO 9409833 B1 WO9409833 B1 WO 9409833B1
Authority
WO
WIPO (PCT)
Prior art keywords
plasma
artificial kidney
wearable
portable
tubing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1993/011352
Other languages
French (fr)
Other versions
WO1994009833A9 (en
WO1994009833A1 (en
Filing date
Publication date
Priority claimed from US07/970,041 external-priority patent/US5284470A/en
Application filed filed Critical
Priority to AU58265/94A priority Critical patent/AU5826594A/en
Publication of WO1994009833A1 publication Critical patent/WO1994009833A1/en
Publication of WO1994009833B1 publication Critical patent/WO1994009833B1/en
Publication of WO1994009833A9 publication Critical patent/WO1994009833A9/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Abstract

A portable artificial kidney (10) in the form of a self-contained unit whose size and shape is such that it is light-weight and relatively small. It can be worn or attached to a patient in such a manner that it will not interfere with normal physical activities. The artificial kidney has a blood plasma separator unit that receives impure whole blood from the body of a patient and it separates a predetermined amount of plasma therefrom and returns the remainder of the blood back to the patient's body. The separated plasma is then transmitted through a chemical treatment unit (10) where the contaminated plasma is relieved of uric acid, creatinine, phosphate, and ammonium ions. The detoxified plasma is then transmitted to a water removal unit (50) and then the detoxified plasma is returned to the patient's circulatory system.

