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WO1987003278A3 - Procedes de synthese pour obtenir des derives d'acide cyclopentanecarboxylique - Google Patents

Procedes de synthese pour obtenir des derives d'acide cyclopentanecarboxylique Download PDF

Info

Publication number
WO1987003278A3
WO1987003278A3 PCT/EP1986/000678 EP8600678W WO8703278A3 WO 1987003278 A3 WO1987003278 A3 WO 1987003278A3 EP 8600678 W EP8600678 W EP 8600678W WO 8703278 A3 WO8703278 A3 WO 8703278A3
Authority
WO
WIPO (PCT)
Prior art keywords
acid derivatives
synthetic routes
cyclopentanecarboxylic acid
cyclohexane
cyclopentane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1986/000678
Other languages
English (en)
Other versions
WO1987003278A1 (fr
WO1987003278A2 (fr
Inventor
Laurence John Nummy
H Glenn Corkins
Louis S Scarano
Dennis P Byrne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of WO1987003278A1 publication Critical patent/WO1987003278A1/fr
Publication of WO1987003278A2 publication Critical patent/WO1987003278A2/fr
Publication of WO1987003278A3 publication Critical patent/WO1987003278A3/fr
Priority to DK390787A priority Critical patent/DK390787D0/da
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Une méthode de contraction de cycles est appliquée à la préparation de dérivés de cyclopentane, notamment d'acide 2,2,5,5-tétraméthylcyclopentanecarboxylique à partir de composés de cyclohexane. Dans un aspect, une diazocétone de cyclohexane est mise en réaction avec une amine (par exemple un ester d'alanine) pour former l'amide correspondant d'acide de cyclopentane.
PCT/EP1986/000678 1985-11-27 1986-11-25 Procedes de synthese pour obtenir des derives d'acide cyclopentanecarboxylique Ceased WO1987003278A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK390787A DK390787D0 (da) 1985-11-27 1987-07-27 Cyklopentancarboxylderivater og fremgangsmaade til fremstilling deraf

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80248185A 1985-11-27 1985-11-27
US802,481 1985-11-27

Publications (3)

Publication Number Publication Date
WO1987003278A1 WO1987003278A1 (fr) 1987-06-04
WO1987003278A2 WO1987003278A2 (fr) 1987-06-04
WO1987003278A3 true WO1987003278A3 (fr) 1987-07-02

Family

ID=25183817

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1986/000678 Ceased WO1987003278A2 (fr) 1985-11-27 1986-11-25 Procedes de synthese pour obtenir des derives d'acide cyclopentanecarboxylique

Country Status (4)

Country Link
EP (1) EP0247199A1 (fr)
JP (1) JPS63501720A (fr)
IL (1) IL80577A0 (fr)
WO (1) WO1987003278A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2476505A (en) * 2009-12-23 2011-06-29 Univ Reading Process for the production of diketones

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3151986A (en) * 1962-05-02 1964-10-06 Monsanto Co Free-flowing fumaric and adipic acid compositions
FR1559131A (fr) * 1967-02-07 1969-03-07
EP0128654A2 (fr) * 1983-06-13 1984-12-19 Cumberland Packing Corporation Edulcorants dérivés de gem-diaminoalcanes
EP0196461A2 (fr) * 1985-03-01 1986-10-08 Kyowa Hakko Kogyo Co., Ltd. Dérivés de cyclopentane

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3151986A (en) * 1962-05-02 1964-10-06 Monsanto Co Free-flowing fumaric and adipic acid compositions
FR1559131A (fr) * 1967-02-07 1969-03-07
EP0128654A2 (fr) * 1983-06-13 1984-12-19 Cumberland Packing Corporation Edulcorants dérivés de gem-diaminoalcanes
EP0196461A2 (fr) * 1985-03-01 1986-10-08 Kyowa Hakko Kogyo Co., Ltd. Dérivés de cyclopentane

Non-Patent Citations (14)

