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WO1992010147A1 - Fil dentaire contenant de la nicotine - Google Patents

Fil dentaire contenant de la nicotine Download PDF

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Publication number
WO1992010147A1
WO1992010147A1 PCT/US1991/009363 US9109363W WO9210147A1 WO 1992010147 A1 WO1992010147 A1 WO 1992010147A1 US 9109363 W US9109363 W US 9109363W WO 9210147 A1 WO9210147 A1 WO 9210147A1
Authority
WO
WIPO (PCT)
Prior art keywords
nicotine
oral hygiene
hygiene composition
dental floss
fluoride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1991/009363
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English (en)
Inventor
Steven J. Mondre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/627,657 external-priority patent/US5035252A/en
Application filed by Individual filed Critical Individual
Publication of WO1992010147A1 publication Critical patent/WO1992010147A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F47/00—Smokers' requisites not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C15/00—Devices for cleaning between the teeth
    • A61C15/04—Dental floss; Floss holders
    • A61C15/041—Dental floss
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention relates to dental floss, oral hygiene compositions and an applicator therefor. More particularly, the present invention relates to dental floss treated with a source of nicotine and, preferably, to nicotine-containing dental floss. The present invention also relates to oral hygiene compositions containing a source of nicotine and an applicator therefor. More particularly, the present invention relates to a novel dental floss combination, a novel oral hygiene composition and applicator therefor, and related methods for alleviating the urge to smoke tobacco while at the same time providing for the beneficial periodontal and oral hygiene effects resulting from frequent dental flossing, brushing, rinsing and/or gum massaging.
  • tars are the causative agents in cigarette smoke most implicated in the induction of cancers such as lung, larynx, oral cavity, esophageal, bladder, kidney, pancreatic, stomach and uterine and cervical cancers.
  • Tars are also considered responsible for the induction of the hepatic microsomal enzyme systems which result in more rapid deactivation of a variety of drugs such as benzodiazepines as well as anti-depressants and analgesics. Tars are also responsible for the production of broncho-pulmonary diseases, including pulmonary emphysema, chronic bronchitis, and smoker's respiratory syndrome.
  • Carbon monoxide a deadly gas
  • Carbon monoxide is an important health hazard even in minute quantities because it combines with the hemoglobin in the blood so that the hemoglobin can no longer carry sufficient oxygen to fully supply the tissues.
  • the stimulant effect of the nicotine in the smoke causes an increase in cardiac workload and oxygen demand, whereas the carbon monoxide effectly blocks the ability of the heart muscle to capture the needed oxygen.
  • carbon monoxide and nicotine work together in a synergistically negative manner in a way which often results in muscular hypoxia or anoxia, and can ultimately result in cardiac damage.
  • carbon monoxide has also been implicated as a causative agent in the development of such disorders as coronary artery disease " and atherosclerosis.
  • Nicotine appears to be the most pharmacologically active substance in tobacco smoke, yet it appears to be not as significant from a health standpoint as the tars and carbon monoxide. However, nicotine is very important from another standpoint, i.e. it is the reinforcing substance in tobacco smoke which initiates and maintains the addiction. In this respect, a theme commonly heard among workers in the field of smoking research is: "People would be disinclined to smoke cigarettes if an alternate route of nicotine delivery could be devised.” -3-
  • the nicotine gum referred to above has produced mouth ulcers in a number of individuals resulting in its rejection.
  • the nicotine gum produces some gastric absorption with the resultant first pass through the liver and consequent rapid loss of activity.
  • people with artificial teeth have difficulty with gum in general; this is important as many people who experience the medical problems associated with years of smoking also tend to have generally poor dental hygiene and/or dental quality, and may also have artificial teeth.
  • Nicotine itself has been subjected to considerable study. Nicotine is a liquid alkaloid which is colorless, volatile and strongly alkaline. On exposure to air it turns brown. It is known to be very lipid soluble. The Merck Index, 9th Edition, 1976, page 847, indicates that nicotine base is readily absorbed through mucous membrane and intact skin, but the salts are not. On the other hand, nicotine has no known therapeutic application (The Pharmacological Basis of Therapeutics, fifth edition, Goodman and Gilman, 1970, page 588) and has been primarily used in research as an experimental tool for investigating neural function.
