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WO1989010736A1 - Matieres dentaires antibacteriennes - Google Patents

Matieres dentaires antibacteriennes Download PDF

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Publication number
WO1989010736A1
WO1989010736A1 PCT/SE1989/000253 SE8900253W WO8910736A1 WO 1989010736 A1 WO1989010736 A1 WO 1989010736A1 SE 8900253 W SE8900253 W SE 8900253W WO 8910736 A1 WO8910736 A1 WO 8910736A1
Authority
WO
WIPO (PCT)
Prior art keywords
chlorhexidine
antibacterial
resin
slowly released
restorative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/SE1989/000253
Other languages
English (en)
Inventor
Dan W. Ericson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO1989010736A1 publication Critical patent/WO1989010736A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
    • A61K6/69—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/30—Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
    • A61K6/887—Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A61K6/889—Polycarboxylate cements; Glass ionomer cements

Definitions

  • the present invention concerns a group of dental restorative and luting cements which have been combined with antibacterial compounds and thereby have achieved an increased antibacterial activity against oral microorganisms.
  • the cements can be based on glasspolyalkenoats or dental composite resins, to be applied in thicker layers compared to a varnish, thereby containing a larger amount of anitbacterial compounds.
  • the antibacterial compound(s) are leaking from the cement(s) which have been made soluble in oral fluids, having the properties of a matrix that allow sustained release of a drug.
  • Dental caries and perfodontitis are caused by microbial plaques on the tooth surfaces.
  • Bacteria belonging to the Streptococus mutans group are strongly associated with the developement of caries.
  • These microorganisms are highly sensitive to chlorhexidine in various forms as chlorhexidine-gluconate, chlorhexidine-acetate and chlorhexidine-hydrochloride.
  • the present invention is a thicker layer of resin or cement as carrier, which can contain substantially more chlorhexidine or other antibacterial compunds compared to a convetional varnish.
  • the present invention describes a dental cement that is in contrast to the above, highly soluble in oral fluids and will dissolve after 1-4 weeks on the teeth.
  • This important feature of the material will give a delivery system were a high concentration of an antibacterial compound is combined with a dissolving carrier, it is not an advantage to either have a non-soluble carrier (2) or lower concentration (1 ) of antibacterial compounds if one is aiming at eliminating mutans streptococci from the teeth, as in a profylactic approach towards the treatment of dental caries.
  • a restorative material is permanently placed in a cavity, the damage in terms of a cavity has already been done.
  • a non-soluble material is placed on sound dental surfaces, eventually, it will lose its antibacterial properties and become a retention site for microorganisms and increase the risk of disease.
  • the present invention can be described by the following example.
  • Glasspolyalkenoate materials such as a restorative cement (Chemfil, De Trey Dentsply Ltd, England) or a luting cement AquaCem (De Trey Dentsply) are mixed with water containing various amounts of chlorhexidine gluconate or acetate rangeing from 0 to 20 per cent.
  • Discs are made and placed on agar medium containing an inoculum of mutans streptococci or lactobacilli. After incubation, an inhibition zone is seen around the discs corresponding to the amount of chlorhexidine present in the disc. The same discs are transferred to freshly inoculated agar plates repeatedlty, until their antibacterial properties are lost.
  • the addition of chlorhexidine gives a clear dose-response inhibition of the bacterial growth.
  • the antibacterial effect is maintained through at least 15 changes of freshly inoculated bacteria with 48 hours of incubation each time. A corresponding antibacterial effect is seen when bacteria are grown in a broth medium and incubated with the chlorhexidine containing discs.
  • the high fluoride content is also important as a caries preventive measure.
  • the chlorhexidine is relased from the discs as determined by spectrophotometric measurements at 251 nm.
  • the glasspolyalkenoates has the advantage of containing a substantial amount of fluoride which is also released from the material, making the tooth structures less susceptible to decay.

Landscapes

  • Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Dental Preparations (AREA)

Abstract

La présente invention concerne un groupe de ciments de reconstitution dentaire et de lutage qui ont été combinés avec des composés antibactériens et de ce fait présentent une activité antibactérienne accrue contre les microorganismes buccaux. Ces ciments peuvent être à base de polyalcenoats de verre ou de résines composites dentaires, et s'appliquent en couches épaisses comparé à un vernis, renfermant ainsi une plus grande quantité de composés antibactériens. Le ou les composés antibactériens s'échappent du ou des ciments qui ont été rendus solubles dans des fluides buccaux et présentent les caractéristiques d'une matrice permettant la libération étalée d'un médicament.
PCT/SE1989/000253 1988-05-06 1989-05-05 Matieres dentaires antibacteriennes Ceased WO1989010736A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8801719A SE8801719D0 (sv) 1988-05-06 1988-05-06 Antibakteriella tandfyllnads- och cementeringsmaterial
SE8801719-9 1988-05-06

