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WO1990008529A3 - 7-alkoxycoumarins, dihydropsoralens, and benzodipyranones as photo-activated therapeutic agents and inhibitors of epidermal growth factor - Google Patents

7-alkoxycoumarins, dihydropsoralens, and benzodipyranones as photo-activated therapeutic agents and inhibitors of epidermal growth factor Download PDF

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Publication number
WO1990008529A3
WO1990008529A3 PCT/US1990/000704 US9000704W WO9008529A3 WO 1990008529 A3 WO1990008529 A3 WO 1990008529A3 US 9000704 W US9000704 W US 9000704W WO 9008529 A3 WO9008529 A3 WO 9008529A3
Authority
WO
WIPO (PCT)
Prior art keywords
benzodipyranones
alkoxycoumarins
dihydropsoralens
inhibitors
photo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1990/000704
Other languages
French (fr)
Other versions
WO1990008529A2 (en
Inventor
Ned Duane Heindel
Michele Carole Siller
Jeffrey Dean Laskin
Michael A Gallo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rutgers State University of New Jersey
Lehigh University
Original Assignee
Rutgers State University of New Jersey
Lehigh University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rutgers State University of New Jersey, Lehigh University filed Critical Rutgers State University of New Jersey
Publication of WO1990008529A2 publication Critical patent/WO1990008529A2/en
Publication of WO1990008529A3 publication Critical patent/WO1990008529A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)

Abstract

A photochemotherapeutic compound of formula (I), wherein (i) n is zero, W is a (C1-16) alkyl, alkenyl, or alkynyl linear or branched chain hydrocarbon, having no more than four O, N, or S atoms in or attached to the chain; or (ii) n is 1, W is CR2, and R, R', and R'' are independently H or CH3; or (iii) n is 2, W is CR2, and R, R', and R'' are independently H or CH3; and A, B, C, and D are independently selected from hydrogen, alkyl, aryl, halogen, amino, aminoalkyl, nitro, alkoxy, aryloxy, hydroxy, carboxy, haloalkyl, or haloalkoxy.
PCT/US1990/000704 1989-01-23 1990-01-23 7-alkoxycoumarins, dihydropsoralens, and benzodipyranones as photo-activated therapeutic agents and inhibitors of epidermal growth factor Ceased WO1990008529A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30086989A 1989-01-23 1989-01-23
US300,869 1989-01-23

Publications (2)

Publication Number Publication Date
WO1990008529A2 WO1990008529A2 (en) 1990-08-09
WO1990008529A3 true WO1990008529A3 (en) 1990-09-20

Family

ID=23160933

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1990/000704 Ceased WO1990008529A2 (en) 1989-01-23 1990-01-23 7-alkoxycoumarins, dihydropsoralens, and benzodipyranones as photo-activated therapeutic agents and inhibitors of epidermal growth factor

Country Status (1)

Country Link
WO (1) WO1990008529A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9027449D0 (en) * 1990-12-19 1991-02-06 Duck Edward W Skin care composition
US6255324B1 (en) 1998-11-25 2001-07-03 Ned D. Heindel Amino-and mercurio-substituted 4′,5'-dihydropsoralens and therapeutical uses thereof
US7026484B2 (en) * 2001-02-23 2006-04-11 Ligand Pharmaceuticals Incorporated Tricyclic androgen receptor modulator compounds and methods
US8731655B2 (en) 2009-05-12 2014-05-20 Mallinckrodt Llc Compounds containing acyclic N-N bonds for phototherapy
WO2010132554A2 (en) 2009-05-12 2010-11-18 Mallinckrodt Inc. Diaza heterocyclic compounds for phototherapy
CN115197236B (en) * 2022-06-29 2023-09-19 广西中医药大学 Linear type glabra A analogue and preparation and application thereof
CN119409706A (en) * 2024-10-30 2025-02-11 中国科学院新疆理化技术研究所 Furanocoumarin enantiomers in fig fruit and preparation method and use thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4151291A (en) * 1976-11-24 1979-04-24 Unicler Ethers of 7-hydroxy-coumarin useful as medicaments
US4208426A (en) * 1977-07-28 1980-06-17 Eisai Co., Ltd. Pyranochromone derivatives and therapeutic composition comprising same for treatment of allergic diseases
US4260630A (en) * 1977-08-29 1981-04-07 Agence Nationale De Valorisation De La Recherche (Anvar) Skin diseases
US4312883A (en) * 1979-08-20 1982-01-26 Consiglio Nazionale Delle Ricerche Furocoumarin for the photochemotherapy of psoriasis and related skin diseases
US4452811A (en) * 1977-11-17 1984-06-05 Fidia S.P.A. Monohalogenated derivatives of 7-hydroxy-coumarin, pharmaceutical compositions containing the same and methods of using said compositions
US4737517A (en) * 1983-07-29 1988-04-12 Fidia, S.P.A. Coumarin derivatives, pharmaceutical compositions containing the same, and the use thereof in the treatment of cancer

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4151291A (en) * 1976-11-24 1979-04-24 Unicler Ethers of 7-hydroxy-coumarin useful as medicaments
US4208426A (en) * 1977-07-28 1980-06-17 Eisai Co., Ltd. Pyranochromone derivatives and therapeutic composition comprising same for treatment of allergic diseases
US4260630A (en) * 1977-08-29 1981-04-07 Agence Nationale De Valorisation De La Recherche (Anvar) Skin diseases
US4452811A (en) * 1977-11-17 1984-06-05 Fidia S.P.A. Monohalogenated derivatives of 7-hydroxy-coumarin, pharmaceutical compositions containing the same and methods of using said compositions
US4312883A (en) * 1979-08-20 1982-01-26 Consiglio Nazionale Delle Ricerche Furocoumarin for the photochemotherapy of psoriasis and related skin diseases
US4737517A (en) * 1983-07-29 1988-04-12 Fidia, S.P.A. Coumarin derivatives, pharmaceutical compositions containing the same, and the use thereof in the treatment of cancer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF HETEROCYCLIC CHEMISTRY, Vol. 24, (March-April 1987), RODIGHIERO et al., "Synthesis of Methyl Derivatives of 8-Desmethylxanthyleting and 8-Desmethylsoseline, Potential Antiproliverative Agents", pages 485-88. *

Also Published As

Publication number Publication date
WO1990008529A2 (en) 1990-08-09

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