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WO1987002666A3 - Bicyclic alkoxy- and alkylthio-substituted aminoalcohols - Google Patents

Bicyclic alkoxy- and alkylthio-substituted aminoalcohols Download PDF

Info

Publication number
WO1987002666A3
WO1987002666A3 PCT/EP1986/000595 EP8600595W WO8702666A3 WO 1987002666 A3 WO1987002666 A3 WO 1987002666A3 EP 8600595 W EP8600595 W EP 8600595W WO 8702666 A3 WO8702666 A3 WO 8702666A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkylthio
bicyclic alkoxy
substituted aminoalcohols
aminoalcohols
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1986/000595
Other languages
French (fr)
Other versions
WO1987002666A2 (en
Inventor
Giampaolo Picciola
Mario Riva
Franco Ravenna
Piergiorgio Gentili
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Maggioni Winthrop SpA
Original Assignee
Maggioni Winthrop SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858526913A external-priority patent/GB8526913D0/en
Priority claimed from GB868615561A external-priority patent/GB8615561D0/en
Application filed by Maggioni Winthrop SpA filed Critical Maggioni Winthrop SpA
Publication of WO1987002666A2 publication Critical patent/WO1987002666A2/en
Priority to DK314187A priority Critical patent/DK314187A/en
Priority to NO872702A priority patent/NO872702L/en
Priority to KR870700558A priority patent/KR870700609A/en
Publication of WO1987002666A3 publication Critical patent/WO1987002666A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/22—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Novel bicyclic alkoxy- and alkylthio-substituted aminoalcohols of formula (I). The compounds show anti-hypertensive, platelet aggregation inhibiting, hypolipemic, antianoxic, spasmolytic, antithrombotic, calcium antagonizing and neuroleptic activity.
PCT/EP1986/000595 1985-10-31 1986-10-18 Bicyclic alkoxy- and alkylthio-substituted aminoalcohols Ceased WO1987002666A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DK314187A DK314187A (en) 1985-10-31 1987-06-19 BICYCLIC ALCOXY AND ALKYLTHIO SUBSTITUTED AMINOAL ALCOHOLS
NO872702A NO872702L (en) 1985-10-31 1987-06-26 BICYCLIC ALCOXY AND ALKYL-TIO-SUBSTITUTED AMINOAL ALCOHOLS.
KR870700558A KR870700609A (en) 1985-10-31 1987-06-29 Bicyclic alkoxy and alkylthio-substituted amino alcohols

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8526913 1985-10-31
GB858526913A GB8526913D0 (en) 1985-10-31 1985-10-31 Amino-alcohols
GB868615561A GB8615561D0 (en) 1986-06-25 1986-06-25 Aminoalcohols
GB8615561 1986-06-25

Publications (2)

Publication Number Publication Date
WO1987002666A2 WO1987002666A2 (en) 1987-05-07
WO1987002666A3 true WO1987002666A3 (en) 1987-08-27

Family

ID=26289964

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1986/000595 Ceased WO1987002666A2 (en) 1985-10-31 1986-10-18 Bicyclic alkoxy- and alkylthio-substituted aminoalcohols

Country Status (5)

Country Link
KR (1) KR870700609A (en)
AU (1) AU6541686A (en)
DK (1) DK314187A (en)
GR (1) GR862624B (en)
WO (1) WO1987002666A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197833B1 (en) 1995-07-24 2001-03-06 Apollo Biopharmaceutics, Inc. Neuroprotective effects of polycyclic phenolic compounds
US5859001A (en) * 1996-01-11 1999-01-12 University Of Florida Research Foundation, Inc. Neuroprotective effects of polycyclic phenolic compounds
WO1997003661A1 (en) * 1995-07-24 1997-02-06 University Of Florida Research Foundation, Incorporated Use of non-estrogen polycyclic phenol compounds for the manufacture of a medicament for conferring neuroprotection to cells

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0092391A2 (en) * 1982-04-15 1983-10-26 Kyowa Hakko Kogyo Co., Ltd Novel piperidine derivatives and pharmaceutical compositions containing same
JPS60100542A (en) * 1983-11-07 1985-06-04 Otsuka Pharmaceut Factory Inc 1,4,5,8-tetraalkoxynaphthalene derivative
EP0076530B1 (en) * 1981-10-01 1985-12-11 Janssen Pharmaceutica N.V. Novel n-(3-hydroxy-4-piperidinyl)benzamide derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0076530B1 (en) * 1981-10-01 1985-12-11 Janssen Pharmaceutica N.V. Novel n-(3-hydroxy-4-piperidinyl)benzamide derivatives
EP0092391A2 (en) * 1982-04-15 1983-10-26 Kyowa Hakko Kogyo Co., Ltd Novel piperidine derivatives and pharmaceutical compositions containing same
JPS60100542A (en) * 1983-11-07 1985-06-04 Otsuka Pharmaceut Factory Inc 1,4,5,8-tetraalkoxynaphthalene derivative

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, Volume 103, No. 15, 14 October 1985, (Columbus, Ohio, US), see page 698, Abstract 123196w, & JP, A, 60100542 (Otsuka Pharmaceutical Factory, Inc.) 4 June 1985 *

Also Published As

Publication number Publication date
GR862624B (en) 1987-03-03
AU6541686A (en) 1987-05-19
DK314187D0 (en) 1987-06-19
WO1987002666A2 (en) 1987-05-07
KR870700609A (en) 1987-12-30
DK314187A (en) 1987-06-19

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