  • a nicotine-containing lozenge be compounded with lactose (or a lactose-containing substance), a known antidote to nicotine poisoning and the unpleasant nausea and discomforts associated with nicotine ingestion, such as described in published European Patent Application No. 0 251 642.
  • lozenges and/or chewing gums have a tendency to promote dental decay in the nature of dental caries, particularly in the interproximal surfaces of the teeth.
  • Flossing of the teeth is known in the art to help remove plaque from the tooth surface. Further, it is known in the art to apply dentrifice medicaments to dental floss. For example. Lynch, United States Patent Nos. 4,632,937 and
  • 4,627,975 discloses coating dental floss with a solution of a dentrifice formulation containing monoalkyl and dialkyl ethers of dianhydrohexitols, which is said to be effective in the treatment of oral surfaces and cavities to reduce irritation and plaque accumulation caused by the action of bacteria.
  • Newman et al.. United States Patent No. 4,548,219 disclose a fluoride-coated dental floss which has bactericidal activity; and Tarrson et al., United States Patent No. 4,162,688, disclose fluoride medicated dental floss and a dispenser for the wet application of fluoride to floss.
  • Hofmann et al. United States Patent No. 3,992,519, describe an oral hygiene composition in toothpaste, mouthwash or chewing gum form comprising an antibacterial component, a vitamin component and a surfactant component.
  • a nicotine-containing oral hygiene composition there is provided a novel composition which produces both a beneficial periodontal effect and aids in alleviating an individual's urge to engage in tobacco smoking.
  • toothbrushes having storage chambers for " the retention of and, ultimately, for the application of, cleansing agents to the tooth surface.
  • Muglia United States Patent No. 3,592,551 discloses an aerosol charged toothbrush.
  • Other disclosures of toothbrushes having storage chambers include, inter alia, Eguchi, United States Patent No. 4,963,046; Dahl et al.. United States Patent No. 3,879,139; Broughton, United States Patent No. 3,937,235; Meyer et al.. United States Patent No. 4,068,974; Rodriguez, United States Patent No. 4,332,497; and Green, United States Patent No. 4,522,524.
  • a novel article of manufacture 10 which can be employed to apply a nicotine-containing oral hygiene composition to the gum surface which produces both a beneficial periodontal effect and aids in alleviating an individual's urge to engage in tobacco smoking.
  • the term "bristleless” refers to a head of the claimed 15 toothbrush which is substantially free of bristles which are perpendicular, or substantially perpendicular, to the neck and/or handle of the toothbrush, and which have an aspect ratio (length to diameter) of greater than about 12.5.
  • a typical toothbrush contains bristles ranging from 20 about .25 in. to about .50 in. in length and the bristles each have a diameter of about 0.02 in. giving an aspect ratio of about 12.5 to about 25.
  • the Butler 411 toothbrush has 42 bundles of 35 bristles, each bristle being .016 inches in diameter and 0.5 inches long giving an aspect 25 ratio of 31.5.
  • these and other objects of the invention are broadly achieved by providing a source of nicotine, i.e., nicotine, a nicotine derivative and/or a nicotine-containing compound, to a monofilament dental floss, multifilament dental floss or the like, whereby the source of nicotine is applied to the oral cavity, preferably to the periodontal areas, and permitted to enter the body.
  • a source of nicotine i.e., nicotine, a nicotine derivative and/or a nicotine-containing compound
  • the objects of the invention are broadly achieved by providing an oral hygiene composition containing a source of nicotine, i.e., nicotine, a nicotine derivative and/or a nicotine- containing compound, such as a toothpaste, a tooth gel, a tooth powder, a mouthwash or the like, whereby the source of nicotine is applied to the oral cavity, preferably the periodontal areas, and permitted to enter the body.
  • a source of nicotine i.e., nicotine, a nicotine derivative and/or a nicotine- containing compound, such as a toothpaste, a tooth gel, a tooth powder, a mouthwash or the like
  • the objects of the invention are broadly achieved by providing a nicotine-delivery system comprised of a nicotine-containing oral hygiene composition in combination with or through the ' use of an applicator.
