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WO1990005523A3 - Phenanthrolinedicarboxylate esters, 4-aminoquinoline and isoquinoline derivatives as inhibitors of hiv reverse transcriptase - Google Patents

Phenanthrolinedicarboxylate esters, 4-aminoquinoline and isoquinoline derivatives as inhibitors of hiv reverse transcriptase Download PDF

Info

Publication number
WO1990005523A3
WO1990005523A3 PCT/US1989/004774 US8904774W WO9005523A3 WO 1990005523 A3 WO1990005523 A3 WO 1990005523A3 US 8904774 W US8904774 W US 8904774W WO 9005523 A3 WO9005523 A3 WO 9005523A3
Authority
WO
WIPO (PCT)
Prior art keywords
phenanthrolinedicarboxylate
aminoquinoline
esters
inhibitors
reverse transcriptase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1989/004774
Other languages
French (fr)
Other versions
WO1990005523A2 (en
Inventor
Irene W Althaus
Fritz Reusser
William Gary Tarpley
Louis L Skaletzky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of WO1990005523A2 publication Critical patent/WO1990005523A2/en
Publication of WO1990005523A3 publication Critical patent/WO1990005523A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

This invention relates to a new medical use of some phenanthrolinedicarboxylate esters, 4-aminoquinoline and isoquinoline derivatives as drugs to treat human patients afflicted with a human immunodeficiency virus. The compounds have formulae (IA), (IB), (IC), (ID), where R, R1, R2, R', R'1, R'', R''1, R''2, R3, R4 and X are defined in Claim 1.
PCT/US1989/004774 1988-11-15 1989-10-30 Phenanthrolinedicarboxylate esters, 4-aminoquinoline and isoquinoline derivatives as inhibitors of hiv reverse transcriptase Ceased WO1990005523A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US27156788A 1988-11-15 1988-11-15
US271,567 1988-11-15
US27936488A 1988-12-02 1988-12-02
US279,364 1988-12-02
US28744888A 1988-12-20 1988-12-20
US287,448 1988-12-20

Publications (2)

Publication Number Publication Date
WO1990005523A2 WO1990005523A2 (en) 1990-05-31
WO1990005523A3 true WO1990005523A3 (en) 1990-07-12

Family

ID=27402391

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1989/004774 Ceased WO1990005523A2 (en) 1988-11-15 1989-10-30 Phenanthrolinedicarboxylate esters, 4-aminoquinoline and isoquinoline derivatives as inhibitors of hiv reverse transcriptase

Country Status (3)

Country Link
AU (1) AU4488989A (en)
CA (1) CA2002414A1 (en)
WO (1) WO1990005523A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3002700B2 (en) * 1990-08-29 2000-01-24 化研生薬株式会社 Anti-AIDS virus agent
AU1580492A (en) * 1991-03-14 1992-10-21 Upjohn Company, The Reissert compounds as anti-hiv agents
JPH06504791A (en) * 1991-04-10 1994-06-02 オクタマー，インコーポレイティド Methods for inhibition of retrovirus replication
DE4344452A1 (en) * 1993-12-24 1995-06-29 Hoechst Ag Aza-4-iminoquinolines, process for their preparation and their use
DE69835430T2 (en) 1997-05-30 2007-03-08 Takeda Pharmaceutical Co. Ltd. Sulphonamide derivatives, their preparation and their use
CN1290254A (en) 1998-02-05 2001-04-04 武田药品工业株式会社 Sulfonamide derivatives process for producing the same and utilization thereof
CN108473435A (en) 2015-10-05 2018-08-31 纽约市哥伦比亚大学理事会 The treatment of the removing and protein sickness of the activator of autophagy tide and phospholipase D and the protein masses including TAU

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3790577A (en) * 1970-10-05 1974-02-05 Ici Ltd Pyridoquinoline dicarboxylic acid derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3790577A (en) * 1970-10-05 1974-02-05 Ici Ltd Pyridoquinoline dicarboxylic acid derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Chemical Abstracts, vol. 104, no. 11, 17 March 1986,(Columbus, Ohio, US), Z. Szulc et al: "The syntheses and properties of tricyclic azines as potential interferon inducers and antivirus agents", see page 650, abstract 88460z, & Stud. Org. Chem. (Amsterdam) 1984, 18 (Bio-Org. Heterocycl.), 363-6 *

Also Published As

Publication number Publication date
CA2002414A1 (en) 1990-05-15
WO1990005523A2 (en) 1990-05-31
AU4488989A (en) 1990-06-12

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