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WO1990007111A3 - Method for predicting biological activity of antibiotics, and novel non beta-lactam antibacterial agents derived therefrom - Google Patents

Method for predicting biological activity of antibiotics, and novel non beta-lactam antibacterial agents derived therefrom Download PDF

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Publication number
WO1990007111A3
WO1990007111A3 PCT/GB1989/001493 GB8901493W WO9007111A3 WO 1990007111 A3 WO1990007111 A3 WO 1990007111A3 GB 8901493 W GB8901493 W GB 8901493W WO 9007111 A3 WO9007111 A3 WO 9007111A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibiotics
biological activity
derived therefrom
antibacterial agents
novel non
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB1989/001493
Other languages
French (fr)
Other versions
WO1990007111A2 (en
Inventor
Saul Wolfe
Stephen Bruder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Queens University at Kingston
Original Assignee
Queens University at Kingston
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Queens University at Kingston filed Critical Queens University at Kingston
Publication of WO1990007111A2 publication Critical patent/WO1990007111A2/en
Publication of WO1990007111A3 publication Critical patent/WO1990007111A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

A molecular model of the interaction of various non β-lactam antibiotics with the active site of a penicillin receptor has been developed so that it is now possible to predict the ''fit'' and ''reactivity'' of potential antibacterial compounds with this receptor. Novel structural types and compounds are defined.
PCT/GB1989/001493 1988-12-14 1989-12-13 Method for predicting biological activity of antibiotics, and novel non beta-lactam antibacterial agents derived therefrom Ceased WO1990007111A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28450288A 1988-12-14 1988-12-14
US284,502 1988-12-14

Publications (2)

Publication Number Publication Date
WO1990007111A2 WO1990007111A2 (en) 1990-06-28
WO1990007111A3 true WO1990007111A3 (en) 1990-07-12

Family

ID=23090445

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1989/001493 Ceased WO1990007111A2 (en) 1988-12-14 1989-12-13 Method for predicting biological activity of antibiotics, and novel non beta-lactam antibacterial agents derived therefrom

Country Status (7)

Country Link
EP (1) EP0449871A1 (en)
JP (1) JPH03170053A (en)
CN (1) CN1046168A (en)
AU (1) AU4750990A (en)
CA (1) CA2005545A1 (en)
IL (1) IL92715A0 (en)
WO (1) WO1990007111A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05503691A (en) * 1989-12-29 1993-06-17 ユニバーシティ・テクノロジーズ・インターナショナル・インコーポレイテッド Methods for designing tertiary structure models of biologically active ligands, including agonists and antagonists, and novel synthetic antagonists based on angiotensin
HUT65361A (en) * 1989-12-29 1994-05-02 Univ Technologies Int Method for modelling tertiary structures of biologically active ligands including agonists and antagonists thereto and novel synthetic antagonists based on angiotensin
GB9010941D0 (en) * 1990-05-16 1990-07-04 Erba Carlo Spa Delta 2-cephem sulphones
CN119861173B (en) * 2023-10-20 2025-10-17 中国石油化工股份有限公司 Method, device and equipment for tracing gas pollution leakage under complex diffusion conditions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2245662B3 (en) * 1973-07-24 1977-05-20 Hoechst Ag
WO1982003860A1 (en) * 1981-04-29 1982-11-11 Gillet Claude Derivatives of 1,4-thiazane-carboxylic acid,preparation and utilization thereof and compositions containing same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2245662B3 (en) * 1973-07-24 1977-05-20 Hoechst Ag
WO1982003860A1 (en) * 1981-04-29 1982-11-11 Gillet Claude Derivatives of 1,4-thiazane-carboxylic acid,preparation and utilization thereof and compositions containing same

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
Archiv der Pharmazie, Vol. 321, No. 9, 1988 H.-D. Höltje et al: "Molecular modelling Studie zur differentiellen bindung von B-lactamen an penicillin-bindende proteine ", *
Canadian Journal of Chemistry, Vol. 66, No. 11, 1988 S Wolfe et al: "Conformation-activity relationships and the mechanism of action of penicillin ", *
Canadian Journal of Chemistry, Vol. 66, No. 11, 1988 S Wolfe et al: "MMPEN:Development and evaluation of penicillin parameters for Allinger's MMP2(85) programme ", *
Canadian Journal of Chemistry, Vol. 66, No. 11, 1988 S Wolfe et al: "Theoretical conformational analysis of peptides. Evolution of a strategy and its application to cholecystokinen analogs ", *
Int.J.Peptide Protein Res., Vol. 24, 1984 H Chuman et al: "Backbone conformations, bend structures, helix structures and other tests of an improved conformational energy program for peptides: ECEPP83 ", *
Nature, Vol. 325, 1987 Y Nozaki et al: "Binding of a non B-lactam antibiotic to penicillin binding proteins ", *
Patent Abstracts of Japan, Vol 10, No 193, C351, abstract of JP 61- 12691, publ 1986-01-21 *
Reviews of Infectious Diseases, Vol. 10, No. 4, 1988 J-M Ghuysen: "Bacterial active-site serine penicillin-interactive proteins and domains: mechanism, structure and evolution ", *
Tetrahedron, Vol. 45, No. 7, 1989 N.E. Allen et al: "Molecular modeling of y-lactam analogues of B-lactam antibacterial agents: synthesis and biological evaluation of selected penem and carbapenem analogues ", *

Also Published As

Publication number Publication date
AU4750990A (en) 1990-07-10
CA2005545A1 (en) 1990-06-14
CN1046168A (en) 1990-10-17
JPH03170053A (en) 1991-07-23
WO1990007111A2 (en) 1990-06-28
EP0449871A1 (en) 1991-10-09
IL92715A0 (en) 1990-09-17

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