[go: up one dir, main page]

WO1993008775A1 - Generateur de pression d'air - Google Patents

Generateur de pression d'air Download PDF

Info

Publication number
WO1993008775A1
WO1993008775A1 PCT/SE1992/000755 SE9200755W WO9308775A1 WO 1993008775 A1 WO1993008775 A1 WO 1993008775A1 SE 9200755 W SE9200755 W SE 9200755W WO 9308775 A1 WO9308775 A1 WO 9308775A1
Authority
WO
WIPO (PCT)
Prior art keywords
membrane
air pressure
pressure generator
generator according
elongate member
Prior art date
Application number
PCT/SE1992/000755
Other languages
English (en)
Inventor
Ingvar Hansson
Per HÄLLJE
Roy Saario
Original Assignee
Hb Proxima
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hb Proxima filed Critical Hb Proxima
Publication of WO1993008775A1 publication Critical patent/WO1993008775A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M13/00—Insufflators for therapeutic or disinfectant purposes, i.e. devices for blowing a gas, powder or vapour into the body
    • A61M13/003—Blowing gases other than for carrying powders, e.g. for inflating, dilating or rinsing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F11/00—Methods or devices for treatment of the ears or hearing sense; Non-electric hearing aids; Methods or devices for enabling ear patients to achieve auditory perception through physiological senses other than hearing sense; Protective devices for the ears, carried on the body or in the hand

