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WO1991000117A1 - Nebuliseur - Google Patents

Nebuliseur Download PDF

Info

Publication number
WO1991000117A1
WO1991000117A1 PCT/GB1990/001036 GB9001036W WO9100117A1 WO 1991000117 A1 WO1991000117 A1 WO 1991000117A1 GB 9001036 W GB9001036 W GB 9001036W WO 9100117 A1 WO9100117 A1 WO 9100117A1
Authority
WO
WIPO (PCT)
Prior art keywords
membrane
flap
support grid
outlet
chamber
Prior art date
Application number
PCT/GB1990/001036
Other languages
English (en)
Inventor
Andrew William Blower
John Stuart Corbett
Andrew Reginald Clark
Michael John Clarke
Original Assignee
Fisons Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fisons Plc filed Critical Fisons Plc
Publication of WO1991000117A1 publication Critical patent/WO1991000117A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K15/00—Check valves
    • F16K15/14—Check valves with flexible valve members
    • F16K15/144—Check valves with flexible valve members the closure elements being fixed along all or a part of their periphery

Definitions

  • This invention relates to improvements in devices for the inhalation of medicaments, in particular to an aerosol r-acer device or holding chamber with an improved respiratory valve.
  • spacer comprise a 'pear-shaped' or cylindrical chamber provided at one end with an inlet to receive the inhaler and at the other end with a mouthpiece including a respiratory valve.
  • the respiratory valve typically comprises a rubber membrane with two crossed slits forming four flaps in the centre of the membrane which are lifted upon inhalatory effort by the patient, thereby permitting the aerosol cloud contained within the chamber to be inhaled.
  • the flaps are supported by an X-shaped grid, the limbs of the 'X' extending along the lines of the slits.
  • this invention provides an aerosol spacer device comprising a chamber provided at one end with an inlet to receive an aerosol cloud and at the other end with an outlet including a one-way valve comprising a support grid and a membrane, characterised in that the membrane has a central flap supported at its periphery by the support grid such that, when the flap is lifted out of the plane of the rest of the membrane, the passage of air through the central portion of the valve is unimpeded by the support grid.
  • the spacer device according to the invention is advantageous principally in that the quality of the aerosol cloud inhaled, in terms of the proportion of aerosol particles which are sufficiently fine to penetrate deep into the lung, is better than that achieved using comparable known spacer devices.
  • the device is also advantageous in that the valve is more easily actuated by the breath of children than is the case with other, known devices. Furthermore, the need for accurate coordination of inhalation and dispensing of a dose of medicament is reduced.
  • the flap is preferably of partially circular shape.
  • the flap may, for example, be formed by an arcuate slit in the membrane, the slit preferably describing approximately 300° of arc.
  • the support grid conveniently includes an annular portion of similar diameter to that of the flap such that the flap is supported at its edge by the annular portion and air is able to flow unimpeded through the annulus when the flap is lifted.
  • the annular portion of the support grid is preferably connected to the walls of the outlet by a plurality of radial members spaced angularly, preferably equiangularly, around the annulus.
  • the membrane is preferably of elastomeric material and is preferably circular.
  • the diameter of the membrane is preferably less than about 6cm, eg about 5cm.
  • the flap when it is of partially circular form, is preferably of diameter from about 1 to 2.5cm, eg about 2cm.
  • the outlet is preferably provided downstream of the membrane with one or more bleed outlets which permit egress of air should the user mistakenly exhale into the outlet. This helps to prevent the membrane being deformed, eg by the flap being blown back into the chamber.
  • the performance of the device may be substantially improved by appropriate choice of the shape of the device.
  • an aerosol spacer device comprising a chamber having a frustoconical portion having at its smaller end an inlet to receive an aerosol cloud, characterised in that the angle of taper of the frustoconical portion is between 10° and 25° per side and the length of the frustoconical portion is between 0.50 and 0.65 of the total length of the chamber.
  • the angle of taper of the frustoconical portion is preferably greater than 15 ° .
  • the angle of taper of the frustoconical portion is preferably less than 20°.
  • the length of the frustoconical portion is preferably greater than 0.55 of the total length of the chamber.
  • the length of the frustoconical portion is preferably less than 0.60 of the total length of the chamber.
  • the total length of the chamber is preferably between 15cm and 25cm, and the volume of the chamber is preferably between about 500 and 1000cm 3 .
  • the spacer device may be manufactured from any suitable material, with plastics, especially clear plastics such as polycarbonate, being particularly convenient.
  • aerosol spacer devices can be used only with metered dose inhalers having a particular shape of outlet. This means that when a patient uses two different medications, eg a prophylactic drug and a bronchodilator, he requires two different spacer devices which are bulky and inconvenient to carry.
  • an aerosol spacer device comprising a chamber provided at one end with an inlet and at the other end with a mouthpiece, characterised in that the inlet is so shaped as to accept and retain more than one shape of metered dose inhaler outlet.
  • Figure 1 is an exploded side view of an aerosol spacer device according to the invention
  • Figure 2 is a view along line II-II 1 in Figure 1
  • Figure 3 is a plan view of a membrane forming part of a respiratory valve used in the device of Figures 1 and 2
  • Figure 4 is a side view of the assembled device of Figures 1 and 2.
  • an aerosol spacer device comprises a first chamber portion (1) , a second chamber portion (2) , a valve membrane (3) and a mouthpiece (4) .
  • First chamber portion (1) is provided at one end with an inlet to receive a metered dose inhaler (shown by the dashed lines) .
  • the inlet is so shaped as to accept more than one kind of metered dose inhaler.
  • Second chamber portion (2) has a flange (5) at its larger end, flange (5) fitting closely inside the larger end of first chamber portion (1) to form a chamber.
  • second chamber portion (2) has a second flange (6) .
  • Mouthpiece (4) fits closely over second flange (6) , holding valve membrane (3) captive between mouthpiece (4) and second chamber portion (2) .
  • the mouth of second flange (6) facing mouthpiece (4) carries a support grid (7,8) comprising a central annular portion (7) linked to the walls of second flange (6) by four radial members (8) .
  • An arcuate slit (9) describing approximately 300° of arc defines a central flap (10) in valve membrane (3) (see Figure 3) .
  • Slit (9) terminates in two small holes (11) which prevent tearing of membrane (3) beyond the ends of slit (9) .
  • Three radial slits (12) extend outwardly from slit (9) to points approximately halfway between slit (9) and the edge of membrane (3) .
  • the assembled device is shown in Figure 4.
  • a frustoconical portion extends from the inlet towards mouthpiece (4) .
  • the angle of taper of the frustoconical portion is 17° and its length (indicated by A in the Figure 4) is 105mm.
  • the total length of the chamber (indicated by B) is 185mm.
  • the device is assembled as described above with radial slits (12) aligned with radial members (8) .
  • a metered dose inhaler is inserted into the smaller end of first chamber portion (1) and actuated, dispensing a dose of medicament into the device.
  • Inhalation by the patient at mouthpiece (4) opens flap (10) , allowing air and the cloud of medicament to pass through the valve.
  • flap (10) is pressed back against support grid (7,8) preventing exhaled air entering the chamber.
  • Small bleed holes (not shown) in mouthpiece (4) permit the escape of exhaled air thereby relieving the pressure exerted on membrane (3) .

