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WO1990010017A1 - Facteur de regeneration osseuse et peridentaire avec matieres et procedes correspondants - Google Patents

Facteur de regeneration osseuse et peridentaire avec matieres et procedes correspondants Download PDF

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Publication number
WO1990010017A1
WO1990010017A1 PCT/US1990/001025 US9001025W WO9010017A1 WO 1990010017 A1 WO1990010017 A1 WO 1990010017A1 US 9001025 W US9001025 W US 9001025W WO 9010017 A1 WO9010017 A1 WO 9010017A1
Authority
WO
WIPO (PCT)
Prior art keywords
factor
growth factor
cells
periodontal ligament
pdl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1990/001025
Other languages
English (en)
Inventor
Victor P. Terranova
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CYTOTAXIS Inc
Original Assignee
CYTOTAXIS Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CYTOTAXIS Inc filed Critical CYTOTAXIS Inc
Publication of WO1990010017A1 publication Critical patent/WO1990010017A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Definitions

  • the invention also relates to a composition useful for periodontal regeneration which comprises a pharmaceutically acceptable amount of said PDL-CTX factor and a pharmaceutically acceptable medium.
  • the invention further relates to a kit useful for periodontal regeneration, which includes said PDL-CTX factor.
  • Figure 4 is a graphical representation of data which shows the effect of various concentrations of TGF- ⁇ and TGF-ß on the chemotaxis of PDL cells where migration is assayed using ASSAY 1, all factors are allowed to bind to TTC conditioned dentin (dentin preconditioned in 100 mg/ml of tetracycline HCl) for 30 minutes at 37oC in 100% humidity, PDL cell
  • NH 2 terminal sequence data indicate a unique peptide.
  • Information from the NIH (U.S. National Institutes of Health) data banks indicates that there is no
  • a chemotactic factor for PDL cells is
  • the present invention further relates to an isolated periodontal ligament cellattractant protein obtainable from human periodontal ligament cells, said protein comprising an initial amino acid sequence, from the N-terminal, as follows: Val Pro Asp Ser Ser Ala His Lys Lys Ala ... .
  • the separated or PDL-CTX factor or concentrate thereof is a component of the composition of the invention.
  • a pharmaceutically acceptable amount of the PDL-CTX factor will vary depending upon the intended use, and depending upon the activity of the concentrate. The acceptable amount also may be in an acceptable dosage form for application to teeth or to bone. The acceptable amount of the factor is combined with a pharmaceutically acceptable medium to form the composition of the invention.
  • porous type 1 collagen barriers (100 ⁇ m pore size) are overlayed on gelatin-coated 1 ⁇ m pore Nuclepore filters and the selection procedure repeated.
  • the cells that migrate through the collagen barriers attach to the collagen-coated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Facteur isolé d'attraction des cellules de ligaments péridentaires (PDL-CTX), utile pour la régénération péridentaire et osseuse, comprenant une protéine tirée des cellules de ligaments péridentaires. Ce facteur exerce une attraction chimique sur les cellules de ligaments péridentaires (PDL-). Il peut être combiné avec des facteurs de croissance polypeptidique dans des composés et des kits. Les procédés de régénération péridentaire comprennent l'utilisation du facteur PDL-CTX, l'utilisation de cellules PDL pour une meilleure réaction chimiotactique au facteur PDL-CTX, et/ou l'utilisation d'une membrane basale artificielle à sélection cellulaire.
PCT/US1990/001025 1989-02-23 1990-02-22 Facteur de regeneration osseuse et peridentaire avec matieres et procedes correspondants Ceased WO1990010017A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31449789A 1989-02-23 1989-02-23
US314,497 1989-02-23

Publications (1)

Publication Number Publication Date
WO1990010017A1 true WO1990010017A1 (fr) 1990-09-07

Family

ID=23220194

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1990/001025 Ceased WO1990010017A1 (fr) 1989-02-23 1990-02-22 Facteur de regeneration osseuse et peridentaire avec matieres et procedes correspondants