Definitions

  • the present invention relates to ' an air pressure generator for generating pressure pulses for the treatment of ears, said pulses being intended to be transmitted to the interior of an ear, said generator comprising a housing, a membrane located in said housing and means for actuating said membrane.
  • the air pressure generator according to the invention is inter alia intended to influence the hydrodynamic system of the inner ear and is for instance very suitable for use in the method for treatment of Meniere's disease described in EP-A1-0266474.
  • a device of the kind described above is disclosed in the published International Patent Application WO 83/02556.
  • This prior art device thus comprises first means for generating a static pressure level in a reservoir and second means for varying the static pressure level.
  • Said first means is a diaphragm pump comprising a membrane actuated by a piston rod and said second means comprises a valve for temporarily reducing the static pressure in the reservoir. It seems that the parameters are adapted to different treatments or to different patients solely by a manual adjustment of the mechanical parts of the device.
  • a similar device is disclosed in the International Patent Application WO 86/01399.
  • This device comprises two rotary pumps. Each pump is connected to a respective three-way valve. Both valves are connected to an ear plug.
  • the speeds of the pumps and the positions of the valves can be controlled in response to a program stored in a micro ⁇ computer and in response to a pressure transducer sensing the momentary pressure.
  • the program in the microcomputer is to contain all necessary data regarding the parameters for the series of pressure pulses.
  • the pulses are intended to have a substantially sinusoidal modulation.
  • a continuously working pump building up a continuous superat ospheric pressure may produce high-frequency overtones which are undesirable when treating ears according to the method described above.
  • Such undesirable overtones also can be produced by valves when such are used for generating the pressure variations. It also has proved to be important that the pressure pulses follow the desired softly shape.
  • the objects of the invention is to create an improved air pressure generator which avoids the undesirable high frequency overtones described above and which generates pressure pulses having a softly curved shape.
  • an air pres ⁇ sure generator of the kind described introductorily is designed such that said membrane and said housing form a chamber connected by suitable connecting means to the ear, said chamber and said connecting means forming a closed system in the working position of the generator, said pressure pulses being generated by the direct action of the displacements of said membrane caused by said actuating means on the enclosed air in said closed system.
  • said membrane is pre-tensioned and, if necessary, is moved to a pre-tensioned zero position by means of said actuating means when the generator is to be used and such that said actuating means comprises an elongate member which is attached to said membrane and which is driven by an electrical motor, said elongate member comprising a first and a second part being provided with complementary threads being in engagement with each other, said parts being rotatable relative to each other by means of said electrical motor in response to signals from a control circuit, by which means said membrane can displaced, thus generating said air pressure pulses.
  • These parts can be made in a very light-weight design and consequently there is no large inertia to be overcome when the rotational speed or direction of the motor is changed. This means that the air pressure generator can respond very fast to signals from the control circuit.
  • One advantage is that the membrane will not flutter in an uncontrolled way around the neutral, untensioned position, which would mean that it would be difficult to control the shape of the pulses.
  • a pre-tensioned membrane will however generate pulses with the desired softly rounded shape.
  • FIG 1 illustrates a relatively detailed section through a preferred embodiment of an air pressure generator according to the invention.
  • the tubes connecting the generator to the ear and the electronic and electric circuits controlling the generator are only illustrated schematically.
  • Fig 2 illustrates an alternative driving system in an air pressure generator utilizing a friction wheel mechanism.
  • Fig 3 is a section III - III in Fig 2.
  • Fig 4 illustrates another driving system utilizing a rack and pinion mechanism.
  • Fig 5 illustrates yet another driving system, utilizing a cogged belt.
  • the air pressure generator comprises a generally cylindrical main housing 1 with a central bore 2.
  • the upper end of the housing 1 is closed by a mounting plate 3 attached to the housing by means of screws 4.
  • the mounting plate 3 is provided with a central hole 5 for the shaft 6 of a reversible electrical DC motor 1 r which is attached to the upper side of the mounting plate 3 by means of screws 8.
  • the hole 5 is coaxial with the central bore 2 of the housing 1.
  • the motor may for instance be a DC-micromotor of the type 2842 006 C supplied by Minimotor SA in Switzerland. This motor has an angular acceleration exceeding the necessary 40 000 rad/sec 2 .
  • any suitable similar motor may be used, including step motors and motors provided with pulse counters.
  • the shaft 6 of the motor 7 is coupled to an actuating rod comprising two parts 9 and 10 by means of a coupling 11.
  • the upper part of the first or upper part 9 of the ac ⁇ tuating rod is rotatably journalled in a bearing 12 loca ⁇ ted in the upper part of the central bore 2.
  • the lower part of the part 9 is provided with threads.
  • the second or lower part 10 of the actuating rod is tubular and is provided with internal threads.
  • the second part 10 is non- rotatably but slideably supported in a slide bearing 48 located in the lower part of the central bore 2.
  • the lower end of the second part 10 of the actuating rod is located in a chamber 13 formed in the lower part of the housing 1 by a circumferential flange 14 and a lower mounting plate 15 attached to the housing 1 by means of screws 50.
  • Two plates 19 and 20 are attached to the lower end of the second part 10 by means of a screw 21 threaded into the internal threads of the second part 10.
  • One of the plates 19, 20 is provided with a circumferential groove clamping a complementary bead 17 on the inner rim of a ring-shaped, elastic membrane 16 which for instance may be made of rubber.
  • the outer rim of the membrane 16 is also provided with a circumferential bead 18 clamped in a circumferential groove between the mounting plate 15 and the rim of the flange 14. A movement of the second part 10 upwards or downwards thus will result in a movement of the membrane 16.
  • the plates 19, 20, the membrane 16 and the lower mounting plate 15 form an air-tight chamber 24 in the chamber 13 having an outlet 22 for connection to an air tube or conduit 23.
  • the lower mounting plate 15 also is provided with a check valve 29 allowing air to enter the air-tight chamber 24.
  • One important function of the check valve 29 is to prevent any negative pressures in the chamber 24 when the membrane moves upwardly since such negative pressures may be harmful to the ear.
  • the remaining part of the chamber 13 is vented to the ambient atmosphere by means of an opening 49.
  • the housing 1 further is provided with a relatively large opening 25 in its side which is intersected by a lon ⁇ gitudinal, excentric bore 26.
  • the bore accommodates a longitudinal sensor rod 27 attached to the upper plate 19 and the opening 25 accommodates a plug 28 carrying two optical sensors 30,31 located a longitudinal distance from each other such that the sensor rod 27 will pass the sensors when moved longitudinally in the bore 26.
  • the optical sensors thus can emit a signal each time the end of the sensor rod passes a sensor.
  • the sensor rod 27 also will lock the plate 19, and thus also the second part 10, against rotation.
  • the air conduit 23 is connected to a pressure sensor or transducer 32 via a conduit 38 and to a pressure relief valve 33 via conduits 37 and 39.
  • the conduit 37 also is connected to an ear plug 35 for connection to an ear 36 via a conduit 40, a restrictor valve 34 and a conduit 41.
  • the function of the pressure relief valve 33 is to prevent any harmful high pressures that may caused in the chamber 24 and the air conduits in case of a malfunction of the air pressure generator.
  • the pressure relief valve 33 may for instance be set to open at a pressure of 35 cm H 2 0.
  • the restrictor valve 34 serves to equalize and smoothen the pressure pulses in case the pulses for some reason should become deformed.
  • a further important function of the restrictor valve 34 is that may delay the build up of the pressure in the conduit 41 leading to the ear plug 35 if the pressure relief valve for some reason should be slow in responding.
  • a control unit 37 which comprises a power supply unit and a microprocessor is connected to the motor 7, to the pressure transducer 32 and to the optical sensors 30, 31 via leads 42, 43, 44, 45, 46 and 47.
  • the control unit is arranged to vary, and, when necessary, to reverse the polarity of, the power supplied to the DC motor 7 in response to signals received from the optical sensors 30, 31 and the pressure transducer 32 in dependance of a program stored in the microcomputer.
  • the program also contains parts controlling the optical sensors 30, 31 in such a way that they will serve as limit switches sensing and defining the upper and the lower position of the sensor rod 27 and thus also the upper and lower limits for the movement of the actuating rod and the membrane.
  • a program containing the desired momentary pressure expressed as a function of the time for a specific treatment (for instance sinusoidal functions of the kind described in the above-mentioned EP-A-0266474) is stored into the micro-computer as a reference.
  • the program normally is adapted to a particular patient and/or to a particular treatment.
  • the parameters may for instance be chosen as follows:
  • Pulse length 0.1 - 2.0 sec
  • The. number of pulses is of course limited in dependence of the chosen frequency.
  • the active pulse-train should have a maximal duration of 2 seconds.
  • the pulse length is however only relevant in single-pulse mode.
  • the control unit 37 When the air pressure generator is switched on, the control unit 37, by means of the upper optical sensor 30, checks if the upper end of the sensor rod 27 is located at the optical sensor. If not, the control unit 37 will supply power to the electrical motor 7 until the end of the sensor rod 27 reaches the upper sensor 30. During this movement, air will enter the chamber 24 through the check valve 29. In this position the membrane 16 will be pre- tensioned and the chamber 24 will contain a defined volume of air. This air volume will be sealed from the ambient atmosphere when the ear plug 35 is inserted in the ear 36.
  • the ear plug When the treatment is to begin, the ear plug is inserted into the ear and the air pressure generator is started, which results in that the control unit 37 energizes the motor 7 which starts to rotate, causing the second rod part 10 and the membrane 16 to move downwards. This raises the air pressure in the chamber 24 and in the conduits.
  • the air pressure in the chamber 24 and in the air conduits is continuously monitored by the control unit 37 by means of the pressure transducer 32 and is continuously compared with the desired pressure at this particular point of time as stored in the control unit. Any differences between the actual pressure and the desired pressure will immediately be transformed into a change in the electrical power supplied to the motor, which in turn results in a change in the speed or the direction of travel of the actuating rod and the membrane.
  • the curve has such a shape that the membrane oscillates around a point located somewhere in the upper half of the distance between the upper and the lower limit of travel depending on the desired maximum and minimum pressure. Should there however be a small air leak in the system, for instance at the ear plug, this will be compen ⁇ sated for in that the point of oscillation of the membrane will slowly be moved downwards concurrent with the loss of pressure until the sensor rod reaches the lower limit switch. A signal will then be sent to the control unit which will cause the actuating rod and the membrane to return to the original upper position during which movement air may be admitted through the check valve 29. The treatment then can continue if this is desired.
  • limit switches have been illustrated as comprising optical sensors, but may of course comprise any kind of remotely-sensing devices, such as magnetical sensors. Although it for instance is conceivable to use mechanical micro-switches, it is preferable to use limit devices not touching the movable mechanical parts.
  • the second part 10 of the actuating rod is locked against rotation by means of the sensor rod 27.
  • This of course can be achieved in any other suitable way, for instance by means of splines or similar. It may also be possible to sense the movement of the second part directly without using a separate sensor rod.
  • the actuating means may comprise a friction wheel 260 frictionally engaging an actuating rod 209 located in a longitudinal bore 202 in a housing 201 and attached to the membrane 216 in the same way as the actuating rod in the preferred embodiment described above.
  • the air pressre generator comprises control systems and connections identical or similar to the systems described above in connection with the preferred embodiment.
  • the friction wheel 260 is attached to the shaft of the electrical motor 207 and in the embodiment depicted is provided with two flanges 265 so that the wheel will partly embrace the actuating rod, which in this case is partly circular in section.
  • the actuating rod is supported by two supporting wheels 264, 265 opposite to the friction wheel and the rod is clamped between the friction wheel and the supporting wheels with a predetermined force.
  • This force may for instance be obtained by adjusting the relative positions of the motor and the supporting wheels accordingly or by spring-biasing the the friction wheels against the supporting wheels or vice versa.
  • One possibility is to design the friction wheel as comprising two beveled discs, their beveled sides facing each other, which are spring- loaded against each other and which consequently form the flanges.
  • the friction wheel may be shaped in many different ways as long as there is an frictional engagement between wheel and rod. This frictional engagement will ensure that the rod moves in dependence of the rotations of the electric motor in response to signals from the control system.
  • Two limit switches 231 and 232 detect the movements of the actuating rod 209.
  • the actuating means may also for instance comprise a rack driven directly by a pinion mounted on the shaft of the electrical motor as illustrated in Fig 4.
  • actuating rod 109 is located in a longitudinal bore in a housing 101.
  • the rod is provided with a longitudinal row of teeth or serrations
  • the cogs or teeth on the rod 309 in the bore 302 in the housing 301 have been exchanged against cogs or teeth 367 on a cogged endless belt 365 attached to the rod by means of a screw 364 and carried on a pinion or cog wheel 366 on the shaft of an electrical motor 307 and on a supporting wheel 361.
  • the rod is supported opposite the wheels 360 and 361 by means of supporting wheels 362 and 363.
  • the belt of course could be attached to the pinion and be provided with cogs or teeth cooperating with cogs or teeth on the rod.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Otolaryngology (AREA)
  • Biophysics (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Invalid Beds And Related Equipment (AREA)
  • Respiratory Apparatuses And Protective Means (AREA)

