WO1994007508A1 - Preparation for treating seborrhoea and other inflammatory conditions of the skin - Google Patents
Preparation for treating seborrhoea and other inflammatory conditions of the skin Download PDFInfo
- Publication number
- WO1994007508A1 WO1994007508A1 PCT/HU1992/000037 HU9200037W WO9407508A1 WO 1994007508 A1 WO1994007508 A1 WO 1994007508A1 HU 9200037 W HU9200037 W HU 9200037W WO 9407508 A1 WO9407508 A1 WO 9407508A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- weight
- parts
- preparation
- camphor
- boric acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/22—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
Definitions
- the present invention relates to a preparation for treating seborrhoea and other inflammatory conditions of the skin and a process for the preparation thereof.
- Seborrhoeal skin symptoms may occur at any time of life, seborrhoeal acne frequently occurs when one is young.
- seborrhoea For treating seborrhoea generally the ethanol solution of salicylic acid, ointments containing salicylic acid, mercu ⁇ ry sulphide or sulphur or suspensions containing mercury sulphide and sulphur as active ingredient and a siccative agent are recommended (Formulae Normales, V. edition, Medi- cina K ⁇ nyvkiad ⁇ , Budapest, pages 165, 206, 217 and 167). The effect of these preparations is, however, not satisfactory, besides when using these preparations allergic reactions arise frequently.
- the invention is based on the recognition that by the combined use of boric acid and camphor a preparation can be obtained which complies with these purposes.
- the activity of the preparation can be enhanced by the addition of sulphur.
- the preparation of the invention comprises the mix ⁇ ture of an ethanolic camphor solution and an aqueous boric acid solution, wherein the weight ratio of camphor and boric acid is between 15 : 0,2 and 2 : 3, and if desired a siccative and/or an itching alleviating substance.
- the preparation may also contain sulphur as an additive.
- siccative and itching alleviating substance preferably talc and zinc oxide can be used.
- the preparation can be prepared by mixing the ethanolic solution of camphor with the aqueous solution of boric acid, if desired adding to the mixture a siccative and/or itching alleviating substance, homogenizing the mixture and if necessary diluting it with water to the desired volume.
- a total amount of 4 to 30 parts by weight of siccative and/or it ⁇ ching alleviating substances preferably 2 to 15 parts by weight of talc and 2 to 15 parts by weight of zinc oxide and if desired 2 to 15 parts by weight of precipitated sulphur are mixed, 2 to 15 parts by weight of camphor dissolved in ethanol and 0,2 to 3 parts by weight of boric acid dissolved in water are added, the mixture is homogenized and completed with water to 100 parts by weight.
- glycerin and/or a surface active agent can also be added to the preparation.
- the advantages of the preaparation according to the invention are the following. It alleviates the seborrhoeal skin symptoms, relieves pain and itching, does not cause any allergic reaction, besides it can be used for treating other inflammatory skin symptoms as well.
- the invention is illustrated by the following Examp ⁇ les.
- camphor 100 g of camphor are dissolved in 610 g of 96 % ethanol and 290 g of distilled water are added to the solu ⁇ tion.
- 30 g of boric acid are dissolved in 970 g of water. The two solutions are mixed.
- the preparation is applied once or twice daily to the skin surface to be treated.
- the suspension is applied once or twice daily to the skin surface to be treated.
- the first group consisted of seborrhoeal patients treated for a long period with ethanolic salicylic acid solution but no lasting result was attained.
- the second group consisted of patients suffering from pubertal seborr ⁇ hoea and the third group consisted of patients suffering from strong seborrhoeal acne, recovering with distorting cicatrization. These patients were treated for years without any result with ointments containing mercury sulphide or suspensions containing sulphur.
- the patients of the first group applied the preparation of Example 1 twice daily, in the mornig and in the evening to the skin surface to be treated after the usual cleaning treatment.
- the improvement could be seen already after three or four days, at the end of the third or fourth week the seborrhoeal complaints completely disappea ⁇ red.
- the patients of the second group applied the suspen ⁇ sion of Example 2 once daily, in the evening to the skin surface to be treated after the usual cleaning treatment. An improvement could be seen already after three or four days, after two to three months the complaints completely disap ⁇ peared. In order to preserve this condition during puberty the suspension is to be applied twice per week.
- the patients of the third group applied the suspen ⁇ sion of Example 3 twice daily to the skin surface to be treated after the usual cleaning treatment. An improvement also in this case could be seen after three or four days, after five to six months the skin became aesthetically perfect. Thereafter for one to two years the skin should be treated once daily.
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a preparation for treating seborrhoea and other inflammatory conditions of the skin comprising the mixture of an ethanolic camphor solution and an aqueous boric acid solution and if desired a siccative and/or an itching alleviating substance. The preparation alleviates the seborrhoeal skin symptoms, relieves pain and itching, does not cause any allergic reaction, besides it can be used for treating other inflammatory skin symptoms as well.
Description
Preparation for treating seborrhoea and other inflammatory conditions of the skin
Field of the invention
The present invention relates to a preparation for treating seborrhoea and other inflammatory conditions of the skin and a process for the preparation thereof.
