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WO1993002654A3 - A method of inducing hemoglobin synthesis in red blood cells and uses therefor - Google Patents

A method of inducing hemoglobin synthesis in red blood cells and uses therefor Download PDF

Info

Publication number
WO1993002654A3
WO1993002654A3 PCT/US1992/006685 US9206685W WO9302654A3 WO 1993002654 A3 WO1993002654 A3 WO 1993002654A3 US 9206685 W US9206685 W US 9206685W WO 9302654 A3 WO9302654 A3 WO 9302654A3
Authority
WO
WIPO (PCT)
Prior art keywords
red blood
blood cells
uses therefor
inducing
hemoglobin synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1992/006685
Other languages
French (fr)
Other versions
WO1993002654A2 (en
Inventor
Arthur J Sytkowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beth Israel Deaconess Medical Center Inc
Original Assignee
Beth Israel Deaconess Medical Center Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beth Israel Deaconess Medical Center Inc filed Critical Beth Israel Deaconess Medical Center Inc
Publication of WO1993002654A2 publication Critical patent/WO1993002654A2/en
Publication of WO1993002654A3 publication Critical patent/WO1993002654A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Methods of inducing hemoglobin synthesis in red blood cell precursor cells are disclosed. Also disclosed are red blood cells with increased hemoglobin content made by the methods and their use in treating conditions of decreased oxygen-carrying capacity of the blood or any disorder or condition, which requires an increased supply of hemoglobin in a vertebrate.
PCT/US1992/006685 1991-08-09 1992-08-10 A method of inducing hemoglobin synthesis in red blood cells and uses therefor Ceased WO1993002654A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74286791A 1991-08-09 1991-08-09
US742,867 1991-08-09

Publications (2)

Publication Number Publication Date
WO1993002654A2 WO1993002654A2 (en) 1993-02-18
WO1993002654A3 true WO1993002654A3 (en) 1993-03-18

Family

ID=24986569

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1992/006685 Ceased WO1993002654A2 (en) 1991-08-09 1992-08-10 A method of inducing hemoglobin synthesis in red blood cells and uses therefor

Country Status (2)

Country Link
AU (1) AU2449092A (en)
WO (1) WO1993002654A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5646042A (en) * 1992-08-26 1997-07-08 Ribozyme Pharmaceuticals, Inc. C-myb targeted ribozymes
US5658780A (en) 1992-12-07 1997-08-19 Ribozyme Pharmaceuticals, Inc. Rel a targeted ribozymes
US5985554A (en) * 1994-11-02 1999-11-16 Takeda Chemical Industries, Ltd. Method of probing the function of proteins or peptides encoded by partially sequenced cDNAs by inhibiting protein synthesis with antisense oligonucleotides
FR2737554B1 (en) * 1995-08-03 1997-08-29 Commissariat Energie Atomique ROTATING FUSION OVEN
DE10112360A1 (en) * 2001-03-08 2002-09-12 Max Delbrueck Centrum Transformed blood cells and their use in drug screening

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0298450A2 (en) * 1987-07-07 1989-01-11 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Hybridoma cell lines, monoclonal antibodies and their use for immunocytochemical detection or fluorescence-activated sorting of cells expressing the c-myb protein and pharmaceutical compositions
WO1990005445A1 (en) * 1988-11-07 1990-05-31 Temple University Of The Commonwealth System Of Higher Education Antisense oligonucleotides to c-myb proto-oncogene and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0298450A2 (en) * 1987-07-07 1989-01-11 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Hybridoma cell lines, monoclonal antibodies and their use for immunocytochemical detection or fluorescence-activated sorting of cells expressing the c-myb protein and pharmaceutical compositions
WO1990005445A1 (en) * 1988-11-07 1990-05-31 Temple University Of The Commonwealth System Of Higher Education Antisense oligonucleotides to c-myb proto-oncogene and uses thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BLOOD vol. 78, no. 4, 15 August 1991, SAUNDERS, NEW YORK, US; pages 991 - 995 Y. CHERN ET AL. 'Induction of hemoglobin synthesis by downregulation of MYB protein with an antisense oligonucleotide' *
CLINICAL RESEARCH vol. 38, no. 2, April 1990, THOROFARE, N.J.,US; page 289A Y. CHERN ET AL. 'A c-myb antisense oligonucleotide induces erythropoiesis in-vitro in the absence of erythropoietin' *
Meeting of the association of american physicians, The american society for clinical investigation, and the american federation for clinical research, Washington, D.C., USA May 4-7,1990 abstract *
PROC. NATL ACAD. SCI. vol. 86, no. 9, May 1989, NATL. ACAD SCI., WASHINGTON, DC.,US; pages 3379 - 3383 G. ANFOSSI ET AL. 'An oligomer complementary to c-myb-encoded mRNA inhibits proliferation of human myeloid leukemia cell lines' cited in the application *
PROC. NATL. ACAD SCI. vol. 85, no. 23, December 1988, NATL. ACAD SCI., WASHINGTON, DC, US; pages 8900 - 8904 K. TODOKORO ET AL. 'Down-regulation of c-myb gene expression is a prequisite for erythropoietin-induced erythroid differentiation' *

Also Published As

Publication number Publication date
AU2449092A (en) 1993-03-02
WO1993002654A2 (en) 1993-02-18

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