  • a nicotine-delivery system comprised of a nicotine-containing oral hygiene composition in combination with or through the ' use of an applicator.
  • the nicotine being highly lipid soluble, is absorbed directly and rapidly through the oral tissues thereby satisfying the nicotine habit while minimizing or eliminating side effects which would otherwise be caused when absorbing nicotine through the lungs along with products of combustion, or through the digestive tract.
  • Such a delivery system can assist a person to quit smoking, and at the same time help to counter any possible deleterious dental effects, particularly deleterious periodontal effects, which often accompany long- term oral use of tobacco products.
  • a nicotine-containing dental floss, nicotine- containing oral hygiene composition may be used to supply the smoker with an alternate source of nicotine, for example, in the dose range of from 15 to 25 nanograms per liter of blood, so that the need for cigarettes is reduced or eliminated.
  • an alternate source of nicotine for example, in the dose range of from 15 to 25 nanograms per liter of blood, so that the need for cigarettes is reduced or eliminated.
  • an interspersing regimen can be adopted wherein the nicotine-containing dental floss, oral hygiene composition and/or nicotine-delivering applicator according to the invention may be alternated with cigarettes to slowly extinguish the reinforcing properties of the non- pharmacological factors, and also reduce the severity of the initial termination of smoking as well as the incidence of relapse. As the non-pharmacological factors become reduced in importance, it then becomes easier to treat the nicotine addiction.
  • Nicotine absorbed through oral cavity, and particularly through the periodontal tissues, is not transported first through the liver where 80-90 percent of nicotine deactivation occurs, but goes directly and rapidly into systemic circulation with rapid rises in nicotine blood level. Thus, the nicotine habit can be satisfied while subjecting the body to far lesser quantities of nicotine.
  • blood levels of nicotine can be easily adjusted to acceptable " and effective dosages for the suppression of craving by varying the amount and duration of nicotine delivery. This is difficult if not possible to accomplish with nicotine gums, or nicotine lozenges, because the person's rate of chewing is a major factor which manipulates dosage.
  • the instant invention will provide a means for those, unable or unwilling to quit smoking, to ingest nicotine without subjecting themselves and their environment to smoking with its attendant dangers of carbon monoxide and tars.
  • "second hand" smoke is recognized as a significant health hazard in our society, and may cost the economy hundreds of millions of dollars a year in lost productivity, medical costs and related expenses.
  • Use of the present invention would also allow ingestion of nicotine in places where smoking is prohibited, to avoid the consequences of performance decrements resulting from acute withdrawals.
  • the use of nicotine-containing dental floss or oral hygiene composition would at least eliminate carbon monoxide, thereby avoiding the deleterious effects of smoking on the fetus due to the blocking effects of carbon monoxide on oxygen absorption.
  • FIG. 1 depicts a gingiva-massaging device useful in the practice of the present invention.
  • dental floss which is treated with, or an oral hygiene composition which contains a source of nicotine, e.g., nicotine (or 3-(l-methyl-2-pyrrolidinyl)pyridine) , a pharmacologically active derivative thereof, .or a nicotine or nicotine derivative-containing compound, alone or in combination with a pharmaceutically acceptable carrier, which is useful in the alleviation of an individual's urge to smoke tobacco and in the prophylaxis of periodontal disease.
  • a source of nicotine e.g., nicotine (or 3-(l-methyl-2-pyrrolidinyl)pyridine)
  • a pharmacologically active derivative thereof e.g., a nicotine or nicotine derivative-containing compound
  • the treatment method provide a substantially uniform dispersal of a source of nicotine, such as nicotine, nicotine derivative, or nicotine- or nicotine derivative-containing compound on the surface of, or impregnated into, the dental floss.
  • the dental floss can be of varying configuration, including mono-filament and multi-filament design, according to end use. In this manner, it is believed, although the inventor does not wish to be bound by any particular theory, that while flossing the nicotine dispersed on the surface, or into the body, of the dental floss, is released into the mouth of the individual and subsequently is rapidly absorbed through the gums and into the bloodstream, thereby providing quick relief from the urge to smoke.
