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WO1993016180A3 - Sequences for a 90k tumor-associated antigen, immunoregulin-95 (ir-95) - Google Patents

Sequences for a 90k tumor-associated antigen, immunoregulin-95 (ir-95) Download PDF

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Publication number
WO1993016180A3
WO1993016180A3 PCT/EP1993/000382 EP9300382W WO9316180A3 WO 1993016180 A3 WO1993016180 A3 WO 1993016180A3 EP 9300382 W EP9300382 W EP 9300382W WO 9316180 A3 WO9316180 A3 WO 9316180A3
Authority
WO
WIPO (PCT)
Prior art keywords
antigen
fragment
tumor
molecular weight
breast cancer
Prior art date
Application number
PCT/EP1993/000382
Other languages
French (fr)
Other versions
WO1993016180A1 (en
WO1993016180A2 (en
Inventor
Axel Ullrich
Irmingard Sures
Mohammad Azam
Stefano Iacobelli
Clara Natoli
Original Assignee
Max Planck Gesellschaft
Uni Degli Studi G D Annunzio C
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft, Uni Degli Studi G D Annunzio C filed Critical Max Planck Gesellschaft
Publication of WO1993016180A1 publication Critical patent/WO1993016180A1/en
Publication of WO1993016180A2 publication Critical patent/WO1993016180A2/en
Publication of WO1993016180A3 publication Critical patent/WO1993016180A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

This invention provides substantially purified tumor-associated 90K antigen, or fragment(s) thereof, especially from: the culture fluid of the human breast cancer cell line, CG-5; the serum of a breast cancer patient; or the ascitic fluid from an ovarian cancer patient. The native antigen, which has a molecular weight of about 95,000 daltons, is present as a high molecular weight complex. The purification and characterization of the antigen is provided as well as uses thereof. The nucleotide sequences which encode the 90K antigen, or fragment(s) thereof, vehicles containing the genetic sequence, hosts transformed therewith, and production of the antigen, or fragments thereof, by the transformed host are also provided.
PCT/EP1993/000382 1992-02-17 1993-02-17 Sequences for a 90k tumor-associated antigen, immunoregulin-95 (ir-95) WO1993016180A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITRM920100A IT1254309B (en) 1992-02-17 1992-02-17 GENETIC SEQUENCES FOR 90K ANTIGEN ASSOCIATED WITH CANCER.
ITRM92A000100 1992-02-17

Publications (3)

Publication Number Publication Date
WO1993016180A1 WO1993016180A1 (en) 1993-08-19
WO1993016180A2 WO1993016180A2 (en) 1993-08-19
WO1993016180A3 true WO1993016180A3 (en) 1993-09-30

Family

ID=11400692

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1993/000382 WO1993016180A2 (en) 1992-02-17 1993-02-17 Sequences for a 90k tumor-associated antigen, immunoregulin-95 (ir-95)

Country Status (5)

Country Link
CN (1) CN1076489A (en)
AU (1) AU3497893A (en)
IT (1) IT1254309B (en)
WO (1) WO1993016180A2 (en)
ZA (1) ZA931101B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1049895A (en) * 1993-11-05 1995-05-23 New York University Methods relating to ir-95
US7081517B2 (en) 2000-01-10 2006-07-25 Chiron Corporation Genes differentially expressed in breast cancer
WO2001051515A2 (en) * 2000-01-10 2001-07-19 Chiron Corporation Genes differentially expressed in breast cancer
AU3483001A (en) * 2000-02-04 2001-08-14 Corixa Corp Compositions and methods for the therapy and diagnosis of ovarian cancer
ITRM20090081A1 (en) * 2009-02-25 2010-08-26 Stefano Iacobelli USE OF 90K PROTEIN INHIBITORS FOR THE PREPARATION OF A MEDICATION FOR THE CURE OR PREVENTION OF TUMORS.
CN101962405A (en) * 2010-09-30 2011-02-02 南开大学 Humanized breast cancer antigen and antibody thereof
CN110455848B (en) * 2018-05-08 2024-02-23 国家纳米科学中心 Iron ion longitudinal relaxation time sensor based on complexing reaction amplified signal, construction method and application thereof
EP3880706A1 (en) 2018-11-12 2021-09-22 MediaPharma S.r.l. Bispecific antibodies directed against human 90k and either endosialin or her3

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986002735A1 (en) * 1984-11-02 1986-05-09 Oncogen Monoclonal antibodies and antigens for human non-small cell lung carcinomas
EP0453419A2 (en) * 1990-04-23 1991-10-23 Consiglio Nazionale Delle Ricerche Use of the SP-2 monoclonal antibody for diagnostics and for monitoring of the HIV infection progress

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986002735A1 (en) * 1984-11-02 1986-05-09 Oncogen Monoclonal antibodies and antigens for human non-small cell lung carcinomas
EP0453419A2 (en) * 1990-04-23 1991-10-23 Consiglio Nazionale Delle Ricerche Use of the SP-2 monoclonal antibody for diagnostics and for monitoring of the HIV infection progress

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BREAST CANCER RESEARCH AND TREATMENT vol. 11, no. 1, 1988, BOSTON, US pages 19 - 30 Iacobelli, S. et al.; 'Measurement of a monoclonal antibody defined antigen 90K in sera of patients with ovarian cancer.' cited in the application *

Also Published As

Publication number Publication date
ZA931101B (en) 1994-08-17
ITRM920100A0 (en) 1992-02-17
IT1254309B (en) 1995-09-14
ITRM920100A1 (en) 1993-08-17
WO1993016180A2 (en) 1993-08-19
AU3497893A (en) 1993-09-03
CN1076489A (en) 1993-09-22

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