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WO1992007254A3 - Utilisation de substances a ponts bisulfures - Google Patents

Utilisation de substances a ponts bisulfures Download PDF

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Publication number
WO1992007254A3
WO1992007254A3 PCT/EP1991/001877 EP9101877W WO9207254A3 WO 1992007254 A3 WO1992007254 A3 WO 1992007254A3 EP 9101877 W EP9101877 W EP 9101877W WO 9207254 A3 WO9207254 A3 WO 9207254A3
Authority
WO
WIPO (PCT)
Prior art keywords
substances
bidged
disulphide
bridges
linked
Prior art date
Application number
PCT/EP1991/001877
Other languages
German (de)
English (en)
Other versions
WO1992007254A2 (fr
Inventor
Kurt Lang
Thomas Subkowski
Juergen Schweden
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of WO1992007254A2 publication Critical patent/WO1992007254A2/fr
Publication of WO1992007254A3 publication Critical patent/WO1992007254A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne l'utilisation de substances reliées au niveau intermoléculaire par des ponts S-S afin de produire des anticorps et l'utilisation de ces substances comme substances d'étalonnage lors de la détermination de poids moléculaires.
PCT/EP1991/001877 1990-10-10 1991-10-01 Utilisation de substances a ponts bisulfures WO1992007254A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4032127.4 1990-10-10
DE19904032127 DE4032127A1 (de) 1990-10-10 1990-10-10 Verwendung von disulfidverbrueckten proteinen und peptiden

Publications (2)

Publication Number Publication Date
WO1992007254A2 WO1992007254A2 (fr) 1992-04-30
WO1992007254A3 true WO1992007254A3 (fr) 1992-06-11

Family

ID=6415997

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1991/001877 WO1992007254A2 (fr) 1990-10-10 1991-10-01 Utilisation de substances a ponts bisulfures

Country Status (2)

Country Link
DE (1) DE4032127A1 (fr)
WO (1) WO1992007254A2 (fr)

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4507233A (en) * 1981-04-22 1985-03-26 Oriental Yeast Co., Ltd. Colored molecular weight marker
US4713366A (en) * 1985-12-04 1987-12-15 The Ohio State University Research Foundation Antigenic modification of polypeptides
JPH01233297A (ja) * 1988-03-15 1989-09-19 Dainippon Pharmaceut Co Ltd ペプチド、その抗体およびエンドセリンの定量
EP0380443A2 (fr) * 1989-01-25 1990-08-01 Ciba-Geigy Ag Anticorps monoclonaux spécifiques pour hirudin
EP0384144A1 (fr) * 1989-01-26 1990-08-29 Kowa Company, Ltd. Composition pharmaceutique contre les maladies provoquées par la vasoconstriction
JPH0315752A (ja) * 1989-06-13 1991-01-24 Dai Ichi Pure Chem Co Ltd 分子量マーカー
WO1991004045A1 (fr) * 1989-09-20 1991-04-04 Board Of Regents, The University Of Texas System Prophylaxie et therapie du syndrome d'immunodeficience acquise
EP0438332A1 (fr) * 1990-01-16 1991-07-24 Clonatec Peptides dérivant de la glycoprotéine d'enveloppe de virus HIV, leurs applications à la détection d'une infection due à ces virus et à la vaccination contre le SIDA

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4507233A (en) * 1981-04-22 1985-03-26 Oriental Yeast Co., Ltd. Colored molecular weight marker
US4713366A (en) * 1985-12-04 1987-12-15 The Ohio State University Research Foundation Antigenic modification of polypeptides
JPH01233297A (ja) * 1988-03-15 1989-09-19 Dainippon Pharmaceut Co Ltd ペプチド、その抗体およびエンドセリンの定量
EP0380443A2 (fr) * 1989-01-25 1990-08-01 Ciba-Geigy Ag Anticorps monoclonaux spécifiques pour hirudin
EP0384144A1 (fr) * 1989-01-26 1990-08-29 Kowa Company, Ltd. Composition pharmaceutique contre les maladies provoquées par la vasoconstriction
JPH0315752A (ja) * 1989-06-13 1991-01-24 Dai Ichi Pure Chem Co Ltd 分子量マーカー
WO1991004045A1 (fr) * 1989-09-20 1991-04-04 Board Of Regents, The University Of Texas System Prophylaxie et therapie du syndrome d'immunodeficience acquise
EP0438332A1 (fr) * 1990-01-16 1991-07-24 Clonatec Peptides dérivant de la glycoprotéine d'enveloppe de virus HIV, leurs applications à la détection d'une infection due à ces virus et à la vaccination contre le SIDA

