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WO1994006913B1 - Proteines recombinees d'une souche pakistanaise du virus de l'hepatite e et leur utilisation dans des procedes diagnostiques et des vaccins - Google Patents

Proteines recombinees d'une souche pakistanaise du virus de l'hepatite e et leur utilisation dans des procedes diagnostiques et des vaccins

Info

Publication number
WO1994006913B1
WO1994006913B1 PCT/US1993/008849 US9308849W WO9406913B1 WO 1994006913 B1 WO1994006913 B1 WO 1994006913B1 US 9308849 W US9308849 W US 9308849W WO 9406913 B1 WO9406913 B1 WO 9406913B1
Authority
WO
WIPO (PCT)
Prior art keywords
protein
recombinant
reading frame
hepatitis
expression vector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1993/008849
Other languages
English (en)
Other versions
WO1994006913A3 (fr
WO1994006913A2 (fr
Filing date
Publication date
Application filed filed Critical
Priority to DE69334299T priority Critical patent/DE69334299D1/de
Priority to AT93922703T priority patent/ATE449178T1/de
Priority to CA002144855A priority patent/CA2144855C/fr
Priority to JP6508363A priority patent/JPH08504096A/ja
Priority to EP93922703A priority patent/EP0662133B1/fr
Priority to AU51625/93A priority patent/AU689447C/en
Publication of WO1994006913A2 publication Critical patent/WO1994006913A2/fr
Publication of WO1994006913A3 publication Critical patent/WO1994006913A3/fr
Publication of WO1994006913B1 publication Critical patent/WO1994006913B1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Abstract

Souche du virus de l'hépatite E en provenance du Pakistan (SAR-55) impliquée dans une épidémie d'une hépatite non-A, non-B, à transmission entérique et à présent appelée hépatite E. L'invention se rapporte à l'expression de la région structurale entière de SAR-55, désignée comme cadre de lecture ouvert 2 (ORF-2), dans un système d'expression eucaryotique. La protéine exprimée est capable de former des particules analogues au virus de l'hépatite E, qui peuvent être utilisées comme un antigène dans des dosages immunologiques et diagnostiques, et comme un immunogène ou un vaccin protégeant contre l'infection par le virus de l'hépatite E.
PCT/US1993/008849 1992-09-18 1993-09-17 Proteines recombinees d'une souche pakistanaise du virus de l'hepatite e et leur utilisation dans des procedes diagnostiques et des vaccins Ceased WO1994006913A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
DE69334299T DE69334299D1 (de) 1992-09-18 1993-09-17 Rekombinante proteine eines pakistani stammes von hepatitis e-virus sowie ihre verwendung in diagnostischen verfahren und als vakzine
AT93922703T ATE449178T1 (de) 1992-09-18 1993-09-17 Rekombinante proteine eines pakistani stammes von hepatitis e-virus sowie ihre verwendung in diagnostischen verfahren und als vakzine
CA002144855A CA2144855C (fr) 1992-09-18 1993-09-17 Proteines recombinantes d'une souche pakistanaise de virus de l'hepatite e et leurs utilisations dans des methodes diagnostiques et des vaccins
JP6508363A JPH08504096A (ja) 1992-09-18 1993-09-17 Ｅ型肝炎パキスタン株の組換えタンパク質ならびに診断法およびワクチンにおけるそれらの利用
EP93922703A EP0662133B1 (fr) 1992-09-18 1993-09-17 Proteines recombinees d'une souche pakistanaise du virus de l'hepatite e et leur utilisation dans des procedes diagnostiques et des vaccins
AU51625/93A AU689447C (en) 1992-09-18 1993-09-17 Recombinant proteins of a pakistani strain of hepatitis E and their use in diagnostic methods and vaccines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94726392A 1992-09-18 1992-09-18
US07/947,263 1992-09-18

Publications (3)

Publication Number Publication Date
WO1994006913A2 WO1994006913A2 (fr) 1994-03-31
WO1994006913A3 WO1994006913A3 (fr) 1994-06-09
WO1994006913B1 true WO1994006913B1 (fr) 1994-08-04

Family

ID=25485852

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/008849 Ceased WO1994006913A2 (fr) 1992-09-18 1993-09-17 Proteines recombinees d'une souche pakistanaise du virus de l'hepatite e et leur utilisation dans des procedes diagnostiques et des vaccins

Country Status (9)

