[go: up one dir, main page]

WO1994009006A1 - 3a,6-hexahydroisoindoles pontes et hydroisoquinolines et hydrobenzazepines apparentees et leur utilisation comme agents pharmaceutiques et de radio-imagerie - Google Patents

3a,6-hexahydroisoindoles pontes et hydroisoquinolines et hydrobenzazepines apparentees et leur utilisation comme agents pharmaceutiques et de radio-imagerie Download PDF

Info

Publication number
WO1994009006A1
WO1994009006A1 PCT/US1993/009160 US9309160W WO9409006A1 WO 1994009006 A1 WO1994009006 A1 WO 1994009006A1 US 9309160 W US9309160 W US 9309160W WO 9409006 A1 WO9409006 A1 WO 9409006A1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
mammal
alkyl
sep
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1993/009160
Other languages
English (en)
Inventor
Engelbert Ciganek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
DuPont Merck Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DuPont Merck Pharmaceutical Co filed Critical DuPont Merck Pharmaceutical Co
Publication of WO1994009006A1 publication Critical patent/WO1994009006A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention se rapporte à de nouveaux composés contenant de l'azote répondant à la formule (I) et (II), à des compositions pharmaceutiques contenant lesdits composés ainsi qu'à des procédés d'utilisation desdits composés pour traiter des psychoses physiologiques et/ou induites par médicaments et comme agents antidyskinétiques.
PCT/US1993/009160 1992-10-09 1993-10-01 3a,6-hexahydroisoindoles pontes et hydroisoquinolines et hydrobenzazepines apparentees et leur utilisation comme agents pharmaceutiques et de radio-imagerie Ceased WO1994009006A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95913592A 1992-10-09 1992-10-09
US07/959,135 1992-10-09

Publications (1)

Publication Number Publication Date
WO1994009006A1 true WO1994009006A1 (fr) 1994-04-28

Family

ID=25501709

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/009160 Ceased WO1994009006A1 (fr) 1992-10-09 1993-10-01 3a,6-hexahydroisoindoles pontes et hydroisoquinolines et hydrobenzazepines apparentees et leur utilisation comme agents pharmaceutiques et de radio-imagerie

Country Status (1)

Country Link
WO (1) WO1994009006A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106588772A (zh) * 2016-12-19 2017-04-26 广西中医药大学 重松节油长叶烯衍生物及其制备和应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB770624A (en) * 1953-10-20 1957-03-20 Geschickter Fund Med Res Substituted endoxy-perhydroisoindolines
US4508723A (en) * 1977-05-17 1985-04-02 Ciba Geigy Corporation 6-Azaoligocycloalkylmethyleneaminopenam compounds
US4855430A (en) * 1987-11-12 1989-08-08 American Home Products Corporation Polycyclicamine with psychotropic activity
US5216018A (en) * 1992-02-14 1993-06-01 Du Pont Merck Pharmaceutical Company Hydroisoindolines and hydroisoquinolines as psychotropic

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB770624A (en) * 1953-10-20 1957-03-20 Geschickter Fund Med Res Substituted endoxy-perhydroisoindolines
US4508723A (en) * 1977-05-17 1985-04-02 Ciba Geigy Corporation 6-Azaoligocycloalkylmethyleneaminopenam compounds
US4855430A (en) * 1987-11-12 1989-08-08 American Home Products Corporation Polycyclicamine with psychotropic activity
US5216018A (en) * 1992-02-14 1993-06-01 Du Pont Merck Pharmaceutical Company Hydroisoindolines and hydroisoquinolines as psychotropic

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ARM. KHIM. ZH., vol. 30, no. 7, 1977, pages 578 - 581 *
CHEMICAL ABSTRACTS, vol. 51, no. 2, 25 January 1960, Columbus, Ohio, US; abstract no. 16558d, "4,7-Endoxyperhydroisoindolines" *
CHEMICAL ABSTRACTS, vol. 88, no. 5, 30 January 1978, Columbus, Ohio, US; abstract no. 37559g, G. O. TOROSYAN ET AL: "Studies on amines and ammonium compounds. CXXXIII. Intramolecular cyclization of benzoic acid allyl-2,4-pentadienyl(furfuryl)amides" page 480; *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106588772A (zh) * 2016-12-19 2017-04-26 广西中医药大学 重松节油长叶烯衍生物及其制备和应用

Similar Documents

Publication Publication Date Title
US6777406B2 (en) Substituted pyrroloquinolines and pyridoquinolines as serotinin agonists and antagonists
EP1192165B1 (fr) Gamma-carbolines fusionnees a heterocycles substitues
US7592454B2 (en) Substituted hexahydro-pyridoindole derivatives as serotonin receptor agonists and antagonists
JP2874878B2 (ja) 新規化合物、その製法及びそれを含む医薬組成物
KR20030070073A (ko) 세로토닌 효능제 및 길항제로서의 치환된 피리도인돌
US5216018A (en) Hydroisoindolines and hydroisoquinolines as psychotropic
JP2002114679A (ja) ７−ヘテロ−ビシクロ［２．２．１］−ヘプタン類を含んでなる医薬組成物
KR20030036689A (ko) 대사자극성 글루타메이트 수용체 길항제
CA2042860A1 (fr) 1-azacycloalcanes bicycliques
CZ296928B6 (cs) Tetracyklický derivát tetrahydrofuranu substituovaný halogenem, zpusob jeho prípravy a pouzití a prostredek s jeho obsahem
KR20110010783A (ko) Ｍｒｉ로서의 아릴 케톤
Noland et al. Diels–Alder/Ene Reactivities of 2-(1′-Cycloalkenyl) thiophenes and 2-(1′-Cycloalkenyl) benzo [b] thiophenes with N-Phenylmaleimides: Role of Cycloalkene Ring Size on Benzothiophene and Dibenzothiophene Product Distributions
JPWO1997020845A1 (ja) ピロロアゼピン誘導体
US6638934B2 (en) Substituted pyrazinoquinoxaline derivatives as serotonin receptor agonist and antagonists ligands
JPH04234845A (ja) 新規コリンエステラーゼ阻害剤としての三環式環状アミン
NZ233645A (en) 3-(hetero)aryl-substituted-3,4 dehydropiperidine derivatives; preparatory processes and pharmaceutical compositions
WO1994009006A1 (fr) 3a,6-hexahydroisoindoles pontes et hydroisoquinolines et hydrobenzazepines apparentees et leur utilisation comme agents pharmaceutiques et de radio-imagerie
Bartoccini et al. Synthesis and Reactivity of Uhle’s Ketone and Its Derivatives
Kiren et al. A facile synthesis of 5-alkoxypyrrol-2 (5H)-ones using a modified aza-Achmatowicz oxidation
Bell et al. An approach to some spiro oxindole alkaloids through cycloaddition reactions of 3-methylideneindolin-2-one
WO1994009007A1 (fr) 3a,6-octahydroisoindoles pontes et hydroisoquinolines et hydrobenzazepines apparentees et leur utilisation comme agents pharmaceutiques et de radio-imagerie
JPH0242080A (ja) ヘテロ四環ラクタム誘導体
CA1080705A (fr) Azabicycloalcanes et leurs precurseurs
JP2000507240A (ja) ピペリジン誘導体
JP4721495B2 (ja) ジヒドロベンゾフラン誘導体、その製造法及び剤

Legal Events

Date Code Title Description
AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase