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WO1988003952A3 - Glycopeptides immunogeniques du cytomegalovirus humain - Google Patents

Glycopeptides immunogeniques du cytomegalovirus humain Download PDF

Info

Publication number
WO1988003952A3
WO1988003952A3 PCT/US1987/003041 US8703041W WO8803952A3 WO 1988003952 A3 WO1988003952 A3 WO 1988003952A3 US 8703041 W US8703041 W US 8703041W WO 8803952 A3 WO8803952 A3 WO 8803952A3
Authority
WO
WIPO (PCT)
Prior art keywords
hcmv
monoclonal antibody
human cytomegalovirus
hybridoma
adenovirus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1987/003041
Other languages
English (en)
Other versions
WO1988003952A2 (fr
Inventor
Nancy O Lussenhop
Bruce E Kari
Richard C Gehrz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Childrens Hospital Inc
Original Assignee
Childrens Hospital Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Hospital Inc filed Critical Childrens Hospital Inc
Priority to JP88500947A priority Critical patent/JPH02500951A/ja
Publication of WO1988003952A2 publication Critical patent/WO1988003952A2/fr
Publication of WO1988003952A3 publication Critical patent/WO1988003952A3/fr
Priority to FI892539A priority patent/FI892539A0/fi
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/085—Herpetoviridae, e.g. pseudorabies virus, Epstein-Barr virus
    • C07K16/089—Cytomegalovirus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Anticorps monoclonal produit par un procédé consistant à (a) immuniser une souris avec des virions du HCMV; (b) fusionner des cellules de rate provenant de ladite souris avec des cellules provenant d'une lignée de myélomes pour produire des hybridomes; (c) sélectionner à partir desdits hybridomes un hybridome produisant un anticorps monoclonal (i) qui est réactif avec le HCMV, mais ne réagit pas avec l'herpès simplex, l'adénovirus, le virus d'Epstein Barr ou le virus Varicella, et dans lequel ledit anticorps monoclonal est capable de neutraliser le HCMV, ou (ii) qui est réactif avec le HCMV, l'herpès simplex et l'adénovirus, et lequel anticorps est capable de neutraliser le HCMV en l'absence de complément; et (d) à réaliser l'expansion clonale dudit hybridome.
PCT/US1987/003041 1986-11-24 1987-11-18 Glycopeptides immunogeniques du cytomegalovirus humain Ceased WO1988003952A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP88500947A JPH02500951A (ja) 1986-11-24 1987-11-18 ヒトサイトメガロウイルスの免疫原性糖ペプチド
FI892539A FI892539A0 (fi) 1986-11-24 1989-05-24 Immunogena glykopeptider av humant sytomegalovirus.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93378986A 1986-11-24 1986-11-24
US933,789 1986-11-24

Publications (2)

Publication Number Publication Date
WO1988003952A2 WO1988003952A2 (fr) 1988-06-02
WO1988003952A3 true WO1988003952A3 (fr) 1988-11-17

Family

ID=25464508

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1987/003041 Ceased WO1988003952A2 (fr) 1986-11-24 1987-11-18 Glycopeptides immunogeniques du cytomegalovirus humain

Country Status (6)

