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WO1990013281A3 - Method of suppressing hiv infection - Google Patents

Method of suppressing hiv infection Download PDF

Info

Publication number
WO1990013281A3
WO1990013281A3 PCT/US1990/002319 US9002319W WO9013281A3 WO 1990013281 A3 WO1990013281 A3 WO 1990013281A3 US 9002319 W US9002319 W US 9002319W WO 9013281 A3 WO9013281 A3 WO 9013281A3
Authority
WO
WIPO (PCT)
Prior art keywords
hiv infection
hiv
suppressing hiv
suppressing
infection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1990/002319
Other languages
French (fr)
Other versions
WO1990013281A2 (en
Inventor
Donald C Anderson
C Wayne Smith
Robert Rothlein
Robert J Eckner
Roger D Rossen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor College of Medicine
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Baylor College of Medicine
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor College of Medicine, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Baylor College of Medicine
Publication of WO1990013281A2 publication Critical patent/WO1990013281A2/en
Anticipated expiration legal-status Critical
Publication of WO1990013281A3 publication Critical patent/WO1990013281A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • C07K14/70553—Integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A therapeutic method for suppressing or preventing the infection of leukocytes with HIV in an individual exposed to or effected by HIV. The invention may be used in the treatment of diseases, such as AIDS (Acquired Immunodeficiency Syndrome) which are caused by HIV.
PCT/US1990/002319 1989-04-28 1990-04-27 Method of suppressing hiv infection Ceased WO1990013281A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34486889A 1989-04-28 1989-04-28
US344,868 1989-04-28

Publications (2)

Publication Number Publication Date
WO1990013281A2 WO1990013281A2 (en) 1990-11-15
WO1990013281A3 true WO1990013281A3 (en) 2004-04-22

Family

ID=23352400

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1990/002319 Ceased WO1990013281A2 (en) 1989-04-28 1990-04-27 Method of suppressing hiv infection

Country Status (3)

Country Link
AU (1) AU5568290A (en)
WO (1) WO1990013281A2 (en)
ZA (1) ZA903258B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991018010A1 (en) * 1990-05-15 1991-11-28 Swinburne Limited Inhibition of viral infection using intercellular adhesion molecule-1-like peptides and/or analogues thereof
US6197298B1 (en) 1991-04-19 2001-03-06 Tanox, Inc. Modified binding molecules specific for T lymphocytes and their use as in vivo immune modulators in animals
US5872222A (en) * 1991-04-19 1999-02-16 Tanox Biosystems, Inc. Conjugates of polymers and antibodies specific for T lymphocytes, and their use as adjuvants
US6106835A (en) * 1991-04-19 2000-08-22 Tanox, Inc. Modified binding molecules specific for T or B lymphocytes and their use as in vivo immune modulators
US6129916A (en) * 1991-04-19 2000-10-10 Tanox, Inc. Method of Increasing activation on proliferation of T cells using antibody-microbead conjugates
CA2065658A1 (en) * 1991-04-19 1992-10-20 Tse-Wen Chang Conjugates of liposomes or microbeads and antibodies specific for t lymphocytes and their use in vivo immune modulators
US6534057B2 (en) * 1993-03-19 2003-03-18 Allen D. Allen Method increasing the delayed-type hypersensitivity response by infusing LFA-1-specific antibodies
EP0831907A4 (en) * 1995-06-06 2005-05-04 D Allen Allen Method for treating molluscum contagiosum resulting from hiv infection
CN1402797A (en) 1999-06-24 2003-03-12 约翰·霍普金斯大学 Compositions and methods for preventing transepithelial transmission of HIV
US7396530B2 (en) 2004-06-09 2008-07-08 Genentech, Inc. Method of treating granuloma annulare or sarcoid
US20090317404A1 (en) * 2005-10-14 2009-12-24 Johns Hopkins University Reduction and prevention of cell-associated hiv transepithelial migration, microbides and other formulations and methods

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988006592A1 (en) * 1987-02-26 1988-09-07 Dana-Farber Cancer Institute, Inc. Cloning of lfa-1
EP0289949A2 (en) * 1987-05-04 1988-11-09 Dana Farber Cancer Institute Intercellular adhesion molecules, and their binding ligands

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988006592A1 (en) * 1987-02-26 1988-09-07 Dana-Farber Cancer Institute, Inc. Cloning of lfa-1
EP0289949A2 (en) * 1987-05-04 1988-11-09 Dana Farber Cancer Institute Intercellular adhesion molecules, and their binding ligands

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
AIDS, Vol. 2, No. 3, 1988, Amiel et al., "LFA-1 expression in HIV infection", see pages 211-213. *
Clinical Research , Vol. 37, No. 2, 1989 Rossen et al., "HIV-1 stimulated expression of CD11/CD18 and ICAM-1 in monocytes and T cells: a possible mechanism for extra vascular dissemination of HIV-infected cells see page 608A. *
Federal Proceedings, 1987, vol. 4. No. 4, Folks et al., "Regulation of HIV expression in a monocyte cell line", see page 1515. *
International Archives of Allergy Appl. Immunology, Vol. 83(suppl. 1) 1987, Amiel et al., "LFA-1 expression in HIV infection". See abstract. *
Journal of Clinical Investigation, Vol. 79, No. 6, 1987, Petit et al., "Human immunodeficiency virus inflection down-regulates HLA class II expression and induces differentiation in promonocytic U937 cells", see abstract. *
Journal of Experimental Medicine, Vol. 169, April 1989, T. Subota et al., "A cytotoxic T lymphocyte virus replication in pheupheral blood lymphocytes", see pages 1429-1433. *
Science, Vol. 244, 02 June 1989, Hildreth et al., "Involvement of a leukocyte adhesion receptor (LFA-1) in HIV-induced syncytium formation", see pages 1075-1078. *
The Journal of Cell Biology, Vol. 107, July 1988, Dustin et al., "Lymphocyte function-associated antigen-1 (LFA-1) interaction with intra cellular adhesion molecule-1 (ICAMO1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells", see pages 321-331. *
The Journal of Immunology, Vol. 137, No. 1, 01 July 1986, Dustin et al., "Induction by Il-1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1)", see entire article. *
The Journal of Immunology, Vol. 137, No. 4, 15 August 1986, Rothlein et al., "A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1", see entire article. *
The Journal of Immunology, Vol. 144, No. 3, 01 February 1990, Valentin et al. "The leukocyte adhesion glycoprotein CD18 participates in HIV-1-induced syncytia formation in monocytoid and T cells", see pages 934-937. *
V International Conference on Aids, Montreal, Canada, 4-9 Jume 1989, Valentin et al., "Inhibition of HIV-1 induced syncytia formation by monoclonal antibodies to the membrane adhesion protein in CD18", see abstract #TC03, pg. 515 *

Also Published As

Publication number Publication date
AU5568290A (en) 1990-11-29
ZA903258B (en) 1991-02-27
WO1990013281A2 (en) 1990-11-15

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