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WO1991009593A3 - 5-ht3 antagonists for treatment of nausea, bradycardia of hypotension associated with myocardial instability - Google Patents

5-ht3 antagonists for treatment of nausea, bradycardia of hypotension associated with myocardial instability Download PDF

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Publication number
WO1991009593A3
WO1991009593A3 PCT/GB1990/001996 GB9001996W WO9109593A3 WO 1991009593 A3 WO1991009593 A3 WO 1991009593A3 GB 9001996 W GB9001996 W GB 9001996W WO 9109593 A3 WO9109593 A3 WO 9109593A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
bradycardia
nausea
antagonists
hypotension associated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB1990/001996
Other languages
French (fr)
Other versions
WO1991009593A2 (en
Inventor
Edward Stewart Johnson
Thomas Conway Hamilton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Priority to KR1019920701481A priority Critical patent/KR920703037A/en
Publication of WO1991009593A2 publication Critical patent/WO1991009593A2/en
Publication of WO1991009593A3 publication Critical patent/WO1991009593A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

A method for the treatment and/or prophylaxis of nausea and bradycardia and/or hypotension associated with myocardial instability in mammals, such as humans, which method comprises administering to the mammal in need of such treatment and/or prophylaxis an effective and/or prophylactic amount of a 5-HT3 receptor antagonist, such as a compound of formula (I): X-A-R, or a pharmaceutically acceptable salt thereof, wherein X is a phenyl group or a monocyclic 5 or 6 membered heteroaryl group, either of which group is optionally fused to a saturated or unsaturated 5-7 membered carbocyclic or heterocyclic ring; A is a linking moiety; and R is a saturated azabicyclic moiety or an imidazolyl moiety.
PCT/GB1990/001996 1989-12-21 1990-12-20 5-ht3 antagonists for treatment of nausea, bradycardia of hypotension associated with myocardial instability Ceased WO1991009593A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019920701481A KR920703037A (en) 1989-12-21 1990-12-20 5-HT₃antagonists for the Treatment of Hypotension, Goji, and bradycardia Associated with Myocardial Instability

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898928837A GB8928837D0 (en) 1989-12-21 1989-12-21 Pharmaceuticals
GB8928837.7 1989-12-21

Publications (2)

Publication Number Publication Date
WO1991009593A2 WO1991009593A2 (en) 1991-07-11
WO1991009593A3 true WO1991009593A3 (en) 1991-09-05

Family

ID=10668280

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1990/001996 Ceased WO1991009593A2 (en) 1989-12-21 1990-12-20 5-ht3 antagonists for treatment of nausea, bradycardia of hypotension associated with myocardial instability

Country Status (9)

Country Link
EP (1) EP0506813A1 (en)
JP (1) JPH05502872A (en)
KR (1) KR920703037A (en)
AU (1) AU7051691A (en)
CA (1) CA2071994A1 (en)
GB (1) GB8928837D0 (en)
IE (1) IE904603A1 (en)
WO (1) WO1991009593A2 (en)
ZA (1) ZA9010219B (en)

Cited By (3)

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US7576094B2 (en) 2004-12-13 2009-08-18 Eli Lilly And Company Spiro derivatives as lipoxygenase inhibitors
US9108961B2 (en) 2010-05-17 2015-08-18 Forum Pharmaceuticals, Inc. Crystalline form of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride
US9585877B2 (en) 2012-05-08 2017-03-07 Forum Pharmaceuticals, Inc. Methods of maintaining, treating or improving cognitive function