Country Link
US (3) US6706873B1 (fr)
EP (1) EP0662133B1 (fr)
JP (3) JPH08504096A (fr)
KR (2) KR100332602B1 (fr)
AT (1) ATE449178T1 (fr)
CA (1) CA2144855C (fr)
DE (1) DE69334299D1 (fr)
ES (1) ES2336282T3 (fr)
WO (1) WO1994006913A2 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6214970B1 (en) 1988-06-17 2001-04-10 Genelabs Technologies, Inc. Hepatitis E virus antigens and uses therefor
US6291641B1 (en) 1988-06-17 2001-09-18 Genelabs Technologies, Inc. Hepatitis E virus antigens and uses therefor
US6455492B1 (en) * 1988-06-17 2002-09-24 Genelabs Technologies, Inc. Hepatitis E virus vaccine and method
US5686239A (en) * 1988-06-17 1997-11-11 Genelabs Technologies, Inc. Hepatitis E virus peptides and methods
US6787145B1 (en) 1992-09-18 2004-09-07 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Recombinant proteins of a pakistani strain of hepatitis E and their use in diagnostic methods and vaccines
ES2336282T3 (es) 1992-09-18 2010-04-09 The Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services Proteinas recombinantes de una cepa paquistani de hepatitis e y su utilizacion en metodos de diagnostico y vacunas.
US6207416B1 (en) 1992-09-18 2001-03-27 The United States Of America As Represented By The Department Of Health And Human Services Recombinant proteins of a Pakistani strain of hepatitis E and their use in diagnostic methods and vaccines
WO1995008632A1 (fr) * 1993-09-24 1995-03-30 The Macfarlane Burnet Centre For Medical Research Limited Antigenes immunoreactifs du virus de l'hepatite e
CN1148450C (zh) * 1994-10-03 2004-05-05 美国健康及大众服务部部长 戊型肝炎巴基斯坦病毒株的重组蛋白及其在诊断方法和疫苗中的用途
US6054567A (en) * 1997-04-11 2000-04-25 The United States Of America As Represented By The Department Of Health And Human Services Recombinant proteins of a pakistani strain of hepatitis E and their use in diagnostic methods and vaccines
US6458562B1 (en) 1998-04-09 2002-10-01 The United States Of America As Represented By The Secretary Of Health And Human Services Recombinant proteins of a Pakistani strain of hepatitis E and their use in diagnostic methods and vaccines
US6930176B2 (en) 1999-12-01 2005-08-16 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Major neutralization site of hepatitis E virus and use of this neutralization site in methods of vaccination and in methods of screening for neutralizing antibodies to hepatitis E virus
US20040234542A1 (en) * 2001-05-07 2004-11-25 Xiang-Jin Meng Recombinant orf2 proteins of the swine hepatitis e virus and their use as a vaccine and as a diagnostic reagent for medical and veterinary applications
BR122015016384B8 (pt) * 2001-11-08 2021-07-27 Beijing Wantai Biological Pharmacy Entpr Co Ltd polipeptídio recombinante ou isolado, molécula de ácido nucléico, kit de diagnóstico para detectar a infecção pelo vírus da hepatite e, composição de vacina, composição farmacêutica, vetor de expressão recombinante, célula hospedeira transformada e uso do polipeptídeo recombinante ou isolado
US7122314B2 (en) * 2002-01-30 2006-10-17 Id Biomedical Corporation Methods for detecting vancomycin-resistant microorganisms and compositions therefor
EP1773990A2 (fr) * 2004-08-04 2007-04-18 Applied Research Systems ARS Holding N.V. Capsule contenant des cellules transgeniquement modifiees, methode pour les preparer et utilisation de ces dernieres pour vacciner et immuniser
US9487837B2 (en) * 2008-10-06 2016-11-08 Morehouse School Of Medicine Exosome-mediated diagnosis of hepatitis virus infections and diseases
WO2010099547A1 (fr) * 2009-02-27 2010-09-02 The Regents Of The University Of California Système d'administration d'antigène multiple utilisant une particule de type virus de l'hépatite e
US8906862B2 (en) 2009-02-27 2014-12-09 The Regents Of The University Of California Multiple antigen delivery system using hepatitis E virus-like particle
US8906863B2 (en) 2009-02-27 2014-12-09 The Regents Of The University Of California Proteolysis-resistant capsid of chimeric hepatitis E virus as an oral delivery vector
KR101648106B1 (ko) * 2014-04-29 2016-08-17 대한민국 A형 간염 바이러스 항원 및 e형 간염 바이러스 항원 동시 생산방법 및 생산된 항원을 함유하는 간염 예방 백신 및 진단 키트
KR102492326B1 (ko) 2022-07-14 2023-01-26 김성남 휴대용 악취배출 호신구

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5024939A (en) * 1987-07-09 1991-06-18 Genentech, Inc. Transient expression system for producing recombinant protein
US5885768A (en) 1988-06-17 1999-03-23 The United States Of America As Represented By The Department Of Health And Human Services Hepatitis E virus peptide antigen and antibodies
US6214970B1 (en) 1988-06-17 2001-04-10 Genelabs Technologies, Inc. Hepatitis E virus antigens and uses therefor
US5741490A (en) 1988-06-17 1998-04-21 Genelabs Technologies, Inc. Hepatitis E virus vaccine and method
US6455492B1 (en) * 1988-06-17 2002-09-24 Genelabs Technologies, Inc. Hepatitis E virus vaccine and method
US5686239A (en) * 1988-06-17 1997-11-11 Genelabs Technologies, Inc. Hepatitis E virus peptides and methods
CN1075112C (zh) 1990-04-05 2001-11-21 基因实验室有限公司 制备hev蛋白质和检测hev感染的方法
WO1993014203A1 (fr) 1992-01-21 1993-07-22 Tsumura & Co. Lymphotoxines, vecteur d'expression pour lymphotoxines, et production de lymphotoxines au moyen de ce vecteur
US6207416B1 (en) * 1992-09-18 2001-03-27 The United States Of America As Represented By The Department Of Health And Human Services Recombinant proteins of a Pakistani strain of hepatitis E and their use in diagnostic methods and vaccines
ES2336282T3 (es) 1992-09-18 2010-04-09 The Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services Proteinas recombinantes de una cepa paquistani de hepatitis e y su utilizacion en metodos de diagnostico y vacunas.
WO1995008632A1 (fr) 1993-09-24 1995-03-30 The Macfarlane Burnet Centre For Medical Research Limited Antigenes immunoreactifs du virus de l'hepatite e
EP0736087A1 (fr) 1993-12-22 1996-10-09 Abbott Laboratories Anticorps monoclonaux diriges contre l'antigene orf-2 d'hev et procedes d'utilisation
US9115603B2 (en) * 2012-07-24 2015-08-25 Electratherm, Inc. Multiple organic Rankine cycle system and method

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