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WO1993005837A1 - Inhalateur pour medicaments en aerosol - Google Patents

Inhalateur pour medicaments en aerosol Download PDF

Info

Publication number
WO1993005837A1
WO1993005837A1 PCT/US1992/007903 US9207903W WO9305837A1 WO 1993005837 A1 WO1993005837 A1 WO 1993005837A1 US 9207903 W US9207903 W US 9207903W WO 9305837 A1 WO9305837 A1 WO 9305837A1
Authority
WO
WIPO (PCT)
Prior art keywords
inlet
receiving chamber
centerline
wall
conduit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1992/007903
Other languages
English (en)
Inventor
Keith H. Bishop
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to EP92920197A priority Critical patent/EP0610240A1/fr
Priority to JP5506245A priority patent/JPH0822314B2/ja
Priority to CA002119887A priority patent/CA2119887A1/fr
Publication of WO1993005837A1 publication Critical patent/WO1993005837A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans

Definitions

  • This invention relates to inhalation devices for delivering medicaments in aerosol form to the respiratory system.
  • the active ingredients are usually present in the container in suspended particulate form, having very small particle sizes, or in solution with a propellant or other- liquid.
  • the dispensing containers are typically • actuated by depressing a nozzle into the container, releasing a "puff" which contains a measured dose of medication. This dose is introduced into a patient's nasal passages or, more commonly, a patient's mouth for inhalation.
  • the final particle size of solids or. liquids for inhalation should be in a narrow range, most preferably about 0.5 to 10 micrometers. Larger . particles than 10 micrometers tend to not be efficiently carried into a patient's bronchia and lungs, commonly depositing in the oropharyngeal area. Very small particles, such as less than 0.5 micrometers, frequently are not well retained within the bronchia or lungs, but are readily exhaled by the patient. Aerosol canisters which are currently in use contain the appropriate medication, plus various excipients, surfactants and a propellant material. Typically, pressures inside the canister can be as high as 6.9 x 10 5 newtons per square meter (100 pounds per square inch) .
  • the medication is normally introduced into inspired air which is traversing a tube called a "spacer".
  • the medication dose is frequently delivered in the approximate center of the spacer diameter, so that inspired air will dilute and carry the medication particles into the lower respiratory system.
  • Proper use of a spacer normally involves coordination of dose release from the aerosol canister, simultaneously with initiation of inspiration, then filling the lungs as full as possible with air and delaying expiration for as long as possible.
  • the present invention resides in an apparatus for dispensing an aerosol medication, contained in a canister, for inhalation, the apparatus comprising an inlet for receiving pressurized fluid, a receiving chamber connected to the inlet, having a reduced cross- sectional width and having a centered projection extending toward the inlet, a duct for conducting air to the patient, and a conduit for supplying pressurized fluid from the receiving chamber to the duct.
  • Figure 1 is a cross-sectional diagram, illustrating an embodiment of the apparatus of the invention.
  • Figure 2 is a top view of the apparatus shown in Figure 1.
  • Figure 3 is a cross-sectional diagram showing components included within the apparatus of Figure 1.
  • Figure 4 is a cross-sectional expanded diagram, showing a portion of the components of Figure 3.
  • the apparatus further comprises inner body 18, which contains a fluid stream duct 20,. connected to fluid conduit 22 which is able to receive air from open areas around the canister support.
  • the fluid stream duct has a longitudinal centerline represented by line C-C, and terminates with a spherical segment 30, through which the fluid conduit extends.
  • Inlet 24 is adapted to receive a nozzle from the above-noted aerosol canister, and preferably engages in sealing relationship about such nozzle.
  • a lower portion of the inlet is reduced in cross- sectional width by oblique segment 36, and extends into receiving chamber 28.
  • One wall of the receiving chamber is an extension of a wall of the inlet.
  • the receiving chamber has a floor, and extending Upward therefrom, a projection 26, which preferably is a cylindrical rod. Located above the termination of the rod, and preferably along the centerline of fluid stream duct 20, is " chamber outlet conduit 32, linking the receiving chamber to the fluid stream duct.
  • the inlet has a centerline represented by line A-A
  • the receiving chamber has a centerline represented by line B-B, displaced from and parallel to the inlet centerline. Both centerlines A-A and B-B are. preferably perpendicular to fluid stream duct , centerline C-C.
