[go: up one dir, main page]

WO1988003150A3 - Preparations aminoacides contenant des peptides de n,n'-bis-l-aminoacide-l-cystine et destinees a l'administration orale et parenterale - Google Patents

Preparations aminoacides contenant des peptides de n,n'-bis-l-aminoacide-l-cystine et destinees a l'administration orale et parenterale Download PDF

Info

Publication number
WO1988003150A3
WO1988003150A3 PCT/EP1987/000631 EP8700631W WO8803150A3 WO 1988003150 A3 WO1988003150 A3 WO 1988003150A3 EP 8700631 W EP8700631 W EP 8700631W WO 8803150 A3 WO8803150 A3 WO 8803150A3
Authority
WO
WIPO (PCT)
Prior art keywords
amino acid
cystine
oral
bis
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1987/000631
Other languages
German (de)
English (en)
Other versions
WO1988003150A2 (fr
Inventor
Peter Stehle
Peter Fuerst
Werner Fekl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfrimmer and Co Pharmazeutische Werke Erlangen GmbH and Co KG
Original Assignee
Pfrimmer and Co Pharmazeutische Werke Erlangen GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfrimmer and Co Pharmazeutische Werke Erlangen GmbH and Co KG filed Critical Pfrimmer and Co Pharmazeutische Werke Erlangen GmbH and Co KG
Publication of WO1988003150A2 publication Critical patent/WO1988003150A2/fr
Publication of WO1988003150A3 publication Critical patent/WO1988003150A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Confectionery (AREA)
  • Cosmetics (AREA)

Abstract

Les peptides de N,N'-bis-L-aminoacide-L-cystine conviennent comme doneurs de cystine hydrosolubles dans des préparations orales ou parentérales aminoacides ou oligopeptidiques, car ils se désintègrent rapidement dans l'organisme en dépit de leur stabilité lors de la stérilisation à chaud. Les nouveaux tripeptides de cystine dans lesquels la cystine est substituée par deux aminoacides avec au moins 3 atomes de carbone, peuvent être fabriqués de manière connue en soi à partir de cystéine par la méthode N-carboxy-anhydride et par oxydation pour obtenir le tripeptide de cystine.
PCT/EP1987/000631 1986-10-24 1987-10-23 Preparations aminoacides contenant des peptides de n,n'-bis-l-aminoacide-l-cystine et destinees a l'administration orale et parenterale Ceased WO1988003150A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3636334.0 1986-10-24
DE3636334 1986-10-24

Publications (2)

Publication Number Publication Date
WO1988003150A2 WO1988003150A2 (fr) 1988-05-05
WO1988003150A3 true WO1988003150A3 (fr) 1988-07-14

Family

ID=6312449

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1987/000631 Ceased WO1988003150A2 (fr) 1986-10-24 1987-10-23 Preparations aminoacides contenant des peptides de n,n'-bis-l-aminoacide-l-cystine et destinees a l'administration orale et parenterale

Country Status (9)

Country Link
US (1) US4968696A (fr)
EP (1) EP0264953B1 (fr)
JP (1) JPH01501706A (fr)
AT (1) ATE63316T1 (fr)
AU (1) AU605214B2 (fr)
DE (1) DE3769910D1 (fr)
ES (1) ES2039402T3 (fr)
GR (1) GR3001922T3 (fr)
WO (1) WO1988003150A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT402931B (de) * 1986-11-07 1997-09-25 Pharmacia Gmbh Verfahren zur herstellung von neuen cystinverbindungen und derenverwendung
US5102871A (en) * 1989-04-24 1992-04-07 Kyowa Hakko Kogyo Co., Ltd. Nutrient composition
DK53191D0 (da) * 1991-03-25 1991-03-25 Carlbiotech Ltd As Organosvovlforbindelse og farmaceutisk praeparat indeholdende en saadan forbindelse
SG46640A1 (en) * 1991-11-29 1998-02-20 Hoechst Ag Peptides with an insulin like action
FR2711529B1 (fr) * 1993-10-28 1996-07-05 Clintec Nutrition Cy Composition à base d'acides aminés destinée au traitement d'une infection ou d'une agression engendrant une réaction inflammatoire, chez les animaux et chez l'homme.
FR2872042B1 (fr) * 2004-06-29 2006-09-15 Soc Extraction Principes Actif Utilisation d'un dipeptide dimerise en tant qu'agent actif dans ou pour la preparation une composition cosmetique et/ou dermatologique
JP5668271B2 (ja) * 2008-12-25 2015-02-12 ユーハ味覚糖株式会社 シスチン−アミノ酸複合体及びその製造方法
US20110262965A1 (en) 2010-04-23 2011-10-27 Life Technologies Corporation Cell culture medium comprising small peptides
US20130130317A1 (en) 2010-08-02 2013-05-23 Kyowa Hakko Kirin Co., Ltd Method for producing substance
EP4138771B1 (fr) * 2020-04-20 2024-03-06 Evonik Operations GmbH Compositions comprenant des peptides cys