  • Dosage and duration of nicotine administration according to the present invention can be controlled in several ways separately and/or in combination.
  • a carrier can be mixed with the nicotine which will either speed or slow its passage through the oral tissues and into the bloodstream.
  • the thickness of the dental floss diameter of a monofilament dental floss, or the number of strands and/or thickness of the strands of multifilament dental floss can be varied to either increase or decrease the amount of nicotine available to be transferred from the dental floss to the oral tissues.
  • the concentration of nicotine in the dental floss can be either decreased or increased in order to reduce or increase the duration or effect of treatment or the amount of dosing.
  • the nicotine base can be carried by a suitable solvent such as propylene glycol, glycerin, mineral oil, polyethylene glycol, DMSO or alcohol. It may also be mixed with water in which the alkaloid is readily soluble, thereby forming a water soluble salt; such a salt, however, is less lipid soluble and penetrates the oral tissues more slowly than the alkaloid base.
  • a suitable solvent such as propylene glycol, glycerin, mineral oil, polyethylene glycol, DMSO or alcohol. It may also be mixed with water in which the alkaloid is readily soluble, thereby forming a water soluble salt; such a salt, however, is less lipid soluble and penetrates the oral tissues more slowly than the alkaloid base.
  • the nicotine may be diluted to reduce dangers of misuse; for example, the nicotine may be mixed with an oil such as indicated above.
  • Other types of fillers may be utilized as well; for example, the nicotine may be retained in a gelatinous base.
  • the dose and duration of nicotine administration are precisely controllable.
  • the total dosage and delivery rate can easily be adjusted to suit the needs of the particular patient, i.e. a different dose of nicotine will be desirable to reduce the craving of a one pack-a-day smoker versus a three pack-a-day smoker. According to the present invention, it is possible to mimic smoking in terms of the amount of nicotine delivered, thereby reducing or eliminating dependence on any form of tobacco.
  • the source of nicotine e.g., nicotine, nicotine derivative or nicotine- containing compound, such as nicotine oil, available commercially
  • nicotine may be used alone, or is dissolved in an orally acceptable carrier to form a nicotine-containing mixture.
  • the mixture is stirred to substantially uniformly disperse the nicotine, nicotine derivative or nicotine-containing compound throughout the mixture.
  • Preferred orally acceptable carriers are selected from the group comprising water, alcohols such as ethanol, propylene glycol, waxes such as polyethylene glycol (sold under the trademark "CARBOWAX" by Challenge Products of Osage Beach, Mo.), glycerol, and sugar solutions.
  • Suitable fluoride compositions are alkali or alkaline earth metal fluorides such as sodium fluoride, sodium monofluorophosphate, ammonium fluoride, n- alkyl-3-pyridinium methanol fluoride as described in United States Patent No. 4,098,879; and stannous fluoride as described in United States Patent No. 4,548,219.
  • To the mixture may also be added dyes and flavorings such as cherry or orange flavor and oil of wintergreen and the like.
  • additives such as medicaments, astringents, detergents, polishing agents, sweeteners, gelling agents, thickeners, pigments and other antibacterial agents, such as those known to persons skilled in the art may be added to the nicotine-mixture in amounts sufficient to impart their particular characteristic.
  • the string of floss waxed or unwaxed, as commercially available, such as from John 0. Butler Company of Chicago, IL is allowed to come into contact with the mixture containing the source of nicotine, such as by soaking or drawing the string through the solution using an apparatus designed for that purpose.
  • the mixture containing the source of nicotine can be used as soaked or drawn, or is allowed to air dry and solidify in, or on the surface of, the floss.
  • the preferred treated floss has a coating comprising from about 0.1 to about 0.8 mg of nicotine per inch of dental floss.
  • oral hygiene compositions are contemplated by the present invention. Preferred are toothpastes, tooth gels, toothpowders and mouthwashes. It is only necessary that the oral hygiene composition contains an effective amount of nicotine to satisfy the user's craving for nicotine. Dosage of nicotine administration may be controlled as described hereinabove with respect to dental floss.