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Nébuliseur ou flacon à aérosol composé d'un flacon (1) muni à une extrémité d'une entrée pour recevoir un nuage d'aérosol et à l'autre, d'une sortie comprenant une soupape unidirectionnelle incluant une grille de support (7, 8) et une membrane (3). Celle-ci a un volet central (10) soutenu à sa périphérie par la grille de support (7, 8) de sorte que, lorsque le volet est surélevé par rapport à la surface du reste de la membrane, le passage de l'air par la partie centrale de la soupape ne soit pas entravé par la grille de support.
PCT/GB1990/001036 1989-07-05 1990-07-04 Nebuliseur WO1991000117A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898915420A GB8915420D0 (en) 1989-07-05 1989-07-05 Inhalation device
GB8915420 1989-07-05

Publications (1)

Publication Number Publication Date
WO1991000117A1 true WO1991000117A1 (fr) 1991-01-10

Family

ID=10659588

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1990/001036 WO1991000117A1 (fr) 1989-07-05 1990-07-04 Nebuliseur

Country Status (2)

Country Link
GB (1) GB8915420D0 (fr)
WO (1) WO1991000117A1 (fr)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5427089A (en) * 1989-04-17 1995-06-27 Glaxo Group Limited Valved auxiliary device for use with aerosol container
EP0691862A4 (fr) * 1994-02-02 1996-10-30 Baxter Int Valve a fente pour conduit d'ecoulement de gaz de nebuliseur
RU2129022C1 (ru) * 1994-01-27 1999-04-20 Астра Актиеболаг Спейсер
US6000394A (en) * 1994-10-26 1999-12-14 Paul Rizau Pari-Werk Gmbh Generation of an aerosol of an exact dose
US6293279B1 (en) 1997-09-26 2001-09-25 Trudell Medical International Aerosol medication delivery apparatus and system
US6345617B1 (en) 1997-09-26 2002-02-12 1263152 Ontario Inc. Aerosol medication delivery apparatus and system
US7404400B2 (en) 1998-12-09 2008-07-29 Cipla Limited Spacer device for inhaler
US7562656B2 (en) 2002-05-02 2009-07-21 Hydrate, Inc. Aerosol medication inhalation system
USRE43174E1 (en) 2000-04-11 2012-02-14 Trudell Medical International Aerosol delivery apparatus
US9700689B2 (en) 2002-05-21 2017-07-11 Trudell Medical International Medication delivery apparatus and system and methods for the use and assembly thereof
CN109715236A (zh) * 2016-07-13 2019-05-03 弗劳恩霍夫应用研究促进协会 在患者人工呼吸或支持呼吸期间呼吸控制施用粉末形式的气溶胶
EP4494680A1 (fr) * 2019-07-24 2025-01-22 Trudell Medical International Inc. Chambre de maintien portable

