[go: up one dir, main page]

WO1990007321A3 - Lymphocyte receptor homing sequences and their uses - Google Patents

Lymphocyte receptor homing sequences and their uses Download PDF

Info

Publication number
WO1990007321A3
WO1990007321A3 PCT/US1989/005067 US8905067W WO9007321A3 WO 1990007321 A3 WO1990007321 A3 WO 1990007321A3 US 8905067 W US8905067 W US 8905067W WO 9007321 A3 WO9007321 A3 WO 9007321A3
Authority
WO
WIPO (PCT)
Prior art keywords
homing
proteins
lymphocyte receptor
homing sequences
inhibiting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1989/005067
Other languages
French (fr)
Other versions
WO1990007321A2 (en
Inventor
Irving L. Weissman
Bernard Holzmann
Mark H. Siegelman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Publication of WO1990007321A2 publication Critical patent/WO1990007321A2/en
Anticipated expiration legal-status Critical
Publication of WO1990007321A3 publication Critical patent/WO1990007321A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Proteins are identified as homing receptors for Peyer's patches and lymph nodes, where the proteins may be used for inhibiting homing of lymphocytes or providing for homing of drugs or other compositions for in vivo diagnosis or therapy. In addition, nucleic acid compositions are provided which may be used for expression of the proteins or fragments thereof or for transforming cells to provide for enhanced homing capability or for inhibiting or modulating such homing.
PCT/US1989/005067 1988-12-23 1989-11-10 Lymphocyte receptor homing sequences and their uses Ceased WO1990007321A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US28920188A 1988-12-23 1988-12-23
US289,201 1988-12-23
US31573689A 1989-02-24 1989-02-24
US315,736 1989-02-24

Publications (2)

Publication Number Publication Date
WO1990007321A2 WO1990007321A2 (en) 1990-07-12
WO1990007321A3 true WO1990007321A3 (en) 2010-05-27

Family

ID=26965504

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1989/005067 Ceased WO1990007321A2 (en) 1988-12-23 1989-11-10 Lymphocyte receptor homing sequences and their uses

Country Status (3)

Country Link
EP (1) EP0462111A4 (en)
JP (1) JPH04504501A (en)
WO (1) WO1990007321A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776775A (en) * 1989-02-21 1998-07-07 Dana-Farber Cancer Institute Anti-LAM 1-3 antibody and hybridoma
US7238668B1 (en) 1989-09-01 2007-07-03 Fred Hutchinson Cancer Research Center Inhibition of lymphocyte adherence with CS-1-peptides and fragments thereof
US7803904B2 (en) 1995-09-01 2010-09-28 Millennium Pharmaceuticals, Inc. Mucosal vascular addressing and uses thereof
US6551593B1 (en) 1995-02-10 2003-04-22 Millennium Pharmaceuticals, Inc. Treatment of Inflammatory bowel disease by inhibiting binding and/or signalling through α 4 β 7 and its ligands and madcam
US7750137B2 (en) 1995-09-01 2010-07-06 Millennium Pharmaceuticals, Inc. Mucosal vascular addressins
US7147851B1 (en) 1996-08-15 2006-12-12 Millennium Pharmaceuticals, Inc. Humanized immunoglobulin reactive with α4β7 integrin
US6111090A (en) * 1996-08-16 2000-08-29 Schering Corporation Mammalian cell surface antigens; related reagents
RU2404805C2 (en) 2005-08-25 2010-11-27 Аризона Боард Оф Риджентс Он Бехаф Оф Зе Юниверсити Оф Аризона Method of inhibiting migration of cancer cells
UA116189C2 (en) 2011-05-02 2018-02-26 Мілленніум Фармасьютікалз, Інк. COMPOSITION OF ANTI-α4β7 ANTIBODY
SMT201700515T1 (en) 2011-05-02 2018-01-11 Millennium Pharm Inc Formulation for anti- 4 7 antibody
WO2024249568A1 (en) 2023-05-30 2024-12-05 Paragon Therapeutics, Inc. Alpha4beta7 integrin antibody compositions and methods of use

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3852236T2 (en) * 1987-08-11 1995-04-06 Univ Leland Stanford Junior Procedure for controlling leukocyte extravasation.

