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WO1993018055B1 - Peptides stimulating cytotoxic lymphocytes respone to hiv-1 gp160 - Google Patents

Peptides stimulating cytotoxic lymphocytes respone to hiv-1 gp160

Info

Publication number
WO1993018055B1
WO1993018055B1 PCT/US1993/001925 US9301925W WO9318055B1 WO 1993018055 B1 WO1993018055 B1 WO 1993018055B1 US 9301925 W US9301925 W US 9301925W WO 9318055 B1 WO9318055 B1 WO 9318055B1
Authority
WO
WIPO (PCT)
Prior art keywords
hiv
acid sequence
amino acid
respone
peptides
Prior art date
Application number
PCT/US1993/001925
Other languages
French (fr)
Other versions
WO1993018055A3 (en
WO1993018055A2 (en
Filing date
Publication date
Priority claimed from US07/847,311 external-priority patent/US5976541A/en
Application filed filed Critical
Priority to AU37878/93A priority Critical patent/AU668927B2/en
Priority to EP93907180A priority patent/EP0630385A1/en
Priority to CA002131153A priority patent/CA2131153C/en
Publication of WO1993018055A2 publication Critical patent/WO1993018055A2/en
Publication of WO1993018055A3 publication Critical patent/WO1993018055A3/en
Publication of WO1993018055B1 publication Critical patent/WO1993018055B1/en

Links

Abstract

Peptides having high activity in the eliciting of a cytotoxic T lymphocyte response to the HIV-1 envelope glycoprotein gp160 are described. The activation of 12-15 residue peptides by proteolytic degradation to shorter peptides is shown as are general techniques for characterizing such activation processes.

Claims

49AMENDED CLAIMS[received by the International Bureau on 14 April 1994 (14.04.94); original claim 1 amended; remaining claims unchanged (1 page)]
1. A polypeptide comprising an amino acid sequence that is a portion of the HIV envelope glycoprotein gpl60 which elicits an immune response characterized by response of both HC class I-restricted and MHC class-II restricted elements of the mammalian immune system, said polypeptide eliciting said response in a solution at a concentration of peptide of less than 3 X 10"7 M.
2. An isolated polypeptide according to claim 1, wherein said portion of the HIV envelope glycoprotein gplβO is the region homologous to amino acids 318-327 of isolate IIIB.
3. An isolated polypeptide having an amino acid sequence selected from the group consisting of: RGPGRAFVTI, IGPGRAFYTT, IGPGRAFYAT, KGPGRVIYAT, IGPGRAFHTT, IGPGRTLYAR, LGPGRVWYTT, and IGPGRAFRTR.
4. An isolated polypeptide having the amino acid sequence RGPGRAFVTI .
PCT/US1993/001925 1992-03-06 1993-03-08 Peptides stimulating cytotoxic lymphocytes respone to hiv-1 gp160 WO1993018055A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU37878/93A AU668927B2 (en) 1992-03-06 1993-03-08 Peptides stimulating cytotoxic lymphocytes response to HIV-I GP 160
EP93907180A EP0630385A1 (en) 1992-03-06 1993-03-08 Potent peptide for stimulation of cytotoxic t lymphocytes specific for the hiv-1 envelope
CA002131153A CA2131153C (en) 1992-03-06 1993-03-08 Peptides stimulating cytotoxic lymphocytes response to hiv-i gp 160

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/847,311 US5976541A (en) 1988-01-26 1992-03-06 Potent peptide for stimulation of cytotoxic T lymphocytes specific for the HIV-1 envelope
US847,311 1992-03-06

Publications (3)

Publication Number Publication Date
WO1993018055A2 WO1993018055A2 (en) 1993-09-16
WO1993018055A3 WO1993018055A3 (en) 1994-03-17
WO1993018055B1 true WO1993018055B1 (en) 1994-06-09

Family

ID=25300315

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/001925 WO1993018055A2 (en) 1992-03-06 1993-03-08 Peptides stimulating cytotoxic lymphocytes respone to hiv-1 gp160

