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WO1992006199A3 - Antibody inductor peptides inhibiting retroviruses of the hiv type and antibodies specific for said peptides - Google Patents

Antibody inductor peptides inhibiting retroviruses of the hiv type and antibodies specific for said peptides Download PDF

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Publication number
WO1992006199A3
WO1992006199A3 PCT/FR1991/000758 FR9100758W WO9206199A3 WO 1992006199 A3 WO1992006199 A3 WO 1992006199A3 FR 9100758 W FR9100758 W FR 9100758W WO 9206199 A3 WO9206199 A3 WO 9206199A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptides
hiv
inductor
antibody
antibodies specific
Prior art date
Application number
PCT/FR1991/000758
Other languages
French (fr)
Other versions
WO1992006199A2 (en
Inventor
Luc Montagnier
Danielle Berneman
Denise Guetard
Elmostafa Bahraoui
Rietschoten Jurphaas Van
Solange Chamaret
Alain Blanchard
Original Assignee
Pasteur Institut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9013324A external-priority patent/FR2668488A1/en
Application filed by Pasteur Institut filed Critical Pasteur Institut
Priority to DE69117965T priority Critical patent/DE69117965T2/en
Priority to EP91919407A priority patent/EP0550691B1/en
Publication of WO1992006199A2 publication Critical patent/WO1992006199A2/en
Publication of WO1992006199A3 publication Critical patent/WO1992006199A3/en
Priority to GR960401549T priority patent/GR3020185T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/30—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycoplasmatales, e.g. Pleuropneumonia-like organisms [PPLO]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1253—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Mycoplasmatales, e.g. Pleuropneumonia-like organisms [PPLO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • AIDS & HIV (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

New peptide (I) able to induce in vivo prodn. of antibodies (Ab) in which inhibit infection by HIV comprises an amino acid sequence consisting of a sequence derived from a mycoplasmal protein. Also new are (1) peptides (Ia), derived from the gp/60 or nef proteins of HIV, having a high degree of isology (or homology) with (I) and able to induce Ab with inhibit infection of T-lymphocytes by HIV; (2) the tripeptide TPL; (3) recombinant or hybrid peptides which include (I) or (Ia) sequences; (4) purified proteins (II) from M. pirum (a) having mol. wt. 130 kD (the adhesion) and recognised by Ab raised against GVVSTPLVNLINGQ (Ib) or (b) having mol. wt. below 65 kD; (5) mono- or poly-clonal Ab against (I), (Ia) or the recombinant/hybrid proteins.
PCT/FR1991/000758 1990-09-27 1991-09-27 Antibody inductor peptides inhibiting retroviruses of the hiv type and antibodies specific for said peptides WO1992006199A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE69117965T DE69117965T2 (en) 1990-09-27 1991-09-27 PEPTIDES THAT INDUCATE HIV RETROVIRUS INHIBITING ANTIBODIES, AND ANTIBODIES TARGETED AGAINST THESE PEPTIDES
EP91919407A EP0550691B1 (en) 1990-09-27 1991-09-27 Antibody inductor peptides inhibiting retroviruses of the hiv type and antibodies specific for said peptides
GR960401549T GR3020185T3 (en) 1990-09-27 1996-06-07 Antibody inductor peptides inhibiting retroviruses of the hiv type and antibodies specific for said peptides

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR9011951 1990-09-27
FR90/11951 1990-09-27
FR9013324A FR2668488A1 (en) 1990-10-26 1990-10-26 New peptide(s) common to mycoplasm adhesion molecule and HIV proteins
FR90/13324 1990-10-26

Publications (2)

Publication Number Publication Date
WO1992006199A2 WO1992006199A2 (en) 1992-04-16
WO1992006199A3 true WO1992006199A3 (en) 1992-05-29

Family

ID=26228256

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1991/000758 WO1992006199A2 (en) 1990-09-27 1991-09-27 Antibody inductor peptides inhibiting retroviruses of the hiv type and antibodies specific for said peptides

Country Status (8)

