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WO1992017200A3 - Formulations stables a base d'ion metal et d'hormone de croissance - Google Patents

Formulations stables a base d'ion metal et d'hormone de croissance Download PDF

Info

Publication number
WO1992017200A3
WO1992017200A3 PCT/US1992/002365 US9202365W WO9217200A3 WO 1992017200 A3 WO1992017200 A3 WO 1992017200A3 US 9202365 W US9202365 W US 9202365W WO 9217200 A3 WO9217200 A3 WO 9217200A3
Authority
WO
WIPO (PCT)
Prior art keywords
metal ion
growth hormone
stable growth
hgh
formulations
Prior art date
Application number
PCT/US1992/002365
Other languages
English (en)
Other versions
WO1992017200A2 (fr
Inventor
Brian C Cunningham
Michael G Mulkerrin
James A Wells
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of WO1992017200A2 publication Critical patent/WO1992017200A2/fr
Publication of WO1992017200A3 publication Critical patent/WO1992017200A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Cette invention concerne des complexes stables d'hormone de croissance humaine (hGH) et d'ion métal bivalent permettant d'obtenir des formulations stabilisées de hGH par formation de dimères ion métal-hGH. Les dimères stables sont caractérisés et les formulations thérapeutiques de zinc et hGH sont également décrites.
PCT/US1992/002365 1991-03-28 1992-03-25 Formulations stables a base d'ion metal et d'hormone de croissance WO1992017200A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67664591A 1991-03-28 1991-03-28
US676,645 1991-03-28

Publications (2)

Publication Number Publication Date
WO1992017200A2 WO1992017200A2 (fr) 1992-10-15
WO1992017200A3 true WO1992017200A3 (fr) 1992-12-23

Family

ID=24715358

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1992/002365 WO1992017200A2 (fr) 1991-03-28 1992-03-25 Formulations stables a base d'ion metal et d'hormone de croissance

Country Status (2)

Country Link
AU (1) AU1757092A (fr)
WO (1) WO1992017200A2 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763394A (en) * 1988-04-15 1998-06-09 Genentech, Inc. Human growth hormone aqueous formulation
US5981485A (en) * 1997-07-14 1999-11-09 Genentech, Inc. Human growth hormone aqueous formulation
US6022858A (en) * 1991-12-20 2000-02-08 Novo Nordisk A/S Pharmaceutical formulation of human-growth hormone pretreated with zinc salt
SE9201073D0 (sv) * 1992-04-03 1992-04-03 Kabi Pharmacia Ab Protein formulation
US6087324A (en) * 1993-06-24 2000-07-11 Takeda Chemical Industries, Ltd. Sustained-release preparation
ZA965368B (en) * 1995-07-14 1997-01-14 Novo Nordisk As A pharmaceutical formulation
US6197350B1 (en) 1996-12-20 2001-03-06 Takeda Chemical Industries, Ltd. Method of producing a sustained-release preparation
ZA9711731B (en) * 1996-12-31 1998-07-01 Monsanto Co Aqueous glycerol formulations of somatotropin
US6191107B1 (en) * 1997-09-26 2001-02-20 Takeda Chemical Industries, Ltd. Complex of human growth hormone and zinc
CA2308317A1 (fr) * 1997-10-31 1999-05-14 Smithkline Beecham Corporation Nouveaux complexes metalliques
CA2308135A1 (fr) * 1997-10-31 1999-05-14 John G. Gleason Nouveaux complexes metalliques
CN100526463C (zh) 1999-06-28 2009-08-12 杰南技术公司 利用二价金属离子制备Apo-2配体的方法
AU2001259111B2 (en) 2000-04-19 2005-12-08 Durect Corporation Sustained release formulations comprising growth hormone
MXPA03001092A (es) 2000-08-07 2003-09-25 Nektar Therapeutics Al Corp Polvos de proteina de haz de 4 helices secados por rocio, inhalables, que tienen agregacion minimizada.
JP4724354B2 (ja) 2001-02-23 2011-07-13 ジェネンテック， インコーポレイテッド 注射用の崩壊性ポリマー
ES2554106T3 (es) 2001-06-21 2015-12-16 Genentech, Inc. Formulación de liberación sostenida
US20040186051A1 (en) 2001-10-02 2004-09-23 Kelley Robert F Apo-2 ligand variants and uses thereof
AU2003247609A1 (en) 2002-06-24 2004-01-06 Genentech, Inc. Apo-2 ligand/trail variants and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB885798A (en) * 1958-12-06 1961-12-28 Organon Labor Ltd Preparations of the growth hormone
EP0216485A1 (fr) * 1985-08-12 1987-04-01 International Minerals And Chemical Corporation Libération prolongée d'hormones stimulantes de croissance
WO1989009614A1 (fr) * 1988-04-15 1989-10-19 Genentech, Inc. Formulation d'hormones de croissance humaine
EP0343696A2 (fr) * 1984-10-04 1989-11-29 Monsanto Company Zinc-somatotropines

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB885798A (en) * 1958-12-06 1961-12-28 Organon Labor Ltd Preparations of the growth hormone
EP0343696A2 (fr) * 1984-10-04 1989-11-29 Monsanto Company Zinc-somatotropines
EP0216485A1 (fr) * 1985-08-12 1987-04-01 International Minerals And Chemical Corporation Libération prolongée d'hormones stimulantes de croissance
WO1989009614A1 (fr) * 1988-04-15 1989-10-19 Genentech, Inc. Formulation d'hormones de croissance humaine

Also Published As

Publication number Publication date
WO1992017200A2 (fr) 1992-10-15
AU1757092A (en) 1992-11-02

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