Non-Patent Citations (21)

* Cited by examiner, † Cited by third party
Title
CELL, Volume 56, issued 24 March 1989, GOLDSTEIN et al., "A Human Lymphocyte Homing Receptor, the Hermes Antigen is Related to Cartilage Proteoglycan Core and Link Proteins", pages 1063-1072. *
CELL, Volume 56, issued 24 March 1989, JOHNSTON et al., "Cloning of GMP-140, a Granule Membrane Protein of Platelets and Endothelium: Sequence Similarity to Proteins Involved in Cell Adhesion and Inflammation", pages 1033-1044. *
CELL, Volume 56, issued 24 March 1989, LASKY et al., "Cloning of a Lymphocyte Homing Receptor Reveals a Lectin Domain", pages 1045-1055. *
CELL, Volume 56, issued 24 March 1989, STAMENKOVIC et al., "A Lymphocyte Molecule Implicated in Lymph Node Homing is a Member of the Cartilage Link Protein Family", pages 1057-1062. *
JOURNAL OF MOLECULAR BIOLOGY, Volume 196, issued 12 January 1987, VAN HET SCHIP et al., "Nucleotide Sequence of the Encoded Yolk Precursor Protein", pages 245-260. *
NATURE, Volume 304, issued 07 July 1983, GALLATIN et al., "A Cell-Surface Molecule Involved in Organ-Specific Homing of Lymphocytes", pages 30-34. *
NATURE, Volume 309, issued 17 May 1984, MROCZKOWSKI et al., "ATP-Stimulated Interaction Between Epidermal Growth Factor Receptor and Supercoiled DNA", pages 270-273. *
NATURE, Volume 309, issued 28 June 1984, XU et al., "Human Epidermal Growth Factor Receptor cDNA is Homologous to a Variety of RNAs Overproduced in A431 Carcinoma Cells", pages 806-810. *
NATURE, Volume 309, issued 31 May 1984, ULLRICH et al., "Human Epidermal Growth Factor Receptor cDNA Sequence and Aberrant Expression of the Amplified Gene in A431 Epidermoid Carcinoma Cells", pages 418-425. *
NATURE, Volume 320, issued 13 March 1986, NODA et al., "Existence of Distinct Sodium Channel Messenger RNAs in Rat Brain", pages 188-192. *
NUCLEIC ACIDS RESEARCH, Volume 12, No. 2, issued 1984, BURCH et al., "Identification and Sequence Analysis of the 5' End of the Major Chicken Vitellogenin Gene", pages 1117-1135. *
PROC. NATL. ACAD. SCI. U.S.A., Volume 78, No. 2, issued February 1981, SHINODA et al., "Complete Amino Acid Sequence of the Fc Region of a Human O Chain", pages 785-789. *
SCIENCE, Volume 224, issued 25 May 1984, LIN et al., "Expression Cloning of Human EGF Receptor Complementary DNA: Gene Amplification and Three Related Messenger RNA Products in A431 Cells", pages 843-848. *
SCIENCE, Volume 231, issued 21 February 1986, SIEGELMAN et al., "Cell Surface Molecule Associated with Lymphocyte Homing is Ubiquitinated Branched-Chain Glycoprotein", pages 823-829. *
SCIENCE, Volume 231, issued 21 February 1986, St. JOHN et al., "Expression Cloning of a Lymphocyte Homing Receptor cDNA: Ubiquitin is the Reactive Species", pages 845-850. *
SCIENCE, Volume 243, issued 03 March 1989, BEVILACQUA et al., "Endothelial Leukocyte Adhesion Molecule 1- an Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins", pages 1160-1165. *
SCIENCE, Volume 243, issued 03 March 1989, SIEGELMAN et al., "Mouse Lymph Node Homing Receptor cDNA Clone Encodes a Glycoprotein Revealing Tandem Interaction Domains", pages 1165-1172. *
See also references of EP0462111A1 *
THE JOURNAL OF IMMUNOLOGY, Volume 143, No. 10, issued 15 November 1989, JUTILA et al., "Function and Regulation of the Neutrophil MEL-14 Antigen In Vivo: Comparison with LFA-1 and MAC-1", pages 3318-3324. *
THE JOURNAL OF IMMUNOLOGY, Volume 143, No. 10, issued 15 November 1989, ZHOU et al., "Molecular Cloning and Expression of Pgp-1", pages 3390-3395. *
UBIQUITIN, Edited by MARTIN RECHSTEINER, issued 1988, PLENUM PUBLISHING CORPORATION, SIEGELMAN et al., "Lymphocyte Homing Receptors, Ubiquitin and Cell Surface Proteins", pages 239-269. *