* Cited by examiner, † Cited by third party
Title
Bulletin de la Societe Chimique de France, No. 9, 1966, A. MARQUET et al. : "Sur la Synthese de l'Acide (R) Trimethyl-1,2,2 Ceto-4 Cyclopentane Carboxylique", pages 2956-2959 see pages 2956: compounds 2,3; page 2957, right-hand column *
CHEMICAL ABSTRACTS, Volume 51, No. 21, 10 November 1957, (Columbus, Ohio, US), N.A. DOMNIN et al. : "Polymethylene Cycles. XXIII. Synthesis and Transformations of Dihydrazones of Cyclohexane- and Cyclo-Pentanediones", see column 16314, abstract c-g, & Zhur. Obshchei Khim. 27, 656-65 (1957) *
CHEMICAL ABSTRACTS, Volume 83, No. 11, 15 September 1975, (Columbus, Ohio, US), K. UEDA et al. : "Wolff Rearrangement of 2-Diazo-3,4-bis(Diphenylmethylene) Cyclobutanone into 1,2-bis(Diphenylmethylene)-Cyclopropanes", see page 526, Abstract 96649f, & Chem. Lett. 1975, (7), 779-80 *
J. Am. Chem. Soc., Volume 72, 1950, N.J. LEONARD et al. : "The Influence of Steric Configuration on the Ultra-Violet Absorption of 1,2-Diketones", pages 5388-5397 see page 5390 *
J. Am. Chem. Soc., Volume 80, 5 June 1958 D.D. COFFMAN et al.: "Syntheses of Free-Radical Reactions. I. Oxidative Coupling Effected by Hydroxyl Radicals" pages 2864-2872 see the whole document cited in the application *
J. Am. Chem. Soc., Volume 80, 5 June 1958, D.D. COFFMAN et al.: "Syntheses of Free-Radical Reactions. I. Oxidative Coupling Effected by Hydroxyl Radicals" pages2864-2872 see the whol document cited in the application *
J. Het. Chem., Volume 14, May 1977, J.T. CARLOCK et al.: "A Noteworthy Improvement of the 3-Diazo-4-Oxo-3,4-Dihydroquinoline Photosynthesis of Indole-3-Carboxamides", see pages 519-520 *
J. Org. Chem., Volume 45, No. 22, 1980, American Chemical Society, (US), J. ELZINGA et al.: "Synthesis and Chemistry of a Bicyclobutane-Bridged Alpha-Diazo Ketone" , pages 4337-4348, see page 4337: scheme 1; page 4346, left-hand column *
J. ZABICKY: "The Chemistry of the Carbonyl Group", Volume 2, 1970, Interscience Publishers, (London, GB), Chapter VI: "Other Enolic Carbonyl Compounds. B. Enediols", see pages 227-228 *
Methoden der Organischen Chemie (Houben-Weyl), 4th edition, Volume X/4, "Stickstoffverbindungen I, part 4, 1968, Georg Thieme Verlag, (Stuttgart, DE), pages 567-580 see pages 567, 568, 580 *
Organic Reactions, Volume 23, J.J. BLOOMFIELD et al. : "The Acyloin Condensation", pages 259-403: chapter 2 see pages 264 and 325 *
Organic Syntheses, Collective, Volume 2, John Wiley & Sons, Inc., (New York, US), J.M. SNELL et al. : "Butyroin", see pages 114-116 *
Tetrahedron Letters, No. 9, 1979, Pergamon Press Ltd, (GB) F. KAPLAN et al.: "Conformational Control of Decomposition Pathways of alpha-Diazoketones", pages 759-762 see the whole document *
Tetrahedron, Volume 36, No. 10, 1980, Pergamon Press Ltd, (Oxford, GB), J. TSUJI et al.: "Facile Oxidative Conversion of Hydrazides of Carboxylic Acids to Corresponding Acids, Esters and Amides using Copper Compounds", pages 1311-1315 see the whole document *

Also Published As

Publication number Publication date
EP0247199A1 (fr) 1987-12-02
IL80577A0 (en) 1987-02-27
WO1987003278A2 (fr) 1987-06-04
JPS63501720A (ja) 1988-07-14

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