  • the liquid vehicle is preferably one in which nicotine is readily soluble.
  • Suitable for this purpose include aqueous ethanol, aqueous isopropanol, aqueous n-propanol, aqueous sorbitol, aqueous glycerol, aqueous 1,2-propyleneglycol, aqueous 1,4-butanediol and mixtures of any of the foregoing.
  • the liquid vehicle may further comprise flavoring agents, sweeteners, dyestuffs, thickeners, antioxidants, mixtures of any of the foregoing and the like. It is further contemplated that an orally acceptable antibacterial agent be included. These are well known to those skilled in the art and may comprise esters of p-hydroxybenzoic acid and/or o-hydroxybenzoic and such pharmaceutically acceptable as menthyl salicylate or phenyl salicylate.
  • Typical flavoring agents include peppermint oil, spearmint oil, wintergreen oil, aniseed oil, clove oil. eucalyptus oil, cinnamon oil, geranium oil, coriander oil, menthol, anisol, a ⁇ ethole and mixtures of any of the foregoing.
  • Preferred sweeteners are sodium saccharine, and sodium cyclamate and "NUTRASWEET".
  • the oral hygiene composition may include pharmaceutically effective amounts of anticariogenic fluoride components such as those known to those skilled in the art including alkali or alkaline earth metal (e.g. sodium or stannous) and ammonium fluorides and flourophosphates and n-alkyl-3-pyridinium methanol fluoride. Especially preferred are sodium monofluorophosphate and stannous fluoride.
  • any pharmaceutically suitable paste, gel or powder carrier may be employed. These are well known to those skilled in the art. It is only necessary that the carrier contain an effective amount of a source of nicotine to satisfy the user's craving for nicotine.
  • the carrier also contains a cleansing agent such as a dentrifice which normally takes the form of a liquid, paste or powder.
  • a cleansing agent such as a dentrifice which normally takes the form of a liquid, paste or powder.
  • a mild abrasive and various pharmaceutical ingredients conducive to cleaning teeth as well as flavoring agents, sweeteners, dyestuffs, thickeners, antioxidants, mixtures of any of the foregoing and the like. These are described more fully hereinabove.
  • the present invention is further directed to a nicotine-delivering gingiva massaging article of manufacture.
  • the device allows a nicotine-containing treatment fluid to come into contact with the gums.
  • the device is a hand held unit having a handle, preferably with a reservoir contained therein, in communication with a neck, which is preferably hollow. Integral with the neck is a bristleless head of the device, as heretofore described, which may be in the form of a gingiva massaging pad attached to the surface of the head.
  • the device also preferably further contains a check valve to prevent fluid in the mouth from entering through the head and into the neck. Applying pressure by a pressure applying means to the reservoir expels the nicotine-containing treatment fluid from the reservoir through the neck, into the bristleless head, and into contact with the gums.
  • the device is provided in "single dose" configuration, i.e., in the nature of a disposable device which contains sufficient treatment solution to effect or mimic the dose of nicotine provided by a single cigarette, or in the nature of a non- disposable device in which the reservoir is refillable but can only contain an amount of treatment solution to effect or mimic the dose of nicotine provided by a single cigarette.
  • the nicotine-delivering gingiva massaging device 2 comprises a handle section 4, a neck section 6 and a head section 8.
  • the handle section 4 has contained therein a reservoir 12 adapted for containing a nicotine-treatment fluid.
  • the sidewalls 10 of the reservoir 12 comprise a flexible resilient material. The user may squeeze the sidewalls 10 causing the reservoir 12 to contract to a contracted state of lesser volume, thereby forcing the nicotine-containing treatment fluid to be forced out of the reservoir 12 and eventually into gingiva massaging pad 20 as described more fully hereinbelow. When released, the resiliency of the sidewalls 10 returns them to their natural state, as shown in FIG. 1.
  • a check valve 22 is located covering a vent hole 24 that extends through the sidewall 10 near the top.
  • the vent hole 24 allows air to flow into reservoir 12 when it is expanded back to its natural state.
  • the check valve 22 prevents air or fluid from passing through the vent hole 24 when reservoir 12 is squeezed.