Abstract

L'invention concerne un générateur de pression d'air pour produire des impulsions de pression destinées au traitement des oreilles, lesdites impulsions devant être appliquées par exemple au conduit auditif externe d'une oreille. Ledit générateur comporte un boîtier (1, 101, 201, 301) et une membrane souple (16, 116, 216, 316) située dans ledit boîtier, ainsi que des organes (7, 107, 207, 307, 9, 109, 209, 309) pour actionner ladite membrane. La membrane et ledit boîtier forment une chambre (24) reliée à l'oreille (36) par des éléments de raccordement appropriés (23, 37, 40, 41, 35), ladite chambre et lesdits éléments de raccordement formant un système fermé dans la position de travail du générateur. Lesdites impulsions de pression sont produites par l'action directe des mouvements de ladite membrane, provoqués par lesdits organes d'actionnement, sur l'air inclus dans ledit système fermé.
PCT/SE1992/000755 1991-11-08 1992-11-03 Generateur de pression d'air WO1993008775A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9103303A SE9103303D0 (sv) 1991-11-08 1991-11-08 Air pressure generator
SE9103303-5 1991-11-08

Publications (1)

Publication Number Publication Date
WO1993008775A1 true WO1993008775A1 (fr) 1993-05-13

Family

ID=20384273

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE1992/000755 WO1993008775A1 (fr) 1991-11-08 1992-11-03 Generateur de pression d'air

Country Status (3)

Country Link
AU (1) AU2925492A (fr)
SE (1) SE9103303D0 (fr)
WO (1) WO1993008775A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997023178A1 (fr) * 1995-12-22 1997-07-03 Pascal Medical Ab Dispositif permettant d'influencer le systeme hydrodynamique de l'oreille interne
GB2318736A (en) * 1996-10-30 1998-05-06 Bridge House Lab Ltd Method and Apparatus for Ear Irrigation
US6629938B1 (en) 1998-07-06 2003-10-07 Medtronic, Inc. Apparatus for treatment of ménière's disease and similar conditions
WO2003099177A1 (fr) 2002-05-21 2003-12-04 Medtronic Xomed, Inc. Appareil pour deplacer directement la cloison separant l'oreille moyenne de l'oreille interne a une frequence infrasonore
WO2014175257A1 (fr) * 2013-04-23 2014-10-30 第一医科株式会社 Dispositif portable pouvant traiter la maladie de meniere et des symptômes similaires a celle-ci

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB190910695A (en) * 1909-05-05 1910-01-06 Gustave Frantz Lyon Improvements in Harps.
GB191023385A (en) * 1910-10-10 1911-10-10 Edward Hawkesworth Hackett Improvements in Apparatus for Treating Certain Forms of Deafness.
SU812287A1 (ru) * 1978-11-20 1981-03-15 Университет дружбы народов им.Патриса Лумумбы Способ лечени тугоухости
WO1983002556A1 (fr) * 1982-01-22 1983-08-04 Barbara Densert Appareil permettant d'influencer le systeme hydrodynamique a l'interieur d'une oreille
US4757807A (en) * 1986-11-07 1988-07-19 Barbara Densert Method and apparatus for treating Meniere's disease