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1282390B (de) * 1965-09-09 1968-11-07 Gen Electric Rueckschlagventil
US4470412A (en) * 1982-03-19 1984-09-11 Trutek Research, Inc. Inhalation valve
CA1210304A (fr) * 1983-07-25 1986-08-26 Michael A. Coll Systeme de soupapes pour eliminer les gaz d'anesthesie ou d'analgesie et soupapes du meme genre

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1282390B (de) * 1965-09-09 1968-11-07 Gen Electric Rueckschlagventil
US4470412A (en) * 1982-03-19 1984-09-11 Trutek Research, Inc. Inhalation valve
CA1210304A (fr) * 1983-07-25 1986-08-26 Michael A. Coll Systeme de soupapes pour eliminer les gaz d'anesthesie ou d'analgesie et soupapes du meme genre

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5427089A (en) * 1989-04-17 1995-06-27 Glaxo Group Limited Valved auxiliary device for use with aerosol container
RU2129022C1 (ru) * 1994-01-27 1999-04-20 Астра Актиеболаг Спейсер
US6435176B1 (en) * 1994-01-27 2002-08-20 Astra Aktiebolag Spacer for use with a metered dose inhaler
EP0691862A4 (fr) * 1994-02-02 1996-10-30 Baxter Int Valve a fente pour conduit d'ecoulement de gaz de nebuliseur
US6000394A (en) * 1994-10-26 1999-12-14 Paul Rizau Pari-Werk Gmbh Generation of an aerosol of an exact dose
US6293279B1 (en) 1997-09-26 2001-09-25 Trudell Medical International Aerosol medication delivery apparatus and system
US6345617B1 (en) 1997-09-26 2002-02-12 1263152 Ontario Inc. Aerosol medication delivery apparatus and system
US6435177B1 (en) 1997-09-26 2002-08-20 Trudell Medical International Aerosol medication delivery apparatus and system
US7404400B2 (en) 1998-12-09 2008-07-29 Cipla Limited Spacer device for inhaler
USRE43174E1 (en) 2000-04-11 2012-02-14 Trudell Medical International Aerosol delivery apparatus
USRE45068E1 (en) 2000-04-11 2014-08-12 Trudell Medical International Aerosol delivery apparatus
USRE46050E1 (en) 2000-04-11 2016-07-05 Trudell Medical International Aerosol delivery apparatus
US7562656B2 (en) 2002-05-02 2009-07-21 Hydrate, Inc. Aerosol medication inhalation system
US8973571B1 (en) 2002-05-02 2015-03-10 Pre Holding, Inc. Aerosol medication inhalation system
US9308335B2 (en) 2002-05-02 2016-04-12 Pre Holding, Inc. Aerosol medication inhalation system
US9700689B2 (en) 2002-05-21 2017-07-11 Trudell Medical International Medication delivery apparatus and system and methods for the use and assembly thereof
US9814849B2 (en) 2002-05-21 2017-11-14 Trudell Medical International Medication delivery apparatus and system and methods for the use and assembly thereof
US10881816B2 (en) 2002-05-21 2021-01-05 Trudell Medical International Medication delivery apparatus and system and methods for the use and assembly thereof
CN109715236A (zh) * 2016-07-13 2019-05-03 弗劳恩霍夫应用研究促进协会 在患者人工呼吸或支持呼吸期间呼吸控制施用粉末形式的气溶胶
CN109715236B (zh) * 2016-07-13 2023-04-14 弗劳恩霍夫应用研究促进协会 在患者人工呼吸或支持呼吸期间呼吸控制施用粉末形式的气溶胶
EP4494680A1 (fr) * 2019-07-24 2025-01-22 Trudell Medical International Inc. Chambre de maintien portable

Also Published As

Publication number Publication date
GB8915420D0 (en) 1989-08-23

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