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WO1993013409A1 - Detecteur et procede de neutralisation d'une solution oxydante - Google Patents

Detecteur et procede de neutralisation d'une solution oxydante Download PDF

Info

Publication number
WO1993013409A1
WO1993013409A1 PCT/US1992/010990 US9210990W WO9313409A1 WO 1993013409 A1 WO1993013409 A1 WO 1993013409A1 US 9210990 W US9210990 W US 9210990W WO 9313409 A1 WO9313409 A1 WO 9313409A1
Authority
WO
WIPO (PCT)
Prior art keywords
electrodes
neutralization
oxidant
solution
bath
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1992/010990
Other languages
English (en)
Inventor
Gregory R. Holland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of WO1993013409A1 publication Critical patent/WO1993013409A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/4166—Systems measuring a particular property of an electrolyte
    • G01N27/4168—Oxidation-reduction potential, e.g. for chlorination of water

Definitions

  • Known processes for addressing this problem include processes wherein the treated article is subjected to a bath of a neutralization liquid for neutralizing or diluting the residual oxidant, or an excess amount of a neutralizing material such as catalase is placed in the hydrogen peroxide bath.
  • a neutralization liquid for neutralizing or diluting the residual oxidant, or an excess amount of a neutralizing material such as catalase is placed in the hydrogen peroxide bath.
  • the article must be left in the resulting neutralization bath for a period of time to allow a suitable neutralization of the residual oxidant. If the article is removed from the neutralization bath before a suitable neutralization period has passed, unneutralized residual oxidant may be present on the article with enough concentration to create the problems noted above. Therefore, the ability to determine when residual oxidant (e.g., hydrogen peroxide) is sufficiently neutralized would provide significant advantages.
  • residual oxidant e.g., hydrogen peroxide
  • Another problem confronting the soft contact lens user occurs when the user adds a neutralizing agent such as catalase to a disinfecting solution such as 3% H 2 0 2 . In such case, all of the solutions are clear. If the user forgets whether or not the catalase was added to in the H 2 0 2 solution, the user may mistake an unneutralized solution for a neutralized one.
  • a neutralizing agent such as catalase
  • the present invention relates to apparatus and methods for detecting the sufficient neutralization of an oxidant, such as a disinfectant, and to oxidant treatment systems and processes which employ such apparatus and methods.
  • an article such as a soft contact lens
  • a neutralization agent is added to the bath so as to form a neutralizing solution to neutralize or dilute residual disinfectant in the bath and on or absorbed in the article.
  • a platinum body may be located in the disinfecting solution as a neutralizer.
  • Figure 1 is a schematic diagram of a detection apparatus according to a first embodiment of the invention.
  • Figure 5 is a perspective view of a contact lens container according to an embodiment of the invention.
  • Embodiments of the invention may employ other oxidants or disinfectant solutions which, when combined with a neutralizing agent, provide a neutralization solution having electrolytic properties that diminish as the oxidant or disinfectant neutralizes.
  • the disinfectant solution sold under the trademark OXYSEPT * , of Allergan, Inc. is a suitable disinfectant solution.
  • One electrode e.g., the first electrode 16 will be positively charged (relative to the other electrode 18) and will, therefore, be considered the anode.
  • the other electrode e.g., the second electrode 18, will acquire a negative charge (compared to the first electrode) and will, therefore, be considered the cathode.
  • the combination of the electrolyte properties of the neutralization solution 12 with residual disinfectant dispersed therein and the two electrodes 16 and 18 form a rudimentary electrolyte battery structure (hereinafter referred to as "the rudimentary battery structure") which generates a potential between the first and second electrodes.
  • Load 30 may be any suitable type of electronic indicating device such as discussed above. However, since load 30 is powered by external power source 28, as opposed to by the power generated from the rudimentary battery structure, load 30 may be chosen from devices which consume a greater amount of power than, for example, load 24 shown in Figure 1.
  • power source 28 may be either an AC or a DC power source and load 30 may be a corresponding AC or DC electronic indicating device.
  • Figure 3 shows another embodiment of the present invention wherein a lead connected to an electrode, e.g., lead 20 connected to electrode 16, is connected as a control input of a first switch S-1.
  • a power source 28 is connected to the input terminal of switch S-1 and a load L-l is connected to the output terminal of S-1 in a manner similar to the manner in which power source 28 and load 30 are connected to switch 26 in Figure 2.
  • Switch S-2 operates in an opposite manner from switch S-1. That is, switch S-2 operates to conduct power between its input terminal and its output terminal when the signal at the control terminal is low. On the other hand, switch S-2 operates to open the circuit between its input and its output terminals when the signal at its control terminal is of a sufficiently high magnitude (e.g., a high voltage). This type of switch device is well known.
  • the input terminal of switch S-2 is connected to power source 28 and the output of switch S-2 is connected to a second load L-2.
  • a current sensor (not shown) can be connected in series with the power source so as to detect or measure the magnitude of current flowing between the electrodes.
  • a conductivity path between the immersed ends of the electrodes, through the solution must be present. The ability of the solution to conduct current will thereby affect the magnitude of current flowing between the electrodes for a particular power source output potential. Since the ability of the solution to conduct current (the conductivity of the solution) is dependent on the concentration of unneutralized disinfectant in the solution, the magnitude of current detected or measured by the current sensor can provide a detection or measurement of the concentration of unneutralized oxidant disinfectant present in the solution.
  • a power source and current sensor (or voltage sensor) arrangement as discussed above can provide both functions of accelerating, stimulating or effecting the degradation of oxidant disinfectant in the solution and monitoring the affect of the degradation.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)