Country Link
EP (2) EP0550691B1 (en)
AT (1) ATE135407T1 (en)
CA (1) CA2092546A1 (en)
DE (1) DE69117965T2 (en)
DK (1) DK0550691T3 (en)
ES (1) ES2087311T3 (en)
GR (1) GR3020185T3 (en)
WO (1) WO1992006199A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5773293A (en) * 1992-01-27 1998-06-30 Icos Corporation Anti-ICAM-4 antibodies and hybridomas
US5753502A (en) * 1993-08-05 1998-05-19 Icos Corporation Neuron-specific ICAM-4 promoter
US5700658A (en) * 1992-01-27 1997-12-23 Icos Corporation ICAM-4 materials and methods
FR2696186B1 (en) * 1992-09-28 1994-12-02 Pasteur Institut Mycoplasma strains. Cytopathogenic fermentans and in vitro diagnostic and immunization methods using such strains.
FR2705970B1 (en) * 1993-06-04 1995-08-04 Pasteur Institut Identification of the adhesin gene of M. Pirum.
DE4430601A1 (en) * 1994-08-22 1996-02-29 Beiersdorf Ag Cell adhesion peptides for modifying the adhesion behavior of eukaryotic cells to one another
DE50015096D1 (en) 1999-11-16 2008-05-21 Geneart Ag THE GENOME OF HIV-1 INTERSUBTYPS (C / B ') AND ITS APPLICATIONS
EP2905031A1 (en) * 2014-02-10 2015-08-12 B Cell Design A new non-HIV vaccine antigen from the vaginal microbiota capable of inducing a mucosal neutralizing protective antibody response against HIV infection

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986002383A1 (en) * 1984-10-18 1986-04-24 Institut Pasteur Envelope antigens of lymphadenopathy associated virus and their applications
US4945041A (en) * 1983-11-17 1990-07-31 Board Of Regents Monoclonal antibodies for Mycoplasma pneumoniae and use for diagnosis of pneumonia

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4945041A (en) * 1983-11-17 1990-07-31 Board Of Regents Monoclonal antibodies for Mycoplasma pneumoniae and use for diagnosis of pneumonia
WO1986002383A1 (en) * 1984-10-18 1986-04-24 Institut Pasteur Envelope antigens of lymphadenopathy associated virus and their applications

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Comptes Rendus de l'Academie des Sciences, vol. 311, no. 12, 6 décembre 1990, (Paris, FR), L. MONTAGNIER et al.: "Inhibition de l'infectiosité de souches prototypes du VIH par des anticorps dirigés contre une séquence peptidique de mycoplasma", pages 425-430, voir le document en entier *
GENE, vol. 64, 1988, (Amsterdam, NL), J.M. INAMINE et al.: "Nucleotide sequence of the P1 attachment protein gene of Mycoplasma pneumoniae", pages 217-229, voir figure 4, acides aminées correspondantes à nucleotides 680-700,3870-3894,4130-4190 *
Infection and Immunity, vol. 57, no. 4, avril 1989, S.F. DALLO et al.: "DNA and protein sequence homologies between the adhesins of Mycoplasma genitalium and Mycoplasma pneumoniae", pages 1059-1065, voir figure 3, en particulier les séquences sous-lignées *
International Journal of Peptide and Protein Research, vol. 35, no. 1, janvier 1990, (Munksgaard, DK), J.M. SABATIER et al.: "Large fragments of nef-protein and gp110 envelope gycoprotein from HIV-1", pages 63-72, voir page 64, séquence P3 *

Also Published As

Publication number Publication date
DE69117965T2 (en) 1996-11-14
DE69117965D1 (en) 1996-04-18
GR3020185T3 (en) 1996-09-30
ATE135407T1 (en) 1996-03-15
EP0550691A1 (en) 1993-07-14
CA2092546A1 (en) 1992-03-28
EP0550691B1 (en) 1996-03-13
DK0550691T3 (en) 1996-07-29
WO1992006199A2 (en) 1992-04-16
EP0736542A1 (en) 1996-10-09
ES2087311T3 (en) 1996-07-16

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