Background of the invention
Seborrhoeal skin symptoms may occur at any time of life, seborrhoeal acne frequently occurs when one is young. For treating seborrhoea generally the ethanol solution of salicylic acid, ointments containing salicylic acid, mercu¬ ry sulphide or sulphur or suspensions containing mercury sulphide and sulphur as active ingredient and a siccative agent are recommended (Formulae Normales, V. edition, Medi- cina Kδnyvkiadό, Budapest, pages 165, 206, 217 and 167). The effect of these preparations is, however, not satisfactory, besides when using these preparations allergic reactions arise frequently.
It is an object of the invention to provide a prepa¬ ration which alleviates the seborrhoeal skin symptoms and does not exhibit any harmful side effect.
Disclosure of the invention
The invention is based on the recognition that by the combined use of boric acid and camphor a preparation can be obtained which complies with these purposes. The activity of the preparation can be enhanced by the addition of sulphur.
The preparation of the invention comprises the mix¬ ture of an ethanolic camphor solution and an aqueous boric acid solution, wherein the weight ratio of camphor and boric acid is between 15 : 0,2 and 2 : 3, and if desired a siccative and/or an itching alleviating substance. In addition to the above ingredients the preparation may also contain sulphur as an additive.
As siccative and itching alleviating substance preferably talc and zinc oxide can be used.
According to the invention the preparation can be prepared by mixing the ethanolic solution of camphor with the aqueous solution of boric acid, if desired adding to the mixture a siccative and/or itching alleviating substance, homogenizing the mixture and if necessary diluting it with water to the desired volume.
According to a preferred embodiment of the process 2 to 15 parts by weight of camphor dissolved in ethanol and 0,2 to 3 parts by weight of boric acid dissolved in water are mixed and the mixture is completed with water to 100 parts by weight.
According to another preferred embodiment a total amount of 4 to 30 parts by weight of siccative and/or it¬ ching alleviating substances, preferably 2 to 15 parts by weight of talc and 2 to 15 parts by weight of zinc oxide and if desired 2 to 15 parts by weight of precipitated sulphur are mixed, 2 to 15 parts by weight of camphor dissolved in ethanol and 0,2 to 3 parts by weight of boric acid dissolved in water are added, the mixture is homogenized and completed with water to 100 parts by weight. If desired glycerin and/or a surface active agent can also be added to the preparation.
The advantages of the preaparation according to the invention are the following. It alleviates the seborrhoeal
skin symptoms, relieves pain and itching, does not cause any allergic reaction, besides it can be used for treating other inflammatory skin symptoms as well.
The invention is illustrated by the following Examp¬ les.
Example 1
100 g of camphor are dissolved in 610 g of 96 % ethanol and 290 g of distilled water are added to the solu¬ tion. 30 g of boric acid are dissolved in 970 g of water. The two solutions are mixed.
The preparation is applied once or twice daily to the skin surface to be treated.
Example 2
15 g of talc and 15 g of zinc oxide are mixed.
120 g of the camphor solution prepared in Example 1 and 70 g of the boric acid solution prapared in Example 1 are added to the mixture and the suspension thus obtained is homogenized.
The suspension is applied once or twice daily to the skin surface to be treated.
Example 3
30 g of talc, 15 g of zinc oxide and 20 g of precipi¬ tated sulphur are mixed.
120 g of the camphor solution prepared in Example 1 and 70 g of the boric acid solution prepared in Example 1 are added to the mixture and the suspension thus obtained is homogenized.
Experimental data
The effectiveness of the preparation according to the invention was examined on three groups, each comprising 50 persons.
The first group consisted of seborrhoeal patients treated for a long period with ethanolic salicylic acid solution but no lasting result was attained. The second group consisted of patients suffering from pubertal seborr¬ hoea and the third group consisted of patients suffering from strong seborrhoeal acne, recovering with distorting cicatrization. These patients were treated for years without any result with ointments containing mercury sulphide or suspensions containing sulphur.
The patients of the first group applied the preparation of Example 1 twice daily, in the mornig and in the evening to the skin surface to be treated after the usual cleaning treatment. The improvement could be seen already after three or four days, at the end of the third or fourth week the seborrhoeal complaints completely disappea¬ red.
The patients of the second group applied the suspen¬ sion of Example 2 once daily, in the evening to the skin surface to be treated after the usual cleaning treatment. An improvement could be seen already after three or four days, after two to three months the complaints completely disap¬ peared. In order to preserve this condition during puberty the suspension is to be applied twice per week.
The patients of the third group applied the suspen¬ sion of Example 3 twice daily to the skin surface to be treated after the usual cleaning treatment. An improvement also in this case could be seen after three or four days, after five to six months the skin became aesthetically perfect. Thereafter for one to two years the skin should be
treated once daily.
Claims
1. A preparation for treating seborrhoea and other inflammatory conditions of the skin comprising the mixture of an ethanolic camphor solution and an aqueous boric acid solution and if desired a siccative and/or an itching alleviating substance.