  • the apparatus also includes alignment recess
  • FIG. 2 the apparatus is shown in a top view.
  • outer housing 12 having the canister support 14, reduced section 16, inlet 24, projection 26, receiving chamber 28, and alignment recess 38.
  • the dashed lines indicate the outline of fluid stream duct 20, although no portion of this element will be visible from a top view.
  • centerline C-C has been shown, intersecting centerline D-D of the inlet.
  • a juncture of oblique segment 36 (Fig. 1) and a wall of the receiving chamber coincide with line D-D; chamber outlet conduit 32 (Fig. 1) will be located on the side of projection 26 which is opposite the oblique segment.
  • FIG. 4 there is presented an enlarged-scale cross-section showing components of the rearmost area of inner body 18. Centerlines A-A, B-B and C-C are included for orientation purposes. This drawing more clearly shows the relationships of inlet and receiving chamber components, the inlet preferably having beveled edge 34 for facilitating alignment with a canister nozzle, and more clearly showing the preferred embodiment wherein projection 26 terminates at a point below chamber outlet conduit 32. Also preferred is the provision of a rounded top surface for projection 26.
  • the apparatus has a total length along line C-C of 68.7 mm (2.703 inches), a height along line A-A of 47.6 mm
  • Fluid stream duct 20 has a diameter of 21.8 mm (0.860 inches) at the open end, and a 6.60 mm (0.26 inches) radius at the closed end.
  • Fluid conduit 22 has a rectangular cross-section, when viewed from the opened end of fluid stream duct 20,. having a height of 3.43 mm (0.135 inches) and a width of 4.95 mm (0.195 inches).
  • Inlet 24 has a diameter of 2.77 mm (0.109 inches) and receiving chamber 28 has a width along line C-C of 1.50 mm (0.059 inches). The width of projection 26 along line C-C is 0.635 mm (0.025 inches).
  • the height along line A-A from the top of inlet 24 to line C-C is 6.86 mm (0.270 inches) and from line C-C to the bottom of projection 26 is 1.27 mm (0.050 inches).
  • Chamber outlet conduit 32 has a diameter of 0.36 mm (0.014 inches) .
  • Oblique segment 36 is set at a 45° angle from the vertical, beginning 5.21 mm (0.205 inches) below the top of inlet 24.
  • Suitable medications for inhalation using this apparatus include, without limitation, albuterol (also called salbutamol) , beclomethasone diproprionate, cromolyn sodium, epinephrine (including various salts and derivatives thereof) , ergotamine tartrate, flunisolide, ipratropium bromide, isoproterenol hydrochloride, metaproterenol sulfate, pirbuterol acetate, terbutaline sulfate, triamcinolone acetonide and others.
  • the apparatus can be used to dispense other medicaments in solution or suspension form, including antianginal preparations, bronchodilators, corticosteroids, antibiotics, antivirals, immunizing agents, insulin and calcium blockers.
  • the apparatus is preferably constructed from thermoplastic substances, such as polyolefins,. polycarbonate, alloys such as polycarbonate-styrene or acrylonitrile-butadiene-styrene, and the like. Most preferred are those materials having the lowest coefficients of linear thermal expansion, which provide the greatest production uniformity. Certain modifications (not shown) to the disclosed apparatus will be apparent to those skilled in the art.
  • fluid stream duct 20 could have a configuration other than the flared cylindrical cross'-section shown in the drawings, and can be provided with one or more directional changes along its length to further reduce the velocity of aerosol particles.
  • the volume of gases being drawn through the duct be in an expansion mode as it reaches the patient, to further reduce the velocity of the medication dose and minimize aerosol particle impaction upon the wall surfaces of the duct.
  • Spherical segment 30 can be replaced by a surface having another shape, or can have a vertical essentially flat configuration.
  • fluid conduit 22 can have any geometric shape and can be augmented by one or more additional conduits (frequently smaller in cross-section) receiving air from open areas and spaced around spherical segment 30 to generate a more laminar flow of air.
  • supplemental conduits are angularly displaced 120° to either side of fluid conduit 22, as viewed through the open end of fluid stream duct 20; in another embodiment, -1.0- supplemental conduits are displaced 90° to either side of fluid conduit 22. Additional energy can be absorbed from the dispensed aerosol by providing one or more grooves on the upper surface of the projection 26.
  • the oblique segment 36 can have an angle from the vertical greater than, or less than, 45°.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nozzles (AREA)

