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WO1991015200A3 - Use of trinitrobenzenes or carminic acid in the treatment of cancer or viral diseases - Google Patents

Use of trinitrobenzenes or carminic acid in the treatment of cancer or viral diseases Download PDF

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Publication number
WO1991015200A3
WO1991015200A3 PCT/GB1991/000517 GB9100517W WO9115200A3 WO 1991015200 A3 WO1991015200 A3 WO 1991015200A3 GB 9100517 W GB9100517 W GB 9100517W WO 9115200 A3 WO9115200 A3 WO 9115200A3
Authority
WO
WIPO (PCT)
Prior art keywords
carminic acid
cancer
compounds
trinitrobenzenes
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB1991/000517
Other languages
French (fr)
Other versions
WO1991015200A2 (en
Inventor
Washington Odur Ayuko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909007453A external-priority patent/GB9007453D0/en
Priority claimed from GB909012166A external-priority patent/GB9012166D0/en
Priority claimed from GB919103075A external-priority patent/GB9103075D0/en
Priority to JP3506514A priority Critical patent/JPH06501449A/en
Priority to BR919106310A priority patent/BR9106310A/en
Priority to AU75604/91A priority patent/AU662883B2/en
Priority to FI924475A priority patent/FI924475A7/en
Priority to MC91GB9100517D priority patent/MC2246A1/en
Application filed by Individual filed Critical Individual
Publication of WO1991015200A2 publication Critical patent/WO1991015200A2/en
Publication of WO1991015200A3 publication Critical patent/WO1991015200A3/en
Priority to NO92923824A priority patent/NO923824L/en
Anticipated expiration legal-status Critical
Priority to LVP-92-149A priority patent/LV10574B/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds or radicals based on trinitrobenzene, carminic acid and derivatives thereof are useful as anti-cancer and anti-viral agents. Such compounds and formulations based thereon may be administered to a human or animal patient orally or parenterally in a substantially pure aqueous solution/suspension ranging at dilutions between about 10?-3-10-15¿ molar concentrations. In preferred embodiments, one or more of said compounds and an anthraquinone (such as carminic acid) are used. Carminic acid alone exhibits significant anti-viral effects.
PCT/GB1991/000517 1990-04-03 1991-04-03 Use of trinitrobenzenes or carminic acid in the treatment of cancer or viral diseases Ceased WO1991015200A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP3506514A JPH06501449A (en) 1990-04-03 1991-04-03 Use of trinitrobenzenes or carminic acid in the treatment of cancer or viral diseases
BR919106310A BR9106310A (en) 1990-04-03 1991-04-03 FORMULATION FOR NEOPLASM THERAPY OR PROPHYLAXIS OR VIRAL INFECTION PHARMACEUTICAL OR VETERINARY, RADIAL OR COMPOUND FORMULATION, FORMATION FOR VIRAL INFECTION AND AMPHRAKINONE GLYCOSIDE THERAPY
AU75604/91A AU662883B2 (en) 1990-04-03 1991-04-03 Use of trinitrobenzenes or carminic acid in the treatment of cancer or viral diseases
FI924475A FI924475A7 (en) 1990-04-03 1991-04-03 Use of trinitrobenzenes or carminic acid in the treatment of cancer and viral diseases
MC91GB9100517D MC2246A1 (en) 1990-04-03 1991-04-03 USE OF TRINITROBENZENES OR CARMINIC ACID IN THE TREATMENT OF CANCER OR VIRAL DISEASES
NO92923824A NO923824L (en) 1990-04-03 1992-10-01 USE OF TRINITROBENZENES OR CARCAMIC ACID IN TREATMENT OF CANCER OR VIRUS DISEASES
LVP-92-149A LV10574B (en) 1990-04-03 1992-10-05 The therapeutic use of low concentrations of trinitrobenzene, carminic acid and their derivatives as anti-cancer and anti-viral agents

