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WO1990010067A1 - Sequences d'adn codant pour des variantes de pth, variantes de pth, vecteur d'expression, hote bacterien, utilisation et composition therapeutique - Google Patents

Sequences d'adn codant pour des variantes de pth, variantes de pth, vecteur d'expression, hote bacterien, utilisation et composition therapeutique Download PDF

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Publication number
WO1990010067A1
WO1990010067A1 PCT/EP1990/000312 EP9000312W WO9010067A1 WO 1990010067 A1 WO1990010067 A1 WO 1990010067A1 EP 9000312 W EP9000312 W EP 9000312W WO 9010067 A1 WO9010067 A1 WO 9010067A1
Authority
WO
WIPO (PCT)
Prior art keywords
amino acids
terminal
dna sequence
variant
pth
Prior art date
Application number
PCT/EP1990/000312
Other languages
German (de)
English (en)
Inventor
Edgar Wingender
Heiko Mielke
Gisela Bercz
Klaus-Dieter Schlüter
Hubert Mayer
Original Assignee
GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) filed Critical GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF)
Priority to US07/573,219 priority Critical patent/US5457047A/en
Publication of WO1990010067A1 publication Critical patent/WO1990010067A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des séquences d'ADN codant pour des variantes de PTH, ces variantes, des vecteurs d'expression, des hôtes bactériens, leurs applications et compositions thérapeutiques.
PCT/EP1990/000312 1989-02-23 1990-02-23 Sequences d'adn codant pour des variantes de pth, variantes de pth, vecteur d'expression, hote bacterien, utilisation et composition therapeutique WO1990010067A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US07/573,219 US5457047A (en) 1989-02-23 1990-02-23 DNA Sequences coding for PTH variants, PTH variants, expression vector, bacterial host, use and therapeutic composition

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3905606 1989-02-23
DEP3905606.6 1989-02-23

Publications (1)

Publication Number Publication Date
WO1990010067A1 true WO1990010067A1 (fr) 1990-09-07

Family

ID=6374759

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1990/000312 WO1990010067A1 (fr) 1989-02-23 1990-02-23 Sequences d'adn codant pour des variantes de pth, variantes de pth, vecteur d'expression, hote bacterien, utilisation et composition therapeutique

Country Status (4)

Country Link
US (2) US5457047A (fr)
EP (1) EP0411096A1 (fr)
JP (1) JPH03504201A (fr)
WO (1) WO1990010067A1 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2269176A (en) * 1992-07-15 1994-02-02 Sandoz Ltd Parathyroid hormone variants
US5382658A (en) * 1992-04-03 1995-01-17 Allelix Biopharmaceuticals Inc. Stability-enhanced variants of parathyroid hormone
US5599792A (en) * 1992-06-19 1997-02-04 Allelix Biopharmaceuticals Inc. Bone-stimulating, non-vasoactive parathyroid hormone variants
US5814603A (en) * 1992-06-12 1998-09-29 Affymax Technologies N.V. Compounds with PTH activity
EP0847278A4 (fr) * 1995-07-13 1999-01-13 Biomeasure Inc Analogues de la parathormone
US5955574A (en) * 1995-07-13 1999-09-21 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. Analogs of parathyroid hormone
US5969095A (en) * 1995-07-13 1999-10-19 Biomeasure, Inc. Analogs of parathyroid hormone
US6544949B1 (en) 1995-07-13 2003-04-08 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Analogs of parathyroid hormone
US7410948B2 (en) 1995-07-13 2008-08-12 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Analogs of parathyroid hormone

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150328A (en) 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
AU674500B2 (en) 1991-11-04 1997-01-02 Genetics Institute, Llc Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
US5589452A (en) * 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
CA2176942C (fr) 1993-12-07 2011-11-01 Anthony J. Celeste Bmp-12, bmp-13 et compositions de celles-ci pour l'induction de tendons
US5700774A (en) * 1996-03-26 1997-12-23 Genetics Institute, Inc. Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
PT1223990E (pt) 1999-10-15 2004-12-31 Fidia Advanced Biopolymers Srl Formulacoes de acido hialuronico para administracao de proteinas osteogenicas
CA2449008A1 (fr) 2001-06-01 2002-12-12 Wyeth Compositions et methodes pour l'administration systemique de sequences codant pour des proteines morphogenetiques osseuses
TWI267378B (en) 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
PL1675608T3 (pl) 2003-09-12 2007-11-30 Wyeth Corp Stałe fosforanowo wapniowe pałeczki do wstrzyknięć dla dostarczania białek osteogennych
US20060166251A1 (en) * 2005-01-26 2006-07-27 Archambault Joanne M Use of sFRPs as markers of BMP activity
CA2601436A1 (fr) * 2005-03-30 2006-10-05 Wyeth Methodes pour stimuler la pousse des cheveux par administration de proteines bmp
CA2694562A1 (fr) * 2007-08-09 2009-02-12 Usv Limited Nouveau procede orthogonal pour la purification de l'hormone parathyroidienne humaine recombinante (rhpth) (1-34)
US20090227503A1 (en) * 2008-02-07 2009-09-10 University Of Rochester Parathyroid hormone treatment for enhanced allograft and tissue-engineered reconstruction of bone defects

