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WO1991008750A1 - Utilisation de parties de la plante naturelle tinospora - Google Patents

Utilisation de parties de la plante naturelle tinospora Download PDF

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Publication number
WO1991008750A1
WO1991008750A1 PCT/CH1990/000280 CH9000280W WO9108750A1 WO 1991008750 A1 WO1991008750 A1 WO 1991008750A1 CH 9000280 W CH9000280 W CH 9000280W WO 9108750 A1 WO9108750 A1 WO 9108750A1
Authority
WO
WIPO (PCT)
Prior art keywords
tinospora
parts
plant
cell content
natural
Prior art date
Application number
PCT/CH1990/000280
Other languages
German (de)
English (en)
Inventor
Christian Krüger
Original Assignee
Krueger Christian
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Krueger Christian filed Critical Krueger Christian
Publication of WO1991008750A1 publication Critical patent/WO1991008750A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead

Definitions

  • the present invention relates to a new use of parts of plants, in particular stems and / or roots of the natural plant of the genus Tinospora, in particular T. cordifolia, for the production of a pharmaceutical preparation.
  • Tinospora particularly in Tinospora cordifolia, T. malabarica, T. tuberculata, T. capillipes, T. baenzi.geri, T. bakis, Parabaena ssp. and Stephanie tetrandra
  • Tinospora has long been used by the local population and in Ayurvedic mezicine to manufacture preparations for the treatment of a wide variety of complaints and illnesses. It is known, for example, to produce juices or aqueous infusions from parts of the stems of Tinospora cordifolia for internal use in the case of fever, jaundice, diarrhea, skin rashes, chronic rheumatism and general malaise.
  • Tinospora cordifolia are rich in starch and are therefore also used as animal feed.
  • plant parts in particular the cell content of stems and / or roots of the natural plant Tinospora, in particular T. cor- difolia, contains active ingredients which are able to delay or even reverse cancer-like diseases of the human and animal body.
  • the present invention now relates to the use of parts of plants, in particular the cell content of parts of the natural plant of the Tinospora genus, for the production of a pharmaceutical preparation for the treatment of cancerous diseases of the human or animal body.
  • the cell content of the plant parts mentioned, in particular stems and / or roots of Tinospora, in particular T. cordifolia can be used for the preparation of the preparations for treating the cancer-like diseases.
  • the active substances can be extracted from the cell content by physical or chemical methods.
  • the present invention basically relates to a novel cancer treatment on the human body or mammals, it having surprisingly been found that the preparations according to the invention can not only be used therapeutically on their own, but can also be combined with conventional cancer therapies (eg chemotherapy, radiation therapy or surgical interventions) . As such accompanying agents, the preparations can be made before, simultaneously or after conventional treatment can be used.
  • conventional cancer therapies eg chemotherapy, radiation therapy or surgical interventions
  • the preparations can be administered in a wide variety of ways (systemically and / or topically or locally).
  • the amount to be administered for the treatment depends on the weight, the stage of the cancer and the type of administration.
  • sterile gauze immersed in a solution is brought close to the tumor, e.g. for at least one hour, three times a day.
  • Dosage forms of the preparations are described in the examples. It is also to provide 'poss i ch, the desired dose as galenic preparations (pill Tablet ⁇ th, suppositories, creams, oils, gels, sprays etc.), wel ⁇ che parts of the plants, in particular their cell contents included (specifically, the natural plant Tinospora cor ⁇ difolia).
  • compositions usually consist of the active ingredient and pharmaceutically acceptable excipients.
  • the production is conventional.
  • the preparation according to the invention can be used not only orally and systemically, but also locally is therefore particularly suitable for topical administration.
  • Topical is understood here to mean: active substance introduced into a suitable carrier, used directly at the site of the disease in order to exert a local effect.
  • compositions are those for oral, rectal or parenteral (including intramuscular and intravenous) administration, with oral administration being preferred.