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB909007453A GB9007453D0 (en) 1990-04-03 1990-04-03 Tumour therapy
GB9007453.5 1990-04-03
GB9012166.6 1990-05-31
GB909012166A GB9012166D0 (en) 1990-05-31 1990-05-31 Hydrazine derivatives for cancer therapy
GB919103075A GB9103075D0 (en) 1991-02-13 1991-02-13 Trinitrobenzene derivatives and their therapeutic use
GB9103075.9 1991-02-13

Publications (2)

Publication Number Publication Date
WO1991015200A2 WO1991015200A2 (en) 1991-10-17
WO1991015200A3 true WO1991015200A3 (en) 1992-03-05

Family

ID=27265028

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1991/000517 Ceased WO1991015200A2 (en) 1990-04-03 1991-04-03 Use of trinitrobenzenes or carminic acid in the treatment of cancer or viral diseases

Country Status (11)

Country Link
EP (1) EP0524212A1 (en)
JP (1) JPH06501449A (en)
AU (1) AU662883B2 (en)
BR (1) BR9106310A (en)
CA (1) CA2079803A1 (en)
FI (1) FI924475A7 (en)
HU (1) HUT62785A (en)
LV (1) LV10574B (en)
MC (1) MC2246A1 (en)
NO (1) NO923824L (en)
WO (1) WO1991015200A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9103075D0 (en) 1991-02-13 1991-03-27 Washington Odur Ayuko Trinitrobenzene derivatives and their therapeutic use
US5412123A (en) * 1993-02-08 1995-05-02 Glycomed Incorporated Anthraquinone and anthracene derivatives as inhibitors of the cell-adhesion molecules of the immune system
GB2312375B (en) * 1993-05-21 1998-02-25 Radopath Ltd Agents for treatment of cancer
GB9310520D0 (en) 1993-05-21 1993-07-07 Radopath Ltd Arylating agents
DZ1781A1 (en) * 1993-05-21 2002-02-17 Radopah Ltd Arylating agents.
DE69519722D1 (en) * 1994-03-17 2001-02-01 Radopath Pharmaceuticals Inter ACTIVE AGAINST VIRUSES AND CANCER
AU5115396A (en) * 1995-03-17 1996-10-08 Radopath Limited Anti-viral and anti-cancer agents
GB9615619D0 (en) * 1996-03-18 1996-09-04 Radopath Ltd Costimulation of TcR/CD3-induced T-Lymphocytes
AU1903699A (en) * 1997-12-08 1999-06-28 Glycomed Incorporated Disalicylate analog based sialyl lewisx mimetics
WO2020016245A1 (en) * 2018-07-17 2020-01-23 Pili Anthraquinonic derivatives and their use as colouring agents

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4032659A (en) * 1969-03-20 1977-06-28 American Home Products Corporation Method of viral chemoprophylaxis
US4724230A (en) * 1982-09-17 1988-02-09 Therapeutical Systems Corp. Method for producing oncolysis
EP0314580A1 (en) * 1987-10-30 1989-05-03 Institut Pasteur Use of nitrophenyl groups for stimulating the capability of incorporation of a drug into the sensitive cells of a host

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4032659A (en) * 1969-03-20 1977-06-28 American Home Products Corporation Method of viral chemoprophylaxis
US4724230A (en) * 1982-09-17 1988-02-09 Therapeutical Systems Corp. Method for producing oncolysis
EP0314580A1 (en) * 1987-10-30 1989-05-03 Institut Pasteur Use of nitrophenyl groups for stimulating the capability of incorporation of a drug into the sensitive cells of a host