Claims

AMENDED CLAIMS[received by the International Bureau on 6 June 1994 (06.06.94); original claims 1-11 replaced by new claims 1-34 (9 pages)]
1 . A wearable , portable, ligh t-weight artificial kidney comprising : a first means for transmi t ting impure whole blood from a body of a patient to an artificial kidney; a separa tor means configured to separa te a prede termined amount of plasma from said whole blood and a second whole means for returning a remainder of said blood wi th some of the plasma removed back to the pa tient ' s body; a .means configured to chemically trea t and cleanse the plasma that has been separated from the whole blood; a means configured to remove water from the plasma tha t has been separated from the whole blood; a third means configured to return the cleansed plasma to the patien t ' s body; and wherein said artificial kidney is shaped and sized to be completel y worn dail y on the body of the pa tient and weighs less than 15 pounds .
2. A wearable, portable , light-weight artificial kidney as recited in claim 1 further comprising an arterial venous shunt tha t is detachabl y interconnected to said first means , said second means and said third means .
3. A wearable, portable, light-weight artificial kidney as recited in claim 2 wherein said arterial venous shunt is configured to be surgically implanted in the body of the patient.
4. A wearable, portable, light-weight artificial kidney as recited in claim 1 wherein said artificial kidney is in the form of a uni t that is part of a belt that is sized and shaped to be worn by a patient.
5. A wearable, portable, light-weight artificial kidney as recited in claim 1 wherein said separator means comprises a packet housing having a predetermined length of polycarbonate tubing having holes in side walls of said tubing in a range of 0.4-3.0 microns through which plasma passes, said polycarbonate tubing passing concentrically through an interior of a conventional medically approved blood tubing.
6. A wearable, portable, light-weight artificial kidney as recited in claim 5 wherein said concentrically positioned polycarbonate tubing is formed in a convoluted shape that extends from an inlet end of said separator pack housing to an outlet end.
7. A wearable, portable, light-weight artificial kidney as recited in claim 5 wherein said medically approved blood tubing has an inner surface treated with urease.
8. A wearable, portable, light-weight artificial kidney as recited in claim 1 wherein said means for chemically treating and cleansing the plasma that has been separated from the whole blood comprises a packet housing having a predetermined length of
15 tubing through which said plasma passes , said tubing having an inner surface coa ted wi th predetermined adsorbents for removing toxics from said plasma .
9. A wearable, portable, light-weight artificial kidney as recited in claim 1 wherein said means for removing water from the plasma tha t has been separated from the whole blood comprises a packet housing having a predetermined length of polycarbonate tubing having holes in i ts side walls in the range of 0.45 microns or less through which water passes , the in terior of said packet having prede termined desiccants tha t adsorb wa ter.
10. A wearable, portable, ligh t-weigh t artificial kidney comprising : a first means for transmit ting impure whole blood from a body of a pa tien t to an artificial kidney; a separator means configured to continuously and non- cyclicall y separa te a predetermined amount of plasma from said whole blood and a second whole means for continuously and non- cyclicall y returning a remainder of said blood wi th some of the plasma removed back to the patient ' s body; a means configured to continuousl y and non-cyclically chemically trea t and cleanse the plasma tha t has been separa ted from the whole blood; a means configured to continuously and non-cyclically remove water from the plasma that has been separated from the whole blood; and
16 a third means configured to continuously and non-cyclically return the cleansed plasma to the patient ' s body.
11. A wearable, portable, light-weight artificial kidneij as recited in claim 10 further comprising an arterial venous shunt that is detachably interconnected to said first means, said second means and said third means.
12. A wearable, portable, light-weight artificial kidney as recited in claim 11 wherein said arterial venous shunt is configured to be surgically implanted in the body of the patient.
13. A wearable, portable, ligh t-weight artificial kidney as recited in claim 10 wherein said artificial kidney is in the form of a unit that is part of a bel t that is sized and shaped to be worn by a patient.
14. A wearable, portable, light-weight artificial kidney as recited in claim 10 wherein said artificial kidney is shaped and sized to be completely worn on the body of the patient and weighs less than 15 pounds.
15. A wearable, portable, light-weight artificial kidney as recited in claim 10 wherein said separator means comprises a packet housing having a predetermined length of polycarbonate tubing having holes in side walls of said tubing in a range of 0.4-3.0 microns through which plasma passes, said polycarbonate tubing passing concentrically through an interior of a conventional medically approved blood tubing.
16. A wearable, portable, ligh t-weight artificial kidney as recited in claim 15 wherein said concentrically positioned
17 pol ycarbona te tubing is formed in a convolu ted shape tha t extends from an inlet end of said separa tor pack housing to an outlet end.
17. A wearable , portable , light-weight artificial kidney as reci ted in claim 15 wherein said medicall y approved blood tubing has an inner surface trea ted wi th urease.
18. A wearable, portable, ligh t-weight artificial kidney as reci ted in claim 10 wherein said means for chemically treating and cleansing the plasma that has been separated from the whole blood comprises a packet housing having a predetermined length of tubing through which said plasma passes , said tubing ha ving an inner surface coated wi th predetermined adsorbents for removing toxics from said plasma .
19. A wearable, portable, light-weight artificial kidney as reci ted in claim 10 wherein said means for removing water from the plasma tha t has been separated from the whole blood comprises a packet housing having a predetermined length of pol ycarbonate tubing having holes in i ts side walls in the range of 0.45 microns or less through which water passes , the in terior of said packet having predetermined desiccants tha t adsorb wa ter.