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
Advances in veterinary Science and comparative medicine, Band. 33, 1989 F. Brown: "The Development of Chemically Synthesized Vaccines ", *
Chemical Abstracts, Band 112, no. 11, 12 März 1990, (Columbus, Ohio, US), siehe Seite 823, Zusammenfassung 99269k, & JP, A, 01233297 (Preparation of endothelin and its analogs for immunoassay of endothelin in body fluids) 19 September 1989 *
Chemical Abstracts, Band 114, no. 23, 10 Juni 1991, (Columbus, Ohio, US), siehe Seite 893, Zusammenfassung 229411e, & JP, A, 03015752 (Preparation of S-alkylated reduced form of proteins as molecular weight markers) 1991 *
Chemical Abstracts, Band 114, no. 5, 4 Februar 1991, (Columbus, Ohio, US), Goff, Dane A et al. : "Substituted 2-iminothiolanes: reagents for the preparation of disulfide cross-linked conjugates with increased stability ", siehe Seite 30, Zusammenfassung 35554h, & Bioconjugate chem. 1990, 1( 6), 381- 38 *
Chemical Abstracts, Band 80, no. 19, 13 Mai 1974, (Columbus, Ohio, US), Payne, John W. : "Polymerization of proteins with glutaraldehyde. Soluble molecular-weight markers ", siehe Seite 168, Zusammenfassung 105502v, & Biochem. J. 1973, 135( 4), 867- 87 *
Chemical Abstracts, Band 84, no. 11, 15 März 1976, (Columbus, Ohio, US), Whicher, J. et al. : "Synthesis of polymers of Bence-Jones protein for use as molecular weight markers for sodium dodecyl sulphate-polyacrylamide gel electrophoresis ", siehe Seite 188, Zusammenfassung 71106j, & Clin. chim. Acta 1975, 65( 3), 393- 39 *
Chemical Abstracts, Band 88, no. 25, 19 Juni 1978, (Columbus, Ohio, US), King, Te Piao et al. : "Preparation of protein conjugates via intermolecular disulfide bond formation ", siehe Seite 348, Zusammenfassung 185788w, & Biochemistry 1978, 17( 8), 1499-150 *
Chemical Abstracts, Band 95, no. 9, 31 August 1981, (Columbus, Ohio, US), See, Yew Phew et al. : "Comparison of crosslinked and natural polypeptides as standards for molecular weight determination of large polypeptides (guinea pig thyroglobulin) by SDS-gel electrophoresis ", siehe Seite 380, Zusammenfassung 76316q, & Anal. Biochem. 1981, 114( 2), 377- 38 *
Electrophoresis, Band. 9, 1988 Hiroshi S et al.: "A simple method for preparation of molecular weight marker proteins for sodium dodecyl sulfatepolyacrylamide gel electrophoresis by photopolymerizations of hemoglobin subunits ", *
J. Am. Chem. Soc., Band. 113, 1991 James P. Tam et al: "Disulfide Bond Formation in Peptides by Dimethyl Sulfoxide. Scope andApplications ", *
Methods in Enzymology, Band. 178, 1989 David N. Posnett et al: "Multiple Antigenic Peptide Method for Producing Antipeptide Site-specific Antibodies ", *
Molecular Immunology, Band. 16, 1979 P. Laidler: "The controlled disulphide crosslinking of different proteinsas a method for synthesis of combined protein antigens and copolymers of other design ", *

Also Published As

Publication number Publication date
WO1992007254A2 (fr) 1992-04-30
DE4032127A1 (de) 1992-04-16

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