Country Status (5)

Country Link
US (1) US5976541A (en)
EP (1) EP0630385A1 (en)
AU (1) AU668927B2 (en)
CA (1) CA2131153C (en)
WO (1) WO1993018055A2 (en)

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US6210873B1 (en) 1987-08-28 2001-04-03 Board Of Regents, The University Of Texas System Methods and compositions for the priming of specific cytotoxic T-lymphocyte response
US5128319A (en) 1987-08-28 1992-07-07 Board Of Regents, The University Of Texas System Prophylaxis and therapy of acquired immunodeficiency syndrome
WO1994021287A1 (en) * 1993-03-15 1994-09-29 The Government Of The United States Of America As Represented By The Department Of Health And Human Services Peptide coated dendritic cells as immunogens
US5603933A (en) * 1993-08-31 1997-02-18 Board Of Regents, The University Of Texas CD4 peptides for binding to viral envelope proteins
NL9400384A (en) * 1994-03-11 1995-10-02 Smit Victor Retrovirus vaccines, vaccination and immunotherapy against retroviral infections.
GB9426153D0 (en) * 1994-12-23 1995-02-22 Medical Res Council Improvements in or relating to vaccines
US6395714B1 (en) * 1999-02-24 2002-05-28 Aventis Pasteur Limited Expressing gp140 fragment of primary HIV-1 isolate
MXPA02007478A (en) 2000-02-04 2004-08-23 Univ Duke Human immunodeficiency virus vaccine.
WO2001072331A1 (en) * 2000-03-31 2001-10-04 Vaccine Chip Technology Aps Immunostimulating properties of a fragment of tgf-beta
WO2003037264A2 (en) * 2001-10-29 2003-05-08 Genzyme Corporation Therapeutic anti-hiv (vpr) compounds
WO2003051285A2 (en) * 2001-10-29 2003-06-26 Genzyme Corporation Therapeutic anti-hiv (iv9) compounds
US20090214583A1 (en) * 2004-04-30 2009-08-27 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Epitope-enhancement of a human cd4 hiv epitope
EP2620446A1 (en) 2012-01-27 2013-07-31 Laboratorios Del Dr. Esteve, S.A. Immunogens for HIV vaccination
AU2020384323A1 (en) 2019-11-14 2022-06-02 Aelix Therapeutics, S.L. Dosage regimens for vaccines

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WO1986002383A1 (en) * 1984-10-18 1986-04-24 Institut Pasteur Envelope antigens of lymphadenopathy associated virus and their applications
DE3689941D1 (en) * 1985-10-24 1994-08-04 Southwest Found Biomed Res SYNTHETIC PEPTIDES AND THEIR USE FOR DIAGNOSIS AND VACCINATION FOR AIDS AND ARC.
EP0269712A4 (en) * 1986-06-12 1990-06-26 Biogen Nv Peptides involved in the pathogenesis of hiv infection.
EP0273716B1 (en) * 1986-12-30 1993-08-11 THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce Synthetic peptides which induce cellular immunity to the aids virus and aids viral proteins
US5019387A (en) * 1987-09-08 1991-05-28 Duke University Production of antibodies to HIV
US5013548A (en) * 1987-09-08 1991-05-07 Duke University Production of antibodies to HIV
US5820865A (en) * 1988-01-26 1998-10-13 The United States Of America As Represented By The Department Of Health And Human Services Method to induce cytotoxic T Lymphocytes specific for a broad array of HIV-1 isolates using hybrid synthetic peptides
WO1989007112A1 (en) * 1988-01-26 1989-08-10 The United States Of America, As Represented By Th A synthetic antigen evoking anti-hiv response
US5562905A (en) * 1988-04-26 1996-10-08 E. I. Du Pont De Nemours And Company Human immunodeficiency virus (hiv) env-coded peptide capable of eliciting hiv-inhibiting antibodies in mammals
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