Publications (1)

Publication Number Publication Date
WO1989010736A1 true WO1989010736A1 (fr) 1989-11-16

Family

ID=20372255

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE1989/000253 Ceased WO1989010736A1 (fr) 1988-05-06 1989-05-05 Matieres dentaires antibacteriennes

Country Status (2)

Country Link
SE (1) SE8801719D0 (fr)
WO (1) WO1989010736A1 (fr)

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0357327A3 (fr) * 1988-08-25 1990-10-03 National Research Development Corporation Dispositif de libération retardée
DE4019617A1 (de) * 1990-06-20 1992-01-02 Thera Ges Fuer Patente Implantierbares wirkstoffdepotmaterial
US5156835A (en) * 1987-01-30 1992-10-20 Colgate-Palmolive Company Antibacterial antiplaque oral composition
US5178851A (en) * 1987-01-30 1993-01-12 Colgate-Palmolive Company Antiplaque antibacterial oral composition
US5180578A (en) * 1987-01-30 1993-01-19 Colgate-Palmolive Company Antibacterial antiplaque anticalculus oral composition
US5188821A (en) * 1987-01-30 1993-02-23 Colgate-Palmolive Company Antibacterial antiplaque oral composition mouthwash or liquid dentifrice
US5192530A (en) * 1987-01-30 1993-03-09 Colgate-Palmolive Company Antibacterial antiplaque oral composition
US5192531A (en) * 1988-12-29 1993-03-09 Colgate-Palmolive Company Antibacterial antiplaque oral composition
WO1997047272A1 (fr) * 1996-06-14 1997-12-18 Minnesota Mining And Manufacturing Company Cement a base de ionomere et de verre
DE19813686A1 (de) * 1998-03-27 1999-09-30 Roeko Gmbh & Co Antibakteriell wirksames Mittel zur Behandlung oder zum Füllen von Wurzelkanälen und Herstellungsverfahren
WO1999042080A3 (fr) * 1998-02-19 1999-10-07 Oraceutical Llc Compositions durcissables avec des proprietes antimicrobinnes
WO2001074321A3 (fr) * 2000-04-03 2002-05-16 Chx Technologies Inc Utilisation de la chlorhexidine pour la prevention de la carie du cement
US6494717B1 (en) * 1998-09-24 2002-12-17 Advantage Dental Products, Inc. Calcified tissue facing preparation containing an antimicrobial agent
WO2003105785A1 (fr) * 2002-06-12 2003-12-24 Stick Tech Oy Preimpregne antimicrobien, materiau composite et utilisation de ceux-ci
US6726899B2 (en) 1998-09-24 2004-04-27 Advantage Dental Products, Inc. Calcified tissue facing preparation containing antimicrobial agent
EP2384733A1 (fr) 2010-05-07 2011-11-09 Ivoclar Vivadent AG Matières dentaires antimicrobiennes
US20130303622A1 (en) * 2010-04-05 2013-11-14 Uniao Brasileira De Educacao E Assistencia Mantenedora Da Puc Rs Aqueous anti-microbial solution containing chlorhexidine digluconate and tartaric acid, method for preparing same, and anti-microbial orthodontic cement
US8933147B2 (en) 2005-11-17 2015-01-13 3M Innovative Properties Company Anti-microbial dental impression material

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0128655A2 (fr) * 1983-05-11 1984-12-19 The University Of Toronto Innovations Foundation Vernis dentaires antimicrobiens contenant de la benzoine
EP0140766A2 (fr) * 1983-10-07 1985-05-08 The Forsyth Dental Infirmary For Children Appareil intra-alvéolaire pour l'administration d'agents actifs pour le traitement des maladies périodontales
EP0223245A2 (fr) * 1985-11-21 1987-05-27 Mitsui Petrochemical Industries, Ltd. Compositions pouvant être durcies à libération prolongée pour agents actifs dentaires
EP0243002A2 (fr) * 1986-03-25 1987-10-28 Rohto Pharmaceutical Co., Ltd. Composition pharmaceutique pour le traitement de maladies péridontales
EP0264660A2 (fr) * 1986-10-11 1988-04-27 Ivoclar AG Utilisation d'un matériau dentaire pour combattre les caries et la paradontose