Country Link
US (1) US5126130A (fr)
EP (1) EP0332659A1 (fr)
JP (1) JPH02500951A (fr)
AU (1) AU603640B2 (fr)
FI (1) FI892539A0 (fr)
WO (1) WO1988003952A2 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5153311A (en) * 1986-11-24 1992-10-06 The Children's Hospital, Incorporated Immunogenic glycoproteins of human cytomegalovirus gCII
JPH02504551A (ja) * 1987-08-07 1990-12-20 ザ・チルドレンズ・ホスピタル，インコーポレイテッド サイトメガロウイルスの糖タンパク質ａと反応性のモノクローナル抗体
US5547834A (en) * 1988-01-29 1996-08-20 Chiron Corporation Recombinant CMV neutralizing proteins
EP0436537A4 (en) 1988-01-29 1992-04-08 Chiron Corporation Recombinant cmv neutralizing proteins
AU3283789A (en) * 1988-02-22 1989-09-06 Children's Hospital Incorporated, The Immunogenic glycoproteins of human cytomegalovirus
AU3849989A (en) * 1988-07-01 1990-01-23 Children's Hospital Incorporated, The Antibody recognition of fragments from cytomegalovirus
WO1991004277A1 (fr) * 1989-09-14 1991-04-04 Children's Biomedical Research Institute Anticorps monoclonaux specifiques contre une glycoproteine de cytomegalovirus
DE69531148T2 (de) * 1994-01-31 2004-04-29 Trustees Of Boston University, Boston Bibliotheken aus polyklonalen antikörpern
US6376170B1 (en) 1994-10-03 2002-04-23 The Scripps Research Institute Ligand capture-directed selection of antibody
KR20070038556A (ko) * 2004-07-20 2007-04-10 심포젠 에이/에스 항-ｒｈｅｓｕｓ ｄ 재조합 폴리클로날 항체 및 이의 제조방법
WO2006007853A2 (fr) * 2004-07-20 2006-01-26 Symphogen A/S Procedure de caracterisation structurelle d'une proteine polyclonale recombinee ou d'une lignee de cellules polyclonales
EP1963367A4 (fr) * 2005-12-06 2009-05-13 Amgen Inc Etapes de polissage dans des traitements de purification de proteines a etapes multiples
GB0700133D0 (en) 2007-01-04 2007-02-14 Humabs Llc Human cytomegalovirus neutralising antibodies and use thereof
US7947274B2 (en) * 2007-01-04 2011-05-24 Humabs, LLC. Human cytomegalovirus neutralising antibodies and use thereof
US8956823B2 (en) * 2007-08-20 2015-02-17 Bio-Rad Laboratories, Inc. Anti-antibody reagent
CA2734139C (fr) 2007-10-02 2019-12-24 Avaxia Biologics, Inc. Therapie aux anticorps pour une utilisation dans le tube digestif
CN103980363B (zh) * 2008-07-16 2017-04-12 生物医学研究学会 人巨细胞病毒中和抗体及其应用
PL2488202T3 (pl) 2009-10-15 2015-12-31 Avaxia Biologics Inc Przeciwciała terapeutyczne o aktywności miejscowej w przewodzie pokarmowym
WO2011076883A1 (fr) 2009-12-23 2011-06-30 4-Antibody Ag Eléments de liaison pour cytomégalovirus humain

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3959466A (en) * 1974-04-15 1976-05-25 The Wistar Institute Highly attenuated cytomegalovirus vaccine and production thereof
US4783399A (en) * 1984-05-04 1988-11-08 Scripps Clinic And Research Foundation Diagnostic system for the detection of cytomegalovirus
EP0180266B1 (fr) * 1984-10-29 1989-11-23 Shell Internationale Researchmaatschappij B.V. Procédé d'alkoxylation utilisant un catalyseur oxo bimétallique
DE3650032T2 (de) * 1985-12-06 1995-03-09 Teijin Ltd Anticytomegaloviraler menschlicher monoklonaler antikörper und dessen herstellung.
DE3619720A1 (de) * 1986-06-12 1987-12-17 Behringwerke Ag Hauptglykoprotein des menschlichen cytomegalovirus, seine herstellung und verwendung

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Biological Abstracts, volume 80, no. 12, 1985 (Philadelphia, PA., US), E.A. Shuster et al.: "Monoclonal antibody for rapid laboratory detection of cytomegalovirus infections: Characterization and diagnostic application" see page AB-409, abstract 104527, & Mayo. Clin. Proc. 60(9): 577-585, 1985 *
Biological Abstracts, volume 82, no. 11, 1986, (Philadelphia, PA., US) K.S. Kim et al.: "Confirmation of human cytomegalovirus by reverse passive hemagglutination with monoclonal antibodies reactive to the major glycosylated peptide (GP-66)", see page AB-546 - AB-547, abstract 103521 & J. Clin. Microbiol. 24(3): 474-477, 1986 *
Biological Abstracts, volume 82, no. 6, 1986, (Philadelphia, PA., US), Y.I. Matsumoto et al.: "Generation of hybridomas producing human monoclonal antibodies against human cytomegalovirus", see page AB-192, abstract 51594, & Biochem. Biophys. Res. Comm. 137(1): 273-280, 1986 *

Also Published As

Publication number Publication date
AU1107188A (en) 1988-06-16
FI892539A7 (fi) 1989-05-24
EP0332659A1 (fr) 1989-09-20
AU603640B2 (en) 1990-11-22
JPH02500951A (ja) 1990-04-05
WO1988003952A2 (fr) 1988-06-02
FI892539A0 (fi) 1989-05-24
US5126130A (en) 1992-06-30

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