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL245033A (fr) * 1900-01-01
US3794633A (en) * 1969-12-16 1974-02-26 Ciba Geigy Corp Process for the manufacture of peptides containing cystine
US3875136A (en) * 1971-07-07 1975-04-01 Ciba Geigy Corp Process for the manufacture of peptides containing cystine
US4284624A (en) * 1980-05-02 1981-08-18 E. R. Squibb & Sons, Inc. Mixed disulfides
EP0087750A2 (fr) * 1982-02-25 1983-09-07 Kabi Pharmacia GmbH Préparation d'aminoacides contenant des restes glutaminiques
EP0128249A2 (fr) * 1982-06-08 1984-12-19 Smithkline Beckman Corporation Disulfides précurseurs de médicaments anti-microbiaux

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4258193A (en) * 1978-07-13 1981-03-24 Toyo Jozo Kabushiki Kaisha Disulfide derivatives having S--S exchange reactivity

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL245033A (fr) * 1900-01-01
US3794633A (en) * 1969-12-16 1974-02-26 Ciba Geigy Corp Process for the manufacture of peptides containing cystine
US3875136A (en) * 1971-07-07 1975-04-01 Ciba Geigy Corp Process for the manufacture of peptides containing cystine
US4284624A (en) * 1980-05-02 1981-08-18 E. R. Squibb & Sons, Inc. Mixed disulfides
EP0087750A2 (fr) * 1982-02-25 1983-09-07 Kabi Pharmacia GmbH Préparation d'aminoacides contenant des restes glutaminiques
EP0128249A2 (fr) * 1982-06-08 1984-12-19 Smithkline Beckman Corporation Disulfides précurseurs de médicaments anti-microbiaux

Also Published As

Publication number Publication date
WO1988003150A2 (fr) 1988-05-05
DE3769910D1 (de) 1991-06-13
JPH01501706A (ja) 1989-06-15
AU8230187A (en) 1988-05-25
EP0264953A2 (fr) 1988-04-27
EP0264953A3 (en) 1988-08-31
EP0264953B1 (fr) 1991-05-08
ATE63316T1 (de) 1991-05-15
ES2039402T3 (es) 1993-10-01
GR3001922T3 (en) 1992-11-23
US4968696A (en) 1990-11-06
AU605214B2 (en) 1991-01-10

Similar Documents

Publication Publication Date Title
AU7609687A (en) Agents for the treatment of arthroses
DK119785D0 (da) Insulinpraeparat
GR3029791T3 (en) Improved immunogenic compositions against human gastrin 17
UA39158C2 (uk) Похідні n4-оксикарбоніл-5'-дезокси-5-фторцитидину та фармацевтичний препарат на їх основі
AU8230187A (en) N,n'-bis-amino acid-l-cystine-peptide-containing amino acid preparations for oral and parenteral administration
BG97123A (bg) Производни на човешка, стимулирана от жлъчните соли, липаза и фармацевтични състави на тяхна основа
DK0714910T3 (da) Anvendelse af et decapeptid med aktivitet af benzodiazepintype til fremstilling af medikamenter og kosttilskud
GR900100535A (en) Substituted 2-imidazolines and preparation and use thereof
DE69102069D1 (de) 5-aminosalicylsäurederivate zur therapie chronisch entzündlicher baucherkrankungen.
EP0234348A3 (en) N-glycosyl amide derivatives, method for their preparation and their use as medicaments
AU3364289A (en) Process for the preparation of 5-membered nitrogen-containingheteroaromatics
AU9625498A (en) Organ specific nutrition
NZ228023A (en) 24(r)-scymnol; preparatory processes and pharmaceutical compositions
EP0490383A3 (en) Peptides of the hiv-gag protein, their preparation and use
EP0791350A3 (fr) Composition pour l'ondulation permanente des cheveux humains
DK0423326T3 (da) Hidtil ukendt fysiologisk aktivt peptid og calcium-metabolisme-regulerende middel, der omfatter peptidet som effektiv besta
DE69534740D1 (en) Analoge des thymosin alpha 1
IE873332L (en) Substantially pure enxyme-antibody conjugate preparations.
ES2015772A6 (es) Procedimiento e obtencion de nuevos derivados del 5-fluorouracilo, concretamente los n1-acil-sustituidos-n3-orto-toluil-5-fluorouracilo.
IT1254688B (it) Composizioni farmaceutiche somministrabili per via orale a rilascio mirato contenenti acido ursodesossicolico ed acido chenodesossicolico.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU JP US

AK Designated states

Kind code of ref document: A3

Designated state(s): AU JP US