2. A preparation according to claim 1 wherein the weight ratio of camphor to boric acid is between 15 : 0,2 and 2 : 3.
3. A preparation according to Claim 1 containing sulphur as an additive.
4. A process for preparing a preparation for treating se¬ borrhoea and other inflammatory conditions of the skin which comprises mixing the ethanolic solution of camphor with the aqueous solution of boric acid, if desired adding to the mixture a siccative and/or itching alleviating substance, homogenizing the mixture and if necessary diluting it with water to the desired volume.
5. A process according to claim 4 which comprises mixing 2 to 15 parts by weight of camphor dissolved in ethanol and 0,2 to 3 parts by weight of boric acid dissolved in water and completing the mixture with water to 100 parts by weight.
6. A process according to claim 4 which comprises mixing a total amount of 4 to 30 parts by weight of siccative and/or itching alleviating substances, preferably 2 to 15 parts by weight of talc and 2 to 15 parts by weight of zinc oxide and if desired 2 to 15 parts by weight of precipitated sulphur, adding 2 to 15 parts by weight of camphor dissolved in ethanol and 0,2 to 3 parts by weight of boric acid dissolved in water to the mixture and after homogenization comple¬ ting it with water to 100 parts by weight.
7. A process according to claim 4 which comprises adding glycerin and/or a surface active agent to the preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/HU1992/000037 WO1994007508A1 (en) | 1992-10-01 | 1992-10-01 | Preparation for treating seborrhoea and other inflammatory conditions of the skin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/HU1992/000037 WO1994007508A1 (en) | 1992-10-01 | 1992-10-01 | Preparation for treating seborrhoea and other inflammatory conditions of the skin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1994007508A1 true WO1994007508A1 (en) | 1994-04-14 |
Family
ID=10980974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/HU1992/000037 Ceased WO1994007508A1 (en) | 1992-10-01 | 1992-10-01 | Preparation for treating seborrhoea and other inflammatory conditions of the skin |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO1994007508A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2081771A1 (en) * | 1994-08-05 | 1996-03-01 | Arredondo Javier Olaechea | Composition of a liquid product for topical use for burns and bruises. |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB190022465A (en) * | 1900-12-10 | 1901-11-30 | John Gordon Bennet | Improvements in Processes or Treatments for the Cure of Fever Patients. |
| GB190905125A (en) * | 1909-03-03 | 1909-12-23 | Eliza Emily Thomas | A Hair Tonic. |
| US2175780A (en) * | 1939-04-22 | 1939-10-10 | Douglas T Prehn | Prophylactic and therapeutic composition |
| US3035971A (en) * | 1957-12-16 | 1962-05-22 | Cliff L Anderson | Ophthalmic composition |
| GB2078515A (en) * | 1980-06-23 | 1982-01-13 | Tinnell James Edward | Topical anti-viral preparation |
| EP0191214A2 (en) * | 1984-05-17 | 1986-08-20 | Haviva Rivkin | Purifying liquid cleanser comprising antiseptics |
-
1992
- 1992-10-01 WO PCT/HU1992/000037 patent/WO1994007508A1/en not_active Ceased
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB190022465A (en) * | 1900-12-10 | 1901-11-30 | John Gordon Bennet | Improvements in Processes or Treatments for the Cure of Fever Patients. |
| GB190905125A (en) * | 1909-03-03 | 1909-12-23 | Eliza Emily Thomas | A Hair Tonic. |
| US2175780A (en) * | 1939-04-22 | 1939-10-10 | Douglas T Prehn | Prophylactic and therapeutic composition |
| US3035971A (en) * | 1957-12-16 | 1962-05-22 | Cliff L Anderson | Ophthalmic composition |
| GB2078515A (en) * | 1980-06-23 | 1982-01-13 | Tinnell James Edward | Topical anti-viral preparation |
| EP0191214A2 (en) * | 1984-05-17 | 1986-08-20 | Haviva Rivkin | Purifying liquid cleanser comprising antiseptics |
Non-Patent Citations (4)
| Title |
|---|
| "Handbook of Non-Prescription Drugs", Fifth Edition, published 1977, by AMERICAN PHARMACEUTICAL ASSOCIATION, R.E. HOPPONEN, "Acne Products", pages 317-323. * |
| F. WINTER, "Handbuch der Gesamten Parfumerie und Kosmetik", Fourth and Fifth Edition, published 1949, by SPRINGER-VERLAG WIEN, page 907. * |
| G. ZIMMERMANN, "Stoffliste zur Austria-Codex-Fach-Information 1989/90", 22nd Edition, published 1989, by OESTERREICHISCHER APOTHEKER-VERLAG WIEN, page 50, Paragraph "Borsaeure", in Connection with page 188, Paragraph "Kampfer", each Dealing with "Wiener Haussalbe", (Ap. "Zum Goldenen Elefanten", Wien). * |
| R. VOLK, F. WINTER, "Lexikon der Kosmetischen Praxis", published 1936, by VERLAG VON JULIUS SPRINGER WIEN, page 589. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2081771A1 (en) * | 1994-08-05 | 1996-03-01 | Arredondo Javier Olaechea | Composition of a liquid product for topical use for burns and bruises. |
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