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WO1991008196A3 - Process for racemization of optically active arylethanolamines - Google Patents

Process for racemization of optically active arylethanolamines Download PDF

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Publication number
WO1991008196A3
WO1991008196A3 PCT/US1990/006511 US9006511W WO9108196A3 WO 1991008196 A3 WO1991008196 A3 WO 1991008196A3 US 9006511 W US9006511 W US 9006511W WO 9108196 A3 WO9108196 A3 WO 9108196A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
formulae
optically active
substituted
arylethanolamines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1990/006511
Other languages
French (fr)
Other versions
WO1991008196A2 (en
Inventor
Sami Y Kalliney
Mariano V Ruggeri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of WO1991008196A2 publication Critical patent/WO1991008196A2/en
Publication of WO1991008196A3 publication Critical patent/WO1991008196A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A process for preparing a racemic mixture containing approximately equimolar amounts of stereoisomers of formulae: (I) or salts thereof, wherein R?1, R2, R3, R4, R5, and R6¿ independently represent hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, aromatic heterocyclic or substituted aromatic heterocyclic or a salicylamide moiety, with the proviso that R1 is not hydrogen, alkyl or substituted alkyl, or salts thereof, wherein R?7, R8 and R9¿ independently represent any of the values for R?1, R2, R3, R4, R5 and R6¿, comprising the steps of (a) contacting an optically active compound of formula (II) disclosed herein, (b) heating the resin containing the compounds of formula (II) to a temperature effective to yield the racemic mixture of formulae (I); and (c) recovering the compounds of formulae (I) from the resin.
PCT/US1990/006511 1989-11-17 1990-11-15 Process for racemization of optically active arylethanolamines Ceased WO1991008196A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43882689A 1989-11-17 1989-11-17
US438,826 1989-11-17

Publications (2)

Publication Number Publication Date
WO1991008196A2 WO1991008196A2 (en) 1991-06-13
WO1991008196A3 true WO1991008196A3 (en) 1991-08-08

Family

ID=23742186

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1990/006511 Ceased WO1991008196A2 (en) 1989-11-17 1990-11-15 Process for racemization of optically active arylethanolamines

Country Status (2)

Country Link
AU (1) AU7166991A (en)
WO (1) WO1991008196A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4137581A1 (en) * 1991-11-15 1993-05-19 Degussa METHOD FOR CHEMICALLY RACEMIZING 5-MONO SUBSTITUTED HYDANTOINS, DEVICE FOR CARRYING OUT THE METHOD AND USE OF THE HYDANTOINS

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2536360A (en) * 1949-11-25 1951-01-02 Du Pont Racemization of lysine
US4066755A (en) * 1969-07-08 1978-01-03 Allen & Hanburys Limited Phenylaminoethanol derivatives for treating hypertension
US4096186A (en) * 1974-06-29 1978-06-20 Teijin Limited Process for racemizing optically active amino compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2536360A (en) * 1949-11-25 1951-01-02 Du Pont Racemization of lysine
US4066755A (en) * 1969-07-08 1978-01-03 Allen & Hanburys Limited Phenylaminoethanol derivatives for treating hypertension
US4096186A (en) * 1974-06-29 1978-06-20 Teijin Limited Process for racemizing optically active amino compounds

Also Published As

Publication number Publication date
WO1991008196A2 (en) 1991-06-13
AU7166991A (en) 1991-06-26

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