Abstract

Les appareil et procédés de détection de neutralisation insuffisante d'un désinfectant oxydant et de systèmes de désinfection ainsi que les systèmes et techniques de traitement qui utilisent lesdits appareil et procédés, déterminent les propriétés électrolytiques du désinfectant dans une solution neutralisante. Un article tel qu'une lentille de contact se désinfecte dans un bain de solution désinfectante comme le peroxyde d'hydrogène. Après un laps de temps suffisant, un agent neutralisant est ajouté dans le bain désinfectant afin d'obtenir une solution de neutralisation et de neutraliser le désinfectant résiduel. La présence de désinfectant résiduel non neutralisé dans une solution de neutralisation (par exemple au début de la phase de neutralisation) donne à la solution de neutralisation des propriétés électrolytiques, dont la capacité de générer un potentiel électrique. Ce potentiel électrique est déterminé afin de détecter la présence de désinfectant non dissous en quantité ou concentration indésirables dans la solution de neutralisation. Pour ce faire, des électrodes sont placées dans la solution de neutralisation et le potentiel entre les deux électrodes est mesuré.
PCT/US1992/010990 1991-12-20 1992-12-17 Detecteur et procede de neutralisation d'une solution oxydante Ceased WO1993013409A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81098991A 1991-12-20 1991-12-20
US07/810,989 1991-12-20

Publications (1)

Publication Number Publication Date
WO1993013409A1 true WO1993013409A1 (fr) 1993-07-08

Family

ID=25205233

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1992/010990 Ceased WO1993013409A1 (fr) 1991-12-20 1992-12-17 Detecteur et procede de neutralisation d'une solution oxydante

Country Status (2)

Country Link
AU (1) AU3415293A (fr)
WO (1) WO1993013409A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2678045A4 (fr) * 2011-02-23 2015-04-22 Novabay Pharmaceuticals Inc Système de nettoyage de lentilles de contact avec contrôle
US9625744B2 (en) 2013-10-31 2017-04-18 Novabay Pharmaceuticals, Inc. Contact lens cleaning system with insulation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3825483A (en) * 1972-11-06 1974-07-23 Nihon Filter Co Ltd Red-ox potentiometer provided with a ph correction circuit
DE3330358A1 (de) * 1983-08-23 1985-03-14 Walter 2000 Hamburg Nicolai Redoxpotential-messgeraet
US4687997A (en) * 1984-06-22 1987-08-18 Coopervision, Inc. Container with safety features for cleansing medical devices

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3825483A (en) * 1972-11-06 1974-07-23 Nihon Filter Co Ltd Red-ox potentiometer provided with a ph correction circuit
DE3330358A1 (de) * 1983-08-23 1985-03-14 Walter 2000 Hamburg Nicolai Redoxpotential-messgeraet
US4687997A (en) * 1984-06-22 1987-08-18 Coopervision, Inc. Container with safety features for cleansing medical devices

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2678045A4 (fr) * 2011-02-23 2015-04-22 Novabay Pharmaceuticals Inc Système de nettoyage de lentilles de contact avec contrôle
US9625744B2 (en) 2013-10-31 2017-04-18 Novabay Pharmaceuticals, Inc. Contact lens cleaning system with insulation

Also Published As

Publication number Publication date
AU3415293A (en) 1993-07-28

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