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3886132A (en) * 1972-12-21 1975-05-27 Us Health Human parathyroid hormone
US4423037A (en) * 1982-05-13 1983-12-27 The General Hospital Corporation Inhibitors of peptide hormone action
EP0301485A1 (fr) * 1987-07-30 1989-02-01 Gesellschaft für Biotechnologische Forschung mbH (GBF) Vecteurs d'expression et procédé les utilisant pour la production de protéines de fusion de cro/bêta-galactosidase/PTH et de PTH
EP0301484A1 (fr) * 1987-07-30 1989-02-01 Gesellschaft für Biotechnologische Forschung mbH (GBF) Modifications de PTH et compositions thérapeutiques les contenant ou composées d'elles

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3886132A (en) * 1972-12-21 1975-05-27 Us Health Human parathyroid hormone
US4423037A (en) * 1982-05-13 1983-12-27 The General Hospital Corporation Inhibitors of peptide hormone action
EP0301485A1 (fr) * 1987-07-30 1989-02-01 Gesellschaft für Biotechnologische Forschung mbH (GBF) Vecteurs d'expression et procédé les utilisant pour la production de protéines de fusion de cro/bêta-galactosidase/PTH et de PTH
EP0301484A1 (fr) * 1987-07-30 1989-02-01 Gesellschaft für Biotechnologische Forschung mbH (GBF) Modifications de PTH et compositions thérapeutiques les contenant ou composées d'elles

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Acta Endocrinol., Band 287, Suppl. 117, 1988, E. WINGENDER et al.: "Proten Design of Peptide Hormones: Parathyroid Hormone as an Example", seite 63, siehe die Zusammenfassung *
Biochemistry, Band 29, 13. Februar 1990, American Chemical Society, M. CHOREV et al.: "Modifications of Position 12 in Parathyroid Hormone and Parathyroid Hormone Related Protein: Toward the Design of Highly Potent Antagonists", seiten 1580-1586, siehe den ganze artikel, besonders tabelle II auf seite 1583 *
The New England Journal of Medicine, Band 315, Nr. 16, 16. Oktober 1986, M. ROSENBLATT: "Peptide Hormone Antagonists that are Effective in Vivo", seiten 1004-1013 siehe den ganze artikel *

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5382658A (en) * 1992-04-03 1995-01-17 Allelix Biopharmaceuticals Inc. Stability-enhanced variants of parathyroid hormone
US5814603A (en) * 1992-06-12 1998-09-29 Affymax Technologies N.V. Compounds with PTH activity
US5599792A (en) * 1992-06-19 1997-02-04 Allelix Biopharmaceuticals Inc. Bone-stimulating, non-vasoactive parathyroid hormone variants
AT408100B (de) * 1992-07-15 2001-08-27 Novartis Erfind Verwalt Gmbh Pth-analoga
WO1994002510A3 (fr) * 1992-07-15 1994-05-26 Sandoz-Erfindungen Verwaltungsgesellschaft M.B.H. Analogues de parathormone
EP0672057A1 (fr) * 1992-07-15 1995-09-20 Novartis AG Analogues de parathormone
GB2269176B (en) * 1992-07-15 1997-01-08 Sandoz Ltd Peptides
DE4393381B4 (de) * 1992-07-15 2008-07-17 Novartis Ag PTH-Verbindungen mit PTH-ähnlicher Aktivität, Verfahren zu deren Herstellung, diese enthaltende pharmazeutische Zusammensetzungen und deren Verwendungen
GB2269176A (en) * 1992-07-15 1994-02-02 Sandoz Ltd Parathyroid hormone variants
US5955574A (en) * 1995-07-13 1999-09-21 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. Analogs of parathyroid hormone
US5969095A (en) * 1995-07-13 1999-10-19 Biomeasure, Inc. Analogs of parathyroid hormone
US6544949B1 (en) 1995-07-13 2003-04-08 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Analogs of parathyroid hormone
EP1405861A3 (fr) * 1995-07-13 2004-07-21 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Analogues de l'hormone parathyroide
US6921750B2 (en) 1995-07-13 2005-07-26 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Analogs of parathyroid hormone
EP0847278A4 (fr) * 1995-07-13 1999-01-13 Biomeasure Inc Analogues de la parathormone
US7410948B2 (en) 1995-07-13 2008-08-12 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Analogs of parathyroid hormone
CN100412091C (zh) * 1995-07-13 2008-08-20 提议和科学执行公司 甲状旁腺素类似物
USRE40850E1 (en) 1995-07-13 2009-07-14 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Analogs of parathyroid hormone
US7632811B2 (en) 1995-07-13 2009-12-15 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Analogs of parathyroid hormone

Also Published As

Publication number Publication date
EP0411096A1 (fr) 1991-02-06
JPH03504201A (ja) 1991-09-19
US5455329A (en) 1995-10-03
US5457047A (en) 1995-10-10

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