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
ANTICANCER RESEARCH, vol. 7, no. 4B, July-August 1987, (Athens, GR), T. FUJII et al.: "Effect of PSK on prohibited immunity of splenectomized mice", pages 845-848, see results; discussion *
BIOORGANIC CHEMISTRY, vol. 8, no. 1, March 1979, (London, GB), J.W. LOWN et al.: "Reactions of the antitumor agent carminic acid and derivatives with DNA", pages 17-24, see abstract *
COMPTES RENDUS DES SEANCES DE LA SOCIETE DE BIOLOGIE ET DE SES FILIALES, vol. 167, no. 8, 1973, (Paris, FR), C. DEBY et al.: "Influence d'un régime enrichi en acides gras non saturés sur la toxicité du diphénylpicrylhydrazyl", pages 1302-1305, see abstract *
IMMUNITY TO CANCER. II. PROCEEDINGS OF THE 2ND CONFERENCE ON IMMUNITY TO CANCER, Williamsburg, Virginia, 9-11 November 1987, Alan R. Liss, Inc., (New York, US), A.M. FRIEDMAN et al.: "Prevention of tumor growth and enhancement of cell-mediated immunity by an antigen-specific contrasuppressor factor fram a T cell hybridoma", pages 281-288, see the whole article *
IMMUNOLOGY, vol. 51, no. 4, April 1984, (Oxford, GB), I. ENANDER et al.: "Mononuclear cells, mast cells and mucous cells as part of the delayed hypersensitivity response to aerosolized antigen in mice", pages 661-668, see abstract *
IMMUNOLOGY, vol. 54, no. 2, February 1985, (Oxford, GB), P.M. COMOGLIO et al.: "Enhancement of immunity against RSV-induced sarcomas by generation of hapten-reactive helper T lymphocytes", pages 289-295, see the whole article, esp. page 291, figure 1 *
IMMUNOLOGY, vol. 66, no. 4, April 1989, (Oxford, GB), I. KIMBER et al.: "Regulation of lymphocyte proliferation in contact sensitivity: homeostatic mechanisms and a possible explanation of antigenic competition", pages 577-582, see the whole article *
LIFE SCIENCES, vol. 42, no. 15, 1988, (Oxford, GB), J.M. JAMISON et al.: "Enhancement of the antiviral and interferon-inducing activities of poly r(A-U) by carminic acid", pages 1477-1483, see page 1474, table 1 *
PATENT ABSTRACTS OF JAPAN, vol. 5, no. 102 (C-61)[774], 2 July 1981, & JP,A,5643210 (KOUTAKU HAYASHI) 21 April 1981, see abstract *
REV. CHIR., ONCOL., RADIOL., ORL, OFTALMOL., STOMATOL.: ONCOL., vol. 28, no. 2, 1989, (RO), N. MIHAIL et al.: "Cytostatic action of histological stains for nucleic acids", pages 115-121, see pages 115-116 *
REVUE EUROPEENNE D'ETUDES CLINIQUES ET BIOLOGIQUES, vol. 15, no. 6, 1970, (Paris, FR), C. DEBY et al.: "Effect of a stable free-radical on the survival of x-irradiated mice", pages 678-682, see results *
THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 156, no. 1, 1st July 1982, (New York, US), W.R. THOMAS et al.: "Hapten-specific T cell lines mediating delayed hypersensitivity to contact-sensitizing agents", pages 300-305, see results; discussion *
ZHURNAL OBSCHEI KHIMII, vol. 32, no. 12, December 1962, (SU), M.A. IKRINA et al.: "Investigations in the field of the chemistry of free radicals of the hydrazine series VIII" (applicant's translation), pages 3952-3957, see the whole article (cited in the application) *

Also Published As

Publication number Publication date
EP0524212A1 (en) 1993-01-27
HUT62785A (en) 1993-06-28
JPH06501449A (en) 1994-02-17
NO923824L (en) 1992-11-26
CA2079803A1 (en) 1991-10-04
HU9203148D0 (en) 1992-12-28
NO923824D0 (en) 1992-10-01
LV10574B (en) 1995-08-20
FI924475L (en) 1992-10-05
BR9106310A (en) 1993-04-20
AU7560491A (en) 1991-10-30
FI924475A0 (en) 1992-10-05
AU662883B2 (en) 1995-09-21
FI924475A7 (en) 1992-10-05
LV10574A (en) 1995-04-20
WO1991015200A2 (en) 1991-10-17
MC2246A1 (en) 1993-03-25

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