  • the forms of administration are conventional (active ingredient with liquid carrier and / or finely comminuted solid carrier).
  • pills such as pills, suppositories, oils, emulsions etc. are also provided in a conventional manner.
  • the stems of well-grown Tinospora corifolia plants are cleaned, peeled and cut into smaller pieces, which are then crushed. 4 parts by weight of water are added to 1 part by weight of the mass obtained in this way, and the whole is mixed to form a uniform, mush-like mass, from which the fibrous substances are subsequently removed. The rest is freed from supernatant water by decanting or evaporation, dried and processed into a powder.
  • the powder obtained in this way can later be mixed with water at any time in order to produce a thinly liquid paste to be administered orally to the patient or a more consistent paste for external application on a diseased part of the body.
  • Example 2 Washed and crushed stems or roots of Tinospora Cordifolia are crushed and pressed without adding water, whereby the contents of the plant cells are obtained in the form of a juice. This can be administered orally to the patient with or without the addition of water or applied externally to the diseased part of the body.
  • Example 3 Roots or stems of mature Tinospora cordifolia are cleaned and cut into pieces, which are then left to dry. The dried pieces are ground into a powder that can be stored dry and dust-free. For use, 1 part by weight of the powder is mixed with 6 parts by weight of water. The mixture obtained is left to stand for 8 to 12 hours and then filtered. The solution, freed from the solid filter residues, can be used internally or externally by the patient.
  • Example 4 Fresh stems or roots of Tinospora cordifolia are washed, cut into pieces, dried and ground to a coarse-grained powder. For use, 16 parts by weight of water are added to 1 part by weight of the powder. The mixture obtained is then evaporated to 1/8 of its original amount and then filtered. The liberated from the solid filter residue solution can be used alone or mixed with other substances to the patient internally • or external administration.
  • Example 5 500 g small pieces of stems or roots of the Tinospora eordifolia plant are ground and then prepared in 1500 g of water for 12 hours. Afterwards, the mixture is gently stirred and filtered. The filter residues obtained are mixed again with 1500 g of water and finally filtered off. The aqueous solution obtained is mixed with the solution obtained by the first filtration, after which the solution mixture is evaporated until a semi-liquid mass is obtained. This can be stored in glass bottles and used for internal or external applications, whether with or without the addition of water and / or other substances.
  • Example 6 500 g small pieces of stems or roots of the Tinospora eordifolia plant are ground and then prepared in 1500 g of water for 12 hours. Afterwards, the mixture is gently stirred and filtered. The filter residues obtained are mixed again with 1500 g of water and finally filtered off. The aqueous solution obtained is mixed with the solution obtained by the first filtration, after which the solution mixture is evaporated until a semi-liquid mass is
  • Plant Tinospora c'ordifolia are drinkable with 2500 g
  • the alcoholic solution obtained in this way contains the active ingredients extracted from the cell content of the plant and can be stored for a long period of time and, if necessary, for internal or external use
  • Example 7 Cleaned, fresh roots of Tinospora cordifolia were cut into pieces, ground and mixed with water to give a spreadable paste for external use.
  • a juice for internal use was pressed from cleaned, fresh roots of the plant mentioned.
  • the paste was applied externally to the neck of an adult woman suffering from throat cancer several times a day, and the juice was also used orally several times a day.
  • the woman had previously been treated in several hospitals for eight years with radiation and other common methods of combating cancer without any improvement.
  • the disease was described at the beginning of treatment with the Paste and juice had progressed so far that the patient could not swallow solid or liquid food and had to be artificially fed.
  • 500 g of stems of the Tinospora cordifolia plant are finely ground or ground.
  • the fine powder obtained is mixed with water and processed into a paste.
  • This paste is mixed with other substances, e.g. Honey or sugar, mixed and given to the patient internally (orally).
  • a preparation according to Example 1 was also used.
  • a preparation according to Example 4 was also used for topical application.