20. A wearable, portable, ligh t-weight artificial kidney comprising : a first means for transmit ting impure whole blood from a body of a pa tient to an artificial kidney; a separator means configured to separate at substantially normal blood pressure a predetermined amount of plasma from said
18 whole blood and a second whole means for returning at substantially normal blood pressure a remainder of said blood with some of the plasma removed back to the patient 's body; a means configured to chemically treat and cleanse the plasma that has been separated from the whole blood; a means configured to remove water from the plasma that has been separated from the whole blood; and a third means configured to return at substantially normal blood pressure the cleansed plasma to the patient ' s body.
21. A wearable, portable, light-weight artificial kidney as recited in claim 20 further comprising an arterial venous shunt that is detachably interconnected to said first means, said second means and said third means.
22. A wearable, portable, light-weight artificial kidney as recited in claim 21 wherein said arterial venous shunt is configured to be surgically implanted in the body of the patient.
23. A wearable, portable, ligh t-weight artificial kidney as recited in claim 20 wherein said artificial kidney is in the form of a unit that is part of a bel t that is sized and shaped to be worn by a patient.
24. A wearable, portable, light-weight artificial kidney as recited in claim 20 wherein said artificial kidney is shaped and sized to be completely worn daily on the body of the patient and weighs less than 15 pounds .
25. A wearable, portable, light-weight artificial kidney as recited in claim 20 wherein said separator means comprises a
19 packet housing having a predetermined length of polycarbonate tubing having holes in side walls of said tubing in a range of 0.4-3.0 microns through which plasma passes, said polycarbonate tubing passing concentrically through an interior of a conventional medically approved blood tubing.
26. A wearable, portable, ligh t-weight artificial kidney as recited in claim 25 wherein said concentrically positioned polycarbonate tubing is formed in a convoluted shape that extends from an inlet end of said separator pack housing to an outlet end.
27. A wearable, portable, light-weight artificial kidney as recited in claim 25 wherein said medically approved blood tubing has an inner surface treated with urease.
28. A wearable, portable, ligh t-weight artificial kidney as recited in claim 20 wherein said means for chemically treating and cleansing the plasma that has been separated from the whole blood comprises a packet housing having a predetermined length of tubing through which said plasma passes, said tubing having an inner surface coated with predetermined adsorbents for removing toxics from said plasma.
29. A wearable, portable, light-weight artificial kidney as recited in claim 20 wherein said means for removing water from the plasma that has been separated from the whole blood comprises a packet housing having a predetermined length of polycarbonate tubing having holes in its side walls in the range of 0.45
20 microns or less through which wa ter passes , the interior of said packet having predetermined desiccants that adsorb wa ter.
30. A blood/plasma separa tor unit for a wearable, portable , ligh t-weight artificial kidney for separa ting a predetermined amount of plasma from the whole blood of a patient and then returning the remainder of the blood wi th some of the plasma removed back into the patient ' s body comprising : a packet housing having an inlet port for receiving whole blood, said inlet port being in communication wi th a prede termined length of tubing having holes in its side walls in the range of 0.4-3.0 microns through which plasma passes; said tubing passing concentricall y through the interior of a predetermined length of passageway formed of material that is compa tible wi th h uman blood, said passageway having an outlet port for dispensing plasma that has been separated from the whole blood; said tubing having an outlet port for dispensing blood which has had some of its plasma removed.
31. A blood/plasma separator unit as recited in claim 30 wherein said concentrical l y positioned passageway is formed in a convolu ted shape tha t extends from the intle t end of said separa tor pack housing to its outlet end.
32. A blood/plasma separa tor unit as recited in claim 30 wherein the inner surface of said passageway is treated with urease.
21
33. A plasma chemical treatment unit for a wearable, portable, ligh t-weight artificial kidney for detoxifying plasma that has been separa ted from the whole blood of a patient that has been passed through a blood/plasma separa ting unit, said plasma chemical unit comprising: a packet housing having an inlet port and an outle t port, a passageway having a predetermined length extends between said inlet port and said outlet port, said passageway having an inner surface coated wi th predetermined adsorbents for removing toxics such as urease, uric acid, crea tine, and phosphates from said plasma as i t passes therethrough .
34. A water removal unit for a wearable, portable, light¬ weight artificial kidney for removing excess wa ter from plasma that has been separated from the whole blood of a patient that has passed through a blood/plasma separator unit and a plasma chemical treatment uni t comprising: a packet housing having an inlet port and an outlet port, a predetermined length of tubing is connected between said inlet port and outlet port, said tubing having side walls having holes in the range of 0.45 microns or less through which water from the plasma passes, the interior of said packet surrounding said tubing having predetermined dessicants that adsorb said water.
22
PCT/US1993/011352 1992-11-02 1993-11-02 Wearable, portable, light-weight artificial kidney Ceased WO1994009833A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU58265/94A AU5826594A (en) 1992-11-02 1993-11-02 Wearable, portable, light-weight artificial kidney

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/970,041 US5284470A (en) 1992-11-02 1992-11-02 Wearable, portable, light-weight artificial kidney
US07/970,041 1992-11-02

Publications (3)

Publication Number Publication Date
WO1994009833A1 WO1994009833A1 (en) 1994-05-11
WO1994009833B1 true WO1994009833B1 (en) 1994-07-07
WO1994009833A9 WO1994009833A9 (en) 1994-07-21

Family

ID=25516348

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/011352 Ceased WO1994009833A1 (en) 1992-11-02 1993-11-02 Wearable, portable, light-weight artificial kidney

Country Status (5)

Country Link
US (1) US5284470A (en)
CN (1) CN1086440A (en)
AU (1) AU5826594A (en)
TW (1) TW230192B (en)
WO (1) WO1994009833A1 (en)

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