Country Status (5)

Country Link
EP (1) EP0413794A4 (fr)
JP (1) JPH03505218A (fr)
AU (2) AU5197790A (fr)
CA (1) CA2027583A1 (fr)
WO (1) WO1990010017A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5270300A (en) * 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
WO1994006399A1 (fr) * 1992-09-15 1994-03-31 Creative Biomolecules, Inc. Regeneration tissulaire periodontique induite par des morphogenes
US5368858A (en) * 1991-01-31 1994-11-29 Robert F. Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage
US5656593A (en) * 1991-03-11 1997-08-12 Creative Biomolecules, Inc. Morphogen induced periodontal tissue regeneration
US6531445B1 (en) 1991-03-11 2003-03-11 Curis, Inc. Protein-induced morphogenesis in liver tissue

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3382562D1 (de) * 1982-09-24 1992-06-25 Us Health Wiederherstellung von gewebe bei tieren.

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
Bio. Abstract Vol. 84 Abstract No. 96079 1987 MIKE et al. "Mitogenic Activity of Cementum Components to Gingival Fibroblasts" see the Abstract. *
Cancer Research Vol. 45, issued August 1985, pp 3517-3521 HUJANEN et al. "Migration of Tumor Cells of Organ-Derived Chemoattractants" see the Abstract *
J. Cell Biology Vol. 101 December 1985, pp 2330-2337 TERRANOVA et al. "Human Endothelial Cells are Chemotactic to Endothelial Cell Growth Factor and Heparin" see the Abstract and Discussion. *
J. Periodontal Research Vol. 22, issued 1987, pp 248-251 TERRANOVA et al. "Biochemically Medicated Periodontal Regeneration" see the entire article. *
J. Periodontal Research, Vol. 17 issued 1982, pp 530-533 TERRANOVA et al. "Molecular Factors Determining Gingival Tissue Interaction with Tooth Structure" see the entire article. *
J. Periodontology Vol. 57 No. 5, issued May 1986, pp 311-317 TERRANOVA et al. "Chemotoxis of Human Gingival Epitnelial Cells to Laminin" see the Abstract and Discussion. *
J. Periodontology Vol. 58 No. 6 issued June 1987, pp 371-380 TERRANOVA et al. "Extracellular Matrices and Polypeptide Growth Factors as Mediators of Functions of Cells of the Peridontin" see the entire article. *
J. Periodontology Vol. 58, No. 4, April 1987, pp 247-257 "A Biochemical Approach to Periodontal Regeneration" TERRANOVA et al. see the entire article. *
Proc. Natl. Acad. Sci. Vol. 83 pp 465-469, issued January 1986, TERRANOVA et al. "Use of a Reconstituted Basement Membrane to Measure Cell Invasiveness and Select for Highly Invasion Tumor Cells" see the entire article. *
See also references of EP0413794A4 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5368858A (en) * 1991-01-31 1994-11-29 Robert F. Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage
US5656593A (en) * 1991-03-11 1997-08-12 Creative Biomolecules, Inc. Morphogen induced periodontal tissue regeneration
US5733878A (en) * 1991-03-11 1998-03-31 Creative Biomolecules, Inc. Morphogen-induced periodontal tissue regeneration
US6531445B1 (en) 1991-03-11 2003-03-11 Curis, Inc. Protein-induced morphogenesis in liver tissue
US7196056B2 (en) 1991-03-11 2007-03-27 Curis, Inc. Protein-induced morphogenesis of kidney tissue
US5270300A (en) * 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
WO1994006399A1 (fr) * 1992-09-15 1994-03-31 Creative Biomolecules, Inc. Regeneration tissulaire periodontique induite par des morphogenes

Also Published As

Publication number Publication date
EP0413794A4 (en) 1992-02-26
AU5197790A (en) 1990-09-26
EP0413794A1 (fr) 1991-02-27
AU4610993A (en) 1993-12-02
JPH03505218A (ja) 1991-11-14
CA2027583A1 (fr) 1990-08-24

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