  • the check valve 22 may be of various types known to those skilled in the art, and is shown in FIG. 1 as a flexible flap.
  • the handle section 4 also comprises a solid portion
  • the neck 6 is a rigid plastic member integrally attached to the handle 4 at the end opposite the solid handle portion 14.
  • the neck has a narrow channel 16 contained therein in direct communication with reservoir 12.
  • the neck 6 generally has a tapering cross-section which ends in the head 8. Further, a check valve 26 is located in the neck 6 at the base of the head 8.
  • the check valve 26 allows fluid to flow out from the neck channel 16 into the head 8, but prevents any flow in the reverse direction.
  • the check valve 26, similar to the check valve 22, is preferably a flexible flap.
  • the head 8 is a rigid plastic member integrally connected to the neck 6 and the channel 16 continues therethrough.
  • the channel 16 is in direct communication with a duct 18 which opens into an absorbent gingiva massaging pad 20.
  • the gingiva massaging pad 20 is generally comprised of a spongy porous material through which the nicotine-containing treatment fluid may pass, and which is suitable for gingiva massaging.
  • the pad may similarly be, inter alia, an interwoven pad of elastomeric, e.g., polypropylene fibers, or comprised of bristleless fibers, i.e. those which have an aspect ratio of less than about 10.
  • elastomeric e.g., polypropylene fibers
  • bristleless fibers i.e. those which have an aspect ratio of less than about 10.
  • the user detaches the solid portion 14 and fills the reservoir 12 with a "single dose" of nicotine-containing treatment fluid, and reattaches the solid portion 14.
  • the user places the gingiva- massaging pad 20 on the gums and gently massages the gums by moving the pad 20 back and forth while simultaneously applying pressure to the sidewalls 10. This expels treatment fluid out of the reservoir and into pad 20, whereby the treatment fluid comes into contact with the gums.
  • the user continues massaging the gums until the user's craving for nicotine has subsided or until the "single dose" is used up.
  • Check valve 22 prevents any treatment fluid from flowing out vent hole 24 when the sidewalls 10 are squeezed. Further check valve 22 allows air to be drawn into the reservoir 12 when squeezing pressure is released to allow the sidewalls 10 to return to their normal shape.
  • the check valve 26 prevents any suction created by the return of sidewalls 10 to their normal state from drawing any fluid back into the neck 6. This avoids contaminating or diluting any remaining fluid in the reservoir 12 with fluid from the mouth.
  • the check valve 22 also reduces suction at the entrance of the duct 18 by admitting air to the reservoir 12 when the sidewalls 10 return to their natural -state. If the reservoir 12 still contains treatment fluid after the user has treated the gums, the user may retain it in the reservoir 12 for later use.
  • the nicotine-containing treatment fluid may comprise any relatively low viscosity orally acceptable carrier solution containing a source of nicotine, such as nicotine, nicotine-containing compound or a nicotine-derivative.
  • Preferred fluid carriers are the mouthwash or the dental floss solution described hereinabove.
  • other treatment fluid delivery means can be employed, such as an aerosol charged delivery system. These are describe in the literature and are well-known to those skilled in the art.
  • the dental floss, oral hygiene composition or treatment fluid of the present invention preferably comprises sufficient nicotine so that one flossing, brushing, rinsing or application is substantially equivalent to the amount of nicotine released into the bloodstream by smoking a single cigarette.
  • one flossing, brushing, rinsing or application comprises the release of from about 0.5 to about 2.0 g nicotine, more preferably from about 0.7 to about 1.5 mg nicotine, and most preferably from about 1.0 to about 1.2 mg nicotine.
  • Marlboro 100's, for example, are reported to contain 1.2 mg nicotine average per cigarette.
  • the individual desirous of quitting smoking need only floss, brush, rinse or apply the treating solution in a normal manner with the nicotine-treated dental floss, nicotine containing oral hygiene composition or nicotine-containing treatment fluid of the present invention to alleviate the urge to smoke.
  • the individual will floss, rinse, brush or apply the treatment fluid once each in the morning and evening and at times where pangs to smoke occur during the day.