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JP2699794B2 (en) * 1992-03-12 1998-01-19 三菱化学株式会社 Thieno [3,2-b] pyridine derivative
GB9305593D0 (en) * 1993-03-18 1993-05-05 Smithkline Beecham Plc Pharmaceuticals
PE20021019A1 (en) 2001-04-19 2002-11-13 Upjohn Co SUBSTITUTED AZABYCLE GROUPS
AR036041A1 (en) 2001-06-12 2004-08-04 Upjohn Co HETEROCICLIC AROMATIC COMPOUNDS REPLACED WITH QUINUCLIDINE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
AR036040A1 (en) 2001-06-12 2004-08-04 Upjohn Co MULTICICLIC HETEROARYL COMPOUNDS REPLACED WITH QUINUCLIDINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
AP1635A (en) 2001-10-02 2006-07-14 Upjohn Co Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease.
US6849620B2 (en) 2001-10-26 2005-02-01 Pfizer Inc N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease
MXPA04004373A (en) 2001-11-09 2004-08-11 Upjohn Co Azabicyclic-phenyl-fused-heterocyclic compounds and their use as alpha7 nachr ligands.
DE10164139A1 (en) 2001-12-27 2003-07-10 Bayer Ag 2-heteroaryl carboxamides
BR0307714A (en) 2002-02-15 2005-02-09 Upjohn Co Azabicyclic-Substituted Benzoylamides and Thioamides for Treatment of CNS-Related Disorders
EP1476448A2 (en) 2002-02-19 2004-11-17 PHARMACIA & UPJOHN COMPANY Azabicyclic compounds for the treatment of disease
AU2003219690A1 (en) 2002-02-19 2003-09-09 Pharmacia And Upjohn Company Fused bicyclic-n-bridged-heteroaromatic carboxamides for the treatment of disease
PL210065B1 (en) 2002-09-25 2011-11-30 Memory Pharm Corp Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof
EP1697378B1 (en) 2003-12-22 2007-11-21 Memory Pharmaceuticals Corporation Indoles, 1h-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof
EP1735306A2 (en) 2004-03-25 2006-12-27 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof
EP1742944B1 (en) 2004-04-22 2010-11-10 Memory Pharmaceuticals Corporation Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof
KR20070015607A (en) 2004-05-07 2007-02-05 메모리 파마슈티칼스 코포레이션 1H-indazole, benzothiazole, 1,2-benzoisoxazole, 1,2-benzoisothiazole, and chromone and preparation and use thereof
ATE455776T1 (en) 2004-12-22 2010-02-15 Memory Pharm Corp NICOTINIC ALPHA-7 RECEPTOR LIGANDS AGAINST CNS DISEASES
US8106066B2 (en) 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof

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Patent Citations (24)

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GB2152049A (en) * 1983-12-23 1985-07-31 Sandoz Ltd Benzoic acid derivative
GB2153821A (en) * 1984-01-25 1985-08-29 Glaxo Group Ltd 3-Imidazolylmethyl-1,2,3,9-tetrahydro-4H-carbazol-4-one derivatives
EP0191562A2 (en) * 1985-01-23 1986-08-20 Glaxo Group Limited Tetrahydrocarbazolone derivatives
EP0200444A2 (en) * 1985-04-27 1986-11-05 Beecham Group Plc Azabicyclononyl-indazole-carboxamide having 5-HT antagonist activity
EP0210840A2 (en) * 1985-07-24 1987-02-04 Glaxo Group Limited Substituted imidazolylmethyltetrahydro-carbazolones
EP0219193A1 (en) * 1985-07-24 1987-04-22 Glaxo Group Limited Tetrahydrocarbazolone derivatives, processes for their preparation and pharmaceutical compositions containing them
EP0247266A1 (en) * 1986-01-07 1987-12-02 Beecham Group Plc Indole derivatives having an azabicyclic side chain, process for their preparation, intermediates, and pharmaceutical compositions
EP0266730A1 (en) * 1986-11-03 1988-05-11 Merrell Dow Pharmaceuticals Inc. Esters of hexadydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one and related compounds
EP0269452A2 (en) * 1986-11-28 1988-06-01 Glaxo Group Limited Use of ketone derivatives for the manufacture of medicaments
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7576094B2 (en) 2004-12-13 2009-08-18 Eli Lilly And Company Spiro derivatives as lipoxygenase inhibitors
US9108961B2 (en) 2010-05-17 2015-08-18 Forum Pharmaceuticals, Inc. Crystalline form of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride
US9273044B2 (en) 2010-05-17 2016-03-01 Forum Pharmaceuticals, Inc. Crystalline form of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate
US9550767B2 (en) 2010-05-17 2017-01-24 Forum Pharmaceuticals, Inc. Crystalline form of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate
US9585877B2 (en) 2012-05-08 2017-03-07 Forum Pharmaceuticals, Inc. Methods of maintaining, treating or improving cognitive function

Also Published As

Publication number Publication date
AU7051691A (en) 1991-07-24
CA2071994A1 (en) 1991-06-22
IE904603A1 (en) 1991-07-03
ZA9010219B (en) 1991-11-27
WO1991009593A2 (en) 1991-07-11
KR920703037A (en) 1992-12-17
JPH05502872A (en) 1993-05-20
GB8928837D0 (en) 1990-02-28
EP0506813A1 (en) 1992-10-07

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