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0128655A2 (fr) * 1983-05-11 1984-12-19 The University Of Toronto Innovations Foundation Vernis dentaires antimicrobiens contenant de la benzoine
EP0140766A2 (fr) * 1983-10-07 1985-05-08 The Forsyth Dental Infirmary For Children Appareil intra-alvéolaire pour l'administration d'agents actifs pour le traitement des maladies périodontales
EP0223245A2 (fr) * 1985-11-21 1987-05-27 Mitsui Petrochemical Industries, Ltd. Compositions pouvant être durcies à libération prolongée pour agents actifs dentaires
EP0243002A2 (fr) * 1986-03-25 1987-10-28 Rohto Pharmaceutical Co., Ltd. Composition pharmaceutique pour le traitement de maladies péridontales
EP0264660A2 (fr) * 1986-10-11 1988-04-27 Ivoclar AG Utilisation d'un matériau dentaire pour combattre les caries et la paradontose

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, Vol. 99, (1983), abstract no. 99:181435h, J. Oral Rehabil. 1983, 10(5), 373-81 (Eng). *

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5156835A (en) * 1987-01-30 1992-10-20 Colgate-Palmolive Company Antibacterial antiplaque oral composition
US5178851A (en) * 1987-01-30 1993-01-12 Colgate-Palmolive Company Antiplaque antibacterial oral composition
US5180578A (en) * 1987-01-30 1993-01-19 Colgate-Palmolive Company Antibacterial antiplaque anticalculus oral composition
US5188821A (en) * 1987-01-30 1993-02-23 Colgate-Palmolive Company Antibacterial antiplaque oral composition mouthwash or liquid dentifrice
US5192530A (en) * 1987-01-30 1993-03-09 Colgate-Palmolive Company Antibacterial antiplaque oral composition
EP0357327A3 (fr) * 1988-08-25 1990-10-03 National Research Development Corporation Dispositif de libération retardée
US5192531A (en) * 1988-12-29 1993-03-09 Colgate-Palmolive Company Antibacterial antiplaque oral composition
DE4019617A1 (de) * 1990-06-20 1992-01-02 Thera Ges Fuer Patente Implantierbares wirkstoffdepotmaterial
WO1997047272A1 (fr) * 1996-06-14 1997-12-18 Minnesota Mining And Manufacturing Company Cement a base de ionomere et de verre
US6136885A (en) * 1996-06-14 2000-10-24 3M Innovative Proprerties Company Glass ionomer cement
WO1999042080A3 (fr) * 1998-02-19 1999-10-07 Oraceutical Llc Compositions durcissables avec des proprietes antimicrobinnes
US6281265B1 (en) 1998-02-19 2001-08-28 Salim A. Nathoo Curable compositions with antimicrobial properties
DE19813686A1 (de) * 1998-03-27 1999-09-30 Roeko Gmbh & Co Antibakteriell wirksames Mittel zur Behandlung oder zum Füllen von Wurzelkanälen und Herstellungsverfahren
EP0951893A3 (fr) * 1998-03-27 2001-09-05 ROEKO GmbH + Co. Dentalerzeugnisse Produit antibactérien pour l'obturation des canaux des racines dentaires et son procédé de préparation
US6494717B1 (en) * 1998-09-24 2002-12-17 Advantage Dental Products, Inc. Calcified tissue facing preparation containing an antimicrobial agent
US6726899B2 (en) 1998-09-24 2004-04-27 Advantage Dental Products, Inc. Calcified tissue facing preparation containing antimicrobial agent
EP1123060A4 (fr) * 1998-09-24 2005-03-16 Advantage Dental Products Inc Preparation d'incrustation vestibulaire pour tissus calcifies contenant un agent bactericide
WO2001074321A3 (fr) * 2000-04-03 2002-05-16 Chx Technologies Inc Utilisation de la chlorhexidine pour la prevention de la carie du cement
WO2003105785A1 (fr) * 2002-06-12 2003-12-24 Stick Tech Oy Preimpregne antimicrobien, materiau composite et utilisation de ceux-ci
US8933147B2 (en) 2005-11-17 2015-01-13 3M Innovative Properties Company Anti-microbial dental impression material
US20130303622A1 (en) * 2010-04-05 2013-11-14 Uniao Brasileira De Educacao E Assistencia Mantenedora Da Puc Rs Aqueous anti-microbial solution containing chlorhexidine digluconate and tartaric acid, method for preparing same, and anti-microbial orthodontic cement
EP2384733A1 (fr) 2010-05-07 2011-11-09 Ivoclar Vivadent AG Matières dentaires antimicrobiennes

Also Published As

Publication number Publication date
SE8801719D0 (sv) 1988-05-06

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