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB190910695A (en) * 1909-05-05 1910-01-06 Gustave Frantz Lyon Improvements in Harps.
GB191023385A (en) * 1910-10-10 1911-10-10 Edward Hawkesworth Hackett Improvements in Apparatus for Treating Certain Forms of Deafness.
SU812287A1 (ru) * 1978-11-20 1981-03-15 Университет дружбы народов им.Патриса Лумумбы Способ лечени тугоухости
WO1983002556A1 (fr) * 1982-01-22 1983-08-04 Barbara Densert Appareil permettant d'influencer le systeme hydrodynamique a l'interieur d'une oreille
US4757807A (en) * 1986-11-07 1988-07-19 Barbara Densert Method and apparatus for treating Meniere's disease

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DERWENT'S ABSTRACT, Accession No. M8755 D/50, week 8150; & SU,A1,812 287, (LUMUMBA UNIV), 20 November 1978. *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997023178A1 (fr) * 1995-12-22 1997-07-03 Pascal Medical Ab Dispositif permettant d'influencer le systeme hydrodynamique de l'oreille interne
US6159171A (en) * 1995-12-22 2000-12-12 Pascal Medical Ab Device for affecting the hydrodynamic system of the inner ear
GB2318736A (en) * 1996-10-30 1998-05-06 Bridge House Lab Ltd Method and Apparatus for Ear Irrigation
US6629938B1 (en) 1998-07-06 2003-10-07 Medtronic, Inc. Apparatus for treatment of ménière's disease and similar conditions
WO2003099177A1 (fr) 2002-05-21 2003-12-04 Medtronic Xomed, Inc. Appareil pour deplacer directement la cloison separant l'oreille moyenne de l'oreille interne a une frequence infrasonore
US7179238B2 (en) 2002-05-21 2007-02-20 Medtronic Xomed, Inc. Apparatus and methods for directly displacing the partition between the middle ear and inner ear at an infrasonic frequency
WO2014175257A1 (fr) * 2013-04-23 2014-10-30 第一医科株式会社 Dispositif portable pouvant traiter la maladie de meniere et des symptômes similaires a celle-ci
JP5818049B2 (ja) * 2013-04-23 2015-11-18 第一医科株式会社 メニエール病および類似の症状の治療ができる可搬可能な装置
CN105163697A (zh) * 2013-04-23 2015-12-16 第一医科株式会社 能够治疗梅尼埃病及类似症状的可携带装置
US10271992B2 (en) 2013-04-23 2019-04-30 Daiichi Medical Co., Ltd. Portable device for treating Meniere's disease and similar conditions

Also Published As

Publication number Publication date
AU2925492A (en) 1993-06-07
SE9103303D0 (sv) 1991-11-08

Similar Documents

Publication Publication Date Title
US6064797A (en) Volumetric flow equalizing drive control wheel
US12188286B2 (en) Assembly and method
RU2010126176A (ru) Способ управления транспортным средством с гидростатическим приводом
NO301607B1 (no) Drivinnretning for svingdör
CA2481541A1 (fr) Cylindre electrique
CA2358592A1 (fr) Moyens d'emission de lumiere pour traitement medical externe utilisant de la lumiere
MXPA00012919A (es) Aparato para el tratamiento para la enfermedad de meniere y condiciones similares.
WO1993008775A1 (fr) Generateur de pression d'air
US4512710A (en) Robot forearm
JP4250917B2 (ja) マッサージ機
JP2000300374A (ja) リラックス装置
US5624383A (en) Method of and means for providing force feedback in continuous passive motion systems
WO2005038290A3 (fr) Element de montage d'un capteur activement amorti et electroniquement programmable
NO953835L (no) Skinnekjöretöy med variabel karosseristilling
RU96105066A (ru) Насосная система высокого давления и способ ее функционирования
KR940001861A (ko) 혈압계 및 맥파계에서의 압력 강하 속도 제어방법 및 장치
US10918335B2 (en) Sensing module capable of reducing noise
JPH05285665A (ja) 電動機駆動による点溶接ガンの加圧力制御装置
CN112018962B (zh) 电机驱动装置及其摆动装置
ATE392501T1 (de) Mikroprozessor-gestützte steuervorrichtung für eine nähmaschine
JP2006280778A (ja) マッサージ機構及びそれを備えたマッサージ機
JP2563628Y2 (ja) 薬液自動注入装置
CN215231657U (zh) 一种桑拿房内光疗灯的安装结构
JP2001149434A (ja) マッサージ機
JP2603378B2 (ja) 油圧調速ブレーキを備えたエアモータ駆動装置

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AT AU BB BG BR CA CH CS DE DK ES FI GB HU JP KP KR LK LU MG MN MW NL NO PL RO RU SD SE UA US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL SE BF BJ CF CG CI CM GA GN ML MR SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

NENP Non-entry into the national phase

Ref country code: CA

122 Ep: pct application non-entry in european phase