Also Published As

Publication number Publication date
EP0462111A4 (en) 1992-07-08
JPH04504501A (en) 1992-08-13
EP0462111A1 (en) 1991-12-27
WO1990007321A2 (en) 1990-07-12

Similar Documents

Publication Publication Date Title
WO1995016038A3 (en) Humanized antibodies and uses thereof
AU2790292A (en) Viral recombinant vectors for expression in muscle cells
EP0853121A3 (en) Human DNase
EP1923467A3 (en) Adenovirus vectors for gene therapy
FI92258B (en) Use of oncostatin-A in diagnostic procedure
ATE183514T1 (en) HUMAN PROTEIN P53 PEPTIDES FOR USE IN HUMAN CYTOTOXIC T CELL RESPONSE-INDUCING COMPOSITIONS AND HUMAN P53 PROTEIN SPECIFIC T LYMPHOCYTES
BG101781A (en) SOLID PREPARATION CONTAINING ACTIVE SUBSTANCE
NZ306653A (en) Isolated dna il-17 receptors
AU6024486A (en) Surgical fastener made from glycolide-rich polymer blends
EP1005540A4 (en) Ikk-beta proteins, nucleic acids and methods
PT1053256E (en) Antibodies to death receptor 4 (dr4) and uses thereof
ATE177757T1 (en) IMPROVED IMMUNOGENIC COMPOSITION AGAINST HUMAN GASTRIN 17
WO1990007321A3 (en) Lymphocyte receptor homing sequences and their uses
WO1998058957A3 (en) Disulfide cross-linked glycoprotein hormone analogs, their preparation and use
TR199700834T1 (en) 1-Aryl-2-Acylamino ethane compounds and their use as neurokinin, particularly as neurokinin 1 antagonists.
CA2294476A1 (en) Semaphorin receptors
EP0228192A3 (en) Renin-inhibitory oligopeptides, their preparation and use
MA19882A1 (en) Derivatives of w-amino acids, their preparation and use as well as the compositions containing these acids.
EP1005539A4 (en) IKK-$g(a) PROTEINS, NUCLEIC ACIDS AND METHODS
NZ230155A (en) N-2,3-butadienyl-n"-substituted-triamindalkanes and alkenes, and pharmaceutical compositions
AU7717087A (en) Proteins and the method for preparing them, DNA sequences, antibodies and their application, poxviruses, transformed or infected cells, pharmaceutical compositions which are useful in the prevention of schistosomiasis and application by way of an agent possessing glutathione s-transferase activity
DE68914700D1 (en) Polymer compositions and their preparation.
EP0344979A3 (en) Alfa-adrenergic receptor antagonists
IL110585A0 (en) Tripeptides, their preparation and pharmaceutical compositions containing them
EP0344980A3 (en) Alpha-adrenergic receptor antagonists

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): JP

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE FR GB IT LU NL SE

AK Designated states

Kind code of ref document: A3

Designated state(s): JP

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE FR GB IT LU NL SE

CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i

Free format text: IN PAT.BUL.16/90,UNDER INID (54) TITLE REPLACE THE EXISTING TEXT BY "LYMPHOCYTE RECEPTOR HOMING SEQUENCES AND THEIR USES"

WWE Wipo information: entry into national phase

Ref document number: 1990902104

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1990902104

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1990902104

Country of ref document: EP

DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)