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WO1993011731A3 - Alicyclic peptidomimetics - Google Patents

Alicyclic peptidomimetics Download PDF

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Publication number
WO1993011731A3
WO1993011731A3 PCT/US1992/010693 US9210693W WO9311731A3 WO 1993011731 A3 WO1993011731 A3 WO 1993011731A3 US 9210693 W US9210693 W US 9210693W WO 9311731 A3 WO9311731 A3 WO 9311731A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
peptidomimetics
alicyclic
crossreactive
preparative
Prior art date
Application number
PCT/US1992/010693
Other languages
French (fr)
Other versions
WO1993011731A2 (en
Inventor
Ralph Hirschmann
Ellen Leahy
Paul Sprengeler
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of WO1993011731A2 publication Critical patent/WO1993011731A2/en
Publication of WO1993011731A3 publication Critical patent/WO1993011731A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Compounds are provided which are crossreactive with peptides such as those bound by G-protein-linked receptors, together with preparative and therapeutic methods therefor. The compounds have general structure (2), wherein at least one of R1, R2, R3, R4, R5 or R6 comprises a chemical functional group which causes the compounds to be crossreactive with the peptide of interest.
PCT/US1992/010693 1991-12-12 1992-12-11 Alicyclic peptidomimetics WO1993011731A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80589591A 1991-12-12 1991-12-12
US805,895 1991-12-12

Publications (2)

Publication Number Publication Date
WO1993011731A2 WO1993011731A2 (en) 1993-06-24
WO1993011731A3 true WO1993011731A3 (en) 1993-11-11

Family

ID=25192819

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1992/010693 WO1993011731A2 (en) 1991-12-12 1992-12-11 Alicyclic peptidomimetics

Country Status (1)

Country Link
WO (1) WO1993011731A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8273900B2 (en) 2008-08-07 2012-09-25 Novartis Ag Organic compounds
JP6954647B2 (en) * 2016-07-07 2021-10-27 学校法人順天堂 Dihydroxy compounds or salts thereof, and Parkinson's disease therapeutic or prophylactic agents

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5095031A (en) * 1990-08-20 1992-03-10 Abbott Laboratories Indole derivatives which inhibit leukotriene biosynthesis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5095031A (en) * 1990-08-20 1992-03-10 Abbott Laboratories Indole derivatives which inhibit leukotriene biosynthesis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PROC. BIOTECH., (USA), issued 1989, OLSON et al., "Concepts and Progress in the Edesign of Peptide Mimetics--...Hormone", pages 348-360. *

Also Published As

Publication number Publication date
WO1993011731A2 (en) 1993-06-24

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