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

On a découvert que dans le contenu cellulaire de l'ensemble de la plante, en particulier dans la tige et les racines de la plante naturelle Tinospora cordifolia, existent des principes actifs qui peuvent être utilisés pour la fabrication de préparations destinées au traitement de maladies cancéreuses du corps humain ou animal.
PCT/CH1990/000280 1989-12-19 1990-12-05 Utilisation de parties de la plante naturelle tinospora WO1991008750A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH454189 1989-12-19
CH4541/89-1 1989-12-19

Publications (1)

Publication Number Publication Date
WO1991008750A1 true WO1991008750A1 (fr) 1991-06-27

Family

ID=4278013

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CH1990/000280 WO1991008750A1 (fr) 1989-12-19 1990-12-05 Utilisation de parties de la plante naturelle tinospora

Country Status (2)

Country Link
AU (1) AU6746990A (fr)
WO (1) WO1991008750A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998005346A1 (fr) * 1996-08-02 1998-02-12 Beth Israel Deaconess Medical Center Nouvelle formulation a base d'herbes medicinales et ses utilisations therapeutiques
WO2002053166A1 (fr) * 2000-12-28 2002-07-11 Wockhardt Limited Utilisation d'extrait de tinospora dans le traitement de maladies modulees par le systeme immunitaire
WO2003097076A1 (fr) * 2002-05-15 2003-11-27 Sahajanand Biotech Private Limited Preparations d'herbes destinees a lutter contre l'adenocarcinome de la prostate
WO2003006033A3 (fr) * 2001-07-11 2004-05-27 Sahajanand Biotech Private Ltd Formulation a base de plantes medicinales
WO2003006036A3 (fr) * 2001-07-11 2004-05-27 Sahajanand Biotech Private Ltd Preparation a base de plantes
WO2003006034A3 (fr) * 2001-07-11 2004-05-27 Sahajanand Biotech Private Ltd Formulation medicinale
US7914824B2 (en) 2004-04-09 2011-03-29 Piramal Life Sciences Limited Herbal extract for renal disorders

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62289565A (ja) * 1986-06-09 1987-12-16 Toubishi Yakuhin Kogyo Kk 新規四環性アルカロイドｆｋ及びその製造方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62289565A (ja) * 1986-06-09 1987-12-16 Toubishi Yakuhin Kogyo Kk 新規四環性アルカロイドｆｋ及びその製造方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Biological Abstracts, Band 75, 1983, (Philadelphia, P.A., US), W. Ruizhen et al.: "The effect of tetrandrine on the growth of ECa-109 cell line in vitro", siehe Seite 43299 *
Biological Abstracts, Band 87, 1989, (Philadelphia, P.A., US), U.M. Thatte et al.: "Comparative study of immunomodulating activity of indian medicinal plants, lithium carbonate and glucan", siehe Seite 9051 *
P.H. List et al.: "Hagers Handbuch der Pharmazeutischen Praxis", Teil C, Band 6, 1979, Springer-Verlag, (Berlin, DE), siehe Seite 187 *
Patent Abstracts of Japan, Band 12, Nr. 186 (C-500)(3033), 31 Mai 1988; & JP-A-62289565 (TOUBISHI YAKUHIN KOGYO K.K.), 16 Dezember 1987 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998005346A1 (fr) * 1996-08-02 1998-02-12 Beth Israel Deaconess Medical Center Nouvelle formulation a base d'herbes medicinales et ses utilisations therapeutiques
WO2002053166A1 (fr) * 2000-12-28 2002-07-11 Wockhardt Limited Utilisation d'extrait de tinospora dans le traitement de maladies modulees par le systeme immunitaire
WO2003006033A3 (fr) * 2001-07-11 2004-05-27 Sahajanand Biotech Private Ltd Formulation a base de plantes medicinales
WO2003006036A3 (fr) * 2001-07-11 2004-05-27 Sahajanand Biotech Private Ltd Preparation a base de plantes
WO2003006034A3 (fr) * 2001-07-11 2004-05-27 Sahajanand Biotech Private Ltd Formulation medicinale
US6780441B2 (en) 2001-07-11 2004-08-24 Sahajanand Biotech Private Limited Composition of eleven herbals for treating cancer
WO2003097076A1 (fr) * 2002-05-15 2003-11-27 Sahajanand Biotech Private Limited Preparations d'herbes destinees a lutter contre l'adenocarcinome de la prostate
US7914824B2 (en) 2004-04-09 2011-03-29 Piramal Life Sciences Limited Herbal extract for renal disorders

Also Published As

Publication number Publication date
AU6746990A (en) 1991-07-18

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