  • the individual will gradually reduce the number of daily flossing, brushings, rinses or gingiva applications until the cravings disappear.
  • the flossing, brushing, rinsing and gingiva applications have the beneficial effect of providing a prophylaxis of periodontal disease by aiding in the removal of plaque from the teeth and massaging of the gingiva.
  • the present invention surprisingly succeeds in turning a bad habit, tobacco smoking, into the good habits of flossing, brushing, rinsing and gingiva massaging, which are likely to continue even when the individual has no more smoking cravings.
  • the above-mentioned patents are hereby incorporated by reference.
  • any nicotine- containing compound may be employed.
  • the floss employed may be of any type, waxed or unwaxed. All such obvious modifications are within the full intended scope of the appended claims.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Dentistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Fil dentaire traité à la nicotine, composition d'hygiène orale et applicateur (2) à cet effet, utilisés pour soulager le besoin de fumer ressenti par les fumeurs. L'applicateur (2) comprend un manche (4) adapté pour contenir un fluide de traitement à la nicotine dans un réservoir (12), une tête (8) et une partie intermédiaire (6).
PCT/US1991/009363 1990-12-14 1991-12-13 Fil dentaire contenant de la nicotine Ceased WO1992010147A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/627,657 US5035252A (en) 1990-12-14 1990-12-14 Nicotine-containing dental floss
US627,657 1990-12-14
US67471091A 1991-03-25 1991-03-25
US674,710 1991-03-25

Publications (1)

Publication Number Publication Date
WO1992010147A1 true WO1992010147A1 (fr) 1992-06-25

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Application Number Title Priority Date Filing Date
PCT/US1991/009363 Ceased WO1992010147A1 (fr) 1990-12-14 1991-12-13 Fil dentaire contenant de la nicotine

Country Status (2)

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AU (1) AU9138891A (fr)
WO (1) WO1992010147A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5783207A (en) * 1985-05-01 1998-07-21 University Of Utah Research Foundation Selectively removable nicotine-containing dosage form for use in the transmucosal delivery of nicotine
US5824334A (en) * 1989-09-05 1998-10-20 University Of Utah Research Foundation Tobacco substitute
US6777194B1 (en) 1999-04-01 2004-08-17 Dakocytomation Denmark A/S Monoclonal antibodies against human protein Mcm3, process for their production, and their use
EP2700395A3 (fr) * 2012-06-29 2016-06-15 Henkel AG & Co. KGaA Produit de nettoyage et de soin activateur de lactoperoxydase pour la bouche et les dents
CN114158762A (zh) * 2020-09-10 2022-03-11 湖南中烟工业有限责任公司 一种发烟剂、发烟材料及其制备方法
RU2782018C1 (ru) * 2021-11-26 2022-10-21 Леонид Борисович Потёмкин Средство для бросающих курить
WO2023096535A1 (fr) * 2021-11-26 2023-06-01 Леонид Борисович ПОТЁМКИН Moyen pour personnes arrêtant de fumer

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US656479A (en) * 1900-03-14 1900-08-21 George W Schellenbach Toothpick.
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US5824334A (en) * 1989-09-05 1998-10-20 University Of Utah Research Foundation Tobacco substitute
US6777194B1 (en) 1999-04-01 2004-08-17 Dakocytomation Denmark A/S Monoclonal antibodies against human protein Mcm3, process for their production, and their use
EP2700395A3 (fr) * 2012-06-29 2016-06-15 Henkel AG & Co. KGaA Produit de nettoyage et de soin activateur de lactoperoxydase pour la bouche et les dents
CN114158762A (zh) * 2020-09-10 2022-03-11 湖南中烟工业有限责任公司 一种发烟剂、发烟材料及其制备方法
CN114158762B (zh) * 2020-09-10 2023-03-03 湖南中烟工业有限责任公司 一种发烟剂、发烟材料及其制备方法
RU2782018C1 (ru) * 2021-11-26 2022-10-21 Леонид Борисович Потёмкин Средство для бросающих курить
WO2023096535A1 (fr) * 2021-11-26 2023-06-01 Леонид Борисович ПОТЁМКИН Moyen pour personnes arrêtant de fumer

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