Abstract

Appareil distribuant un médicament provenant d'un récipient aérosol, l'appareil présentant une admission (24) destinée à recevoir un fluide sous pression ainsi qu'un prolongement de l'admission formant une chambre réceptrice (28). Une partie de paroi de la chambre réceptrice constitue un prolongement d'une paroi d'admission, une autre partie de paroi étant reliée à une paroi d'admission par un segment oblique (36), de manière que la chambre réceptrice présente une largeur de section transversale plus petite que celle de l'admission, et une ligne centrale déplacée par rapport à cette dernière. Ladite chambre réceptrice contient une partie saillante (26) en forme de tige s'étendant vers le haut le long de la ligne centrale de la chambre, ainsi qu'un conduit (32) destiné à transmettre du fluide sous pression de la chambre réceptrice à un conduit (20) de courant de fluide.
PCT/US1992/007903 1991-09-26 1992-09-24 Inhalateur pour medicaments en aerosol Ceased WO1993005837A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP92920197A EP0610240A1 (fr) 1991-09-26 1992-09-24 Inhalateur pour medicaments en aerosol
JP5506245A JPH0822314B2 (ja) 1991-09-26 1992-09-24 エアロゾル薬物用の吸入器
CA002119887A CA2119887A1 (fr) 1991-09-26 1992-09-24 Inhalateur pour medicaments en aerosol

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76660191A 1991-09-26 1991-09-26
US766,601 1991-09-26

Publications (1)

Publication Number Publication Date
WO1993005837A1 true WO1993005837A1 (fr) 1993-04-01

Family

ID=25076934

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1992/007903 Ceased WO1993005837A1 (fr) 1991-09-26 1992-09-24 Inhalateur pour medicaments en aerosol

Country Status (5)

Country Link
EP (2) EP0534749A1 (fr)
JP (1) JPH0822314B2 (fr)
AU (1) AU2595892A (fr)
CA (1) CA2119887A1 (fr)
WO (1) WO1993005837A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000050112A1 (fr) 1999-02-26 2000-08-31 3M Innovative Properties Company Inhalateur doseur a pulverisation lente
WO2017167737A1 (fr) 2016-03-31 2017-10-05 Chiesi Farmaceutici S.P.A. Dispositif d'inhalation d'aérosol

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2844254B1 (fr) 2002-09-10 2006-02-10 Valois Sa Valve de distribution de produit fluide et dispositif de distribution de produit fluide comportant une telle valve
GB2544477A (en) * 2015-11-16 2017-05-24 3M Innovative Properties Co Improvements in or relating to medical actuators

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3980074A (en) * 1973-07-18 1976-09-14 Beecham Group Limited Device for the administration of powders
GB2104393A (en) * 1981-08-13 1983-03-09 Glaxo Group Ltd Medical Inhalation Devices
EP0089070A2 (fr) * 1982-02-23 1983-09-21 FISONS plc Dispositif d'inhalation d'aérosols
US4739754A (en) * 1986-05-06 1988-04-26 Shaner William T Suction resistant inhalator
EP0387222A1 (fr) * 1989-03-07 1990-09-12 Aktiebolaget Draco Dispositif inhalateur

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3114248U (ja) 2005-06-30 2005-09-29 株式会社レイメイ藤井 シュレッダー

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3980074A (en) * 1973-07-18 1976-09-14 Beecham Group Limited Device for the administration of powders
GB2104393A (en) * 1981-08-13 1983-03-09 Glaxo Group Ltd Medical Inhalation Devices
EP0089070A2 (fr) * 1982-02-23 1983-09-21 FISONS plc Dispositif d'inhalation d'aérosols
US4739754A (en) * 1986-05-06 1988-04-26 Shaner William T Suction resistant inhalator
EP0387222A1 (fr) * 1989-03-07 1990-09-12 Aktiebolaget Draco Dispositif inhalateur

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000050112A1 (fr) 1999-02-26 2000-08-31 3M Innovative Properties Company Inhalateur doseur a pulverisation lente
US6615826B1 (en) 1999-02-26 2003-09-09 3M Innovative Properties Company Slow spray metered dose inhaler
WO2017167737A1 (fr) 2016-03-31 2017-10-05 Chiesi Farmaceutici S.P.A. Dispositif d'inhalation d'aérosol

Also Published As

Publication number Publication date
AU2595892A (en) 1993-04-27
EP0534749A1 (fr) 1993-03-31
EP0610240A1 (fr) 1994-08-17
JPH06506621A (ja) 1994-07-28
JPH0822314B2 (ja) 1996-03-06
CA2119887A1 (fr) 1993-04-01

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